Techh.info/biomedtechnology hourly

Life Extension

headlines texts
25.05.2019
06:11 News-Medical.NetBenefit of allogeneic stem cell transplantation in non-Hodgkin lymphoma remains unclear

The German Institute for Quality and Efficiency in Health Care has investigated whether patients suffering from non-Hodgkin lymphoma have (better) chances of recovery when stem cells from another person are transplanted.

Скрыть анонс
03:48 Yahoo.com BusinessUK Financial Watchdog Warns Public of Crypto Clone Firm

The primary financial regulator of the United Kingdom, the Financial Conduct Authority (FCA), warned that ICAP Crypto is a clone firm in a public announcement on May 24. According to the report, ICAP Crypto is a clone firm of ICAP Europe Limited. Clone firms are a type of scam in which the scammers use information from legitimate firms in an attempt to convince targets that they are genuine.

Скрыть анонс
00:11 Reuters.com HealthSeniors who feel their life has purpose may live longer

(Reuters Health) - Seniors who feel their life has purpose may be less likely to die from heart, circulatory and digestive diseases and more likely to live longer, new data suggest.

Скрыть анонс
24.05.2019
22:26 Yahoo.com BusinessWhat Type Of Shareholder Owns Anixa Biosciences, Inc. s (NASDAQ:ANIX)?

Every investor in Anixa Biosciences, Inc. (NASDAQ:ANIX) should be aware of the most powerful shareholder groups. Large...

Скрыть анонс
21:45 StemCellsPortal.comlScientists find new type of cell that helps tadpoles' tails regenerate

CAMBRIDGE (UK), May 2019 — Researchers at the University of Cambridge have uncovered a specialized population of skin cells that coordinate tail regeneration in frogs. These “regeneration-organizing cells” help to explain one of the great mysteries of nature and may offer clues about how this ability might be achieved in mammalian tissues.
It has long been known that some animals can regrow their tails following amputation — Aristotle observed this in the fourth century B.C. — but the mechanisms that support such regenerative potential remain poorly understood.
Using single-cell genomics, scientists at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge developed an ingenious strategy to uncover what happens in different tadpole cells when they regenerate their tails.
Recent Cambridge-led advances in next-generation sequencing mean that

Скрыть анонс
21:44 Reuters.com HealthIncyte's Jakafi wins FDA nod to treat complication of stem cell transplant

The U.S. Food and Drug Administration on Friday approved Incyte Corp's treatment for acute graft-versus-host disease, a complication from stem cell transplant.

Скрыть анонс
16:53 News-Medical.NetCell scientist receives $1.9 million NIH grant to study muscle regeneration

As people age, their muscle regeneration capacity declines in part because they can no longer make enough muscle stem cells to replace damaged tissue.

Скрыть анонс
13:31 StemCellsPortal.comlReview: Translating Stem Cells for Stroke Clinical Trials

A new Concise Review from the laboratory of Cesario V. Borlongan (University of South Florida, USA) summarizes the current state of affairs regarding stem cell therapy in stroke patients, which currently are deemed safe but not effective. The authors believe that failed clinical trials may be due to a loss in translation of optimal stem cell transplantation protocols from the laboratory to clinical trial designs and advise a concerted effort between basic scientists and clinicians, with NIH and Food and Drug Administration guidance, to promote the safe and effective translation of stem cell therapy for stroke in the future. For a fascinating read, head over to STEM CELLS Translational Medicine now!

Скрыть анонс

13:17 StemCellsPortal.comlmTOR Inhibition and Limbal Stem Cell Deficiency

While the regulation of stem cell maintenance and function in a cell‐type and context‐dependent manner requires mammalian target of rapamycin (mTOR) signaling, the effects of mTOR signaling on corneal epithelial stem cells (CESCs) under inflammatory conditions remain unclear. Now, a new STEM CELLS report from the laboratory of Joo Youn Oh (Seoul National University Hospital, Seoul, South Korea) established that mTOR inhibition through rapamycin treatment induces corneal epithelial stem cell apoptosis in vivo, accompanied by the upregulation of sterile neutrophilic inflammation and downregulation of the IL‐10/STAT3 anti‐inflammatory response axis. Overall, Park et al. advise that pro‐inflammatory side-effects must be considered when using rapamycin in the

Скрыть анонс
13:14 News-Medical.NetAMSBIO introduces next-generation feeder-free medium for pluripotent stem cell culture

AMSBIO introduces StemFit Basic04, a next-generation feeder-free medium for the maintenance of Induced Pluripotent Stem and Embryonic Stem cells during the reprogramming, expansion and differentiation phases of stem cell culture.

