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04.08.2020
02:36 News-Medical.Net New biomarkers may identify people with Type 1 diabetes who could benefit from immunotherapy

Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively.

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03.08.2020
23:23 FightAging.Org How Calorie Restriction Improves Intestinal Stem Cell Function

The practice of calorie restriction, eating up to 40% fewer calories while still maintaining an optimal intake of micronutrients, is well demonstrated to slow aging and extend healthy life span in near all species and lineages tested to date. It produces sweeping effects on the operation of metabolism - near everything changes, which has made it something of a challenge to identify the principal points of action. Nonetheless, more efficient operation of the cellular housekeeping mechanisms of autophagy is the most plausible mechanism to account for the majority of the benefits. That calorie restriction fails to extend life when autophagy is disabled is the most telling evidence. The open access paper that I'll point out today is illustrative of a great many similar lines of […]

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19:02 News-Medical.Net Children exposed to trauma show biological signs of aging faster

Children who suffer trauma from abuse or violence early in life show biological signs of aging faster than children who have never experienced adversity, according to research published by the American Psychological Association.

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16:45 StemCellsPortal.coml Study Shows Stem Cell 'Therapy' Injuries Widespread Than we Knew

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16:45 StemCellsPortal.coml Vison-preserving stem cells discovered

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16:01 CNN Health Growing up in a violent environment is likely to lead to accelerated aging and disease risk

Children who grow up in environments of violence or deprivation are more likely to go through puberty earlier, age quickly and have altered brain structure, according to a new review of studies.

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15:38 StemCellsPortal.coml CD146-sorted Mesenchymal Stem Cells Provide for Enhanced Therapeutic Outcomes

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14:28 Phys.org Mitochondrial metabolite mediates longevity through epigenomes

In a study published in Science Advances, researchers from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences revealed that mitochondrial metabolite acetyl-CoA links mitochondrial stress to the nuclear epigenome via NuRD complex for life-span regulation in C. elegans.

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13:31 FightAging.Org Long-Lived Trees are Not Immortal

Trees can adopt a range of strategies not available to animals in order to live for very long periods of time, but they are not immune to mechanisms of aging. That said, those mechanisms are only broadly similar to the biochemistry of aging in animals. It isn't clear that there is anything useful to learn from long-lived plants insofar as human medicine is concerned. Nonetheless, it is an interesting area of study. The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. A recent paper studying ginkgoes, one of the world's longest-lived trees, even found that they may be able to "escape senescence at the whole-plant […]

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02.08.2020
16:10 FightAging.Org Fight Aging! Newsletter, August 3rd 2020

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents A Genomic Search for Longevity-Associated Genes Points to Iron Metabolism in Human Aging Evidence for Oxytocin to Reverse Impairment of Synaptic Plasticity by Amyloid-β Long Term Low Dose Ethanol Intake Modestly Extends Life in Mice Bat Biochemistry Points to […]

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01.08.2020
00:21 ScienceDaily.com Researchers discover stem cells in optic nerve that preserve vision

Researchers have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and provides potential to treat a leading cause of blindness.

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31.07.2020
22:11 ScienceDaily.com Tinkering with roundworm proteins offers hope for anti-aging drugs

Researchers have been able to dial up and down creatures' lifespans by altering the activity of proteins found in roundworm cells that tell them to convert sugar into energy when their cellular energy is running low. Humans also have these proteins, offering up the intriguing possibilities for developing longevity-promoting drugs.

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22:01 FightAging.Org Combining Therapies as the Next Frontier for the Treatment of Aging

There are two activities in medical science in which both the academic research community and clinical development industry are truly terrible at achieving results, or indeed even at getting started at all. The first is transfer of programs from academia to industry. The renowned valley of death in the development of new medical biotechnologies is very real; so very many programs languish undeveloped simply because neither side can effectively coordinate with the other. The second is the testing of synergies between multiple therapies that are applied at the same time to the same patient for the treatment of the same condition. We live in a world in which age-related conditions are the result of multiple distinct contributing mechanisms, so why is it that the exploration […]

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17:47 ScienceDaily.com Spin, spin, spin: researchers enhance electron spin longevity

The electron is an elementary particle, a building block on which other systems evolve. With specific properties such as spin, or angular momentum, that can be manipulated to carry information, electrons are primed to advance modern information technology. An international collaboration of researchers has now developed a way to extend and stabilize the lifetime of the electron's spin to more effectively carry information.

