Techh.info/biomedtechnology hourly

Life Extension

headlines texts
25.03.2019
17:43 News-Medical.NetResearchers report new regenerative medicine approach for treating osteoarthritis of the knee

Researchers at Tokai University report in the journal npj Regenerative Medicine a regenerative medicine approach for treating osteoarthritis of the knee.

Скрыть анонс
17:12 Drugs.comMore Reasons to Follow the Mediterranean Diet

MONDAY, March 25, 2019 -- More and more research supports the health benefits of the Mediterranean diet, the way of eating followed by people who live in countries around the Mediterranean Sea, such as Greece and Italy. Various studies have...

Скрыть анонс
13:37 FightAging.OrgSenescent Cells as a Contributing Cause of Degenerative Disc Disease

At this point, I suspect it will surprise no-one who follows the field to learn that the accumulation of senescent cells is a significant cause of degenerative disc disease. The evidence from a mouse study that is provided in the open access paper here doesn't quite rise to establishing that claim, but it is compelling nonetheless. Given the role of cellular senescence in arthritis, a disease of localized chronic inflammation, it is logical to also expect a role in the degeneration of intervertebral discs, as this is also a condition of aging in which inflammation seems important. Senescent cells, even while present in only comparatively small numbers, generate a potent mix of molecules that spurs chronic inflammation and is destructive of surrounding tissue structure. Fortunately […]

Скрыть анонс
11:32 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Megakaryocyte Production, Radiation-induced Fibrosis Treatment, Ocular Surface Reconstruction, and Oncolytic Viruses!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Gas-Permeable Surfaces Enhance Megakaryocyte Production

Challenges related to storage and fluctuating supply have limited donor‐based platelet transfusions for patients suffering from acute or sustained thrombocytopenia. Researchers led by Andres F. Martinez and William M. Miller (Northwestern University, Evanston, Illinois, USA) hoped to develop cell‐culture technologies that will enable ex vivo and donor‐independent platelet production at a scalable and therapeutically relevant level. Now, the team's new STEM CELLS

Скрыть анонс
08:28 News-Medical.NetModulating stiffness of blood-forming stem cells could facilitate mobilization procedures

Scientists at Winship Cancer Institute of Emory University, Children's Healthcare of Atlanta and Georgia Tech have found that modulating blood-forming stem cells' stiffness could possibly facilitate mobilization procedures used for stem cell-based transplants.

Скрыть анонс
24.03.2019
16:36 FightAging.OrgFight Aging! Newsletter, March 25th 2019

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being […]

Скрыть анонс
23.03.2019
23:38 TechInvestorNews.comSilicon Valley techies are turning to a cheap diabetes drug to help them live longer (CNBC: Top News)

CNBC: Top NewsSilicon Valley techies are turning to a cheap diabetes drug to help them live longer - Doctors feel that taking metformin is mostly safe, but cautioned about the lack of clinical studies. ...

Скрыть анонс
21:55 CNBC health careSilicon Valley techies are turning to a cheap diabetes drug to help them live longer

Doctors feel that taking metformin is mostly safe, but cautioned about the lack of clinical studies.

Скрыть анонс
21:33 CNBC technologySilicon Valley techies are turning to a cheap diabetes drug to help them live longer

Doctors feel that taking metformin is mostly safe, but cautioned about the lack of clinical studies.

Скрыть анонс
01:16 Drugs.comExtra Calcium Safe for the Aging Eye

FRIDAY, March 22, 2019 -- To take calcium or not to take calcium, that is still the question. In a new study that contradicts earlier research, investigators found that adding calcium to your diet will not raise your risk of a common age-related eye...

Скрыть анонс
00:02 ScienceDaily.comSquishing blood stem cells could facilitate harvest for transplants

How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities.

Скрыть анонс
22.03.2019
22:26 StemCellsPortal.comlThe Genetics of Regeneration

CAMBRIDGE, MA (US), March 2019 — When it comes to regeneration, some animals are capable of amazing feats — if you cut the leg off a salamander, for example, it will grow back. When threatened, some geckos drop their tails as a distraction and regrow them later.
Other animals take the process even further. Planarian worms, jellyfish and sea anemones can actually regenerate their entire bodies after being cut in half.
A team of researchers is shedding new light on how animals pull off the feat and uncovered a number of DNA switches that appear to control genes for whole-body regeneration. The study, led by Mansi Srivastava, Ph.D., assistant professor of organismic and evolutionary biology, is described in a March 15 paper in Science.
Using three-banded panther worms to test the process, Dr. Srivastava and Andrew Gehrke, a post-doctoral fellow working in her lab, found that a

Скрыть анонс
20:55 AutoBlog.comLand Rover wins legal battle over Evoque clone Land Wind X7

