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CRISPR

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18.10.2019
10:06 Nature.ComRussian ‘CRISPR-baby’ scientist has started editing genes in eggs from a deaf woman

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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15.10.2019
23:43 News-Medical.NetCRISPR helps find difficult to detect cancer cells

Immunotherapy is one of the latest and most effective armaments against various types of cancers. Some of the immunotherapy drugs such as PD-1 inhibitor Keytruda from Merck can block certain proteins in the cancer cells that can make the cells invisible to the immune system normally. Some of the cancers cells can now develop other ways to disguise themselves from being killed by the immune system.

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23:20 LiveScience.comWidely Publicized Study on CRISPR Babies' Gene Mutation Now Retracted for Errors

A widely publicized study that suggested that the first gene-edited "CRISPR" babies could have shorter lifespans has been retracted due to crucial errors in the analysis.

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17:10 Phys.orgAAV vector integration into CRISPR-induced DNA breaks

To design safe clinical trials, it is crucial to better understand and predict gene editing outcomes in preclinical studies. Bence György and collaborators have shown that adeno-associated viruses (AAVs) can stably integrate into CRISPR-Cas9-induced double-strand breaks, in up to almost half of the therapeutically targeted cells, in vitro and in vivo in mice. The team also showed that CRISPR did not cause an increase in genome-wide integration of AAV, but only at the CRISPR-cut site.

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17:08 News-Medical.NetStudy suggesting that CRISPR babies are likely to die early has been retracted

A research paper that sparked concerns about the lifespan of China's first gene-edited babies has been retracted due to technical errors.

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14.10.2019
18:15 FierceBiotech.comMarrying CRISPR with immuno-oncology to defeat remote tumors

Yale scientists have combined the gene-editing system CRISPR with a type of gene therapy designed to help the immune system find tough-to-spot tumor cells. The technology showed promise in mouse models of triple-negative breast cancer, melanoma and pancreatic cancer.

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06:39 Nature.ComGeneticists retract study suggesting first CRISPR babies might die early

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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10.10.2019
21:51 ScienceDaily.comCRISPR enzyme programmed to kill viruses in human cells

Researchers have now turned a CRISPR RNA-cutting enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

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19:43 News-Medical.NetCRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

Many of the world's most common or deadly human pathogens are RNA-based viruses -- Ebola, Zika and flu, for example -- and most have no FDA-approved treatments.

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18:06 Phys.orgCRISPR enzyme programmed to kill viruses in human cells

Many of the world's most common or deadly human pathogens are RNA-based viruses—Ebola, Zika and flu, for example—and most have no FDA-approved treatments. A team led by researchers at the Broad Institute of MIT and Harvard has now turned a CRISPR RNA-cutting enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

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09.10.2019
19:00 Phys.orgCRISPR-BEST prevents genome instability

Even though CRISPR technologies allow for better manipulation of genomes with many positive effects on modern drug development and the discovery of new and better antibiotics, significant problems such as genome instability and toxicity of the Cas9 protein still remain when using the technology.

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18:19 ScienceDaily.comCRISPR-BEST prevents genome instability

Scientists have developed CRISPR-BEST, a new genome editing tool for actinomycetes. It addresses the problem of genome instability caused by DNA double-stranded breaks in current CRISPR-technologies.

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04.10.2019
19:02 ScienceDaily.comResearchers unlock potential to use CRISPR to alter the microbiome

Researchers have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on specific bacteria.

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17:44 Phys.orgResearchers unlock potential to use CRISPR to alter the microbiome

Researchers at Western University have developed a new way to deliver the DNA-editing tool CRISPR-Cas9 into microorganisms in the lab, providing a way to efficiently launch a targeted attack on specific bacteria.

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05:25 News-Medical.NetUC Davis researchers awarded $1.5 million NIH grant for CRISPR cancer treatment

What if, instead of killing cancer cells or cells about to become cancerous, you could deliver a repair package and fix them? UC Davis researchers have just been awarded $1.5 million from the National Institutes of Health to start work towards that goal.

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03.10.2019
19:24 Nature.ComDaily briefing: Scientists reconstruct butterfly evolutionary history with CRISPR

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02.10.2019
14:06 Technology.orgNew CRISPR-Cas9 variant may boost precision in gene editing

Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase

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01.10.2019
04:03 News-Medical.NetNew CRISPR-Cas9 variant has potential to increase precision during gene therapy

Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans.