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16:45 News-Medical.Net Study offers new possibilities for developing anti-aging drugs

KAIST researchers have been able to dial up and down creatures' lifespans by altering the activity of proteins found in roundworm cells that tell them to convert sugar into energy when their cellular energy is running low.

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13:15 FightAging.Org Fitness in Humans Acts to Reduce Inflammation, But Does Not Reduce the Burden of Cellular Senescence in Muscle Tissue

Fitness produced by training is here shown to correlate with reduced inflammatory signaling, but has no effect on the burden of senescent cells in old muscle tissue. This is interesting, as the accumulation of senescent cells with age is responsible for a sizable fraction of inflammatory signaling in tissues. Senescent cells secrete a potent mix of signals that cause chronic inflammation and tissue dysfunction, and are an important contributing cause of aging. The likely explanation here is that the cellular adaptations to exercise act to reduce harmful aspects of persistent senescent cell signaling. There is a good deal of research to show that senescent cell signaling can be muted to various degrees. This is probably not as a good a strategy for the development of […]

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30.07.2020
23:05 FightAging.Org Bat Biochemistry Points to DNA Repair and Autophagy as Important Determinants of Mammalian Species Longevity

Investigation of the comparative biology of aging is one of many notable communities within the broader research community focused on aging and age-related disease. Scientists use comparisons between different species with very different life spans as a way to try to pin down the mechanisms that are most important in aging. Thus there is work on naked mole-rats versus mice, both similarly sized rodents. Whales capable of living for centuries are compared to smaller mammals that are not. Humans are compared to our nearest primate relatives, all of whom are less long-lived than we are. And so forth. One of the more interesting comparisons to be made is between bats and other mammals. It is quite clear that flight requires considerable metabolic adaptation, and it […]

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15:54 StemCellsPortal.coml “Self-Eating” Process of Stem Cells May Be the Key to New Regenerative Therapies

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15:53 Phys.org Researchers enhance electron spin longevity

The electron is an elementary particle, a building block on which other systems evolve. With specific properties such as spin, or angular momentum, that can be manipulated to carry information, electrons are primed to advance modern information technology. An international collaboration of researchers has now developed a way to extend and stabilize the lifetime of the electron's spin to more effectively carry information.

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10:27 Nanowerk.com Researchers enhance electron spin longevity

Researchers developed a way to extend and stabilize the lifetime of the electron's spin to more effectively carry information.

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08:00 News-Medical.Net GSA receives renewed grant support to advance reporters’ coverage of aging issues

The Gerontological Society of America (GSA) has received renewed grant support to welcome a new cohort of reporters for the Journalists in Aging Fellows Program.

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00:02 DigitalTrends.com Jayapal accuses Facebook of threatening to clone Instagram before buying it

CEO Mark Zuckerberg was grilled about acquiring and copying competitors

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29.07.2020
18:23 Nature.Com Stretch exercises for stem cells expand the skin

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16:44 CNBC technology Start-up investor Alan Patricof, at 85, targets aging Americans with his latest venture fund

The 85-year-old founder of Greycroft and Apax Partners announced a $30 million, early-stage investment firm dedicated to aging Americans.

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13:22 FightAging.Org Naked Mole-Rat Senescent Cells are Unusually Vulnerable to Oxidative Stress

This open access paper expands on earlier work on cellular senescence in long-lived naked mole-rats. Individuals of this species can live as much as nine times longer than equivalently sized rodents, and are near immune to cancer. In other mammals, senescent cells accumulate with age and disrupt tissue function via their inflammatory signaling. Evidence suggests that this is an important cause of degenerative aging, given that selective destruction of these errant cells produces rejuvenation and extended life span in mice. In naked mole-rats, senescent cells exhibit very little of the harmful signaling that occurs in other mammals. These cells also also self-destruct more readily when stressed. That naked mole-rat senescent cells are more prone to self-destruction following oxidative stress is not just a benefit when […]