Filed under: Jaguar,Land Rover,Crossover
Continue reading Land Rover wins legal battle over Evoque clone Land Wind X7

Land Rover wins legal battle over Evoque clone Land Wind X7 originally appeared on Autoblog on Fri, 22 Mar 2019 13:47:00 EDT. Please see our terms for use of feeds.
Permalink |  Email this |  Comments

Скрыть анонс
17:37 TechInvestorNews.comStar Wars: The Clone Wars leaving Netflix in April - CNET (Sean Keane/CNET - Business Tech)

Sean Keane / CNET - Business TechStar Wars: The Clone Wars leaving Netflix in April - CNET - Get your binge in before Netflix executes Order 66. ...

Скрыть анонс
13:59 Phys.orgNot all stem cells are created equal, study reveals

Researchers from the University of Toronto's Institute for Biomaterials and Biomedical Engineering (IBBME) and the Donnelly Centre have discovered a population of cells – dubbed to be "elite" – that play a key role in the process of transforming differentiated cells into stem cells. The finding has important implications for regenerative medicine.

Скрыть анонс
10:54 Rejuvenation ResearchFrailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges

Rejuvenation Research, Ahead of Print.

Скрыть анонс
10:32 News-Medical.NetUnderstanding maintenance of quiescent stem cells in chronic myelogenous leukemia

Most patients with chronic myelogenous leukemia can be treated with tyrosine kinase inhibitors. These drugs are highly effective and lead to deep remission and prolonged survival.

Скрыть анонс
10:21 News-Medical.NetLian wins ENGINE grant for stem-cell-based therapy to treat Type 1 diabetes

Xiaojun "Lance" Lian, assistant professor of biomedical engineering, was one of three recipients of the College of Engineering's ENGineering for Innovation & Entrepreneurship grant for "Small Molecule-Based Definitive Endoderm Kit and Pancreatic Progenitor Kit for Stem Cell Research and Therapy."

Скрыть анонс
10:09 News-Medical.NetBrain process common to sleep and aging discovered

Oxford University researchers have discovered a brain process common to sleep and ageing in research that could pave the way for new treatments for insomnia.

Скрыть анонс
09:14 News-Medical.NetNanofibrous membrane could enhance periodontal tissue regeneration

According to the U.S. Centers for Disease Control and Prevention, about half of all Americans will have periodontal disease at some point in their lives.

Скрыть анонс
02:46 ScienceDaily.comHow 'sleeper cell' cancer stem cells are maintained in chronic myelogenous leukemia

Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular type of bone marrow cell controls quiescence of these treatment-resistant leukemic stem cells. The chemokine is CXCL12, and the particular bone marrow cells expressing it are mesenchymal stromal cells.

Скрыть анонс
02:03 ScienceDaily.comGetting help with the kids slows down ageing in female birds

Seychelles warblers live and breed in family groups on the tiny island of Cousin. In each group, a dominant female and male reproduce. When helpers assist the with incubation and feeding of chicks, the dominant female breeders age more slowly and live longer, a study by biologists shows. The results indicate how cooperative breeding -- which also occurs in other species, including humans -- can increase life span.

Скрыть анонс
21.03.2019
23:23 Phys.orgSleep and aging: Two sides of one coin?

Oxford University researchers have discovered a brain process common to sleep and ageing in research that could pave the way for new treatments for insomnia.

Скрыть анонс
23:21 FightAging.OrgIntron Retention via Alternative Splicing as a Signature of Aging

In recent years researchers have investigated changes in alternative splicing in the context of aging and age-related disease. It is thought to be important in cellular senescence, for example, but that is just one line item in the bigger picture. A given gene can code for multiple different proteins, and alternative splicing is the name given to the processes by which those different proteins are produced. A gene contains discrete DNA sequences called exons and introns, the former passed into the protein production process, and the latter removed during RNA splicing. The canonical protein produced from this genetic blueprint contains all of the exons, joined in sequence, but alternative splicing may drop exons, resulting in a different protein. The balance between the proteins produced from […]

Скрыть анонс
22:07 ScienceDaily.comSleep and ageing: Two sides of one coin?

Researchers have discovered a brain process common to sleep and ageing in research that could pave the way for new treatments for insomnia.

