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18.10.2019
10:36 Technology.orgNew Player in Human Aging

A new character has stepped onstage in the story of human aging: neural excitation. The brain’s neural activity,

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17.10.2019
22:19 FightAging.OrgAutoimmunity Against AT1 Receptor Spurs Endothelial Cellular Senescence and Vascular Aging

The presence of antibodies against the angiotensin II receptor (AT1 receptor) has been noted in a number of conditions involving raised blood pressure, from preeclampsia during pregnancy to the hypertension associated with aging. These antibodies induce dysfunction in vascular smooth muscle, preventing appropriate contraction and dilation in response to circumstances. That in and of itself is enough to produce hypertension, chronically raised blood pressure. In turn, that raised blood pressure causes damage to delicate tissues throughout the body, such as those of the kidney and the brain. It is an important aspect of aging, a way in which low-level molecular damage and disarray localized to blood vessels is converted to structural damage and progressive organ failure throughout the body. In this context, the novel aspect […]

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21:39 ScienceDaily.comStem cell study offers new way to study early development and pregnancy

For the first time, researchers have created mouse blastocyst-like structures, or 'blastoids,' from a single cultured cell. The work could help advance research into development as well as inform issues around pregnancy, infertility, or health problems later in the offspring's life.

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19:14 News-Medical.NetProlonged exposure to blue light may affect longevity

Prolonged exposure to blue light, such as that which emanates from your phone, computer and household fixtures, could be affecting your longevity, even if it's not shining in your eyes.

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18:17 ScienceDaily.comDaily exposure to blue light may accelerate aging, even if it doesn't reach your eyes

Prolonged exposure to blue light, such as that which emanates from your phone, computer and household fixtures, could be affecting your longevity, even if it's not shining in your eyes. New research suggests that the blue wavelengths produced by light-emitting diodes damage cells in the brain as well as retinas, according to a new study in a model organism.

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16:25 Phys.orgStudy reveals how collapse of protein processes is driver of aging and death

Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death. The finding opens a door to a better understanding of the molecular origins of age-related neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, which all entail protein damage.

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15:58 News-Medical.NetMice with hyper-long telomeres live longer in better health, study shows

A chance finding ten years ago led to the creation by researchers of the Spanish National Cancer Research Centre of the first mice born with much longer telomeres than normal in their species.

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13:39 FightAging.OrgWhy Does Reduced Grip Strength Correlate with Chronic Lung Disease in Aging?

In this open access paper, researchers speculate on the common mechanisms underlying the correlation between reduced grip strength and chronic lung disease in old age. The many, complex, and diverse manifestations of aging emerge from a much smaller, simpler set of root causes. Simple forms of damage applied to a very complex system necessarily produce very complex outcomes. Nonetheless, the incidence of many of those outcomes, even when very different from one another, will correlate because they depend to a sizable degree on the same forms of underlying damage. The term "sarcopenia" was first introduced to describe the progressive age-related loss of muscle mass and is correlated with poor health-related quality of life. In this context, the handgrip dynamometer (HGD) is a useful tool to […]

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13:26 FightAging.OrgBusiness Analysts Start to Pay Attention to the Longevity Industry

Larger business analysis concerns are starting to notice that the longevity industry exists. I point out this press release not because the contents are all that interesting or useful - it is very much business as usual in the white paper production community, and the people creating these materials typically have a poor understanding of the biology and the biotechnology - but rather as an indication of progress towards a broader appreciation of the potential to treat aging as a medical condition. Slowly, the eyes of the world are opened. The global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on stem cell research and increasing demand for cell-based assays in research and development. An […]

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10:03 News-Medical.NetRapamycin is more effective at slowing down aging, says researcher

The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today.

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01:00 Drugs.comAging Population, Unhealthy Habits Underlie Expected Cancer Surge

WEDNESDAY, Oct. 16, 2019 -- Due to population growth and aging, the number of cancer cases worldwide is expected to jump 60% by 2040 -- but unhealthy lifestyle habits are likely to make the surge even larger. That's the conclusion from the new...

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00:10 News-Medical.NetType of activity may have effect on brain's response to aging

Running and lifting weights might be a crucial step in helping your body delay the effects of aging, but those exercises may be only part of the story.

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16.10.2019
23:34 News-Medical.NetBrain's neural activity plays a role in human aging, life span

The brain's neural activity-;long implicated in disorders ranging from dementia to epilepsy-;also plays a role in human aging and life span, according to research led by scientists in the Blavatnik Institute at Harvard Medical School.