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00:04 TechnologyReview.comPutin could decide for the world on CRISPR babies

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30.09.2019
22:03 Phys.orgNew CRISPR-Cas9 variant may boost precision in gene editing

Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play a role in gene therapies that require high precision. The study by researchers from Karolinska Institutet's Ming Wai Lau Centre of Reparative Medicine in Hong Kong is published in the journal PNAS.

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27.09.2019
20:55 DigitalTrends.comCRISPR-Cas9 gene editing could one day ‘turn off’ HIV virus in the body

A cure for HIV? Researchers from the UC San Diego School of Medicine have proposed a new genetic-sequencing approach that could provide a kill switch to clear out dormant HIV inside cells.

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00:40 News-Medical.NetResearcher aims to make CRISPR-Cas9 system safer and more precise

The mere mention of gene editing and DNA altering might conjure up images of designer babies, but that is not what researcher Jin Liu has in mind.

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25.09.2019
14:25 Phys.orgNew discoveries map out CRISPR-Cas defense systems in bacteria

For the first time ever, researchers at the University of Copenhagen have mapped how bacterial cells trigger their defense against outside attacks. This could affect how diseases are fought in the future.

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01:30 ScienceDaily.comNew CRISPR class expands genetic engineering toolbox

Biomedical engineers have used a previously unexplored CRISPR technology to accurately regulate and edit target genes in human cells. With this new approach, the researchers hope to dramatically expand the CRISPR-based tools available to biomedical engineers, opening up a new and diverse frontier of genome engineering technologies.

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24.09.2019
19:21 ScienceDaily.comNew discoveries map out CRISPR-Cas defense systems in bacteria

For the first time ever, researchers have mapped how bacterial cells trigger their defense against outside attacks. This could affect how diseases are fought in the future.

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11:50 Nature.ComCRISPR might be the banana’s only hope against a deadly fungus

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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23.09.2019
19:37 News-Medical.NetCRISPR discovery opens up new possibilities for genetic engineering

Scientists have successfully developed a different kind of CRISPR technology, opening up a world of possibility to future developments in the genetic engineering space

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18:03 FierceBiotech.comNew CRISPR approach could improve gene and cell therapies

Biomedical engineers at Duke are developing a new CRISPR system designed to alter the epigenome they believe could address some of the shortcomings of CRISPR-Cas9 and be used to perform many different genome engineering tasks simultaneously.

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18:03 Phys.orgNew CRISPR class expands genetic engineering toolbox

Biomedical engineers at Duke University have used a previously unexplored CRISPR technology to accurately regulate and edit genomes in human cells.

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19.09.2019
01:01 TechnologyReview.comCRISPR could help us cure sickle cell disease. But patients are wary.

How accessible would a cure be to the people who need it?

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18.09.2019
13:44 Technology.orgCRISPR portfolio now at 14 and counting

The U.S. Patent and Trademark Office (USPTO) today awarded the University of California (UC), University of Vienna and

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16.09.2019
15:57 Technology.orgScientists use CRISPR to Treat HIV for the First Time

The patient in question – a 27-year-old male citizen of China – was diagnosed with AIDS back in

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13.09.2019
19:12 News-Medical.NetCRISPR may explain why so many experimental cancer drugs fail

Scientists have used CRISPR–Cas9 to investigate how ten cancer drugs interact with their protein target, revealing some intriguing findings.

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10:02 CNN HealthChinese scientists use CRISPR tool on HIV patient for the first time

A Chinese team from Peking University have used gene editing tool CRISPR-Cas9 on a HIV patient for the first time. They managed to create stem cells resistant to the disease, but weren't able to cure him.

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12.09.2019
19:58 News-Medical.NetScientists attempt to cure HIV using CRISPR, with varying results

Scientists have used the gene-editing technology CRISPR in an attempt to cure a person infected with HIV, with some success.

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01:00 LiveScience.comChinese Scientists Tried to Treat HIV Using CRISPR

Scientists in China have attempted to use CRISPR gene-editing technology to treat a patient with HIV.