Скрыть анонс
11:12 News-Medical.NetWFIRM researchers engineer vascularized functional renal tissues for kidney regeneration

Wake Forest Institute for Regenerative Medicine researchers have shown the feasibility of bioengineering vascularized functional renal tissues for kidney regeneration, developing a partial augmentation strategy that may be a more feasible and practical approach than creating whole organs.

Скрыть анонс
04:13 ScienceDaily.comAllogeneic stem cell transplantation in non-Hodgkin lymphoma: Benefit remains unclear

Meaningful studies are lacking for certain patient groups. Disease-specific registries could help close the data gap.

Скрыть анонс
23.05.2019
20:05 Phys.orgPlant stem cells require low oxygen levels

Plants function as the green lungs of our planet, and rightfully so, as the capacity of a large, single tree releases more than 120 kg of oxygen into the Earth's atmosphere every year through a series of sunlight-fuelled reactions in photosynthesis. However during flood events, plant tissues may experience severe oxygen shortage, a stressful situation that every year leads to substantial loss in yield for all major crops such as rice, wheat and barley.

Скрыть анонс
19:46 ScienceDaily.comPlant stem cells require low oxygen levels

New research reveals that low oxygen is required for proper development of plants.

Скрыть анонс
18:31 News-Medical.NetExperimental noninvasive tool assesses efficacy of stem cell transplantation

Stem-cell based therapies to strengthen the heart muscle and treat other diseases are beginning to show promise in human clinical trials.

Скрыть анонс
17:18 SingularityHub.ComNew Progress in Stem-Cell-Free Regenerative Medicine

Regenerative medicine and stem cells are often uttered within the same breath, for good reason. In animal models, stem cells have reliably reversed brain damage from Parkinson’s disease, repaired severed spinal cords, or restored damaged tissue from diabetes, stroke, blood cancers, heart disease, or aging-related tissue damage. With the discovery of induced pluripotent stem cells […]

Скрыть анонс
12:01 Technology.orgA new pathway for an anti-aging drug

In 1972, Easter Island, called Rapa Nui, famous for its moai statues, offered a new wonder: the discovery

Скрыть анонс
11:22 Technology.org3D-printed device detects biomarkers of preterm birth

Preterm birth (PTB) — defined as birth before the 37th week of gestation — is the leading complication of pregnancy. If

Скрыть анонс
07:57 News-Medical.NetResearchers identify new anti-aging compounds among FDA-approved drugs

Researchers from Gero, Skolkovo Institute of Science and Technology (Skoltech), Moscow Institute of Physics and Technology (MIPT), and University of Arkansas for Medical Sciences (UAMS) collaborated to derive a transcriptomic signature of aging, which they confirmed using large transcriptomic databases.

Скрыть анонс
03:56 ScienceDaily.comA road map to stem cell development

Researchers have developed a way to map retinal cell development and potentially advance regenerative medicine.

Скрыть анонс
02:50 ScienceDaily.com3D-printed device detects biomarkers of preterm birth

Preterm birth (PTB) -- defined as birth before the 37th week of gestation -- is the leading complication of pregnancy. If doctors had a simple, accurate and inexpensive way to identify women at risk for the condition, they could develop better prevention strategies. Now researchers have created a 3D-printed microchip electrophoresis device that can sensitively detect three serum biomarkers of PTB.

Скрыть анонс
02:50 ScienceDaily.comExperimental noninvasive tool monitors effectiveness of stem cell transplantation

Other than clinical observations, the stem cell field lacks a repeatable, time-sensitive, noninvasive tool to assess the effectiveness of transplanted cells in the targeted organ. Researchers analyzed biomarkers secreted from transplanted human stem cells in the recipient blood of a rodent model of heart attack. Analysis of the blood test showed responding cells had changed their gene expression, behavior and secretions, suggesting this liquid biopsy could provide a window into stem cell activity and effectiveness.

