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09.12.2019
17:08 News-Medical.NetAussies can have their health and eat meat too with new version of Mediterranean diet

Barbecued, stir-fried or roasted, there's no doubt that Aussies love their meat. Consuming on average nearly 100 kilograms of meat per person per year, Australians are among the top meat consumers worldwide.

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14:41 FightAging.OrgAre Benefits from Cardiac Stem Cell Therapy Due to an Immune Response to Transplanted Cells?

As this article notes, researchers have recently suggested that the benefits to heart function observed over many years of stem cell therapies are not in fact due to any action of the cells themselves, not even cell signaling mechanisms such as release of exosomes, but are rather due to an immune response to the transplanted cells. The study reported here illustrates the point by showing some degree of regeneration of injured heart tissue to take place in mice when the debris of dead cells is transplanted. We might compare these findings with the body of work showing that delivery of exosomes can spur cardiac regeneration; few portions of the field of stem cell therapy are lacking a good supply of contradictory evidence. For 15 years, […]

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08.12.2019
21:31 News-Medical.NetGenetic features of AML in older patients can predict outcomes after stem cell transplant

For older patients with acute myeloid leukemia, the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the 61st American Society of Hematology (ASH) Annual Meeting.

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20:12 News-Medical.NetThe role of adenosine in neurodegeneration and brain regeneration

The role of adenosine in neurodegeneration and neuroregeneration has led to growing attention on adenosine receptors as potential drug targets in a range of brain disorders, including neuroregenerative therapy and treatment for amyotrophyic lateral sclerosis.

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18:06 FightAging.OrgFight Aging! Newsletter, December 9th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Catalytic Antibody Approach to Amyloid Aggregation This Giving Tuesday, Support Rejuvenation Research at the SENS Research Foundation The Prospects for Restoring Neurogenesis in the Aging Brain Mesodermal Progenitor Cells Enable the

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18:03 SingularityHub.ComWhy AI Will Be the Best Tool for Extending Our Longevity

Dmitry Kaminskiy speaks as though he were trying to unload everything he knows about the science and economics of longevity—from senolytics research that seeks to stop aging cells from spewing inflammatory proteins and other molecules to the trillion-dollar life extension industry that he and his colleagues are trying to foster—in one sitting. At the heart […]

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07.12.2019
13:15 TechnologyReview.comHow does time dilation affect aging during high-speed space travel?

Your space questions, answered.

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01:44 ScienceDaily.com'Conductor' gene found in plant root stem cell 'orchestra'

Researchers lift the veil on the 'conductor' plant root stem cell gene that helps orchestrate and coordinate stem cell division of different root stem cell types, ensuring the harmonic communication necessary for plant growth and maintenance.

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06.12.2019
22:59 StemCellsPortal.comlStem Cell Therapy Helps Broken Hearts Heal in Unexpected Way

CINCINNATI, OH (US), November 2019 — Stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. This is the conclusion of a study published recently in Nature that shows an entirely different way that heart stem cells help the injured heart — not by replacing damaged or dead heart cells as initially proposed.
The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
Mediated by macrophage cells of the immune system, the secondary healing process provided a modest benefit to heart function after heart attack, according to Jeffery Molkentin, Ph.D., principal

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22:59 StemCellsPortal.comlIntestinal Stem Cell Genes May Link Dietary Fat and Colon Cancer

NEW BRUNSWICK, NJ (US), November 2019 — Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers University study.
The study, published in Gastroenterology, describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.
"This is important because scientists have shown that when there's too much dietary fat in the intestine, stem cell numbers increase, boosting susceptibility to colon cancer," said senior author Michael Verzi, Ph.D., an associate professor in the Department of Genetics in the School of Arts and Sciences at Rutgers University-New Brunswick. Dr. Verzi is also a research member in the Genomic Instability and Cancer Genetics Research Program at Rutgers Cancer Institute of New Jersey.
People naturally lose millions of intestinal

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20:55 Phys.orgGenetic typing of a bacterium with biotechnological potential

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p.—the ability of the bacterium to infect its host and inflict a disease—is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs. Now, Kohei Ogura from Kanazawa University and colleagues have performed gene sequencing for various P. putida isolates originating from both environmental and clinical sites.

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20:41 TechnologyReview.comBuyer beware of this $1 million gene therapy for aging

The offshore tests by a startup seek to lengthen people’s telomeres—and their lives.