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11.09.2019
22:13 ScienceMag.orgSome cancer drugs miss their target. CRISPR could improve their aim

Method that generated drug leads may be flawed

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09.09.2019
16:40 Phys.orgGenome engineering with CRISPR/HDR to diversify the functions of hybridoma-produced antibodies

Bioengineers and life scientists incorporate hybridoma technology to produce large numbers of identical antibodies, and develop new antibody therapeutics and diagnostics. Recent preclinical and clinical studies on the technology highlight the importance of antibody isotypes for therapeutic efficacy. In a new study, a research team in Netherlands have developed a versatile Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and homology directed repair (HDR) platform to rapidly engineer immunoglobin domains and form recombinant hybridomas that secrete designer antibodies of a preferred format, species or isotype. In the study, Johan M. S. van der Schoot and colleagues at the interdisciplinary departments of immunology, proteomics, immunohematology, translational immunology and medical oncology, used the platform to form recombinant hybridomas, chimeras and mutants. The stable

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04.09.2019
17:48 SingularityHub.ComCellular Computers Get a Boost with CRISPR

Cancer’s impenetrable secrets partly rely on its mysterious molecular history. As cells turn to the dark side, a whirlwind of DNA changes gradually accumulate. Like flipping multiple interlinked light switches, the cell gradually changes its internal molecular operations, until its once-beneficial nature turns malevolent. Why, when, and how this sinister transformation happens is still unknown, […]

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15:38 ScientificAmerican.ComA CRISPR Doyen Discusses Gene-Editing Challenges

Jennifer Doudna, winner of the 2018 Kavli Prize in Nanoscience, talks to Scientific American about what it’s like to work in perhaps the hottest research area in all of biology. She also... -- Read more on ScientificAmerican.com

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03.09.2019
17:00 News-Medical.NetCRISPR-Cas9 successfully reverses type 2 diabetes in mice

Researchers have used CRISPR-Cas9 to treat obesity and type 2 diabetes in mice, a development that could eventually benefit humans.

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16:28 Phys.orgNovel CRISPR method identifies key genes for Toxoplasma survival

Using a new approach to genetic screening with CRISPR, researchers at the Crick have identified key genes for the survival of the parasite Toxoplasma gondii in mice.

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02.09.2019
18:49 News-Medical.NetSATI gene editing could replace CRISPR

Scientists have developed a new gene editing tool called SATI that is safer than CRISPR.

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01.09.2019
14:19 NewScientist.ComCRISPR could lead to gene-editing fix for a form of male infertility

Infertile male mice have fathered offspring after their condition was fixed by CRISPR – an approach that could help many couples with fertility problems

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10:27 NewScientist.ComGiant virus has evolved its own kind of CRISPR to destroy invaders

The massive mimivirus is so big it has its own kind of CRISPR-like immune system to defend against the tiny viruses that attack it

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29.08.2019
23:14 ScienceMag.orgForget single genes: CRISPR now cuts and splices whole chromosomes

New ability gives biologists tool to rework bacterial genomes in many ways

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27.08.2019
14:42 Phys.orgScientists zero in on cancer treatments using CRISPR

Chemotherapy works off of a basic premise: kill all rapidly-growing cells in an effort to wipe out tumor cells. The tactic, while generally effective, has quite a few off-target casualties, including cells that produce hair and cells that line the stomach.

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26.08.2019
22:03 FierceBiotech.comCRISPR slows the growth of triple-negative breast cancer in mice

A team of researchers at Boston Children's Hospital has developed an innovative way to knock out the oncogene Lipocalin 2 using the editing system CRISPR and has shown its potential for treating triple-negative breast tumors in mice.

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13:37 Technology.orgUsing CRISPR to program gels with new functions

The CRISPR genome-editing system is best-known for its potential to correct disease-causing mutations and add new genes into

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24.08.2019
16:21 ExtremeTech.comNew CRISPR Method Advances the Clock for Genetic Editing

Deoxyribonucleic acid (DNA) molecule, illustration. If genetic editing wasn't crazy enough for your reality, a recent breakthrough in CRISPR technology has paved the way for editing entire gene networks in a single step.
The post New CRISPR Method Advances the Clock for Genetic Editing appeared first on ExtremeTech.

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23.08.2019
16:51 ScienceDaily.comBiomaterials smarten up with CRISPR

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome. It is also being harnessed in ongoing diagnostic approaches for the detection of pathogens and disease-causing mutations in patients.

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14:49 Phys.orgUsing CRISPR to program gels with new functions

The CRISPR genome-editing system is best-known for its potential to correct disease-causing mutations and add new genes into living cells. Now, a team from MIT and Harvard University has deployed CRISPR for a completely different purpose: creating novel materials, such as gels, that can change their properties when they encounter specific DNA sequences.

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09:03 News-Medical.NetHarnessing power of CRISPR to control behavior of DNA-responsive materials

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome.