Скрыть анонс
00:51 Oil Voice[Press] How product longevity and maintenance can help you reduce costs

Purchasing EX equipment can be a solid investment for the long term, saving costs with more durable ...

Скрыть анонс
22.05.2019
21:42 Yahoo.com BusinessWhat Type Of Shareholder Owns Moleculin Biotech, Inc. s (NASDAQ:MBRX)?

If you want to know who really controls Moleculin Biotech, Inc. (NASDAQ:MBRX), then you'll have to look at the makeup...

Скрыть анонс
20:18 News-Medical.NetNovel 3D-printed device detects preterm birth biomarkers

Preterm birth -- defined as birth before the 37th week of gestation -- is the leading complication of pregnancy. If doctors had a simple, accurate and inexpensive way to identify women at risk for the condition, they could develop better prevention strategies.

Скрыть анонс
19:00 Phys.org3-D-printed device detects biomarkers of preterm birth

Preterm birth (PTB)—defined as birth before the 37th week of gestation—is the leading complication of pregnancy. If doctors had a simple, accurate and inexpensive way to identify women at risk for the condition, they could develop better prevention strategies. Now researchers have created a 3-D-printed microchip electrophoresis device that can sensitively detect three serum biomarkers of PTB. They report their results in ACS' journal Analytical Chemistry.

Скрыть анонс
17:13 Drugs.comTake a New View of Aging

WEDNESDAY, May 22, 2019 -- The way you view aging can affect how well you manage stress. Older people who see aging negatively have stronger (negative) emotional reactions to day-to-day stresses, while such events have little effect on the moods of...

Скрыть анонс
16:05 Reuters.com HealthRegenerative medicine firm CollPlant launches Israel R&D center

CollPlant, which makes products for tissue repair and organ manufacturing from its recombinant human collagen, has launched a new research and development center in Israel.

Скрыть анонс
14:01 News-Medical.NetInhibition of CRMP2 phosphorylation promotes axonal regeneration after optic nerve injury

A new study by Professor Toshio Ohshima of Waseda University has found that the inhibition of phosphorylation of collapsing response mediator protein 2, a microtubule-binding protein, suppresses degeneration of nerve fibers and promotes its regeneration after optic nerve injury.

Скрыть анонс
13:36 FightAging.OrgA Conservative View of the Present State of Senolytic Development for Rejuvenation

Here, one of the leading researchers working on the biochemistry of senescent cells - and their relevance to aging - considers the state of development of senolytic therapies. These are treatments, largely small molecule drugs at this stage, but also including suicide gene therapies, immunotherapies, and more, that are capable of selectively destroying some fraction of the senescent cells present in old tissues. There is tremendous enthusiasm in the scientific and development communities for the potential to create significant degrees of rejuvenation via this approach. The results in mice are far and away more impressive and reliable than anything else that has yet been tried in the matter of aging and age-related disease. Simple one time treatments with senolytics lead to significant extension of life […]

Скрыть анонс
13:24 FightAging.OrgRepeated Cycles of Incomplete Healing as a Cause of Aging

The authors of the open access paper here have an intriguing view of the way in which regenerative processes run awry with age, and thus contribute to the aging process. As is the case for many single mechanism proposals regarding aging, I think that the viewpoint is useful, but the mechanism in question is probably not as important to aging as proposed here - it is one of many issues. Nonetheless, this is an interesting example of the way in which it is hard to pin down the ordering of specific mechanisms in aging; it is quite possible to argue for A to cause B or B to cause A and present a good case for either. Here, for example, dysregulated regeneration is thought to […]

Скрыть анонс
11:45 MedicalNewsToday.comMedical News Today: 'Mediterranean diet may protect against depression symptoms'

Research presented at the American Psychiatric Association conference finds a link between Mediterranean diets and a lower depression risk later in life.

Скрыть анонс
08:40 News-Medical.NetInhibition of CRMP2 phosphorylation supports optic nerve regeneration after injury

A new study by Professor Toshio Ohshima of Waseda University has found that the inhibition of phosphorylation of collapsing response mediator protein 2, a microtubule-binding protein, suppresses degeneration of nerve fibers and promotes its regeneration after optic nerve injury.