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18:50 AzoRobotics.comAmputee Bonds with Son Thanks to 3D Printed Bionic Hand

For 21 years, Danny Florence has lived with one hand. But when he became a father, he decided to apply for an Open Bionics Hero Arm. With the help of the maxon driven prosthesis he can now build a...

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14:36 FightAging.OrgReviewing the DNA Damage Response in Aging

Nuclear DNA damage is considered a contributing cause of aging, though at this stage the research community is still proposing and debating processes by which this damage might cause metabolic dysfunction throughout the body. Mutations to nuclear DNA evidently increase cancer risk, but setting this aside, how does random damage to random cells contribute to the declines of age? There are a few possibilities; firstly that the vast majority of nuclear DNA damage, occurring as it does in somatic cells, or in unusued portions of the genome, is irrelevant. Harms are done when mutations affecting function occur in stem cells and progenitor cells, allowing that mutation to spread widely throughout a tissue. The second possibility, more recently proposed, is that all nuclear DNA damage systemically […]

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14:24 Phys.org'Conductor' gene found in plant root stem cell 'orchestra'

In a new paper, researchers at North Carolina State University lift the veil on the "conductor" plant root stem cell gene that helps orchestrate and coordinate stem cell division of different root stem cell types, ensuring the harmonic communication necessary for plant growth and maintenance.

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04:38 MedicalNewsToday.comMedical News Today: Study reveals how diabetes drug promotes healthy aging

Doctors often prescribe metformin for type 2 diabetes. A new mouse study on its liver mechanisms may explain its wider benefits for health and life span.

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05.12.2019
21:08 Drugs.comHow Well Are You Aging? A Blood Test Might Tell

THURSDAY, Dec. 5, 2019 -- Imagine a blood test that could spot whether you are aging too quickly. New research suggests it's not the stuff of science fiction anymore. The scientists analyzed plasma -- the cell-free, fluid part of blood -- from more...

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19:44 Medscape.ComDon't Use Growth Hormone for Anti-Aging, Say New Guidelines

This is "a practical tool...regarding the identification, diagnosis, and treatment of adults and patients transitioning from pediatric to adult care services with growth hormone deficiency."

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19:20 Reuters.com HealthFDA declines to approve Enzyvant regenerative therapy on manufacturing concerns

Privately held drug developer Enzyvant said on Thursday the U.S. Food and Drug Administration declined to approve its regenerative tissue therapy for a rare immunodeficiency disorder and raised concerns about its manufacturing.

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19:19 ScienceMag.orgShould aging lab monkeys be retired to sanctuaries?

Biomedical researchers are increasingly interested in retiring monkeys, but the community is divided

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19:06 Reuters.com HealthFDA declines to approve Enzyvant's regenerative tissue therapy

Privately held drug developer Enzyvant said on Thursday the U.S. Food and Drug Administration declined to approve its regenerative tissue therapy for a rare immunodeficiency disorder and raised concerns about its manufacturing.

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17:17 Phys.orgWith cellular blueprint for lungs, researchers look ahead to organ regeneration

Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung that will make it easier to understand the design principles behind lung function and disease—and to bioengineer new lungs.

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14:37 FightAging.OrgThe Latest on Cellular Senescence in Type 2 Diabetes

One of the more unexpected recent findings relating to cellular senescence is that it appears to be an important part of the mechanisms that lead to loss of the pancreatic β-cells responsible for insulin secretion in both type 1 diabetes and type 2 diabetes - which are very different conditions, despite the shared name. The authors of the brief open access commentary noted here discuss the present state of this research. Age is one of the major risk factors for the development of type 2 diabetes mellitus (T2D). However, the understanding of how cellular aging contributes to diabetes pathogenesis is incomplete and as a result, current therapies do not target this aspect of the disease. In recent work we showed that insulin resistance induced the […]

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14:23 FightAging.OrgOn Making Philanthropy in Support of Rejuvenation Research Attractive to Investors

In this interview, Aubrey de Grey of the SENS Research Foundation talks about how the foundation has sought to make philanthropy in support of the development of rejuvenation therapies an attractive prospect for high net worth investors, people who are usually much more interested in deploying capital into for-profit programs. Since the goal of the SENS community is to move projects from the lab to clinical development, particularly those promising projects in rejuvenation research that have previously lacked funding and moved more slowly than we'd all like, it should be quite compatible with the goals of investors. It makes sense to offer philanthropic support to programs that will later lead to startup biotech companies that are looking for investment. How did Project 21 come into […]