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22.08.2019
22:47 Nanowerk.comBiomaterials smarten up with CRISPR

Programmable CRISPR-responsive smart materials could open the door to novel tissue engineering, bioelectronic, and diagnostic applications.

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21:13 Nature.ComCRISPR cuts turn gels into biological watchdogs

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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21:05 Phys.orgBiomaterials smarten up with CRISPR

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome. It is also being harnessed in ongoing diagnostic approaches for the detection of pathogens and disease-causing mutations in patients.

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16:57 TechnologyReview.comThe next trick for CRISPR is gene-editing pain away

A family of street performers could walk on coals. Here’s how the secret of why they felt no pain could benefit others.

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19.08.2019
17:38 FierceBiotech.comNews of Note—Changing multiple genes with CRISPR; Accelerating recovery after chemo and radiation

The week’s biotech news included a modified form of CRISPR that can edit 25 genes at once; a drug that helps blood cells recover quickly from chemo and radiation; and a CRISPR system that can be used to study neurons.

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10:29 Technology.orgTweaked CRISPR in Neurons Gives Scientists New Power to Probe Brain Diseases

A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR

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18.08.2019
17:04 SingularityHub.ComInside China’s Play to Become the World’s CRISPR Superpower

In some ways, Hercules is pretty standard for the course where beagles are concerned. He likes to run around and generally looks as (borderline insanely) happy as any of his floppy-eared cousins across the world. However, when it comes to muscles, Hercules is to other beagles what a prime Arnold Schwarzenegger is to, well, me. […]

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15.08.2019
19:25 ScienceDaily.comTweaked CRISPR in neurons gives scientists new power to probe brain diseases

Researchers describe a technique that uses a special version of CRISPR to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.

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06:44 GizmagCRISPR breakthrough allows scientists to edit multiple genes simultaneously


We've seen a number of recent improvements to the CRISPR gene editing method, from enhanced precision to novel techniques to block the process. But despite all these innovations, the technique is generally only able to modify one single gene at a time. An incredible new breakthrough from scientists at ETH Zurich has, for the first time, demonstrated a new CRISPR method that can modify dozens of genes simultaneously, allowing for more large-scale cell reprogramming.
.. Continue Reading CRISPR breakthrough allows scientists to edit multiple genes simultaneously Category: Medical Tags: CRISPR ETH Zurich Genetics

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14.08.2019
17:56 ScienceDaily.comRevolutionizing the CRISPR method

Researchers have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously.

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17:27 Phys.orgRevolutionising the CRISPR method

Everyone's talking about CRISPR-Cas. This biotechnological method offers a relatively quick and easy way to manipulate single genes in cells, meaning they can be precisely deleted, replaced or modified. Furthermore, in recent years, researchers have also been using technologies based on CRISPR-Cas to systematically increase or decrease the activity of individual genes. The corresponding methods have become the worldwide standard within a very short time, both in basic biological research and in applied fields such as plant breeding.

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13.08.2019
13:51 ScientificAmerican.ComDespite Controversy, Human Studies of CRISPR Move Forward in the U.S.

The technology that produced a global scandal in China last year has entered into clinical trials to treat sickle cell anemia and an eye disease -- Read more on ScientificAmerican.com

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12.08.2019
22:33 ScientificAmerican.ComScientists Call for Do-Over for Rules on Creating "CRISPR Babies"

On Tuesday, an international commission will meet to develop less ambiguous guidelines for embryo editing -- Read more on ScientificAmerican.com

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09.08.2019
21:40 TechnologyReview.comDon’t change your DNA at home, says America’s first CRISPR law

A California “human biohacking” bill calls for warnings on do-it-yourself genetic engineering kits.

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08.08.2019
10:33 Nature.ComChina approves ethics advisory group after CRISPR-babies scandal

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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02.08.2019
23:35 ScienceMag.orgTop stories: The untold story of 2018’s CRISPR babies, China’s gene-edited crops, and new exoplanets

This week’s top Science news

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22:46 Medscape.ComThe Week That Wasn't: CRISPR Trial, Interspecies Organs, Facebook Mind Reading

A quick overview of three medical stories that are worth a mention.

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15:09 ScienceMag.orgWith its CRISPR revolution, China becomes a world leader in genome editing

Amid controversy over gene-edited babies, government continues to pour resources into work with plants and animals

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01.08.2019
22:23 TechnologyReview.comCRISPR baby maker explored starting a business in designer-baby tourism

He Jiankui met with US investors and entrepreneurs to discuss commercial plans for CRISPR kids.