Скрыть анонс
07:07 GizmagPlacental stem cells found to regenerate heart cells after heart attack


Broken hearts are notoriously difficult to repair. After a heart attack this vital organ remains damaged, which can eventually lead to heart failure and death. Now, researchers have managed to use placental stem cells to regenerate heart cells in mice, which could lead to groundbreaking new treatments for heart attack victims.
.. Continue Reading Placental stem cells found to regenerate heart cells after heart attack Category: Medical Tags: Cells Heart Heart attack Heart Disease Mount Sinai Hospital Stem Cells

Скрыть анонс
06:02 ScienceDaily.comStem cell differences could explain why women are more likely to develop adrenal cancer

Scientists have discovered a potential biological reason why women are more likely to develop adrenal disorders, including cancer. According to the researchers, the answer could lie in the increased turnover of hormone-producing cells found in the adrenal glands of females.

Скрыть анонс
00:12 ScienceDaily.comCertain placental stem cells can regenerate heart after heart attack

Researchers have identified a new stem cell type that can significantly improve cardiac function.

Скрыть анонс
21.05.2019
23:00 FightAging.OrgJournalists Have Very Fragmentary, Incomplete Views of the Longevity Industry

The lengthy and somewhat overwrought article I'll point out today is a good example of the way in which journalists fail when writing on the topic of the growing biotechnology industry that is making the first steps towards the medical control of aging. They talk to just a few people, and thus have a very narrow (generously) or absolutely incorrect (more accurately) view of what might be happening, the prospects for the future, and the shape of the field as a whole. In this case the few people are the folk at AgeLab at MIT, and George Church, with a focus on the veterinary deployment of gene therapies by Rejuvenate Bio, and a fairly traditional Alzheimer's researcher. To speak directly, and without meaning to be […]

Скрыть анонс
19:30 Medscape.ComMediterranean Diet May Keep Late-Life Depression at Bay

Adherence to a Mediterranean diet may guard against late-life depression, new research shows.

Скрыть анонс
17:59 ScienceDaily.comInhibition of protein phosphorylation promotes optic nerve regeneration after injury

Research results suggest that the inhibition of phosphorylation of microtubule-binding protein CRMP2 could be a novel approach to the development of treatments for optic neuropathies, such as glaucoma and traumatic injury.

Скрыть анонс
16:49 News-Medical.NetResearchers explore link between aging fat cells and Alzheimer's

Scientists want to know whether our aging fat cells are important to the onset and progression of Alzheimer's.

Скрыть анонс
13:36 FightAging.OrgCellular Senescence in the Development of Cataracts

The ability to selectively destroy senescent cells through the use of senolytic therapies doesn't make greater understanding of the biochemistry of senescent cells irrelevant, but it does mean that we don't have to wait around for that greater understanding to arrive in order for the development of therapies to get started. Destroy the bad cells now, benefit the patients now, and let the ongoing research proceed at its own pace. The open access paper here is an example of that ongoing research, an exploration of the proteins that might be important in cellular senescence in cataracts, a prominent cause of age-related blindness. Regardless of the outcome here, senolytic therapies should be under development to treat cataracts now, not later. Senescence is a leading cause of […]

Скрыть анонс
10:49 News-Medical.NetZebrafish may help researchers to use blood stem cells instead of bone marrow transplants

Blood diseases such as leukemia and lymphoma are currently treated with bone marrow transplants -- a transfer of blood stem cells from a healthy person to a patient in need.

Скрыть анонс
02:28 SeekingAlpha.comEmergent Bio's typhoid vaccine OK'd in five new EU states

Скрыть анонс
20.05.2019
22:08 FierceBiotech.comMount Sinai researchers isolate placental cells that regenerate damaged hearts in mice

Researchers at the Icahn School of Medicine at Mount Sinai have shown in a study that Cdx2 cells from the placenta can migrate through the circulatory system and target heart injuries. In male mouse models of heart attack, the cells regenerated damaged tissue.