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11:07 Technology.orgWith cellular blueprint for lungs, Yale researchers look ahead to organ regeneration

Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung

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10:41 StemCellsPortal.comlBMP Signaling and Club Cell Regeneration

Markers for cub cells, airways stem cells that can self‐renew and differentiate into other cells, and the signaling pathways involved in their stem cell activities remain poorly understood. However, a new STEM CELLS article from the lab of Huijuan Liu (Shanghai Jiao Tong University, Shanghai, China) has reported, for the first time, the essential nature of the BMPR1A-mediated Tak1‐p38MAPK pathway for club cell regeneration and the repair of the bronchiolar epithelium. Furthermore, Shafiquzzaman et al. identify Prrx1 as a marker for club cells in the adult mouse lung.


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09:58 News-Medical.NetDeep age predictors can help advance aging research

The deep age predictors can help advance aging research by establishing causal relationships in nonlinear systems.

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01:53 Drugs.comSki Your Way to a Healthier Aging Brain

WEDNESDAY, Dec. 4, 2019 -- Cross-country skiing may be good for your brain, a new study suggests. Previous research found that participants of the Vasaloppet, a popular long-distance, cross-country skiing race in Sweden, have a lower risk of heart...

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04.12.2019
23:31 FightAging.OrgThe Prospects for Restoring Neurogenesis in the Aging Brain

Today's open access paper is a review of potential approaches that might be used as a basis for therapies to restore a more youthful level of neurogenesis in the aging mammalian brain. Neurogenesis is the process by which new neurons are created by neural stem cell populations and then integrated into neural networks. In adults, neurogenesis is essential to memory, learning, and the limited degree of regeneration that the brain is capable of enacting. Unfortunately, the supply of new neurons declines with age as the underlying stem cells become ever less active. Beyond making the aging brain more resilient, methods of increasing neurogenesis may prove to be enhancement therapies capable of improving cognitive function even in young people. Any discussion of adult neurogenesis must note […]

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23:27 ScienceDaily.comSome stress in early life extends lifespan

Some stress at a young age could actually lead to a longer life, new research shows.

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21:11 Phys.orgResearchers discover stress in early life extends lifespan

Some stress at a young age could actually lead to a longer life, new research shows.

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21:05 Nature.ComThe integrative biology of type 2 diabetes

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19:35 ScienceDaily.comDiabetes drug has unexpected, broad implications for healthy aging

Metformin is the most commonly prescribed type 2 diabetes drug, yet scientists still do not fully know how it works to control blood sugar levels. Researchers have now used a novel technology to investigate why it functions so well. The findings could also explain why metformin has been shown to extend health span and life span in recent studies.

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16:48 FierceBiotech.comOmeros hits endpoint in pivotal stem cell transplant study

A pivotal trial of Omeros’ narsoplimab in hematopoietic stem cell transplant patients has hit its primary endpoint. Omeros expects to use the data to win FDA approval, although secrecy around the design of the trial means there remains scope for skepticism about the results.

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15:25 NYT Health25 Again? How Exercise May Fight Aging

The muscles of those who worked out looked like those of 25-year-olds and showed less of the inflammation that is tied to health problems as we age.

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13:38 NYT Health25 Again? How Exercise May Fight Aging

The muscles of those who worked out looked like those of 25-year-olds and showed less of the inflammation that is tied to health problems as we age.

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01:01 Reuters.com HealthDrinking milk does not appear to impact longevity

(Reuters Health) - People who consume lots of milk and cheese and yogurt may not necessarily live any longer than those who don't, a recent study suggests.

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01:01 Zdnet.comRussia to invest $31 million in a local Wikipedia clone

Project to be ready by the spring of 2022. Will be managed by a Russian publishing house, and not user-edited.

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03.12.2019
23:35 StemCellsPortal.comlAre All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network meta‐analysis of preclinical studies testing stem cell‐based therapies in experimental neonatal lung injury in the hope of improving regenerative treatments for bronchopulmonary dysplasia (BPD), a common preterm birth complication. While this STEM CELLS Translational Medicine article highlights mesenchymal stem cell-based therapies as the most effective treatments, the authors underscore the lack of head‐to‐head comparisons and the existence of an unclear risk of bias.