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20:15 ScienceMag.orgDid CRISPR help—or harm—the first-ever gene-edited babies?

He Jiankui’s attempt to knock out the CCR5 gene was messy—and so are debates about potential consequences

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31.07.2019
21:13 FierceBiotech.comReversing sickle cell disease with CRISPR-edited stem cells

Scientists at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to boost the production of fetal hemoglobin to treat blood disorders. By targeting a specific population of stem cells, they were able to slash the number of cells required for transplantation by 10-fold in monkey studies.

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16:48 ScienceMag.orgChina’s CRISPR push in animals promises better meat, novel therapies, and pig organs for people

Country tallies many firsts with genome-edited dogs, monkeys, and pigs

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30.07.2019
21:01 DigitalTrends.comCRISPR gene editing to take on inherited blindness in U.S. study

A new study in the United States will use CRISPR gene-editing technology to attempt to treat LCA, a retinal condition that is one cause of inherited blindness. Here's what you need to know.

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08:23 News-Medical.NetFirst ever American gene-editing treatment using CRISPR for genetic disease

In a pathbreaking experiment, a 34-year-old mother of four from Mississippi is in the limelight for volunteering to be the subject of CRISPR-mediated gene editing in the hope of achieving a cure for the painful sickle cell anemia with which she has suffered all her life.

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29.07.2019
18:18 Yahoo ScienceCRISPR Gene Editing Will Be Used Inside Humans For the First Time in Treatment for Blindness

The first study to test the gene-editing technology CRISPR inside the human body is about to get underway in the United States, according to news reports.The study plans to use CRISPR to treat an inherited eye disorder that causes blindness, according to the Associated Press.People with this condition have a mutation in a gene that affects the function of the retina, the light-sensitive cells at the back of the eye that are essential for normal vision. The condition is a form of Leber congenital amaurosis, one of the most common causes of childhood blindness that affects about 2 to 3 newborns out of every 100,000, according to the National Institutes of Health.The treatment will correct the mutation using CRISPR, a tool that allows researchers to precisely edit DNA in a specific spot, the AP reported.Researchers will

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13:37 LiveScience.comCRISPR Gene Editing Will Be Used Inside Humans For the First Time in Treatment for Blindness

The first study to test the gene-editing technology CRISPR inside the human body is about to get underway in the United States, according to news reports.

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09:26 News-Medical.NetNew CRISPR tool enhances RNA editing

CRISPR-based tools helped revolutionize the ability to target genetic mutations linked to disease development. Such tools focus on using the enzymes Cas9 and Cas12 to target DNA, and Cas13 to target RNA. Now, scientists used a new CRISPR platform that expands the capabilities of RNA editing.

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28.07.2019
17:12 SingularityHub.ComFirst Human CRISPR Trial in the US Aims to Cure Inherited Blindness

Gene editing is advancing at a faster pace than most of us can keep up with. One significant recent announcement was gene editing tool CRISPR’s application to non-genetic diseases thanks to a new ability to edit single letters in RNA. Even as CRISPR reaches milestones like this, scientists continue to find new uses for it […]

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27.07.2019
11:36 News-Medical.NetNew CRISPR platform expands the reach of RNA editing to new targets

CRISPR-based tools have revolutionized our ability to target disease-linked genetic mutations. CRISPR technology comprises a growing family of tools that can manipulate genes and their expression, including by targeting DNA with the enzymes Cas9 and Cas12 and targeting RNA with the enzyme Cas13.

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25.07.2019
18:31 Yahoo ScienceWhere Will CRISPR Therapeutics Be in 5 Years?

Investors have high hopes for the $2.7 billion gene editing pioneer, yet there are reasons for both optimism and pessimism.

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17:44 Yahoo ScienceFirst CRISPR study inside the body to start in US


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24.07.2019
20:10 FierceBiotech.comEditing out muscular dystrophy with CRISPR independent of the gene mutation

A Canadian team has developed a CRISPR-based gene activation technique that treats one type of congenital muscular dystrophy type regardless of the mutation type. The system has shown promise in mouse models of the disease.