Скрыть анонс
20:07 StemCellsPortal.comlMesenchymal Stem Cells Protect Kidneys from Lipotoxicity

Researchers led by Sydney C.W. Tang (The University of Hong Kong, China) recently sought to discover if and how mesenchymal stem cells (MSCs) can treat lipotoxicity‐induced kidney injury. Interestingly, Li et al. now report that MSCs ameliorate endoplasmic reticulum stress, inflammation, and apoptosis in palmitic acid‐treated renal tubular cells and high-fat-diet-induced obese kidney in mice via activation of hepatocyte growth factor/c‐Met paracrine signaling in the obese kidney microenvironment. Furthermore, this new STEM CELLS Translational Medicine article suggests that induced pluripotent stem cell (iPSC) derived MSCs may represent a valuable alternative source to bone marrow-derived MSCs for therapeutic application in chronic kidney disease.
Скрыть анонс

20:07 StemCellsPortal.comlMesenchymal Stem Cells Improve Islet β-cell Function

A study from researchers at the lab of Peter M. Jones (King's College London, UK) recently assessed the effects of mesenchymal stem cells (MSCs) on pancreatic islets by investigating the importance of tissue source, coculture protocol configuration and length, the activated/inactivated status of MSCs, and different β‐cell secretory stimuli. Arzouni et al. discovered that 48 hours of preculture with inactivated adipose tissue-derived MSCs in a direct contact co-culture configuration optimally supported β‐cell insulin secretion from islets, thereby supporting this approach as an effective addition to human islet transplantation protocols. See STEM CELLS Translational Medicine now for all the details.

Скрыть анонс

20:07 StemCellsPortal.comlAllogenic Tendon and Mesenchymal Stem Cells for Anterior Cruciate Ligament Reconstruction

Free tendon allografts exhibit generally provide poor outcomes when employed as a material for anterior cruciate ligament (ACL) reconstruction. Researchers led by Zhenhan Deng (Shenzhen University, Shenzhen) and Jinzhong Zhao (Shanghai Jiao Tong University, Shanghai, China) have shown that bone marrow‐derived mesenchymal stem cells (MSCs) combined with a decellularized free tendon allograft is effective in improving ACL reconstruction results. The team now return with a STEM CELLS Translational Medicine study that provides evidence for the efficacy and feasibility of decellularized allogenic semitendinous tendon combined with autologous MSCs as a substitute to free tendon allograft in a rabbit model.


Скрыть анонс
19:31 StemCellsPortal.comlSingle Cell RNA-Sequencing Reveals the Inner Complexity of Stem Cell-derived Retinal Organoids

Review of “Deconstructing Retinal Organoids: Single cell RNA-Seq reveals the cellular components of human pluripotent stem cell-derived retina” from STEM CELLS by Stuart P. Atkinson

Recent advances have permitted the derivation of three‐dimensional retinal organoids containing structures akin to the developing eye from human pluripotent stem cells [1, 2]; however, we currently lack robust methods to accurately define and characterize the heterogeneous cell types within these organoids over time. 

While a few studies have reported single-cell RNA sequencing (scRNA‐Seq) in human retinal tissue and organoids [3-5] (See the STEM CELLS article here!), researchers from the laboratory of Majlinda Lako (Newcastle University, Newcastle-upon-Tyne, UK) postulated that such studies have yet to reveal the full

Скрыть анонс
17:23 StemCellsPortal.comlStudy shows all immature Cells can develop into Stem Cells

COPENHAGEN (DK), May 2019 — All cells in the fetal gut have the potential to develop into stem cells, a new study conducted at the Faculty of Health and Medical Sciences at the University of Copenhagen concludes. The researchers behind the study have discovered that the development of immature intestinal cells – contrary to previous assumptions – is not predetermined, but affected by the cells’ immediate surroundings in the intestines.
This discovery may ease the path to effective stem cell therapy, said Kim Jensen, Ph.D., from the Biotech Research & Innovation Centre (BRIC) and the Novo Nordisk Foundation Center for Stem Cell Biology (DanStem).
“We used to believe that a cell’s potential for becoming a stem cell was predetermined, but our new results show that all immature cells have the same probability for becoming stem cells in the fully developed organ. In principle, it is simply