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23:35 StemCellsPortal.comlTargeted Stem Cell Attack Could Make Transplants Safer

MENLO PARK, CA (US),  — Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could make blood stem cell transplants — powerful but dangerous procedures that are used mainly to treat blood cancers — safer, and thereby broaden their use.
The studies come as evidence piles up that such transplants can also treat some autoimmune disorders and genetic diseases.
The work, to be presented this week at the American Society of Hematology annual meeting in Orlando, Florida, harnesses an understanding of the proteins made by different types of blood stem cell, the cells in the bone marrow that produce the different cellular components of blood.
Blood stem cell transplants work by replacing defective blood-making cells — which can give rise to blood cancer as well as

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21:53 News-Medical.NetIsolated components of Saussurea have positive effect on bone tissue regeneration

Saussurea controversa is a perennial herbaceous plant that has been traditionally used by the people of the Far East, Siberia, Tibet, and Mongolia to treat liver, kidney, digestive tract, and locomotive diseases. Its dried leaves are sold in pharmacies because their decoction is widely used as a medicine against cold and bronchitis. To understand what substances this plant owes its medicinal properties to, a team of scientists from Siberian State Medical University and Tomsk Polytechnic University extracted individual components from the plant and determined their composition.

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20:23 FightAging.OrgThis Giving Tuesday, Support Rejuvenation Research at the SENS Research Foundation

It is Giving Tuesday today, a prompt for each of to think about the change that we would like to see happen in the world, and then do our parts in making it happen. We can all be philanthropists, we can all support the projects that we believe will improve the human condition. In the sciences, it is largely exactly this sort of motivated philanthropy that funds the most important progress, that which takes place at the cutting edge of research. Public funding for research is near always only awarded after the discovery is made, after the proof of principle is demonstrated. Commercial funding tends to arrive later still. The vital work of generating that proof of principle is, in practice, funded through donations made […]

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19:26 ScienceDaily.comHow stem cells decide their identity

Several hundred different cell types of the adult human body are formed during embryonic development, starting from just a few identical stem cells. The differentiation potential of the cells is progressively restricted in the course of this process, causing changes in their morphology and functions.

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18:52 Phys.orgResearch team deciphers how stem cells decide their identity

A research team headed by Prof. Dr. Sebastian Arnold and Jelena Tosic from the Faculty of Medicine at the University of Freiburg has now succeeded in deciphering basic molecular control mechanisms by which stem cells decide which embryonic cell types to turn into. This is achieved at least partially through selective usage of the genes for each different cell type, despite the presence of the identical genetic information in every cell in the body. The scientists have published their findings in the journal Nature Cell Biology.

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13:59 CNN HealthA 'blue zones' diet: Live longer from what you eat

For most of their lives, the world's super-agers have nourished their bodies with whole, plant-based foods, such as leafy vegetables, tubers, nuts, beans and whole grains. And they ate meat fewer than five times monthly.

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04:41 MedicalNewsToday.comMedical News Today: Green spaces in cities can help people live longer

A large meta-analysis of existing studies now suggests that green spaces may protect the residents of urban areas from premature death.

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04:41 MedicalNewsToday.comMedical News Today: Parks with irregular shapes may boost longevity

A new study finds that parks with complex, irregular shapes and more access points are associated with a lower risk of premature mortality.

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04:41 MedicalNewsToday.comMedical News Today: Stem cell discovery could improve treatments for leukemia, other diseases

Scientists have found a way to boost blood stem cell self-renewal in the lab. The finding could improve treatments for leukemia and other blood diseases.

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01:35 News-Medical.NetStem cell therapy shows promise for the first time in spinal cord injury

Researchers have published the results of their work where stem cell therapy has shown promise in a case of spinal cord injury. The results of their case study were published in the latest issue of the journal Mayo Clinic Proceedings last week.

