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CRISPR

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31.07.2020
13:51 Nature.Com A CRISPR first produces squid as clear as glass

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09:05 Technology.org New understanding of CRISPR-Cas9 tool could improve gene editing

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene

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06:06 ScienceDaily.com New understanding of CRISPR-Cas9 tool could improve gene editing

Of the CRISPR-Cas9 tools created to date, base editors have gotten lots of attention because of their seemingly simple editing: they neatly replace one nucleic acid with another, in many cases all that should be needed to fix a genetic disease. Scientists have now determined the structure of the latest base editor as it swaps out nucleic acids, showing why it can go off target but also how it can be improved.

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30.07.2020
21:05 Phys.org New understanding of CRISPR-Cas9 tool could improve gene editing

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic mutations responsible for hereditary diseases.

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05:41 ScienceDaily.com Researchers map mechanisms in the largest CRISPR system

The largest and most complex CRISPR system has been visualized by researchers in a new study. The system may have potential applications in biomedicine and biotechnology, the researchers believe.

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29.07.2020
18:02 Phys.org Researchers map mechanisms in the largest CRISPR system

The largest and most complex CRISPR system has been visualized by researchers from the University of Copenhagen in a new study. The system may have potential applications in biomedicine and biotechnology, the researchers believe.

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17:08 News-Medical.Net Olympus and Cytosurge collaborate to deliver a complete single-cell and CRISPR genetic manipulation solution in the Americas

Olympus, a leading manufacturer of high-end research microscopes, and Cytosurge, a precision manufacturer of cell manipulation technologies, have entered a co-marketing agreement to become a complete system provider to the scientific community’s growing need for next-generation single-cell and CRISPR genetic manipulation solutions.

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27.07.2020
00:27 ScienceDaily.com New CRISPR C-to-G DNA base editor expands the landscape of precision genome editing

The new base editing platform may help researchers understand and correct genetic diseases by selective editing of single DNA 'letters' across nucleobase classes.

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24.07.2020
12:35 News-Medical.Net Olympus and Cytosurge collaborate to deliver a complete single-cell and CRISPR genetic manipulation solution in the Americas

Olympus, a leading manufacturer of high-end research microscopes, and Cytosurge, a precision manufacturer of cell manipulation technologies, have entered a co-marketing agreement to become a complete system provider to the scientific community’s growing need for next-generation single-cell and CRISPR genetic manipulation solutions.

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23.07.2020
23:04 Phys.org New CRISPR DNA base editor expands the landscape of precision genome editing

New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The new base editors are also designed to minimize unintended ("off-target") mutations that could potentially cause undesirable side effects.

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16:39 Phys.org Scientists use CRISPR technology to insert sex-determining gene

Scientists at the University of California, Davis, have successfully produced a bull calf, named Cosmo, who was genome-edited as an embryo so that he'll produce more male offspring. The research was presented in a poster on July 23 at the American Society of Animal Science meeting.

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21.07.2020
17:12 SingularityHub.Com A Newly-Discovered Tiny CRISPR Protein Packs a Giant Punch For Human Gene Editing

The CRISPR family just grew bigger. The newcomer? A tiny DNA-chomping Cas protein, tucked away inside giant viruses. That’s the recent finding from Dr. Jennifer Doudna’s lab, one of the original discoverers of CRISPR, at the University of California, Berkeley. You’ve heard of CRISPR: the wunderkind gene editing tool that’s far easier and cheaper than […]

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12:50 Technology.org Listeria protein provides a CRISPR ‘kill switch’

A single protein derived from a common strain of bacteria found in the soil will offer scientists a

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17.07.2020
08:41 News-Medical.Net Newly identified enzyme provides a new tool in CRISPR genome editing toolbox

A recently discovered hypercompact CRISPR enzyme found only in huge bacteriophages, and known as CRISPR-CasΦ, is functional, a new study by Patrick Pausch, Jennifer Doudna and colleagues reports, and it provides a powerful new tool in the CRISPR genome editing toolbox, including because it can target a wider range of genetic sequences compared to Cas9 and Cas12.