Скрыть анонс
19:57 StemCellsPortal.comlBlood Holds Key to Liver Regeneration

EAST LANSING, MI (US), March 2019 — The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn’t work.
A new Michigan State University study, published in the journal Blood, shows that the blood-clotting protein fibrinogen may hold the key as to why this happens.
“We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration,” said James Luyendyk, Ph.D., a professor of pathobiology in the College of Veterinary Medicine. “But if fibrinogen or platelets are inhibited, then regeneration is delayed.”
Platelets are blood cells that help form clots and stop bleeding. When they receive information

Скрыть анонс
19:57 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Stem Cell-Derived Exosomes, MSC Therapy for Knee Osteoarthritis, Long-term Starvation of MSCs, and Cartilage Endplate Degeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Stem Cell-Derived Exosomes Alleviate Aging Traits

As previous studies discovered that extracellular vesicles (EVs) secreted by human mesenchymal stem cells (MSCs) play roles in tissue repair and regeneration, researchers led by Linzhao Cheng and Vasiliki Mahairaki (Johns Hopkins University School of Medicine, Baltimore, USA) examined EVS derived from human induced pluripotent stem cells (iPSCs) cultured in chemically defined medium free of any exogenous EVs. Interestingly, Liu et al. discovered that iPSCs generated

Скрыть анонс
19:57 StemCellsPortal.comlGene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Review of “Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing” from Cell by Stuart P. Atkinson 

A cardiovascular disease locus present at 9p21.3 strongly influences the risk of coronary artery disease, stroke, and aneurysms [1]; however, deciphering the function of this sizeable human-specific coding gene-free risk haplotype has proven problematic. Subsequent studies have implicated a crucial role for the vascular smooth muscle cells (VSMCs) that compose the majority of blood vessel walls [2], although the senescence of VSMCs in vitro and their known phenotypic heterogeneity across individuals, tissues, and disease states have made them difficult to study [3].

To solve these problems, researchers from the laboratory of Kristin K. Baldwin (The Scripps Research Institute, La Jolla, CA, USA) combined gene-editing and induced

Скрыть анонс
19:57 StemCellsPortal.comlNew Trial of Umbilical Cord Mesenchymal Stem Cells for Osteoarthritis Suggests Safety and Efficacy

Review of “Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Successful animal trials of mesenchymal stem cell (MSC) therapy as a means to inhibit progression to osteoarthritis have encouraged the assessment of MSCs derived from various sources in human patients, including a phase I trial of allogeneic bone marrow MSCs that reported improvements in joint pain and function [1]. Multiple studies, including those from the laboratory of Francisco Espinoza (Universidad de los Andes, Santiago, Chile), have discovered that umbilical cord MSCs exhibit enhanced clonogenic, proliferative, and

Скрыть анонс
18:11 News-Medical.NetTMJ disorders could be treated with tissue-engineered implants after successful animal study

It’s estimated that around 10 million Americans experience a temporomandibular joint (TMJ) disorder, with women being more susceptible than men. Affecting the jaw joint, TMJ disorders are characterized by pain around the jaw, ear, and temple, as well as difficulties in opening the mouth and significant clicking or grinding noises brought on by jaw movement.

Скрыть анонс
13:33 FightAging.OrgChronic Inflammation as the Primary Cause of Declining Bone Regeneration with Age

Researchers here show that it is the chronic inflammation of aging that is the dominant contributing cause of loss of capacity in bone regeneration in later life. We should all feel a degree of relief whenever it turns out that chronic inflammation is the primary proximate cause of an age-related condition. Age-related inflammation is driven by senescent cells and immune system failure. Therapies to remove senescence cells are well advanced in clinical development, and there are many potential lines of work that will lead to ways to reverse the dysfunction of the aged immune system in years to come. The inflammatory profile of an old individual twenty years from now will look very different from the inflammatory profile of an old individual today. A new […]

Скрыть анонс
13:12 Phys.orgFemales live longer when they have help raising offspring

Female birds age more slowly and live longer when they have help raising their offspring, according to new research from the University of Sheffield.

Скрыть анонс
12:35 NYT HealthSugary Drinks Tied to Shorter Life Span

“The optimal intake of these drinks is zero,” said one expert. “They have no health benefits.”

Скрыть анонс
10:08 Gizmag Revolutions: The incredible potential of induced pluripotent stem cells


Revolutions is a series that brings together a hand-picked selection of recent articles bringing together cutting-edge insights into major scientific advances. This installment brings you up to date with the ground-breaking new discoveries made around the regenerative possibilities of induced pluripotent stem cells, which can theoretically be coaxed into any kind of cell in the human body.
.. Continue Reading Revolutions: The incredible potential of induced pluripotent stem cells Category: Medical Tags: Induced Pluripotent Stem Cells (iPS) Regenerative Medicine Revolutions Stem Cells

Скрыть анонс
06:45 Gizmag Brain aging could explain why time feels like it moves faster as we get older