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02.12.2019
22:57 StemCellsPortal.comlTargeted Stem Cell Attack Could Make Transplants Safer

MENLO PARK, CA (US),  — Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could make blood stem cell transplants — powerful but dangerous procedures that are used mainly to treat blood cancers — safer, and thereby broaden their use.
The studies come as evidence piles up that such transplants can also treat some autoimmune disorders and genetic diseases.
The work, to be presented this week at the American Society of Hematology annual meeting in Orlando, Florida, harnesses an understanding of the proteins made by different types of blood stem cell, the cells in the bone marrow that produce the different cellular components of blood.
Blood stem cell transplants work by replacing defective blood-making cells — which can give rise to blood cancer as well as

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20:22 9to5google.comXiaomi’s Wear OS-based Apple Watch clone adds support for iPhones

Xiaomi launched its first Wear OS smartwatch earlier this year and it’s basically an Apple Watch clone running a skinned Wear OS. Now, the Xiaomi Mi Watch is adding support for iPhones with an update.
more…
The post Xiaomi’s Wear OS-based Apple Watch clone adds support for iPhones appeared first on 9to5Google.

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20:06 News-Medical.NetPurification scheme allows collection of elusive blood stem cells from zebrafish

Hematopoietic stem cells are multipotent cells that can develop into every type of blood cell in the body.

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18:23 Drugs.comCards, Board Games Could Be a Win for Aging Brains

MONDAY, Dec. 2, 2019 -- Playing cards and board games like chess, bingo and Scrabble might be the mental workout you need to keep your wits as you age, Scottish researchers suggest. People in their 70s who regularly play board games score higher on...

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11:11 StemCellsPortal.comlAre All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network meta‐analysis of preclinical studies testing stem cell‐based therapies in experimental neonatal lung injury in the hope of improving regenerative treatments for bronchopulmonary dysplasia (BPD), a common preterm birth complication. While this STEM CELLS Translational Medicine article highlights mesenchymal stem cell-based therapies as the most effective treatments, the authors underscore the lack of head‐to‐head comparisons and the existence of an unclear risk of bias.


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01.12.2019
17:18 FightAging.OrgFight Aging! Newsletter, December 2nd 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Notes on the 1st Alcor New York Science Symposium Slower DNA Damage Accumulation in Immune Cells Correlates with Species Life Span The Tight Junctions of the Blood-Brain Barrier in Aging and Neurodegeneration Werner Syndrome is Strongly

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29.11.2019
18:56 Nature.Com Targeted stem-cell attack could make transplants safer

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17:14 StemCellsPortal.comlAdult Tissue-derived Neural Crest-like Stem Cells

Neural crest stem cells are multipotent, easy to isolate from adult tissues, and easy to expand, and a recent concise review from the labs of Pihu Mehrotra and Stelios T. Andreadis (University at Buffalo, Buffalo, New York, USA) summarizes the advantages of using these cells for the treatment of demyelinating disorders and spinal cord injury. The authors also describe how this technology can also be used for disease modeling and drug testing, paving the way for personalized therapeutics for neurological disorders. For all the details, see STEM CELLS Translational Medicine now!


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14:21 AzoRobotics.comInvestor Tej Kohli Expands ‘Venture Philanthropy’ Into 3D-Printed Bionic Arms

Investor Tej Kohli is to fund the purchase of ten bionic arms for children with limb differences in the UK. The Tej Kohli Foundation hopes that its commitment to fund arms for ten children over the...

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14:19 FightAging.OrgReporting on the Aging Research and Drug Discovery Meeting Held at BASAL Life 2019

Earlier this year the Aging Research and Drug Discovery meeting was organized as a part of the broader BASAL LIFE scientific conference. As is traditional for such events, the organizers put together a paper reviewing the proceedings. A few of the early highlights are noted below, but many more presentations are briefly discussed in the open access paper. It is a representative selection of the present distribution of projects and research goals in the scientific community focused on intervention in the aging process. Aging poses profound health-related challenges that need to be tackled to reduce the social and economic burden on our aging society. Multidisciplinary perspectives will be of tremendous importance to understand the underlying molecular processes of aging and to accelerate the discovery and […]

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03:26 News-Medical.NetStem cells do help restore heart function – but in a different way

A new study published in the journal Nature shows that stem cells do work well to repair the damaged heart – but in an entirely different manner than was originally supposed. The study shows that stem cells, whether living or dead, when injected into the area of damage in the heart in mice, activate an intense acute inflammation. This triggers the classic wound healing response which finally results in the partial or complete recovery of mechanical function of the injured area.