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16.07.2020
21:36 Nature.Com Huge virus’s mini-enzymes boost CRISPR’s powers

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13.07.2020
23:50 ScienceDaily.com Listeria protein provides a CRISPR 'kill switch'

A single protein derived from a common strain of bacteria found in the soil will offer scientists a more precise way to edit RNA.

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23:30 Phys.org Listeria protein provides a CRISPR 'kill switch'

A single protein derived from a common strain of bacteria found in the soil will offer scientists a more precise way to edit RNA.

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09.07.2020
22:50 ScienceDaily.com Safer CRISPR gene editing with fewer off-target hits

The CRISPR system is a powerful tool for the targeted editing of genomes, with significant therapeutic potential, but runs the risk of inappropriately editing ''off-target'' sites. However, a new study shows that mutating the enzyme at the heart of the CRISPR gene editing system can improve its fidelity.

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21:08 Phys.org Safer CRISPR gene editing with fewer off-target hits

The CRISPR system is a powerful tool for the targeted editing of genomes, with significant therapeutic potential, but runs the risk of inappropriately editing "off-target" sites. However, a new study publishing July 9, 2020 in the open-access journal PLOS Biology by Feng Gu of Wenzhou Medical University, China, and colleagues, shows that mutating the enzyme at the heart of the CRISPR gene editing system can improve its fidelity. The results may provide a therapeutically safer strategy for gene editing than using the unmodified enzyme system.

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08.07.2020
18:33 Nature.Com A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

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18:07 Phys.org CRISPR enables one-step hybrid seed production in crops

Crop hybrid technologies have contributed to the significant yield improvement worldwide in the past decades. However, designing and maintaining a hybrid production line has always been complex and laborious. Now, researchers in China have developed a new system combining CRISPR-mediated genome editing with other approaches that could produce better seeds compared with conventional hybrid methods and shorten the production timeline by 5 to 10 years. The study appears July 8 in the journal Molecular Plant.

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16:04 News-Medical.Net Horizon Discovery introduces Cas9 and dCas9-VPR stable cell lines to simplify and accelerate CRISPR gene editing workflows

Horizon Discovery Group plc, today announced the introduction of its stably expressing Cas9 and dCas9-VPR cell lines to help accelerate gene knockout.

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02.07.2020
03:20 News-Medical.Net CityU develops CRISPR-assisted method to identify RNA-binding proteins in living cells

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many disease formation.

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01.07.2020
19:49 Phys.org CRISPR-assisted novel method detects RNA-binding proteins in living cells

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many types of disease formation. Research led by biomedical scientists from City University of Hong Kong (CityU) has led to a novel detection method, called CARPID, to identify binding proteins of specific RNAs in living cells. It is expected that the innovation can be applied in various types of cell research, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.

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11:04 Technology.org Light-activated ‘CRISPR’ enables fast, precise gene editing and detection of DNA repair

In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger

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29.06.2020
17:03 Phys.org Three new studies show unwanted changes in human embryo genome after CRISPR-Cas9 editing

Three teams working independently to test the possibility of using CRISPR–Cas9 gene editing to remove genetic defects in human embryos report finding unwanted changes in the genomes. The first team, working at the Francis Crick Institute, edited mutations that can have a major impact on fetal development. The second, working at Columbia University tried to use the gene editor to fix a mutation known to cause blindness. And the third was a team working at Oregon Health & Science University—they were attempting to fix a mutation known to cause a certain heart problem. All three groups have written papers describing their efforts and findings, and have posted them on the bioRxiv preprint server while they await peer-review.

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27.06.2020
19:56 ScienceDaily.com Comparing 13 different CRISPR-Cas9 DNA scissors

Scientists have achieved the most extensive high-throughput analysis of CRISPR-Cas9 activities. The team developed deep-learning-based computational models that predict the activities of SpCas9 variants for different DNA sequences. This study represents a useful guide for selecting the most appropriate SpCas9 variant.