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22:46 FightAging.OrgIncreased Insulin Sensitivity is Not Required for Extension of Healthy Life Span in Mice via Calorie Restriction

The biochemistry surrounding insulin and insulin signaling is very well studied in the context of aging. A number of ways to slow aging in laboratory species involve directly manipulating these signaling pathways. Calorie restriction, like a number of other methods of slowing aging, improves insulin sensitivity, and the consensus in the research community has been that some fraction of the benefits to health and longevity that result from a restricted calorie intake are derived from this change to insulin metabolism. Today's open access paper provides evidence to suggest, surprisingly, that this is not in fact the case. It is possible to block this part of the calorie restriction response, and the effect on health and longevity is much the same. What, then, are the mechanisms […]

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22:13 Drugs.comIrregular Periods, Shorter Life Span?

WEDNESDAY, Oct. 16, 2019 -- Women whose menstrual cycles persistently vary from the 28-day norm may have an increased risk of earlier death, new research suggests. The study found that women who had irregular periods or extra-long menstrual cycles...

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21:06 ScienceDaily.comIn a first, scientists pinpoint neural activity's role in human longevity

Researchers discover that the activity of the nervous system might influence human longevity. Neural excitation linked to shorter life, while suppression of overactivity appears to extend life span. Protein REST, previously shown to protect aging brains from dementia and other diseases, emerges as a key player in molecular cascade related to aging. Findings suggest future avenues for intervention in diseases ranging from Alzheimer's to bipolar disorder.

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20:42 Nature.ComModeration of neural excitation promotes longevity

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20:41 NewScientist.ComDamping down brain cell activity may help us to live longer

Centenarians and other long-lived humans have higher levels of a protein in their brain that seems to reduce neural activity. The discovery could pave the way for longevity drugs

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20:33 News-Medical.NetStony Brook-led study reveals how proteome collapse process drives cell death and aging

Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death.

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16:37 ScienceDaily.comFrailty: The rising global health burden for an aging society

Despite the evidence on risk factors for frailty, and the substantial progress that has been made in frailty awareness, the biological mechanisms underlying its development are still far from understood and translation from research to clinical practice remains a challenge. A new article provides an up-to-date clinical overview on preventing, identifying and managing frailty as well as its global impact and burden.

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09:36 Rejuvenation ResearchSociodemographic, Clinical and Functional Profile of Nonagenarians from Two Areas of Sardinia Characterized by Distinct Longevity Levels

Rejuvenation Research, Ahead of Print.

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15.10.2019
22:53 News-Medical.NetUCLA researchers discover new way to eliminate leukemia stem cells

The introduction of the drug imatinib in 2001 revolutionized the treatment of a type of cancer called chronic myelogenous leukemia. In more than 80% of people with CML who received the drug, the disease went into complete remission.

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19:39 Medscape.ComSlower Walking Speed an Indicator of Accelerated Aging

Gait speed determined at age 45 can provide valuable data on physical and biological aging, with slow gait speed an indicator of potential health concerns.

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10:13 StemCellsPortal.comlPurine Salvaging in Hematopoietic Stem Cells

Given that metabolism controls stem cell function and that purine metabolism represents a critical component of cellular metabolism, researchers from the laboratory of Hartmut Geiger (Universität Ulm, Germany) set out to discover a potential link. In their new STEM CELLS study, Vogel et al. report that the reduced activity of the purine salvaging enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) in hematopoietic stem cells results in reduced fitness, an altered cell cycle profile, and the modulation of mitochondrial function. Overall, the authors suggest that the phenotype of HPRT low hematopoietic stem cells derives from elevated levels of purine degradation rather than a lack of purine recycling, implying a significant role for HPRT-mediated purine

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14.10.2019
23:42 News-Medical.NetSigns of aging detected by a simple walking test at age 45

A new study has shown that the speed at which persons over 45 years of age walk could be an indicator of their brain and body age. The team of researchers from Duke University found that persons who walked slowly were more likely to have “accelerated aging” compared to those who walked faster.

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15:33 FierceBiotech.comReNeuron shares clinical data on stem cell vision loss therapy

ReNeuron has presented detailed data from a phase 1/2a clinical trial of its stem cell treatment for retinitis pigmentosa. Shares in ReNeuron fell more than one-third after the release of top-line data at the start of the month, but the biotech argued the detailed results are positive for its prospects. 