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28.07.2020
16:14 StemCellsPortal.coml Adult Stem Cells/Glaucoma Drug Combo Promotes Diabetic Wound Healing in Mice

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13:15 FightAging.Org Glycosylation Changes in Epidermal Stem Cells as a Biomarker of Aging

Researchers here analyze amounts and types of glycans in stem cells isolated from the skin of old and young mice. The differences observed might serve as a biomarker of aging, but also may be a contributing proximate cause of the age-related decline in skin stem cell function. As is usually the case, connecting downstream changes of this nature to the deeper causes of aging is a project yet to make any meaningful progress. It is also unclear as to whether glycan profile changes are a sizable cause of dysfunction versus all of the other possible proximate causes of stem cell functional decline. Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of […]

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11:01 Technology.org “Self-eating” Process of Stem Cells May be the Key to New Regenerative Therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve

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09:25 News-Medical.Net Researchers show how aging can cause lung regeneration

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

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04:22 News-Medical.Net Researchers identify miRNA that could promote hair regeneration

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration.

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04:05 ScienceDaily.com How airway cells work together in regeneration and aging

Researchers have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

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27.07.2020
23:34 FightAging.Org A Genomic Search for Longevity-Associated Genes Points to Iron Metabolism in Human Aging

As a general rule, one should be skeptical about any and all single studies that identify longevity-associated genes from human data. Typically the results cannot be replicated in different study populations, and the effect sizes are in any case small. Identified gene variants confer only small changes in the odds of reaching a given age. Only a handful of gene variants show up reliably in multiple studies carried out in different human populations. So, unfortunately, however interesting or novel the data in a new study, such as the association of longevity with maintenance of normal iron levels noted in today's open access research paper, there is a good chance that it will remain unconfirmed. Other approaches to determining the genetic contribution to longevity tend to […]

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22:38 ScienceDaily.com Despite debate, even the world's oldest trees are not immortal

The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. Plant biologist now argue that although signs of senescence in long-lived trees may be almost imperceptible to people, this does not mean that they're immortal.

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19:18 ScienceDaily.com Lego-inspired bone and soft tissue repair with tiny, 3D-printed bricks

A new, 3D-printed technology that was inspired by Lego block toys is designed to help heal broken bones, and could one day even lead to lab-made organs for human transplant.

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18:13 Phys.org Despite debate, even the world's oldest trees are not immortal

The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. A recent paper studying ginkgoes, one of the world's longest-lived trees, even found that they may be able to "escape senescence at the whole-plant level," raising questions about the apparent lack of aging in centuries-old trees. However, in a Forum publishing July 27 in the journal Trends in Plant Science, plant biologist Sergi Munné-Bosch argues that although signs of senescence in long-lived trees may be almost imperceptible to people, this does not mean that they're immortal.

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18:12 NYT Science Can Trees Live Forever? New Kindling for an Immortal Debate

Some trees can live for thousands of years, but we may not be around long enough to really know whether they can die of old age.

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16:26 StemCellsPortal.coml Skin Stem Cells Shuffle Sugars as They Age

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15:16 NYT Health A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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12:36 NYT Technology A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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12:22 NYT Science A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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11:05 Technology.org Aging experts call for more dementia care training

The number of people in the U.S. living with Alzheimer’s or dementia is expected to triple by 2050, and

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26.07.2020
18:37 ScienceDaily.com 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, researchers show.

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16:34 FightAging.Org Fight Aging! Newsletter, July 27th 2020

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Epigenetic Clocks are Quirky: the Biological Age of the Heart is Consistently Younger than Chronological Age Eating a Plant Based Diet Correlates with Better Health and Lower Mortality The OneSkin Technologies DNA Methylation Clock for Assessment of Skin Aging […]

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24.07.2020
22:50 FightAging.Org Mechanisms by Which Somatic Mosaicism May Contribute to Degenerative Aging

Cells are liquid bags of molecules, constantly interacting and reacting with one another. Many of those reactions are unwanted and damaging to the molecular machinery of the cell, but repair of structures and replacement of damaged molecules is also a constant and ongoing process. The most efficient repair processes are those that attend the DNA that is folded away in the cell nucleus. Despite these processes, mutational damage to nuclear DNA slips though the layered schemes of protection and repair. It has to: without that damage, evolution would not occur. There is some debate over the degree to which nuclear DNA damage contributes to the aging process. Evidently, and well proven, it is an important reason as to why cancer is an age-related disease - […]

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23.07.2020
22:36 FightAging.Org Do Non-Replicating Cells Exhibit Senescence During the Aging Process?