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09:40 News-Medical.Net Noile-Immune Biotech and C4U team up to develop CRISPR/Cas3 technology

Noile-Immune Biotech Inc., ("Noile-Immune") and C4U Corporation, ("C4U") announced that they have entered into an agreement on joint research and commercialization of next-generation allogeneic gene-modified immune cell therapy combining C4U's CRISPR/Cas3 genome editing technology and Noile-Immune's PRIME (Proliferation inducing and migration enhancing) technology designed to improve proliferation and trafficking of immune cells into solid tumors.

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26.06.2020
16:29 Phys.org Comparing 13 different CRISPR-Cas9 DNA scissors

CRISPR-Cas9 has become one of the most convenient and effective biotechnology tools used to cut specific DNA sequences. Starting from Streptococcus pyogenes Cas9 (SpCas9), a multitude of variants have been engineered and employed for experiments worldwide. Although all these systems are targeting and cleaving a specific DNA sequence, they also exhibit relatively high off-target activities with potentially harmful effects.

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25.06.2020
22:13 ScientificAmerican.Com CRISPR Gene Editing in Human Embryos Wreaks Chromosome Mayhem

Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing -- Read more on ScientificAmerican.com

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18:01 Nature.Com CRISPR gene editing in human embryos wreaks chromosomal mayhem

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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19.06.2020
02:11 News-Medical.Net First genome-wide CRISPR screen reveals genes that control SARS-CoV-2 infection

By performing a genome-wide CRISPR screen on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), U.S. researchers identified novel proviral genes and pathways, and highlighted host genes that may regulate coronavirus disease (COVID-19) pathogenesis, as well as revealing potential targets for novel treatment approaches. Their findings are currently available on the bioRxiv* preprint server.

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18.06.2020
10:04 News-Medical.Net Scientists use CRISPR tool to make rapid, precise cuts in genomic material

In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

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17.06.2020
20:01 ScienceDaily.com Light-activated 'CRISPR' triggers precision gene editing and super-fast DNA repair

In a series of experiments using human cancer cell lines, scientists say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.

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15.06.2020
16:09 StemCellsPortal.coml CRISPR Screen Highlights ZIC2 as an Essential Gene for Human Cardiogenesis

Review of “Genome-Wide CRISPR Screen Identifies ZIC2 As an Essential Gene That Controls the Cell-Fate of Early Mesodermal Precursors to Human Heart Progenitors” from STEM CELLS by Stuart P. Atkinson A recent STEM CELLS article from the laboratory of Kenneth R. Chien (Karolinska Institutet, Stockholm, Sweden) sought to explore the genetic circuit responsible for cardiac progenitor cell formation, which represents one of the earliest steps of human cardiogenesis [1]. In this new study, Xu et al. employed a genome‐wide unbiased CRISPR‐knockout screen as a feasible and straightforward approach to the unbiased discovery of genes associated with a specific phenotype [2, 3]. Their findings now highlight the zinc-finger of the cerebellum 2 (ZIC2)

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16:08 FierceBiotech.com CRISPR and Vertex show durability of gene-editing therapy 

CRISPR and Vertex show durability of gene-editing therapy  ntaylor Mon, 06/15/2020 - 08:54

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12.06.2020
19:45 NewScientist.Com Three people with inherited diseases successfully treated with CRISPR

Two people with beta thalassaemia and one with sickle cell disease no longer need blood transfusions after their blood stem cells were gene edited and put back in their bodies

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17:10 Phys.org Using light to speed up CRISPR-Cas9 gene editing

A team of researchers at Johns Hopkins University has developed a way to speed up the CRISPR-Cas9 gene-editing process by using light-sensitive nucleotides. In their paper published in the journal Science, the group describes their process and its precision. Darpan Medhi and Maria Jasin with the Memorial Sloan Kettering Cancer Center have published a Perspective piece in the same journal issue outlining the evolution of CRISPR-Cas9 gene editing and giving an overview of the work done by the team in Baltimore.