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13:30 FightAging.OrgMany Longevity Enhancing Interventions Work via Upregulation of Autophagy

Many, possibly even most, longevity enhancing interventions tested to date in short lived species produce their effects on aging and life span via an increase in the cellular maintenance processes of autophagy. The major focus of the research community over the past few decades in the matter of aging has been to replicate some of the calorie restriction response, or other responses to cellular stress. Cells responds to lack of nutrients, excessive heat, and so forth, by undertaking greater maintenance efforts for an extended period of time. If the stress is mild and transient, the result is a net benefit. Unfortunately this class of approach doesn't have sizable effects on life span in long-lived species such as our own: if we want to live significantly […]

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13:18 FightAging.OrgChronic Inflammation as a Contributing Cause of B Cell Decline in Aging

B cells are important to the coordination of the immune response. Dysfunctional B cells emerge with age, however, leading to autoimmunity and contributing to immunosenescence, the name given to the general age-related decline in effectiveness of the immune system. Animal studies have shown that selective destruction of the entire B cell population is beneficial in older individuals, improving the immune response: the cells are quickly replaced, but the harmful portion will take much longer to reemerge. Setting all of this to one side, the open access review here is largely focused on more subtle changes in the B cell population and its production in the bone marrow, driven by the effects of age-related chronic inflammation on stem cells and progenitor cells. The alterations of the […]

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12:06 Technology.orgU of T researcher develops nanosystem that promotes regeneration after root canals

A novel nanosystem developed by Anil Kishen, a professor in the University of Toronto’s Faculty of Dentistry, shows promising results

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13.10.2019
17:06 FightAging.OrgFight Aging! Newsletter, October 14th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Data on Exercise as a Treatment for Age-Related Arterial Stiffness The Many Roles of Senescent Cells The SENS Research Foundation on the Beneficial Nature of Senolytic Therapies Lipid Metabolism in Aging and Age-Related Disease Is Displaced

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12.10.2019
23:58 MedicalNewsToday.comMedical News Today: Slow walking speed in midlife linked with faster aging

A new study finds that a slow walking speed at the age of 45 correlates with premature cognitive and physical aging, and that slow gait may predict aging.

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02:13 BBC HealthSlow walking at 45 'a sign of faster ageing'

Gait speed in mid-life indicates how fast the brain and body are ageing, researchers found.

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00:29 News-Medical.NetPopulation aging across the U.S. could lead to pockets of vulnerability to climate change

Population aging projections across the US show a divide between cities and rural areas, which could lead to pockets of vulnerability to climate change.

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11.10.2019
22:41 FightAging.OrgIs Displaced Nuclear DNA a Meaningful Cause of Chronic Inflammation in Aging?

Sterile inflammation arises without external cause, such as infection or injury, and chronic sterile inflammation is a characteristic of aging. Inflammatory signaling becomes constant and pronounced in tissues, and the immune system is constantly roused to action. Processes, such as regeneration from injury, that depend upon a clear cycle of inflammation that starts, progresses, and resolves are significantly disrupted. It is no exaggeration to say that the downstream consequences of chronic inflammation accelerate the progression of all of the common age-related conditions. It is of great importance in atherosclerosis and neurodegenerative conditions, for example. Like raised blood pressure, chronic inflammation is one of the more important mechanisms acting to convert the low-level molecular damage at the root of aging into the various proximate causes of […]

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20:55 Drugs.comHow Fast You Walk Might Show How Fast You're Aging

FRIDAY, Oct. 11, 2019 -- Middle-aged folks who worry about healthy aging would do well to keep an eye on their walking speed. Turns out that the walking speed of 45-year-olds is a pretty solid marker of how their brains and bodies are aging, a new...

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20:28 News-Medical.NetStudy investigates how aging influences fate of fibro-adipogenic progenitors in skeletal muscles

In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases are repaired by resident muscle stem cells, called satellite cells, which promptly exit from quiescence after disruption of muscle architecture to expand, differentiate and drive tissue regeneration.

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19:04 Phys.orgPopulation aging to create pockets of climate vulnerability in the US

Population aging projections across the US show a divide between cities and rural areas, which could lead to pockets of vulnerability to climate change.

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18:59 ScienceDaily.comPopulation aging to create pockets of climate vulnerability in the US

Population aging projections across the US show a divide between cities and rural areas, which could lead to pockets of vulnerability to climate change.

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18:54 9to5mac.comBrydge announces iPad Pro keyboard with trackpad; sues Libra clone seen here

We reported last month on an iPad keyboard with a trackpad, seen above, noting that it appeared to offer interesting-looking competition to Brydge. It now appears it may not be competing for long: Brydge has issued a lawsuit accusing the company behind the device, accusing it of patent infringement.
Although Brydge’s iPad keyboards don’t include a trackpad, its models for the Microsoft Surface and Google Pixel Slate do, and the company has been working for some time on an iPad model with trackpad…
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The post Brydge announces iPad Pro keyboard with trackpad; sues Libra clone seen here appeared first on 9to5Mac.