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28.11.2019
10:11 Technology.orgCoral ecology and robot technology combine to combat bleaching and regenerate reef

Coral experts have scaled up their advanced technological approach to restoring baby corals on damaged areas of the

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06:42 News-Medical.NetUCLA scientists discover link between a protein and human blood stem cell self-renewal

UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions.

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06:13 News-Medical.NetPatients' own stem cells offer a step toward improving motor, sensory function after spinal cord injury

Stem cells derived from a patient's own fat offer a step toward improving -; not just stabilizing - motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.

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04:33 MedicalNewsToday.comMedical News Today: Rapamycin has anti-aging effect on human skin

A small study reveals that rapamycin, a drug with a long history as an immune suppressor, can improve tone and reduce wrinkles and sagging in human skin.

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02:43 News-Medical.NetResearch findings provide novel therapeutic space to induce scarless regenerative healing

Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix.

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00:58 ScienceDaily.comStem cell therapy helps broken hearts heal in unexpected way

A study shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

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27.11.2019
23:46 FightAging.OrgThe Tight Junctions of the Blood-Brain Barrier in Aging and Neurodegeneration

Today's open access paper is a review of the tight junction structures of the blood-brain barrier in aging and neurodegeneration. The blood-brain barrier is a structure of specialized cells that lines the blood vessels that pass through central nervous system tissue. The barrier allows only certain molecules and cells to pass between blood vessels and the central nervous system, thus preserving its separation from the rest of the body. Unfortunately the integrity of the blood-brain barrier breaks down with advancing age, and the entry of unwanted molecules and cells into the brain then contributes to inflammation and tissue dysfunction. A number of studies have shown links between blood-brain barrier dysfunction and the progression of neurodegenerative conditions. Researchers have identified leakage of fibrinogen into the brain […]

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21:30 Nature.ComStem-cell therapies use immune system to repair broken hearts

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21:30 Nature.ComAn acute immune response underlies the benefit of cardiac stem-cell therapy

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21:30 Nature.ComMLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

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21:09 FierceBiotech.comStem cells don't repair injured hearts, but inflammation might, study finds

A team from Cincinnati Children's Hospital tracked stem cells injected into the hearts of mice, and what they found could explain why clinical trials testing stem cell therapies in people with heart disease have been unsuccessful. They believe a smarter approach could be to harness the power of macrophages that provide healing in response to inflammation.

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17:22 Technology.orgHitachi Developed Automation Technology of 3D Culture to Expand Regenerative Medicine Business

Hitachi, Ltd. has announced that Hitachi developed a new automation technology of 3D culture(2), solving problems of the

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14:37 FightAging.OrgNanotics Aims at Preventing Senescent Cells from Evading Immune Surveillance

Nanotics works on a nanoparticle platform that can modulate cell signaling via depletion of arbitrary target signaling molecules, something that has a great many potential uses, such as altering the behavior of the immune system. Given the present level of interest in clearance of senescent cells as an approach to treating aging, it isn't surprising to see platform companies of this ilk turning their attention to the production of senolytic treatments in addition to their existing pipelines. Here the approach is to deny lingering senescent cells the capacity to protect themselves against immune surveillance, and thus enable the immune system to destroy a greater fraction of these errant cells than would otherwise be the case. Many cell signals are normally delivered in an intelligent cell-mediated […]

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13:05 Technology.orgAutism-Related Genetic Mutations Occur in Aging Brains of Alzheimer’s Patients

Researchers believe that autism is caused by mutations that occur sporadically in the egg or sperm or during

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07:33 News-Medical.NetStudy finds autism-related genetic mutations in aging brains of Alzheimer's patients

Researchers believe that autism is caused by mutations that occur sporadically in the egg or sperm or during pregnancy.

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00:04 FightAging.OrgSlower DNA Damage Accumulation in Immune Cells Correlates with Species Life Span

Today's open access research is an assessment of DNA damage accumulation in a variety of species, showing the pace of mutational damage correlates with species life span, at least as assessed here in immune cells from blood samples, and using a marker that identifies the response to short telomeres as well as forms of DNA damage. The DNA of the cell nucleus, the genetic blueprint for near all of the proteins produced in a cell, accumulates damage over time due to the normal haphazard chemical reactions that take place constantly inside cells. These mutational changes are largely irrelevant to cellular operation, but some can cause disruption in metabolism, or, worse, make a cell cancerous, by causing certain proteins to be produced in a broken or […]

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26.11.2019
23:16 News-Medical.NetStem cells do not take the day off on national holidays

While most of us are stuffing ourselves with turkey and pumpkin pie at home on Thanksgiving Day, the staff at one Cedars-Sinai laboratory will be on the job, feeding stem cells.