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05.06.2020
16:16 FierceBiotech.com Stanford team deploys CRISPR gene editing to fight COVID-19

Stanford team deploys CRISPR gene editing to fight COVID-19 arlene.weintraub Fri, 06/05/2020 - 08:25

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03.06.2020
02:50 News-Medical.Net New advance addresses a big challenge with using CRISPR in cancer patients

A mutation unique to certain cancer tumors is a potential homing beacon for safely deploying CRISPR gene editing enzymes to disarm DNA that makes cancer cells resistant to treatment, while ignoring the gene in normal cells where it's critical to healthy function, according to a new study from ChristianaCare's Gene Editing Institute in the journal Molecular Cancer Research.

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01.06.2020
16:02 FierceBiotech.com Regeneron boosts Intellia CRISPR pact with bleeding disorder focus, cash boost

Regeneron boosts Intellia CRISPR pact with bleeding disorder focus, cash boost badams Mon, 06/01/2020 - 07:56

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27.05.2020
15:08 Phys.org Taming CRISPR's collateral damage

CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended "on-target" events, and shown that they often occur in human stem cells.

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26.05.2020
20:33 ScienceDaily.com Directed protein evolution with CRISPR-Cas9

New area of application for gene scissors: Optimized proteins for biomedical research.

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19:33 Phys.org Directed protein evolution with CRISPR-Cas9

"Directed evolution" is the process by which scientists produce tailor-made proteins for cell biology, physiology and biomedicine in the laboratory. Based on this method, Max Planck researchers from Martinsried have now developed a method to optimize proteins directly in mammalian cells. Using the new method, the scientists have produced the fluorescent protein mCRISPRred, which fluoresces brightly in lysosomes—very acidic, all-decomposing cell vesicles—which were previously difficult to label.

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25.05.2020
17:20 News-Medical.Net Researchers recombine entire chromosomes with CRISPR/Cas technology

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants.

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22.05.2020
17:25 ScienceDaily.com CRISPR a tool for conservation, not just gene editing

The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes -- from growing disease-resistant crops to, more recently, a diagnostic test for the virus that causes COVID-19. Now a study involving fish that look nearly identical to the endangered Delta smelt finds that CRISPR can be a conservation and resource management tool, as well. The researchers think its ability to rapidly detect and differentiate among species could revolutionize environmental monitoring.

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08:52 Phys.org CRISPR a tool for conservation, not just gene editing

The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes—from growing disease-resistant crops to, more recently, a diagnostic test for the virus that causes COVID-19.

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20.05.2020
15:04 Phys.org Nature-inspired CRISPR enzymes for expansive genome editing

In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon with the discovery of CRISPR proteins found in bacteria—the most widely used of which is the Cas9 enzyme. In combination with a guide RNA, Cas9 is able to target, cut, and degrade specific DNA sequences.

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19.05.2020
20:10 Phys.org Researchers tap CRISPR technology to connect biology, electronics

In an effort to create first-of-kind microelectronic devices that connect with biological systems, University of Maryland (UMD) researchers are utilizing CRISPR technology in a novel way to electronically turn "on" and "off" several genes simultaneously. Their technique, published in Nature Communications, has the potential to further bridge the gap between the electronic and biological worlds, paving the way for new wearable and "smart" devices.

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18.05.2020
11:28 Nature.Com CRISPR tool scales up to interrogate a huge line-up of viral suspects

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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13.05.2020
20:10 Phys.org CRISPR plants: new non-GMO method to edit plants

An NC State researcher has developed a new way to get CRISPR/Cas9 into plant cells without inserting foreign DNA. This allows for precise genetic deletions or replacements, without inserting foreign DNA. Therefore, the end product is not a genetically modified organism, or GMO.

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11:53 Nature.Com CRISPR tests for coronavirus, unproven therapies and a high-profile resignation

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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08:46 News-Medical.Net New rapid CRISPR-based test for sensitive SARS-CoV-2 detection

A new study reports the approval of a new CRISPR-based coronavirus test that is both sensitive and rapid and intended to help reduce the time required to test symptomatic or potentially contagious cases.

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08.05.2020
23:35 Nature.Com First CRISPR test for the coronavirus approved in the United States

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20:17 ExtremeTech.com FDA Approves CRISPR-Based Coronavirus Test

An MIT spin-off company called Sherlock Biosciences has gotten FDA approval to begin using its CRISPR-based COVID-19 test, which promises to be faster and easy to perform without access to a full lab.  The post FDA Approves CRISPR-Based Coronavirus Test appeared first on ExtremeTech.