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17:01 SingularityHub.ComEditing RNA Expands CRISPR’s Use Far Beyond Genetic Diseases

CRISPR advances have been coming so frequently that it’s hard to keep track. In just a few years, it’s evolved from a nifty genome word editor to a full-on biological Swiss army knife. There’s the classic shutdown-that-faulty-gene version. There’s the change-and-replace-single-DNA-letters version. There are even spinoffs that let you add a gene, edit a bunch […]

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12:02 Technology.orgNewly granted CRISPR patents boost UC’s U.S. portfolio to 10

The University of California has received two new patents for use of the revolutionary CRISPR-Cas9 technology, increasing its

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00:14 Yahoo ScienceCRISPR Could Change Medicine, But Not in the Way Wall Street Expects

The gene-editing approach might prove more useful outside the clinic.

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23.07.2019
17:25 Nature.ComCRISPR conundrum: Strict European court ruling leaves food-testing labs without a plan

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18.07.2019
18:25 AzoNano.comNanoparticles Deliver CRISPR Gene-Editing Tools for Treatment of Hyperlipidemia

A study partnership between Tufts University and the Chinese Academy of Sciences (CAS) has resulted in the development of a considerably enhanced delivery mechanism for the CRISPR/Cas9 gene-editing...

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17:01 News-Medical.NetResearchers develop a more precise version of CRISPR-Cas9 gene-editing system

A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model.

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16.07.2019
02:10 ScienceDaily.comComprehensive review of the future of CRISPR technology in crops

CRISPR is thought of as 'molecular scissors' used to cut and edit DNA, but researchers are now looking far beyond these applications. In a new comprehensive review, they explore the current state of CRISPR in crops, and how scientists can enhance traditional breeding techniques in nontraditional ways to a growing population in the face of climate change, diseases, and pests.

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15.07.2019
18:05 Phys.orgNature plants review explores the current state and future of CRISPR technology in crops

CRISPR is often thought of as "molecular scissors" used for precision breeding to cut DNA so that a certain trait can be removed, replaced, or edited, but Yiping Qi, assistant professor in Plant Science & Landscape Architecture at the University of Maryland, is looking far beyond these traditional applications in his latest publication in Nature Plants. In this comprehensive review, Qi and coauthors in his lab explore the current state of CRISPR in crops, and how scientists can use CRISPR to enhance traditional breeding techniques in nontraditional ways, with the goal of ensuring global food and nutritional security and feeding a growing population in the face of climate change, diseases, and pests.

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17:17 Technology.orgNew CRISPR platform expands RNA editing capabilities

CRISPR-based tools have revolutionized our ability to target disease-linked genetic mutations. CRISPR technology comprises a growing family of tools that

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09:33 News-Medical.NetNanoparticles used to deliver CRISPR gene editing tools into the cell

Researchers from Tufts University and the Chinese Academy of Sciences have developed a novel method to effectively deliver the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) gene editing tools into the liver for genetic studies.

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12.07.2019
23:45 Phys.orgNovel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency

A research collaboration between Tufts University and the Chinese Academy of Sciences has led to the development of a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver, according to a study published recently in the journal Advanced Materials. The delivery uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells' genetic code with as much as 90 percent efficiency. The nanoparticles represent one of the most efficient CRISPR/Cas9 delivery tools reported so far, according to the researchers, and could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications.

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23:29 ScienceDaily.comNovel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency

Researchers have developed a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver. The delivery uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells' genetic code with as much as 90 percent efficiency. The nanoparticles could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications.

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22:25 Nanowerk.comNovel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency

Researchers used lipid nanoparticles to deliver CRISPR/Cas9 gene editing tools for potential treatment of hyperlipidemia.

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11.07.2019
21:09 FierceBiotech.comCRISPR pioneer Zhang targets brain diseases with new RNA-editing system

Broad Institute researchers have developed a new strategy for editing RNA they believe could someday be used to treat brain diseases like Alzheimer’s. In cells, they showed the technology can be used to target 24 disease-causing mutations.

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21:09 Phys.orgNew CRISPR platform expands RNA editing capabilities

CRISPR-based tools have revolutionized our ability to target disease-linked genetic mutations. CRISPR technology comprises a growing family of tools that can manipulate genes and their expression, including by targeting DNA with the enzymes Cas9 and Cas12 and targeting RNA with the enzyme Cas13. This collection offers different strategies for tackling mutations. Targeting disease-linked mutations in RNA, which is relatively short-lived, would avoid making permanent changes to the genome. In addition, some cell types, such as neurons, are difficult to edit using CRISPR/Cas9-mediated editing, and new strategies are needed to treat devastating diseases that affect the brain.

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