The subjective sense that time moves faster as we get older is so universal that scientists have proffered a number of different explanations over the years. A professor of mechanical engineering at Duke University is suggesting a new and strange hypothesis to explain the phenomena, and it has to do with our aging brains.
.. Continue Reading Brain aging could explain why time feels like it moves faster as we get older Category: Science Tags: Brain Eye Neuroscience Perception Sight Time

Скрыть анонс
20.03.2019
23:51 FightAging.OrgT Cell Senescence Is Involved in the Disruption of Glucose Metabolism in Type 2 Diabetes

Cellular senescence is an important contributing cause of aging. Senescent cells accumulate with age and secrete a potent mix of molecules and vesicles, the senescence associated secretory phenotype. This disrupts tissue function in a range of ways, and produces chronic inflammation that accelerates the progression of all of the common age-related conditions. All forms of cell in the body appear to be capable of senescence, and the cells of the immune system are no exception. With advancing age, an increasing number of T cells of the adaptive immune system become senescent, producing the same damaging secretions. Exactly what damage is done by senescent T cells? Firstly, it appears that they contribute to autoimmunity - which is very interesting in light of other work showing that […]

Скрыть анонс
23:40 NYT ScienceChop Up a Worm. It Will Regenerate. Scientists Figured Out Why.

Researchers identified the master control gene that enables worms to grow a new body, capturing the imagination of some humans looking for a fresh start.

Скрыть анонс
21:48 News-Medical.NetStudy identifies gene variant associated with accelerated cellular aging

It is well known that psychiatric stress is associated with accelerated aging. Now, a new study shows that a gene mutation interacts with multiple types of psychiatric stress including post-traumatic stress disorder (PTSD), pain and sleep disturbances in association with cellular aging.

Скрыть анонс
21:22 ScienceDaily.comGene variant associated with cellular aging

It is well known that psychiatric stress is associated with accelerated aging. Now, a new study shows that a gene mutation interacts with multiple types of psychiatric stress including post-traumatic stress disorder (PTSD), pain and sleep disturbances in association with cellular aging.

Скрыть анонс
20:53 Drugs.comWalk, Dance, Clean: Even a Little Activity Helps You Live Longer

WEDNESDAY, March 20, 2019 -- Want a reason to get out of your comfy armchair? Even low levels of regular physical activity -- brisk walking, dancing or gardening -- can reduce your risk of premature death, a new study finds. Americans who got in...

Скрыть анонс
17:16 Nature.ComHow biomaterials will support China’s ageing population

Скрыть анонс
12:29 NYT HealthPhys Ed: Why Lifting Weights Can Be So Potent for Aging Well

People who discovered that they enjoyed and felt capable of completing a weight-training session subsequently joined a new gym and showed up for workouts.

Скрыть анонс
03:52 Gizmag Novel research links an aging gut microbiome with heart disease


An intriguing new study, led by scientists from the University of Colorado Boulder, suggests an aging gut microbiome may be somewhat responsible for the degradation in cardiovascular heath that tends to appear as we grow older. The study is yet another addition to the growing body of evidence affirming the role gut bacteria plays in age-related disease.
.. Continue Reading Novel research links an aging gut microbiome with heart disease Category: Health & Wellbeing Tags: Cardiovascular Gut Bacteria Heart Disease Microbiome

Скрыть анонс
00:04 ScienceDaily.comFountain of youth for heart health may lie in the gut

As our collection of resident gut bacteria changes with age, it increasingly produces harmful metabolites that damage veins and blood vessels, driving disease, a new study suggests.

Скрыть анонс
19.03.2019
21:20 FightAging.OrgTurn.bio: Transiently Reprogramming Cells to Near Pluripotence as a Therapy for Aging

Turn.bio is Gary Hudson's latest company, now that others are running the day to day development at Oisin Biotechnologies. The Turn.bio staff are working on a particular take on the idea of inducing pluripotence in cells in vivo as a form of compensatory therapy for aging. This is a concept that struck me as being fairly crazy the first time I saw it discussed in a research publication. It is certainly possible to reliably reprogram somatic cells of near any sort into what are known as induced pluripotent stem cells, capable of differentiating into any type of cell. This is the foundation for the production of arbitrary cell types for transplantation. But doing it inside a living animal? Surely a recipe for cancer and more […]

Скрыть анонс
19:06 Rejuvenation ResearchDiagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation Research“Aging, Geroscience, and Freedom”

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchThe Plasma NAD+ Metabolome Is Dysregulated in “Normal” Aging

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchAntiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchPleiotropic Effects of French Maritime Pine Bark Extract to Promote Healthy Aging

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchA Clinical Trial Using Methylation Age to Evaluate Current Antiaging Practices

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchGlycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchIntegration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchRed Blood Cell Distribution Width, Vascular Aging Biomarkers, and Endothelial Progenitor Cells for Predicting Vascular Aging and Diagnosing/Prognosing Age-Related Degenerative Arterial Diseases

Rejuvenation Research, Ahead of Print.