Most somatic cells in the body replicate, but sizable populations do not, known as post-mitotic cells, such as varieties of neuron in the central nervous system. Cellular senescence is fundamentally a process by which cell division is halted, a reaction to DNA damage, short telomeres, or a toxic signaling environment. Cells that become senescent swell in size, as though about to divide, but instead remain large. While in that state, they secrete a potent mix of inflammatory molecules that rouse the immune system, degrade surrounding tissue structure, and alter the behavior of nearby cells. In the short term this can be useful, as a way to suppress cancer or aid in wound healing. When sustained for the long term, it is very harmful. Senescent cells […]

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21:05 Phys.org 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science.

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20:27 Drugs.com Could Vegetables Be the Fountain of Youth?

THURSDAY, July 23, 2020 -- If you want to live longer, you should choose beans over beef for your protein, a new analysis suggests. "These findings have important public health implications as intake of plant protein can be increased relatively...

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16:54 StemCellsPortal.coml Expanded Access Protocol Initiated for Stem Cell Treatment for Children With MIC-C Associated With COVID-19

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16:27 StemCellsPortal.coml New Platform Enables Long-Term Tracking of Stem Cell-Derived Tissues After Transplantation

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13:24 FightAging.Org Chronic Neurovascular Inflammation in the Aging Brain

The evidence strongly suggests that chronic inflammation in brain tissue is of great importance in the onset and progression of age-related neurodegenerative conditions. Overactivation of the immune system, resulting in chronic inflammation, is a feature of aging. It arises in part due to the accumulation of senescent cells and their inflammatory secretions, but persistent viral infection and a range of other mechanisms are also implicated. Inflammaging represents a persistent low-grade systemic inflammation with inapparent clinical symptoms. In fact, it operates as a seesaw with a progressive pro-inflammatory "overload". Cytokines, such as interleukins and tumor necrosis factor α (TNFα), as well as a gamut of self-debris originated from dysfunctional cells fuel the constant activated state of the immune system. With aging, accumulation of these endogenous signals […]

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03:40 News-Medical.Net Buckwheat-based diet improves SIRT1 protein that helps enhance longevity

A healthy low-calorie diet that contains plant products can help us improve the level of sirtuin 1 (SIRT1) protein production that is known to increase life expectancy.

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03:13 News-Medical.Net Occupational physical stress may be linked to faster brain aging, poorer memory

A new study out of Colorado State University has found that physical stress in one's job may be associated with faster brain aging and poorer memory.

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00:28 ScienceDaily.com Skin stem cells shuffle sugars as they age

Researchers have shown by in vitro experimentation that changes of glycans in mouse epidermal stem cells may serve as a biomarker of aging. Further, by overexpression of specific glycogenes in mouse keratinocytes, they replicated the glycome profile of aging cells as well as their decreased proliferation ability. These findings hold promise for stem cell research into skin disorders, specifically senile degeneration, wound healing and skin cancer.

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22.07.2020
23:25 FightAging.Org The OneSkin Technologies DNA Methylation Clock for Assessment of Skin Aging

OneSkin Technologies is one of the first generation of startup biotech companies in the longevity industry; you'll find an overview of their programs and technology in an interview with founder Carolina Reis last year. In summary, OneSkin works on both improved models of aging skin, and topical senolytic compounds capable of selectively destroying the senescent cells thought to be responsible for a sizable fraction of skin aging in later life. Unlike other companies in the longevity industry, the OneSkin staff is focused on the cosmetics regulatory path to market. This is in some ways more limited, and in other ways much cheaper and faster than the standard investigational new drug approach with the FDA. Today's news is more on the modelling front of the company's […]

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21.07.2020
21:17 News-Medical.Net Glycome shift' in epidermal stem cells could serve as potential biomarker of aging

Age shows nowhere better than on the skin. The ravages of time on skin and the epidermal stem cells that differentiate to replenish its outer layer have been hypothesized, but there has been no method to evaluate their aging at the molecular level.