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01:59 News-Medical.NetHuman regenerative capacity discovered

Move over, salamanders, we humans can also regrow some of our body tissues. At least, this is what a new study published on October 9, 2019, in the journal Science Advances, reports. Using a mechanism quite similar to that by which amphibians like salamanders, and some zebrafish, grow back lost body parts, human joint cartilage can also regenerate itself.

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10.10.2019
23:20 Phys.orgScientists are decoding the genetic mechanisms of aging

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

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22:27 ScienceDaily.comScientists are decoding the genetic mechanisms of aging

Scientists describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan. The laboratory focuses on research on regeneration and aging.

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22:06 FightAging.OrgLipid Metabolism in Aging and Age-Related Disease

Lipids are everywhere in our biochemistry. Where they are present in cell structures and molecular mechanisms that are important to any specific age-related disease, or are among the underlying root causes of aging, it will tend to be the case that differences between species (and possibly individuals) can lead to changes in the pace of aging and disease. For example, lipid composition determines resistance to oxidative damage to cell membranes. A range of evidence supports the membrane pacemaker hypothesis of aging, in that longer-lived species tend to have more resilient cell membranes, based on their lipid composition. Today's open access paper uses lipids as an anchoring point for a wide-ranging discussion on aging, biomarkers of aging, and the differences in aging between species. The authors […]

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18:37 ScienceDaily.comMaternal obesity speeds up aging in offspring

The effects of maternal obesity even pass across generations to offspring, accelerating the rate of aging of metabolic problems that occur in normal life.

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18:29 News-Medical.NetMDI Biological Laboratory scientist awarded federal grant for aging research

The MDI Biological Laboratory has announced that the U.S. Department of Health and Human Services has awarded a grant in the amount of $373,500 per year for five years to Aric Rogers, Ph.D., to support his research on the cellular and molecular mechanisms governing aging.

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17:32 Drugs.comTying the Knot Is Tied to Longer Life Span, New Data Shows

THURSDAY, Oct. 10, 2019 -- Married folks not only live longer than singles, but the longevity gap between the two groups is growing, U.S. government health statisticians report. The age-adjusted death rate for the married declined by 7% between 2010...

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13:42 FightAging.OrgAn Interview with Amutha Boominathan of the SENS Research Foundation

Amutha Boominathan leads the mitochondrial research program at the SENS Research Foundation, focused on achieving allotopic expression of mitochondrial genes. This is the process of placing mitochondrial genes into the nuclear genome, suitably altered so that the proteins produced are transported back to mitochondria where they are needed. Every cell contains a herd of hundreds of mitochondria, the descendants of ancient symbiotic bacteria that contain a remnant circular genome. Mitochondria are responsible for packaging chemical energy store molecules, but are also deeply integrated into many other cellular processes. Thirteen mitochondrial genes remain in the mitochondrial DNA, the source of proteins vital to the correct operation of these organelles, but far more vulnerable to damage and mutation than nuclear DNA. That damage and mutation is one […]

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12:17 NYT HealthGet a Dog, Live Longer?

Benefits of dog ownership may be particularly pronounced in those who have already had a heart attack.

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11:19 Rejuvenation ResearchCommentary on Some Recent Theses Relevant to Combating Aging: October 2019

Rejuvenation Research, Ahead of Print.

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00:07 9to5mac.comPSA: Despite focus on security, the physical Apple Card is still susceptible to cloning

Apple Card arrived with a number of unique selling points like a super-fast application and approval process, no fees, Daily Cash, and strong security and privacy focus. But even though the physical titanium card doesn’t have any numbers or any other information besides a user’s name, it looks like it is still susceptible to credit card cloning just like any other credit or debit card.
more…
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09.10.2019
23:52 News-Medical.Netβ-blockers could regenerate infant heart muscle, mitigate effects of congenital heart disease

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure throughout the rest of their lives. Yet, according to a Science Translational Medicine study published today by UPMC Children's Hospital of Pittsburgh researchers, β-blockers could supplement surgery to regenerate infant heart muscle and mitigate the lasting effects of congenital heart disease.

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23:06 News-Medical.NetReport: Aging populations, changing lifestyles are main drivers of vision impairment

More than 1 billion people worldwide are living with vision impairment because they do not get the care they need for conditions like short and far sightedness, glaucoma, diabetes, and cataracts, according to the first-ever World Report on Vision issued by the World Health Organization.