Скрыть анонс
19:06 Rejuvenation ResearchCommentary on Some Recent Theses Relevant to Combating Aging: February 2019

Rejuvenation Research, Volume 22, Issue 1, Page 82-88, February 2019.

Скрыть анонс
19:06 Rejuvenation ResearchValidated Living Worldwide Supercentenarians 112+, Living and Recently Deceased: February 2019

Rejuvenation Research, Volume 22, Issue 1, Page 79-81, February 2019.

Скрыть анонс
19:06 Rejuvenation ResearchRapamycin Confers Neuroprotection Against Aging-Induced Oxidative Stress, Mitochondrial Dysfunction, and Neurodegeneration in Old Rats Through Activation of Autophagy

Rejuvenation Research, Volume 22, Issue 1, Page 60-70, February 2019.

Скрыть анонс
19:06 Rejuvenation ResearchStem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice

Rejuvenation Research, Volume 22, Issue 1, Page 51-59, February 2019.

Скрыть анонс
16:27 Yahoo.com BusinessIs the Options Market Predicting a Spike in Senseonics Holdings (SENS) Stock?

Investors need to pay close attention to Senseonics Holdings (SENS) stock based on the movements in the options market lately.

Скрыть анонс
16:02 Phys.orgBiologists develop new method of cloning

DNA, which contains the genetic information of an organism, consists of long chains of nucleotides. In order to study the functions based on the sequence of these building blocks, DNA molecules must be inserted in carrier molecules (plasmid-vectors) to be multiplied. For this cloning process, a research team from the University of Bayreuth has developed a highly efficient, fast and inexpensive method that is versatile enough to be deployed in all areas of biology, biochemistry and biotechnology. A key feature of the method is that it makes any painstaking screening of bacterial colonies unnecessary. The scientists presented their innovation in the journal Scientific Reports.

Скрыть анонс
09:46 News-Medical.NetLack of health insurance may increase Aging immigrants’ risk for cardiovascular disease

Aging immigrants' risk for cardiovascular disease may be heightened by their lack of health insurance, particularly among those who recently arrived in the United States, finds a study led by researchers at NYU Rory Meyers College of Nursing.

Скрыть анонс
06:01 ScienceDaily.com'Inflamm-aging' causes loss of bone healing ability in the elderly

Increases in chronic inflammation -- not the passage of time -- is the main reason why injured bones do not heal as well with age.

Скрыть анонс
18.03.2019
23:35 FightAging.OrgThe Importance of Preventing High Blood Pressure in Aging

Raised blood pressure with age, hypertension, is a major downstream consequence of low-level biochemical damage and cellular dysfunction, converting it into high-level structural damage in the body and brain. Hypertension is an important proximate contributing cause of ultimately fatal age-related conditions of the cardiovascular system, kidneys, brain, and lungs, among others. Pressure damage in delicate tissues degrades function in many organs, particularly in the central nervous system where there is little to no regeneration capable of reversing that damage. More subtly, hypertension also causes heart muscles to enlarge and weaken, contributing to heart failure. Hypertension also accelerates the development of atherosclerosis, through mechanisms independent of other factors such as chronic inflammation. Hypertension is so great a contribution to age-related disease, such an important

Скрыть анонс
21:30 News-Medical.NetStudy: Post-traumatic holocaust survivors transmit negative views on aging to offspring

Favorable views on aging promote a general sense of wellbeing, increase self-efficacy, and motivate older adults to maintain a healthy lifestyle, ultimately influencing their own physical and biological aging. But exposure to trauma, directly or indirectly, may significantly impact these views, according to a new study.

Скрыть анонс
14:29 StemCellsPortal.comlNew Trial of Umbilical Cord Mesenchymal Stem Cells for Osteoarthritis Suggests Safety and Efficacy

Review of “Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Successful animal trials of mesenchymal stem cell (MSC) therapy as a means to inhibit progression to osteoarthritis have encouraged the assessment of MSCs derived from various sources in human patients, including a phase I trial of allogeneic bone marrow MSCs that reported improvements in joint pain and function [1]. Multiple studies, including those from the laboratory of Francisco Espinoza (Universidad de los Andes, Santiago, Chile), have discovered that umbilical cord MSCs exhibit enhanced clonogenic, proliferative, and

Скрыть анонс
14:06 StemCellsPortal.comlGene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Review of “Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing” from Cell by Stuart P. Atkinson 

A cardiovascular disease locus present at 9p21.3 strongly influences the risk of coronary artery disease, stroke, and aneurysms [1]; however, deciphering the function of this sizeable human-specific coding gene-free risk haplotype has proven problematic. Subsequent studies have implicated a crucial role for the vascular smooth muscle cells (VSMCs) that compose the majority of blood vessel walls [2], although the senescence of VSMCs in vitro and their known phenotypic heterogeneity across individuals, tissues, and disease states have made them difficult to study [3].