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20:50 CNN Health Scientists are one step closer to delaying aging

Scientists at the University of California San Diego may be one step closer to being able to delay the aging process.

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18:37 Phys.org Going in the water again: 'Jaws' boat clone supports sharks

The Orca is headed back to the waters of New England, but this time, its mission isn't to hunt sharks. It's to help save them.

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15:23 Zdnet.com Office 365: Microsoft finally retires ageing TLS 1.0 and 1.1

Microsoft Office 365 will no longer support legacy HTTPS protocols TLS 1.0 and 1.1 in Office 365 from October 15.

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13:42 FightAging.Org Small Extracellular Vesicles and the Balance of Signals Between Normal and Senescent Cells in Aging Tissues

In this study, researchers show that small extracellular vesicles can influence the functional status of old tissues. These vesicles are membrane-bound packages of molecules that are used by cells as a form of communication, constantly secreted and taken up. Delivery of vesicles isolated from young tissues (or normal, non-senescent cells) improves function and suppresses the markers of cellular senescence in aged tissues, while delivery of vesicles isolated from old tissues (or senescent cells) degrades the function of young tissues by encouraging cellular senescence. The authors postulate a signaling environment in every tissue that slowly tips towards favoring cellular senescence and dysfunction as aging progresses. Delivering suitable vesicles in large enough numbers, and for a long enough period of time, should tip the balance back - […]

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20.07.2020
22:08 Technology.org Human Sperm Stem Cells Grown in Lab, an Early Step Toward Infertility Treatment

Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial

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21:54 Technology.org Researchers Discover Two Paths of Aging and New Insights on Promoting Healthspan

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries

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16:52 StemCellsPortal.coml New Clues From Fruit Flies About the Critical Role of Sex Hormones in Stem Cell Control

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11:35 Technology.org Turning off “junk DNA” may free stem cells to become neurons

For every cell in the body there comes a time when it must decide what it wants to

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19.07.2020
15:02 FightAging.Org Fight Aging! Newsletter, July 20th 2020

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Reversing the Age-Related Loss of Eosinophils in Visceral Fat Reduces Chronic Inflammation and its Consequences Repetitive Element Activity is Reduced in Mice Subject to Interventions that Modestly Slow Aging In Rats, Navitoclax Removes Senescent Chondrocytes that Contribute to Osteoarthritis […]

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18.07.2020
21:38 News-Medical.Net Type 1 interferon deficiency as a biomarker for detecting patients at risk of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

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00:54 ScienceDaily.com Blood iron levels could be key to slowing aging, gene study shows

Genes linked to aging that could help explain why some people age at different rates to others have been identified by scientists.

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17.07.2020
23:21 FightAging.Org Gain and Loss of Flight as a Tool to Search for Import Factors in Longevity

The capacity for flight is frequently associated with greater species longevity, such as in bats, for example. The present consensus suggests that the cellular adaptations needed to support the greater metabolic capacity required for flight also resist some forms of molecular damage important in aging. This is particularly the case for adaptations in mitochondria, the power plants of cells, where damage and loss of function is known to be important in aging. The membrane pacemaker hypothesis is one way of looking at this; species that evolve cell membranes that are more resilient to oxidative damage will live longer as a result. Today's open access paper reports on the interesting approach of using gain and loss of flight in evolutionary history as a way to look […]

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19:32 ScienceDaily.com Type 1 interferon deficiency: Biomarker of patients at risk of severe COVID-19

Which patients are more likely to develop a severe form of COVID-19? In a new study, researchers describe a unique and unexpected immunological phenotype in severe and critical patients.

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17:54 StemCellsPortal.coml Stem Cell Platform for Evaluation of Nanoplastics

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17:41 StemCellsPortal.coml Conjunctival Epithelial Stem Cells Enriched by p75

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14:57 Phys.org Sperm discovery reveals clue to genetic 'immortality'

New insights into an elusive process that protects developing sperm cells from damage in growing embryos, sheds light on how genetic information passes down, uninterrupted, through generations.