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22:31 FightAging.OrgThe SENS Research Foundation on the Beneficial Nature of Senolytic Therapies

The SENS Research Foundation should need no introduction to this audience, but, just in case, this is one of the few non-profit organizations dedicated to advancing the state of the art in rejuvenation research and development. The focus of the SENS Research Foundation staff is on unblocking lines of research that are presently moving too slowly, rather than on reinforcing success. The co-founder, Aubrey de Grey, assembled the Strategies for Engineered Negligible Senescence (SENS) going on twenty years ago. It was, and is, a synthesis of what is known in the research community regarding the root causes of aging. In the SENS model, a cause of aging is a form of damage that occurs and accumulates as a result of the normal operation of cellular […]

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17:43 ScienceDaily.comHow to make biocatalysts immortal

Oxygen threatens sustainable catalysts that use hydrogen to produce electricity in fuel cells. Researchers have now developed a way to combat this.

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14:22 Phys.orgHow to make biocatalysts immortal

Oxygen threatens sustainable catalysts that use hydrogen to produce electricity in fuel cells. Researchers from Bochum and Marseille have developed a way to combat this.

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13:19 FightAging.OrgDeletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice

Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the loss of stem cell activity with age, throughout the body and not just in the brain, is an evolved response to rising levels of damage that serves to reduce the risk of cancer that arises from the activity of damaged cells. The cost, however, is a slow decline into dysfunction and tissue failure. There are many therapeutic approaches under development in labs and startups that involve ways to force stem cell populations to go back to work, overriding their normal reaction to an aged environment. While this is nowhere as good a class of approach as repairing the underlying damage […]

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11:55 Nanowerk.comHow to make biocatalysts immortal with dendrimers

Oxygen threatens sustainable catalysts that use hydrogen to produce electricity in fuel cells. Researchers have developed a way to combat this.

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08:11 News-Medical.NetDog owners live longer

Taking care of pets has been shown to provide a plethora of health benefits. Now, dog lovers may have a new reason to love their pets more as two new studies found that owning a dog is tied to a longer life, with a lower risk of premature death, especially among those who had a heart attack and stroke.

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08.10.2019
22:51 FightAging.OrgThe Many Roles of Senescent Cells

Long-lived senescent cells accumulate with age, initially quite slowly as they are efficiently removed by the immune system when their own programmed cell death processes fail, but once the immune system starts to decline with age, the burden of cellular senescence ramps up dramatically. Senescent cells secrete a potent mix of signals known as a senescence-associated secretory phenotype (SASP). It spurs chronic inflammation, destructively remodels nearby tissue, encourages nearby cells to also become senescent, and causes all sorts of other issues as well. It is very harmful, and the more senescent cells there are, the worse the consequences. Fortunately, the research and development communities have finally woken up to the fact that senescent cells are an important contributing cause of aging. Numerous animal studies have […]

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20:19 News-Medical.NetAbnormal cell nucleotide levels, compromised nuclear DNA maintenance accelerate ageing

Disturbances in the function of mitochondrial DNA can accelerate the ageing process in ways that are different than previously thought, according to a new Finnish study published in Nature Metabolism.

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19:28 ScienceDaily.comNew study challenges our understanding of premature aging

Disturbances in the function of mitochondrial DNA can accelerate the ageing process in ways that are different than previously thought, according to a new study. Offering a new perspective to ageing, the researchers suggest that accelerated ageing is the result of abnormal cell nucleotide levels and compromised nuclear DNA maintenance.

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19:08 News-Medical.NetMaternal obesity accelerates rate of aging of metabolic problems in offspring

It has long been known that obesity impairs our metabolism and predisposes to diabetes and heart disease. New research in The Journal of Physiology has shown that the effects of maternal obesity even pass across generations to offspring, accelerating the rate of aging of metabolic problems that occur in normal life.

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16:56 News-Medical.NetStudy presents a new view on how mitochondrial dysfunction may contribute to aging

Disturbances in the function of mitochondrial DNA can accelerate the ageing process in ways that are different than previously thought, according to a new Finnish study published in Nature Metabolism.

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16:43 News-Medical.NetSalford scientists identify new drug candidate to starve and suffocate breast cancer stem cells

Scientists have identified a new drug candidate that is able starve and suffocate cancer stem cells, paving the way for new therapies to treat breast cancer patients.

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15:55 Phys.orgResearchers discover how water is regenerated on asteroids

Scientists have discovered how water molecules can be regenerated on asteroids moving through space, in an exciting breakthrough that could extend to other bodies such as the moon.