To solve these problems, researchers from the laboratory of Kristin K. Baldwin (The Scripps Research Institute, La Jolla, CA, USA) combined gene-editing and induced

Скрыть анонс
13:55 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Stem Cell-Derived Exosomes, MSC Therapy for Knee Osteoarthritis, Long-term Starvation of MSCs, and Cartilage Endplate Degeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Stem Cell-Derived Exosomes Alleviate Aging Traits

As previous studies discovered that extracellular vesicles (EVs) secreted by human mesenchymal stem cells (MSCs) play roles in tissue repair and regeneration, researchers led by Linzhao Cheng and Vasiliki Mahairaki (Johns Hopkins University School of Medicine, Baltimore, USA) examined EVS derived from human induced pluripotent stem cells (iPSCs) cultured in chemically defined medium free of any exogenous EVs. Interestingly, Liu et al. discovered that iPSCs generated

Скрыть анонс
13:54 Technology.orgSkin Repair Eliminates ‘Inflamm-Aging’ Linked to Chronic Disease

Skin is the body’s largest organ, and scientists at UC San Francisco and the San Francisco Veterans Administration (VA)

Скрыть анонс
17.03.2019
17:21 FightAging.OrgFight Aging! Newsletter, March 18th 2019

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being […]

Скрыть анонс
15.03.2019
23:44 DigitalTrends.comWestern Digital’s $55 solid-state drive gives new life to your aging PC

Western Digital is hoping that you'll pick up one of its affordable WD Blue SN500 solid-state drives to give your aging PC more storage and a speed boost. WD's NVMe-based drives are up to three times faster than older SATA SSDs.
The post Western Digital’s $55 solid-state drive gives new life to your aging PC appeared first on Digital Trends.

Скрыть анонс
23:05 FightAging.OrgCcna2 as a Novel Regulator of Cellular Senescence

Given the present wave of investment into the treatment of aging, in both the business and research communities, and given the significant valuations put on the first companies working on senolytic drugs to clear senescent cells, it should come as no surprise to see a land rush underway in the investigation of the biochemistry of cellular senescence. The state of funding for any specific field of research is to a sizable degree steered by what is going on in the world of startups and venture capital. When finding a new mechanism is a potential ticket to valuable intellectual property, a startup company, and production of clinical therapies, then there will be more funding available for researchers involved in the search for mechanisms, and more researchers […]

Скрыть анонс
21:30 Nature.ComJapan poised to allow ‘reprogrammed’ stem-cell therapy for damaged corneas

Скрыть анонс
20:15 FinancialExpress.comShilpa Shetty on facing rejections in Bollywood and secret of her longevity

Shilpa Shetty, who started her Bollywood journey with "Baazigar", said the success of the Shah Rukh Khan-starrer did not help her much in getting good roles.

Скрыть анонс
20:03 Geek.comNew, Clone-Like Spiders Found in Colombia Named After ‘Star Wars’ Stormtroopers

Researchers have named four of six bald-legged spiders recently discovered in Colombia Stormtropis, after the Star Wars Stormtroopers soldiers, for their identical appearance and ability to camouflage. Despite being widely distributed across north and central […]
The post New, Clone-Like Spiders Found in Colombia Named After ‘Star Wars’ Stormtroopers appeared first on Geek.com.

Скрыть анонс
13:32 FightAging.OrgProposing the IMM-AGE Metric to Measure the Aging of the Immune System

Determinations of biological age based on ever more detailed measurements of human cellular biochemistry are known as clocks. Biological age is distinct from chronological age, as different people age at somewhat different rates. Aging is an accumulation of cell and tissue damage and the consequences of that damage; more damage means a higher biological age. The best known clock examples are the well known varieties of epigenetic clock, based on patterns of DNA methylation that decorate the genome. In recent years, researchers have been rapidly developing other sorts of clock, using other measures of cellular biochemistry and metabolism. The one here is an example of the type, focused on immune system function. The immune system is the critical function in the body for managing health. […]

Скрыть анонс
03:03 ScienceDaily.comStudy uncovers genetic switches that control process of whole-body regeneration

Researchers are shedding new light on how animals perform whole-body regeneration, and uncovered a number of DNA switches that appear to control genes used in the process.

Скрыть анонс
00:38 LiveScience.comMammoth DNA Briefly 'Woke Up' Inside Mouse Eggs. But Cloning Mammoths Is Still a Pipe Dream.