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22:42 StemCellsPortal.comlRNA Regulation Is Crucial for Embryonic Stem Cell Differentiation

AARHUS (DK), November 2019 — Embryonic stem cells (ESCs) are distinguished by their dual ability to self-renew and their potential to differentiate, both of which require tight regulatory control. During the differentiation of ESCs, various cells develop into specialized cell types such as skin cells, nerve cells, muscle cells, etc. While our understanding of ESC regulation has been dominated by transcriptional and epigenetic models, the role of post-transcriptional regulation via nuclear RNA decay has remained less explored.
Now a Danish research team has identified a disruptive relationship between excess nuclear RNA levels, regulated by the PolyA-tail eXosome Targeting' (PAXT) connection, and transcriptional control by the Polycomb Repressive Complex 2 (PRC2). The researchers propose that excess RNA hampers PRC2 function through its sequestration from DNA. Their results highlight the

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20:15 QuantaMagazine.orgLongevity Linked to Proteins That Calm Overexcited Neurons

New research makes a molecular connection between the brain and aging — and shows that overactive neurons can shorten life span.

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18:51 ScienceDaily.comTendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper's knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. New research reveals the existence of tendon stem cells that could potentially be harnessed to improve tendon healing and even to avoid surgery.

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14:35 FightAging.OrgTopical Rapamycin Evaluated as a Treatment for Skin Aging

Given the attention that descends upon any prospect of reversing skin aging, I should probably open by saying that much of the data here for extended low dose topical treatment with rapamycin over eight months, that regarding visible skin aging and collagen production, is no more exciting than that obtained by any number of other approaches, such as topical application of keratinocyte growth factor (KGF). Effect sizes are the only thing that matters, and also the one thing that all too many observers fail to consider. Looking at the paper, I would say that the primary point of interest is the 50% reduction in markers of cellular senescence in skin. Given what is known of rapamycin this seems unlikely to be a senolytic effect, so […]

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12:14 Technology.orgIntestinal Stem Cell Genes May Link Dietary Fat and Colon Cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role

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11:14 StemCellsPortal.comlKLF2 Enhances Bone Regeneration by MSCs and ECs

A team of researchers led by Mengfei Yu and Huiming Wang (Zhejiang University, Hangzhou, China) recently investigated KLF2 as a novel in vitro marker for mesenchymal stem cells (MSCs) to investigate osteogenesis and angiogenesis following the interaction between KLF2+ MSCs and endothelial cells (ECs). Zhou et al. demonstrated the improved formation of blood vessels via the secretion of angiogenic factors like ANG1 by KLF2-expressing MSCs and the differentiation of MSCs into pericytes through the PDGF‐BB/PDGFR‐ß signaling pathway. Mature ECs, in turn, synergistically enhanced the osteogenesis of KLF2-expressing MSCs through the efficient up‐regulation of VEGF. For more on how synergism between MSCs and ECs can have a profound impact on vascular network

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09:35 Technology.orgTendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper’s knee, and other tendon injuries a

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03:12 News-Medical.NetStudy reports discovery of tendon stem cells

Being made up of flesh and bone, the human body often suffers injuries due to tendon damage caused by various acute or chronic events. As these damaged tissues recover, scar tissue builds up, causing a slow and often painful recovery.

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00:52 News-Medical.NetFDA-approved drug to prevent organ rejection may slow skin aging

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray.

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25.11.2019
23:34 ScienceDaily.comRapamycin may slow skin aging

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray. Rapamycin, a FDA-approved drug normally used to prevent organ rejection after transplant surgery, may also slow aging in human skin, according to a new study.

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22:19 ScienceDaily.comIntestinal stem cell genes may link dietary fat and colon cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study. The study describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.

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21:57 News-Medical.NetArticle reveals new mechanism of programmed aging

Nature has sentenced humans to an inevitable death from the time of birth; the natural instrument of execution is the aging process. According to modern scientific notions, only two root causes of aging can be: stochastic physiological damage or the implementation of a special genetic program in the body.