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13:35 FightAging.Org An Overactive Immune System Protects Against Infection at the Cost of More Rapid Aging

Greater immune activity implies greater inflammation, which has a negative impact on tissue function if maintained over time. In aging, a great deal of damage is done by the chronic inflammation of an overactive immune system. Researchers here provide evidence to indicate that the evolved state of immunity is a balancing act between a faster pace of aging on the one hand, resulting from an immune system that is more active, and vulnerability to infection on the other, resulting from an immune system that is less active. As we age, the immune system gradually becomes impaired. One aspect of this impairment is chronic inflammation in the elderly, which means that the immune system is constantly active and sends out inflammatory substances. Such chronic inflammation is […]

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13:22 FightAging.Org Efforts Continue to Use COVID-19 as a Learning Moment Regarding the Costs of Aging

Near everyone who dies from the SARS-Cov-2 virus responsible for the COVID-19 pandemic is old. The old are vulnerable firstly because their immune systems are much diminished in effectiveness, and secondly because the state of chronic inflammation characteristic of old age makes the cytokine storm that causes much of the SARS-Cov-2 mortality more likely and more severe. Members of the medical research community focused on intervention in the aging process - a way to treat all age-related conditions by addressing their underlying causes - are attempting to use the attention given to COVID-19 to educate the public and policy makers. Any number of influenza seasons, in which the vast majority of the dead are elderly, seems to have failed to get the point across: that […]

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12:31 Technology.org Two Projects Using Hydrogel Biomaterials to Stimulate Tissue Regeneration Move Forward with New Funding

Two innovative UCSF projects in hydrogel therapies to develop new salivary glands and restore muscle loss after facial

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09:07 News-Medical.Net Helping older adults to address healthy longevity in the environment, homes, and communities

Have you thought about what you'd like your life to look like when you're 84?

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05:11 News-Medical.Net Researchers unravel key mechanisms behind the mysteries of aging

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan.

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16.07.2020
23:24 FightAging.Org Reviewing Present Thought on the Evolution of the Calorie Restriction Response

The practice of calorie restriction involves reducing calorie intake by up to 40% while maintaining an optimal intake of micronutrients. It can meaningfully extend life span in short-lived species such as mice, but does not add more than a few years in humans. The effect on lifespan of this and other interventions known to slow aging via upregulation of stress response mechanisms scale down as species life span increases - though, interestingly, the short-term benefits to health look quite similar across mammalian species. The most important mechanism of action in the calorie restriction response, as well as responses to heat and other stresses, appears to be an increased operation of autophagy. Autophagy is the name given to a collection of cellular maintenance processes that break […]

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22:21 Phys.org Researchers discover 2 paths of aging and new insights on promoting healthspan

Molecular biologists and bioengineers at the University of California San Diego have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan.

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22:16 ScienceDaily.com Two paths of aging: New insights on promoting healthspan

Scientists have unraveled key mechanisms behind the mysteries of aging. They isolated two distinct paths that cells travel during aging and engineered a new way to genetically program these processes to extend lifespan. Cells embark upon either a nucleolar or mitochondrial path early in life, and follow this ''aging route'' throughout their entire lifespan through decline and death. At the heart of the controls the researchers found a master circuit that guides these aging processes.

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20:11 Drugs.com Under 50 and Had a Heart Attack? Quit Smoking, and You'll Live Longer

THURSDAY, July 16, 2020 -- If you're a smoker under 50 and you suffer a heart attack, new research suggests kicking the habit may be the best thing you can do to still be around years later. "These results are definitive: among young people who have...