A handful of 28,0000-year-old woolly mammoth cell parts were recently "woken up" for a short time in a new experiment, but cloning the ice age beasts is still a long way off.

Скрыть анонс
14.03.2019
23:03 FightAging.OrgSGLT-2 Inhibitors as Calorie Restriction Mimetics

SGLT-2 inhibitors, or gliflozins, are a newer and still expensive class of anti-diabetic drug. They work by interfering in the trafficking of glucose, preventing the kidney from reclaiming glucose and introducing it back into the bloodstream. The glucose is instead excreted. Analogously to metformin, another anti-diabetic drug, it is proposed that inhibition of SGLT-2 in some ways mimic the effects of calorie restriction, triggering beneficial cellular housekeeping mechanisms that usually only turn on during periods of fasting or low calorie intake. Size of effect and degree of side-effects are always the questions in these matters, however. One should hold back any nascent enthusiasm until able to find reliable answers in the literature. Evidently, a faction of the research community thinks that metformin has a large […]

Скрыть анонс
21:07 Phys.orgStudy uncovers genetic switches that control process of whole-body regeneration

When it comes to regeneration, some animals are capable of amazing feats—if you cut the leg off a salamander, it will grow back. When threatened, some geckos drop their tails as a distraction, and regrow them later.

Скрыть анонс
18:59 InvestorPlace.com7 ETFs to Buy to Ride the Longevity Economy

InvestorPlace - Stock Market News, Stock Advice & Trading Tips
As people live longer, the longevity economy will continue to grow. These seven ETFs to buy give investors the edge.
The post 7 ETFs to Buy to Ride the Longevity Economy appeared first on InvestorPlace.
More From InvestorPlace 2 Toxic Pot Stocks You Should Avoid 15 Stocks Sitting on Huge Piles of Cash The 10 Best Stocks to Buy for the Bull Market’s Anniversary 7 Dividend Stocks With Big Yields

Скрыть анонс
18:46 StemCellsPortal.comlBlood Holds Key to Liver Regeneration

EAST LANSING, MI (US), March 2019 — The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn’t work.
A new Michigan State University study, published in the journal Blood, shows that the blood-clotting protein fibrinogen may hold the key as to why this happens.
“We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration,” said James Luyendyk, Ph.D., a professor of pathobiology in the College of Veterinary Medicine. “But if fibrinogen or platelets are inhibited, then regeneration is delayed.”
Platelets are blood cells that help form clots and stop bleeding. When they receive information

Скрыть анонс
15:47 SeekingAlpha.comEquinor to extend life of 20 Norway offshore platforms

Скрыть анонс
13:31 FightAging.OrgA Review of DNA Methylation Based Epigenetic Clocks as a Measure of Aging

Epigenetic clocks measure DNA methylation of sites on the genome that are patterned in much the same way in every individual of a given age. DNA methylation is an epigenetic marker that serves to regulate the production of protein from a specific gene. A range of different clocks have been constructed based on weighted assessments of methylation at various points on the genome, and the best of them can measure age quite accurately, to within a few years. The clocks were built by working backwards from DNA methylation and age data, and it was discovered along the way that people with methylation patterns characteristic of an older age have a worse prognosis for age-related disease and mortality, or have a greater tendency to already exhibit […]

Скрыть анонс
12:24 Technology.orgGenetically Encoded Sensor Isolates Hidden Leukemic Stem Cells

All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most

Скрыть анонс
11:46 BBC HealthOscar Saxelby-Lee: Mum 'overwhelmed' by stem cell donor campaign

Thousands of people have registered to find a stem cell match for a five-year-old with leukaemia.

Скрыть анонс
00:05 SeekingAlpha.comU.S. Stem Cell reports FY results

Скрыть анонс
13.03.2019
23:46 ScienceDaily.comPesticides influence ground-nesting bee development and longevity

Results from a new study suggest that bees might be exposed to pesticides in more ways than we thought, and it could impact their development significantly. The study looks at the non-target effects of pesticides on ground-nesting bees, a group that actually makes up the majority of bee species.

Скрыть анонс
23:38 FightAging.OrgSigns of Cellular Senescence in Aged Bone Marrow, Contributing to Impaired Generation of Immune Cells

The accumulation of lingering senescence cells with age is apparently there to be discovered in every tissue in the body, and researchers are gathering a great deal of data now that it is generally accepted that these errant cells are one of the causes of aging. The overt signs of cellular senescence in a tissue are much the same throughout the body, even if there may well be significantly different classes of senescent cell still to be categorized. All senescent cells examined to date generate inflammatory, harmful secreted molecules that rouse the immune system, disrupt surrounding cell activities, destructively remodel the extracellular matrix, and more. All of this is a necessary part of regeneration when it takes place over the short term, but when the […]

Скрыть анонс
23:28 Phys.orgPesticides influence ground-nesting bee development and longevity

Results from a new study suggest that bees might be exposed to pesticides in more ways than we thought, and it could impact their development significantly.