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06.05.2020
08:44 News-Medical.Net Harvard’s Wyss Institute joins forces with Cytosurge to improve CRISPR-based multiplexed gene editing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

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04.05.2020
21:11 News-Medical.Net Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

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10:24 News-Medical.Net Scientists develop CRISPR-based test for SARS-CoV-2

Now, a team of scientists at the University of California Santa Barbara has developed a low-cost, rapid, and high-tech test that can detect SARS-CoV-2 effectively. They have developed a CRISPR-based test that is sensitive and effective as traditional tests.

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29.04.2020
18:23 Nature.Com CRISPR screen in regulatory T cells reveals modulators of Foxp3

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28.04.2020
17:47 Nature.Com Cells edited with CRISPR prove safe in humans

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23.04.2020
16:05 ScientificAmerican.Com CRISPR Gene Editing May Help Scale Up Coronavirus Testing

An inexpensive assay based on the technique can provide yes or no answers in under an hour—perhaps even in the home soon -- Read more on ScientificAmerican.com

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22.04.2020
22:47 FierceBiotech.com Reversing diabetes with CRISPR and patient-derived stem cells

Scientists at Washington University in St. Louis developed a way to use CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells and then turn them into beta cells. When transplanted into mice, those beta cells reversed preexisting diabetes in a lasting way, a new publication shows.

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11:07 Technology.org CRISPR helps identify potential Alzheimer’s-related protein

Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer’s

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21.04.2020
21:59 ScienceDaily.com CRISPR helps identify potential Alzheimer's-related protein

Experts have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the 'molecular scissors' of CRISPR/Cas9 to search for new genes related to the neurodegenerative disease. Researchers tested a total of 19,150 individual genes for their effect on amyloid beta levels and ruled out all but one: calcium and integrin-binding protein 1 (CIB1).

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19:28 News-Medical.Net CRISPR helps identify new protein potentially involved in Alzheimer’s disease

Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "molecular scissors" of CRISPR/Cas9 to search for new genes related to the neurodegenerative disease.

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02:50 News-Medical.Net CRISPR technology mobilized for rapid COVID-19 diagnosis

A group of authors from the United States published a study in the scientific journal Nature Biotechnology in which they have described a CRISPR-Cas-based approach for rapid and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – without the need for complex laboratory infrastructure.

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01:24 News-Medical.Net Using genome-wide CRISPR technology to identify leukemia's weakness

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse.

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00:00 ScienceDaily.com Finding leukemia's weakness using genome-wide CRISPR technology

Researchers have used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia.

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20.04.2020
19:47 Technology.org Finding Leukemia’s Weakness Using Genome-Wide CRISPR Technology

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used

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10:53 Technology.org CRISPR-Based ‘Discovery Engine’ for New Cell Therapies to Advance Cancer Treatments

Despite centuries-long efforts to develop cures for cancer, various forms of the disease will kill about 630,000 people in

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17.04.2020
10:44 Technology.org New CRISPR-Based COVID-19 Test Kit Can Diagnose Infection in Less Than an Hour

Scientists have developed an inexpensive new test that can rapidly diagnose COVID-19 infections, a timely advance that comes

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14.04.2020
05:16 News-Medical.Net CRISPR may help in kidney-transplants by detecting viruses

An exciting new study published in the journal Nature Biomedical Engineering in April 2020 reports excellent results with a new test for two common viruses that infect kidney transplant patients. The levels of these viruses shoot up during the acute phase of rejection.

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13.04.2020
23:10 ScienceDaily.com Diagnostics, meet CRISPR

A new diagnostic test to quickly and easily monitor kidney transplant patients for infection and rejection relies on a simple urine sample and a powerful partner: the gene-editing technology CRISPR.

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18:14 Phys.org Research team develops new CRISPR diagnostic test

The simplicity of urine sampling has been combined with the excellent sensing abilities of CRISPR to improve diagnostic testing for kidney transplant patients, an international research team reports in the journal Nature Biomedical Engineering.