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13:39 FightAging.OrgCombining Strategies to Slow Aging to Increase Life Span in Flies by 48%

The research and development communities have little incentive to try combinations of approaches when it comes to intervening in the aging process, or indeed to treat any medical condition. There is little funding and large barriers stand in the way of any effort to combine either existing or novel therapies, such as issues with intellectual property rights. Thus few groups undertake such work. Which is a pity, because one would expect there to be synergies between therapies targeting two different mechanisms affecting the same condition in many cases, or at least for the treatments to be additive in effect. The example here is interesting as a demonstration of such synergies between approaches, but it is worth recalling that the upregulation of stress response mechanisms via […]

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13:27 FightAging.OrgThe Search for Factors in Young Blood that Might be Used to Treat Aging

A fair number of research groups and a few startup companies are engaged in the search for factors in young blood that might explain the effects of parabiosis. Heterochronic parabiosis is a procedure in which the circulatory systems of a young and an old mouse are linked. The young mouse begins to show some early signs of aging, and the old mouse shows a reversal of some measures of aging. The evidence to date is conflicted on the topic of whether or not this effect is due to beneficial components of young blood: it is clearly the case that some signals present in young blood can be delivered on their own to old animals in order to produce benefits; yet blood and plasma transfusions don't […]

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13:05 StemCellsPortal.comlStem Cell-Derived EV Protects the Irradiated Brain

Cranial radiation therapy as a treatment of brain cancers can lead to adverse impacts on cognitive function; however, previous studies from the laboratory of Charles L. Limoli (University of California, Irvine, USA) discovered that human neural stem cells (hNSCs) can provide beneficial neurocognitive effects in the irradiated brain. Now, in a new STEM CELLS Translational Medicine study, Smith et al. revealed that hNSCs and hNSC‐derived extracellular vesicles (EVs) act in a comparable manner to preserve host neuronal morphology, reduce inflammation, and restore neurotrophic factors in the irradiated brain. Overall, this new study provides evidence for “potent far‐reaching neuroprotective effects mediated by grafted stem cells or EVs adjacent and distal to the

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07.10.2019
23:38 News-Medical.NetNew device can accelerate bone regeneration in difficult cases

Within minutes of breaking a bone, the body begins to repair itself.

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22:18 StemCellsPortal.comlStem Cell Studies Offer Hope for Childhood Neurological Condition

SAN FRANCISCO, CA (US), October 2019 —Two new studies by an international team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.
Often diagnosed at birth with symptoms of weakness and breathing difficulties, the progressive neurological problems in PMD are caused by disruptions in the formation of myelin, a fatty layer of insulation covering nerve fibers that enables rapid, long-distance communication and makes up the brain’s white matter. But it has been unclear why myelination fails in PMD, and therapies to help restore this vital substance in the brain have so far remained out of reach. 
For the past decade, scientists from UC San Francisco, Stanford University and the University of Cambridge have been leading complementary

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13:15 FightAging.OrgAn Interview with Sergey Young of the Longevity Vision Fund

The Longevity Vision Fund is the third of the sizable pools of venture funding to emerge of late, after Juvenescence and Life Biosciences, that are dedicated to the new longevity industry. Unlike the other two, the Longevity Vision fund is initially focused on what I would say are initiatives that don't much matter and won't much move the needle on human aging. Only in their second phase do they intend to invest in classes of biotechnology and therapy that may include high value approaches. Despite the way in which senolytics to remove harmful senescent cells outperform everything else to date in reversal of aging and age-related disease, we are still, it seems, somewhat early in the phase of spreading the understanding that repair based strategies […]

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12:03 StemCellsPortal.comlASC Therapy Promotes Bone Regeneration After Bacterial Infection

Review of “Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Decreased bone regeneration due to inflammatory processes after severe bacterial infections remains a common problem in orthopedic surgery and previous studies from researchers led by Björn Behr (Ruhr-Universität Bochum, Germany) found that dysregulated inflammatory responses hindered bone regeneration after debridement following bacterial infection [1, 2]. Specifically, the authors observed reduced levels of osteoblastogenesis and increased levels of osteoclastogenesis and elevated B‐cell activity. 