Скрыть анонс
21:38 ScienceDaily.comHematopoietic stem cells: Making blood thicker than water

A team revealed that Ragnase-1 is a key regulator of the self-renewal and differentiation of hematopoietic stem and progenitor cells. Knockout of this gene in mice resulted in aberrant blood cell composition and hematopoiesis, and caused health-related outcomes such as low hemoglobin, enlarged spleen, and early death. This insight into blood cell homeostasis and differentiation could lead to treatments for diseases such as leukemia in which these regulatory processes go awry.

Скрыть анонс
17:03 CancerNetwork.comStem Cell Transplant Approaches for Patients With Blood Cancers

Dr. Scadden discusses which blood cancer patients are eligible for stem cell transplantation, as well as the latest advances in the field.

Скрыть анонс
17:01 Phys.orgLS2 report: rejuvenation for the antiproton decelerator

The Antiproton Decelerator (AD), sometimes known as the Antimatter Factory, is the world's largest source of antimatter and has been operational since 2000. Here, antiprotons are slowed down and sent into the experiments, where they are combined with antielectrons to produce the most basic antiatom: that of antihydrogen. Over the course of the second long shutdown of CERN's accelerator complex (LS2), the AD will receive several enhancements as well as repairs and refurbishments.

Скрыть анонс
09:17 Yahoo.com BusinessSenseonics Holdings, Inc. (SENS) Q4 2018 Earnings Conference Call Transcript

SENS earnings call for the period ending December 31, 2018.

Скрыть анонс
01:27 Yahoo.com BusinessSenseonics Holdings (SENS) Reports Q4 Loss, Lags Revenue Estimates

Senseonics (SENS) delivered earnings and revenue surprises of 73.33% and -8.75%, respectively, for the quarter ended December 2018. Do the numbers hold clues to what lies ahead for the stock?

Скрыть анонс
12.03.2019
23:23 News-Medical.NetNovel biosensor can isolate and target leukemic stem cells

All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. Understanding how leukemic stem cells are regulated has become an important area of cancer research.

Скрыть анонс
20:14 ScienceDaily.comGenetically encoded sensor isolates hidden leukemic stem cells

Researchers have devised a novel biosensor that can isolate and target leukemic stem cells. It can provide a prototype for precision oncology efforts to target patient-specific cells to fight the deadly disease.

Скрыть анонс
12:53 Technology.orgNew Insight into Aging Hearts

A team led by Harvard Medical School researchers based at Massachusetts General Hospital has found that activity of

Скрыть анонс
12:03 MedicalNewsToday.comMedical News Today: The Mediterranean diet can boost athletic performance in just 4 days

A new study compares the effects of the Mediterranean diet with those of the Western diet on athletic performance and endurance to exercise.

Скрыть анонс
11.03.2019
17:16 StemCellsPortal.comlGenetic ‘Conductor’ of Brain Stem Cells Discovered

TRIESTE (IT), March 2019 — Our brain comprises 85 billion nerve cells and just as many so-called glial cells, which work in close contact with the former to guarantee their proper function. All originate from brain stem cells. But what decides when and how many of them become neurons or glial cells?
A new study led by the Laboratory of Cerebral Cortex Development of SISSA (Scuola Internazionale Superiore di Studi Avanzati) has shown how the Foxg1 gene, already involved in numerous processes of cerebral development and in rare disorders like Rett and West syndromes, plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment.
The work, published in Cerebral Cortex and conducted in collaboration with the University of Cambridge and the IRCCS Burlo Garofolo, opens new

Скрыть анонс
17:04 StemCellsPortal.comlStem cells provide greater insight into rotator cuff disease

ANN ARBOR, MI (US), March 2019 — Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult.
“Chronic tears often result in fat accumulation within the rotator cuff muscles, resulting in negative clinical outcomes including weakening and atrophy of the muscles,” said Manuel Schubert, M.D., resident in orthopedic surgery at Michigan Medicine, University of Michigan. “It’s believed that this process of fat infiltration makes rotator cuff muscle damage one of the most difficult to rehabilitate after injury.”
Dr. Schubert explained that the process of fat accumulation following a tear appears to occur more frequently in rotator cuff muscles than other muscle groups. But why this particular muscle set?
“We wanted to determine if there are cellular, molecular and genetic reasons for why rotator cuff muscles tend to develop this fat

Скрыть анонс
First← Previous12345678910Previous →Last