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07.04.2020
17:37 Phys.org Applying CRISPR beyond Arabidopsis thaliana

Few technologies have made as big a splash in recent years as CRISPR/Cas9, and rightfully so. CRISPR/Cas9, or clustered regularly interspaced palindromic repeats (CRISPR) and associated genes, is a bacterial gene editing toolbox that allows researchers to edit genomic sequences much more precisely and efficiently than previously possible, opening up doors to new ways of doing research. As with many new biotechnologies, the application of CRISPR in biology began with genetic model organisms such as Arabidopsis thaliana. In research presented in a recent issue of Applications in Plant Sciences, Shengchen Shan and colleagues review the prospects for expanding the use of CRISPR for research beyond genetic model plant species.

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06.04.2020
15:45 StemCellsPortal.coml CRISPR-approach May Decipher Axolotl Limb Regeneration

Review of “Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls” from eLife by Stuart P. Atkinson The axolotl can regenerate their limbs, tails, and gills through the formation of a mass of proliferating dedifferentiated cells and pre-existing progenitor and stem cells known as the blastema [1-3]. In a previous attempt to better understand the regeneration process, researchers led by Craig M. Crews (Yale University, New Haven, USA) employed the next-generation sequencing-based tracking of mutant alleles in primary and secondary limbs to demonstrate that high-fidelity limb regeneration involved the replication of small cell populations present in the original limb in the regenerated limb [4]. Furthermore, recent single-cell sequencing of the axolotl limb blastema provided evidence of a shared

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10:25 News-Medical.Net Horizon Discovery expands cell-based CRISPR screening services

Horizon Discovery Group plc, today announced the addition of an arrayed CRISPR knockout screening service for primary human B cells.

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01.04.2020
15:02 FierceBiotech.com CRISPR therapeutics braces for ‘severe impact’ from COVID-19 crisis

It was supposed to be an exciting time of next-gen science, where CRISPR gene-editing was being used in the first series of human trials in the hope that this tech could help cure a range of diseases.

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27.03.2020
17:20 Phys.org Researchers working on simple, low-cost CRISPR-based diagnostic test for infectious diseases

Researchers in the Department of Biomedical Engineering— a shared department in the schools of Dental Medicine, Medicine, and Engineering—have been working to develop a new, low-cost, CRISPR-based diagnostic platform to detect infectious diseases, including the novel coronavirus (SARS-CoV-2).

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14:18 Phys.org Capabilities of CRISPR gene editing expanded

Many basic and clinical researchers are testing the potential of a simple and efficient gene editing approach to study and correct disease-causing mutations for conditions ranging from blindness to cancer, but the technology is constrained by a requirement that a certain short DNA sequence be present at the gene editing site.

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26.03.2020
23:20 Nature.Com All-purpose enzymes boost CRISPR’s powers

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04:56 News-Medical.Net Finding new treatments for muscular dystrophy with CRISPR-Cas9

A new study out of Boston's Children's Hospital has used the gene-editing tool CRISPR-Cas9 to explore the fatal genetic condition called facioscapulohumeral dystrophy (FSHD, one of the family of muscular dystrophies), and to test out the potential utility of various genes involved in this disorder. The research is published in the journal Science Translational Medicine.

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25.03.2020
06:02 News-Medical.Net Humans are not the first to exploit benefits of CRISPR technique, research shows

In recent years, the development of CRISPR technologies and gene-editing scissors in particular have taken the world by storm. Indeed, scientists have learned how to harness these clever natural systems in the biotech and pharmaceutical industries, among other areas.

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04:01 ScienceDaily.com Research breakthrough: Humans are not the first to repurpose CRISPR

We humans are far from the first to exploit the benefits of CRISPR. Groundbreaking research has helped to redefine what CRISPR is. Researchers have discovered that primitive bacterial parasites weaponize CRISPR to engage in battle against one another. This discovery opens up the possibility to reprogram CRISPR to combat multi-drug resistant bacteria.