Now the team returns with a STEM CELLS Translational Medicine study that investigates the

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11:39 StemCellsPortal.comlCD166-CD166 Interaction Enhances Hematopoietic Stem Cell Function

Review of “CD166 engagement augments mouse and human hematopoietic progenitor function via activation of stemness and cell cycle pathways” from STEM CELLS by Stuart P. Atkinson

Previous research from the laboratories of Hal E. Broxmeyer and Edward F. Srour (Indiana University School of Medicine, Indianapolis, Indiana, USA) established CD166, a marker expressed on stem and progenitor cells of all three embryonic lineages, as a marker of immature osteoblasts of the bone marrow stem cell niche [1, 2]. Furthermore, they also defined CD166 as a functional marker of murine and human long-term marrow repopulating hematopoietic stem cells (HSCs) [3]. CD166, or activated leukocyte cell adhesion molecule (Alcam), mediates both homophilic (CD166‐CD166) and heterophilic (CD166‐CD6) interactions [4] and more recent studies from

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11:27 StemCellsPortal.comlRegenerating the Aged and Damaged Intestine by Saying “No” to Notum

Review of “Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium” from Nature by Stuart P. Atkinson

A Paneth cell-containing niche supports the active cycling of intestinal stem cells (ISCs) [1, 2]; however, increased levels of complications observed in the gastrointestinal system with age suggest a reduction in both ISC activity and stem cell niche function. Fascinatingly, a recent Nature study by a team led by Pekka Katajisto (University of Helsinki, Helsinki, Finland) confirmed this hypothesis and established the production of Notum, an extracellular Wnt inhibitor, in aged Paneth cells as a crucial factor in the reduced regenerative potential of the intestinal epithelium that functions by targeting ISC function [3]. However, Pentinmikko et al. also highlight the pharmacological

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06.10.2019
20:22 CNBC health careThis Michigan doctor just launched an online clinic dedicated to anti-aging

Sajad Zalzala wants to make anti-aging therapies accessible to anyone, but there's a lot of research to do before we get there.

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20:20 CNN HealthBeing happier will help you live longer, so learn how to be happier

If you could wish for just one thing, would it be happiness or a long life? Given what researchers tell us, one is likely to produce the other.

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19:12 CNBC technologyThis Michigan doctor just launched an online clinic dedicated to anti-aging

Sajad Zalzala wants to make anti-aging therapies accessible to anyone, but there's a lot of research to do before we get there.

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16:49 FightAging.OrgFight Aging! Newsletter, October 7th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Methionine Metabolism and the Pace of Aging Towards a More Glial-Centric View of Alzheimer's Disease Help to Crowdfund the SENS Research Foundation Transgenic Mouse Project to Move a Mitochondrial Gene into the Cell Nucleus A Deeper Delve

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05.10.2019
18:24 Technology.orgFruit flies live longer with combination drug treatment

A triple drug combination has been used to extend the lifespan of fruit flies by 48 percent in

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16:08 News-Medical.NetResearchers develop new way of 3D printing soft biomaterials

A new way of 3D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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12:53 Phys.orgCommonwealth targets climate change with regeneration projects

The Commonwealth on Friday launched an ideas-sharing network to tackle the effects of climate change through replicable regeneration projects.

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04:08 MedicalNewsToday.comMedical News Today: Aging and cancer: A surprising two way relationship

Although aging is the greatest risk factor for cancer, a recent study demonstrates how aging cells might, paradoxically, hinder cancer progression.

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04.10.2019
22:19 FightAging.OrgTargeting GAS1 to Put Muscle Stem Cells Back to Work in Old Tissues

A great many projects at various stages of development are characterized by their goal of forcing greater stem cell activity in old tissues, but without meaningfully addressing the underlying causes of stem cell decline in later life. This sort of research and development operates at the level of proximate causes, adjusting protein levels to change cell behavior. Among the potential therapies I'd place into this category: telomerase gene therapy; GDF11 upregulation; FGF2 inhibition; NAD+ upregulation; and so on. Muscle stem cells known as satellite cells are one of the better studied stem cell populations in this context, and many of the interventions are focused here. Today's open access research is a representative example, in that the authors describe a portion of the network of genes […]

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16:33 StemCellsPortal.comlAdult Fly Intestine Could Help Understand Intestinal Regeneration

BRISTOL (UK), September 2019 — Intestinal epith,elial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the universities of Bristol, Heidelberg and the German Cancer Research Center (DKFZ) have found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.
The research, published in Nature Communications, used the adult fly intestine, which is remarkably like a human intestine, to understand how IECs sense stress or damage, defend themselves and promote epithelial regeneration.
Stress-sensing pathways are activated upon a variety of stresses in fly IECs, but how these pathways are activated and how they promote IEC resilience and intestinal regeneration are not known.
The

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16:21 StemCellsPortal.comlHow Time Affects the Fate of Stem Cells

LAUSANNE (CH), September 2019 — How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.
In a new study published in Molecular Systems Biology, researchers at the lab of David Suter, M.D., Ph.D., at Ecole Polytechnique Fédérale de Lausanne (EPFL), have found that temporal fluctuations in protein concentrations can determine the type of cell that embryonic stem cells will become.
The scientists studied two important transcription factors, SOX2 and OCT4, whose levels in embryonic stem cells change over time. Both of these transcription factors are important for embryonic stem cell self-renewal and differentiation (or "fate") into specific

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12:10 NYT HealthRegeneration: A Miracle, Against the Odds

Months after I’d shaved my head for cancer treatment, my old hair dropped out of the sky.