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19:28 News-Medical.NetGenes that help intestinal stem cells burn dietary fat may play a role in colon cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study.

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18:15 StemCellsPortal.comlMultiple Doses of Stem Cells Show Potential in Treating Severe Asthma

DURHAM, N.C. (November 20, 2019) - A study released today in STEM CELLS Translational Medicine (SCTM) describes how multiple doses of a type of stem cell called mesenchymal stromal cells (MSCs) might offer a new way to treat people suffering from severe asthma.

An asthma attack is triggered by allergens entering the lungs and causing swelling of the airways. This sets off a domino effect that results in narrowing of the airways from the nose and mouth to the lungs. The most severe cases can lead to death. According to the Centers for Disease Control and Prevention, one in 13 people have asthma. There is no cure, but it can be managed in most cases with proper prevention and treatment.

The study in SCTM, conducted by researchers at the Federal

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16:28 Nature.ComSpace ageing: why sci-fi novels shun the badass older woman

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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04:37 MedicalNewsToday.comMedical News Today: Can the gut microbiome unlock the secrets of aging?

A new study finds that gut bacteria from old mice can help rejuvenate the neurons of younger ones, suggesting that gut bacteria are key to aging.

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24.11.2019
17:50 FightAging.OrgFight Aging! Newsletter, November 25th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents The Strategy of mTORC1 Inhibition Fails a Phase III Trial Heat Shock Proteins as a Basis for Tackling Protein Aggregation in Neurodegenerative Diseases Vaccination and Antiviral Therapies Targeting CMV as an Approach to Reducing

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22.11.2019
23:14 News-Medical.NetHow the digital age impacts longevity and lifestyle

Have you ever wondered how does the digital age affect our longevity? What effect new technologies and knowledge advances have on our life?

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20:59 Reuters.com HealthRoche says Tecentriq cocktail helps liver cancer patients live longer

Swiss drugmaker Roche on Friday said its immunotherapy Tecentriq combined with its Avastin medicine helped people with the most common form of liver cancer to live longer than with an older drug from Germany's Bayer.

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14:27 FightAging.OrgThe Dog Aging Project Forges Ahead with a Large Study

As noted here by the Life Extension Advocacy Foundation, the Dog Aging Project researchers are moving ahead with a large study of companion animals. While much of the study is observational, a sizable cohort will be treated with the mTOR inhibitor rapamycin. Dogs are much closer to humans than mice, so it will be interesting to see what results. Given what is known of the way in which stress response upregulation behaves in different species, we would expect to see similar effects on cellular biochemistry - such as upregulation of autophagy - but smaller relative gains in life span in dogs versus mice. Short-lived species have a much greater plasticity of life span in response to environmental circumstances than longer-lived species, something that probably has […]

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21.11.2019
23:50 FightAging.OrgDogs as a Model of Human Aging

Dogs are an interesting species when it comes to the study of aging. Firstly they are much closer to human metabolism and cellular biochemistry than mice, and secondly selective breeding has generated lineages with a very wide range of sizes and life spans. Thirdly, they occupy a good compromise position in the range of life spans, study cost, and similarity to humans. Mice live short lives, so studies are rapid and comparatively cheap, but there are sizable, important differences between mouse and human biochemistry. Humans live so long that most studies of aging are simply out of the question. Even in non-human primates that live half or less as long as we do, a study of aging and calorie restriction has lasted for decades, and […]

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22:52 Geek.comSnapchat Debuts Weird Aging AR Lens for App Users

Turn into a toddler or grandpa/grandma with Snapchat's new AR filter. (Photo Credit: Snapchat / YouTube) Snapchat is known for its wacky augmented reality filters and now, you can look like an adorable toddler or elderly person, thanks to the app’s new aging AR lens. Earlier this year, Snapchat […]
The post Snapchat Debuts Weird Aging AR Lens for App Users appeared first on Geek.com.

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21:24 Drugs.comAHA News: Obesity, Other Factors May Speed Up Brain Aging

THURSDAY, Nov. 21, 2019 (American Heart Association News) -- The brains of middle-age adults may be aging prematurely if they have obesity or other factors linked to cardiovascular disease, new research has found. Almost one-quarter of adults have...

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