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19:21 StemCellsPortal.coml How randomness and collective dynamics define a stem cell

KLOSTERNEUBURG (AT), July 2020 — Without stem cells, human life would not exist. Due to them, a lump of cells becomes an organ, a fertilized egg develops into a baby and tissues of our body can be continuously renewed. But what actually makes a stem cell? How do they know when to divide to replace a dying cell? Are these a stable population of specially gifted cells? Scientists at the Institute of Science and Technology (IST) Austria discovered that instead, stem cells might emerge due to the collective behavior of cells within the organs. They saw that the shape of the surrounding tissue, jointly to the pattern of seemingly random movements of the cells determined the cell’s role.  The scientists published their study in PNAS on July 1. Their results could lead to a deeper understanding of organ renewal and development. Stem cells are central to organ development and renewal. In most organs, stem cells are located in specific regions and, in some cases, can be

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19:07 StemCellsPortal.coml Study shows RNA plays key role in stem cell differentiation

BOULDER, CO (US), July 2020 — Look deep inside our cells, and you’ll find that each has an identical genome – a complete set of genes that provides the instructions for our cells’ form and function.  But if each blueprint is identical, why does an eye cell look and act differently than a skin cell or brain cell? How does a stem cell – the raw material with which our organ and tissue cells are made – know what to become? In a study published July 6 in Nature Genetics, researchers at the University of Colorado Boulder (CU Boulder) come one step closer to answering that fundamental question, concluding that the molecular messenger RNA (ribonucleic acid) plays an indispensable role in cell differentiation, serving as a bridge between our genes and the so-called “epigenetic” machinery that turns them on and off. When that bridge is missing or flawed, the researchers report, a stem cell on the path to becoming a heart cell never learns how to beat. The paper

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18:37 FightAging.Org Shear Stress in the Aging Heart Makes Immune Cells Inflammatory, Accelerating Cardiovascular Disease

Researchers here note a process by which the hardening of heart valves, known as aortic valve stenosis, accelerates in its later stages. The condition causes greater shear stress in blood flow, which in turn causes immune cells in the bloodstream to become more inflammatory. The resulting greater chronic inflammation in heart tissue accelerates the mechanisms that cause stenosis. This hardening of tissue is due to calcification; a growing fraction of cells in the valves adopt behaviors more appropriate to bone tissue, creating calcium structures. Inflammatory signaling, such as that produced by the presence of senescent cells in aged tissues, is known to contribute to this inappropriate cellular activity. Aortic valve stenosis is the most common type of heart valve disease in the elderly and affects […]

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14:30 Phys.org Blood iron levels could be key to slowing ageing, gene study shows

Genes linked to ageing that could help explain why some people age at different rates to others have been identified by scientists.

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14:17 Technology.org MicroRNA-34a Promotes Vascular Cellular Senescence and Consequent Calcification

With the growing interest in the accumulation of senescent cells as an important cause of aging, and more

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13:35 FightAging.Org Mifepristone Slows Aging in Flies

Researchers here note that mifepristone, an abortifacient drug, slows aging in flies. This is interesting, but the mechanisms of action so far have the look of being quite specific to circumstance and gender - it blocks a detrimental effect of mating in female flies that increases inflammation. So I'd wager that this will turn out to be of academic interest only at the end of the day. If reductions in inflammation are the primary downstream benefit, this class of drug probably compares poorly to senolytics in any case. Studying one of the most common laboratory models used in genetic research - the fruit fly Drosophila - researchers found that the drug mifepristone extends the lives of female flies that have mated. Mifepristone, also known as […]

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13:21 FightAging.Org Targeting Senescent Cells in the Heart

Senescent cells accumulate with age, and their inflammatory secretions disrupt tissue structure and function. In the heart, the presence of senescent cells contributes to fibrosis, hypertrophy, and other aspects of the progression towards heart failure. Since senescent cells actively maintain a disrupted state of cells and tissue, targeted removal can quickly and significant reverse aspects of aging and age-related disease. This has been demonstrated in numerous organs, including the heart, in animal studies. For example, even the structural changes of ventricular hypertrophy can be reversed via treatments that selectively destroy senescent cells. Adult stem cells and progenitor cells are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all cell types of the organ in which they […]

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15.07.2020
22:42 FightAging.Org In Rats, Navitoclax Removes Senescent Chondrocytes that Contribute to Osteoarthritis

Senescent cells are created constantly throughout life, largely as a result of somatic cells reaching the Hayflick limit on replication, but the pace at which they are cleared by programmed cell death or the immune system slows with age. Senescent cells thus accumulate in old tissues, and this accumulation directly contributes to the progression of age-related disease and dysfunction. Senescence cells secrete a mix of molecules that cause chronic inflammation, disrupt tissue structure, and alter surrounding cell behavior. The more senescent cells there are in an organ, the worse the outcome. Fortunately, this contributing cause of aging now has potential solutions. Senolytic treatments are those that selectively destroy some fraction of senescent cells, as much as half in some tissues for first generation senolytic drugs. […]