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11:34 Technology.orgStem Cell Studies Offer Hope for Childhood Neurological Condition

Two new studies by an international team of researchers report progress in using stem cells to develop new

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10:29 News-Medical.NetMR Solutions’ advanced imaging system helps researchers to gain better understanding of aging processes

Research published in Nature by the Korea Advanced Institute of Science (KAIST) found that lymphatic vessels in the scull involved in the clearance of cerebrospinal fluid often become compromised with age. This finding was only possible through advances in imaging technology.

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08:17 News-Medical.Net3D printer could help expedite repair or replace damaged tissues for injured warfighters

The ability to 3D print a variety of healthcare-related products in deployment zones would greatly benefit the nation's warfighters.

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03.10.2019
22:57 Drugs.comAHA News: Growing – and Aging – Hispanic Population at Risk for Dementia

THURSDAY, Oct. 3, 2019 (American Heart Association News) -- The Hispanic population over 65 will nearly quadruple in the next 40 years, eventually representing nearly 1 in 5 older Americans. And growing alongside the population will be the daunting...

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22:01 ScienceDaily.comStem cell studies offer hope for childhood neurological condition

Two new studies report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.

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21:08 Drugs.comAHA News: Growing – and Aging – Hispanic Population at Risk for Dementia

THURSDAY, Oct. 3, 2019 (American Heart Association News) -- The Hispanic population over 65 will nearly quadruple in the next 40 years, eventually representing nearly 1 in 5 older Americans. And growing alongside the population will be the daunting...

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19:54 CNBC technologySnap shares plunge after Facebook's latest clone attempt

Snap shares fell as much as 7% on Thursday after Facebook announced the launch of Threads, a new messaging app for Instagram users.

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19:49 ScienceDaily.comPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers have devised a fully print-in-place technique for printable electronics that is gentle enough to work on delicate surfaces ranging from paper to human skin. This can be accomplished without additional steps to bake, wash or powder-coat materials. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages with patient-specific biosensors.

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19:04 CNBC technologyFacebook launches Instagram Threads, its latest attempt to clone Snapchat

Facebook announces the launch of Threads, a new messaging app for Instagram users.

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18:26 News-Medical.NetPrinted electronics show promise for personalized biosensors, embedded electronic tattoos

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin.

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15:34 Nanowerk.comPrinted electronics open way for electrified tattoos and personalized biosensors

The first demonstration of a fully print-in-place electronics technique is gentle enough to work on surfaces as delicate as human skin and paper.

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15:10 Phys.orgPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages tricked out with patient-specific biosensors.

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13:17 FightAging.OrgReviewing AGEs and ALEs in Oxidative Stress and Aging

Advanced glycation end products (AGEs) and the less discussed advanced lipoxidation end products (ALEs) are an interesting topic in the context of aging. There are in fact two distinct topics here. The first is the presence of persistent cross-links, in which glucosepane AGEs form links between extracellular matrix molecular, degrading the structural properties of tissue, particularly elasticity. These cross-links, arising from the normal operation of metabolism, are resilient and not broken down by our biochemistry. Some form of biotechnology, such as therapies based on enzymes mined from bacterial species that can metabolize glucosepane, will be required to remove their contribution to the aging process. The second topic is that a menagerie of many different short-lived AGEs and ALEs emerge in greater numbers in the aged […]

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02.10.2019
22:51 FightAging.OrgHelp to Crowdfund the SENS Research Foundation Transgenic Mouse Project to Move a Mitochondrial Gene into the Cell Nucleus

The SENS Research Foundation science team is taking the next step in their work on moving mitochondrial genes into the cell nucleus, a process called allotopic expression. Having proven that they can carry out this task with the ATP8 gene in cells, they are now aiming at proof of principle in mice. This will require the production of transgenic mice, using a novel technology funded by the SENS Research Foundation called the maximally modifiable mouse. This mitochondrial project is being crowdfunded at Lifespan.io: you, I, and everyone else can contribute to advancing the state of the art one step further towards eliminating mitochondrial DNA damage as a cause of aging. Mitochondria are the power plants of the cell, a herd of organelles descended from ancient […]

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