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24.03.2020
20:46 Phys.org Humans are not the first to repurpose CRISPR

In recent years, the development of CRISPR technologies and gene-editing scissors in particular have taken the world by storm. Indeed, scientists have learned how to harness these clever natural systems in the biotech and pharmaceutical industries, among other areas.

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18.03.2020
03:56 ScienceDaily.com New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus

Researchers have developed a new kind of CRISPR screen technology to target RNA. The team leveraged their technology for a critical analysis: The COVID-19 public health emergency is due to a coronavirus, which contains an RNA - not DNA - genome.

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17.03.2020
04:27 Nanowerk.com New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus

New genetic screening platform using CRISPR technology for targeting thousands of genes in a massively-parallel fashion; accurate and fast method of finding best guides to detect, target, and knockdown specific RNA targets.

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16.03.2020
20:56 News-Medical.Net Researchers develop new kind of CRISPR screen technology to target RNA

CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases.

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19:57 Phys.org New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus

CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases. However, these genetic screens are limited in scope: They can only edit or target DNA. For many regions of the human genome, targeting DNA may not be effective, and other organisms, such as RNA viruses like coronavirus or flu, cannot be targeted at all with existing DNA-targeting CRISPR screens.

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12.03.2020
13:03 Technology.org Cellular SOS: CRISPR Technique Reveals How Cell’s ‘Power Plants’ Activate Emergency Response

The integrated stress response (ISR) is a well-studied biological circuit that behaves like a disaster response center: it

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11.03.2020
19:09 Nature.Com CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

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02:41 News-Medical.Net CRISPR-Cas system can be used to effectively target colitis pathogen

Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the pathogen that causes colitis - a chronic, degenerative disease of the colon.

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09.03.2020
19:01 Phys.org Researchers establish new viable CRISPR-Cas12b system for plant genome engineering

In a new publication in Nature Plants, assistant professor of Plant Science at the University of Maryland Yiping Qi has established a new CRISPR genome engineering system as viable in plants for the first time: CRISPR-Cas12b. CRISPR is often thought of as molecular scissors used for precision breeding to cut DNA so that a certain trait can be removed, replaced, or edited. Most people who know CRISPR are likely thinking of CRISPR-Cas9, the system that started it all. But Qi and his lab are constantly exploring new CRISPR tools that are more effective, efficient, and sophisticated for a variety of applications in crops that can help curb diseases, pests, and the effects of a changing climate. With CRISPR-Cas12b, Qi is presenting a system in plants that is versatile, customizable, and ultimately provides effective gene editing, activation, and repression all in one system.

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06.03.2020
23:33 ScientificAmerican.Com CRISPR Treatment Inserted Directly into the Body for the First Time

The experiment tests a gene-editing therapy for a hereditary blindness disorder -- Read more on ScientificAmerican.com

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05.03.2020
17:58 Nature.Com CRISPR treatment inserted directly into the body for first time

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04.03.2020
18:51 Yahoo Science Doctors try 1st CRISPR editing in the body for blindness

Scientists say they have used the gene editing tool CRISPR inside someone's body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases. A patient recently had it done at the Casey Eye Institute at Oregon Health & Science University in Portland for an inherited form of blindness, the companies that make the treatment announced Wednesday. “We literally have the potential to take people who are essentially blind and make them see,” said Charles Albright, chief scientific officer at Editas Medicine, the Cambridge, Massachusetts-based company developing the treatment with Dublin-based Allergan.

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17:26 TechnologyReview.com CRISPR was just used in a bid to restore sight to a blind person

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11:25 Phys.org Improved CRISPR gene drive solves problems of old tech

Gene drives use genetic engineering to create a desired mutation in a few individuals that then spreads via mating throughout a population in fewer than 10 generations.

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05:15 ScienceDaily.com Improved CRISPR gene drive solves problems of old tech

Gene drives use genetic engineering to create a desired mutation in a few individuals that then spreads via mating throughout a population in fewer than 10 generations.

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03.03.2020
02:39 Nature.Com Publisher Correction: Targeting of temperate phages drives loss of type I CRISPR–Cas systems

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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