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18:22 Nature.Com Ageing hallmarks exhibit organ-specific temporal signatures

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18:22 Nature.Com A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

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16:16 FierceBiotech.com New Insilico Medicine spinout to tackle longevity, COVID-19

New Insilico Medicine spinout to tackle longevity, COVID-19 badams Wed, 07/15/2020 - 08:49

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14:17 Technology.org Stem Cell Exhaustion in the Aging Lung

Stem cell activity declines with age throughout the body. In some cases this is because stem cells become

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13:35 FightAging.Org Sheer Stress in the Aging Heart Makes Immune Cells Inflammatory, Accelerating Cardiovascular Disease

Researchers here note a process by which the hardening of heart valves, known as aortic valve stenosis, accelerates in its later stages. The condition causes greater sheer stress in blood flow, which in turn causes immune cells in the bloodstream to become more inflammatory. The resulting greater chronic inflammation in heart tissue accelerates the mechanisms that cause stenosis. This hardening of tissue is due to calcification; a growing fraction of cells in the valves adopt behaviors more appropriate to bone tissue, creating calcium structures. Inflammatory signaling, such as that produced by the presence of senescent cells in aged tissues, is known to contribute to this inappropriate cellular activity. Aortic valve stenosis is the most common type of heart valve disease in the elderly and affects […]

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07:39 News-Medical.Net Silver strands and graying hair are not signs of aging in chimpanzees

Silver strands and graying hair is a sign of aging in humans, but things aren't so simple for our closest ape relatives--the chimpanzee. A new study published today in the journal PLOS ONE by researchers at the George Washington University found graying hair is not indicative of a chimpanzee's age.

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04:31 News-Medical.Net Deep Longevity and Human Longevity announce collaboration to deploy AI-powered aging clocks

Today, Deep Longevity Inc, a developer of deep biomarkers of human aging, and Human Longevity Inc announce a collaboration to deploy an extensive range of AI-powered aging clocks.

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14.07.2020
23:04 FightAging.Org Repetitive Element Activity is Reduced in Mice Subject to Interventions that Modestly Slow Aging

Today's open access paper is a companion piece to a recent discussion of repetitive element activity as a potential biomarker of biological aging. In today's paper, the authors note that a number of interventions that modestly slow aging in mice also reduce the activity of repetitive elements in the genome. Many forms of repetitive element are the remnants of ancient viruses, sequences that are capable of copying themselves into new locations in the genome, but are normally suppressed. A fair amount of attention has been given to retrotransposons, one category of repetitive elements, in the context of aging in recent years, but all repetitive elements appear to become more active with age. The systems responsible for repressing their activity begin to run awry, for reasons […]

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14:11 Technology.org It is Challenging to Find Support for Evolutionary Trade-offs Between Reproduction and Aging in Human Data

The disposibility theory of aging is one of numerous evolutionary theories of aging that seek to explain why

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13:41 FightAging.Org Thermoregulation is Impaired by Aging

The old are more vulnerable to all stresses, and heat is no exception. Older people make up a majority of the fatalities in heatwaves. This topic isn't frequently discussed in comparison to other aspects of aging, however. Impairment of the physiological response to heat is a dysfunction of high level processes in numerous organs, not just the skin, and results from a long chain of cause and consequence under the hood. That chain linking low-level molecular damage to high level outcomes is poorly explored, to say the least. This is one of the reasons why targeting the repair of that low-level damage of aging is a more effective strategy for the treatment of aging as a medical condition. Tens of thousands of deaths have been […]

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13:03 Technology.org Fertility decline in ageing fruit flies is about ‘more than just sperm’

Research by the universities of Liverpool and Oxford reveals new insight into age-related fertility decline in male fruit

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13:03 Technology.org NIH researchers reframe dog-to-human aging comparisons

One of the most common misconceptions is that one human year equals seven dog years in terms of

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