Скрыть анонс
17:23 StemCellsPortal.comlCancer Drugs promote Stem Cell properties of Colorectal Cancer

MANNHEIM (DE), May 2019 — Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Mannheim University Medical Center (MUMC) have discovered that a certain group of cancer drugs, MEK inhibitors, activates the cancer-promoting Wnt signaling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses.
The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.
Cells react to external influences via the biochemical reactions of the Wnt signaling pathway. Wnt signals coordinate the development of the early embryo, but also play a role in many pathological processes and in cancer.
While researchers initially assumed that an excessively activated Wnt signaling pathway was

Скрыть анонс
14:13 Phys.orgIntensive silviculture accelerates Atlantic rainforest biodiversity regeneration

An experiment conducted in Brazil in an area of Atlantic Rainforest suggests that intensive silviculture, including the use of herbicide and substantial amounts of fertilizer, is a more effective approach to promoting the regeneration of tropical forest and biomass gain than the traditional method based on manual weeding and less fertilizer.

Скрыть анонс
19.05.2019
16:20 FightAging.OrgFight Aging! Newsletter, May 20th 2019

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being […]

Скрыть анонс
18.05.2019
02:44 StemCellsPortal.comlStem cell scientists clear another hurdle in creating transplant arteries

MADISON, WI (US), May 2019 — Cardiovascular disease is a major cause of death worldwide, and treating it isn’t easy.  The disease wreaks havoc on patients’ blood vessels and can require complex bypass surgery.
Scientists at the Morgridge Institute for Research are working toward a dream of creating artery banks — similar to blood banks common today — with readily available material to replace diseased arteries during surgery. The latest work in the lab of regenerative biologist James Thomson, VMD, Ph.D., puts the science one step closer to that goal.
In a paper published online May 9 in Stem Cell Reports, the Thomson Lab highlights a better way to grow smooth muscle cells (one of the two cellular building blocks of arteries) from pluripotent stem cells. The work also identifies a potential drug for reducing post-surgical risks in patients who undergo

Скрыть анонс
02:44 StemCellsPortal.comlPrince Charming's kiss unlocking brain's regenerative potential?

KYOTO (JP), May 2019 — The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells — neurons — have limited ability to regenerate. Nonetheless, stem cells are a form of natural backup, a vestige of our days as still-developing embryos.
The difficulty is that as we age, our brains' stem cells “fall asleep” and become harder to wake up when repairs are needed. Despite efforts to harness these cells to treat neurological damage, scientists have until recently been unsuccessful in decoding the underlying sleep mechanism.
Now, researchers at Kyoto University studying brain chemistry in mice have revealed the ebb and flow of gene expression that may wake neural stem cells from their slumber. These findings, which may also apply to stem cells elsewhere in the body, were recently published in Genes & Development.
"No one before us has

Скрыть анонс
01:21 Yahoo.com Business75-Year-Old Job Hunters Could Become New Normal in Aging Japan

This could be Japan’s new normal, with people working into their 70s and beyond, adding a new facet to its reputation as a nation of workaholics. Prime Minister Shinzo Abe is seeking to keep people like Kuzuno employed longer so they can pitch into the tax base and ease the burden on government spending, as the country copes with having the world’s fastest aging population. Japan’s graying population has propelled a surge in social security spending, accounting for about one-third of government outlays in the fiscal year that ended in March, much of which was funded by debt.

Скрыть анонс
17.05.2019
15:49 SeekingAlpha.comInternational Stem Cell reports Q1 results

Скрыть анонс
13:31 FightAging.OrgNematodes are Probably Not Useful Models of Mitochondrial Aging

Mitochondria, the power plants of the cell, carry their own DNA, encoding a few proteins essential to mitochondrial operation. Mutational damage to these genes can result in broken mitochondria that take over cells and cause the export of oxidizing molecules, contributing to the progression of aging. Not all mitochondrial DNA damage is the same, however: point mutations versus deletion mutations, for example. Researchers have struggled to produce consistent data in mice and nematodes with increased levels of mitochondrial DNA damage of various sorts. Some mice engineered to have greater mutation rates in mitochondrial DNA exhibit accelerated aging, while others do not, with little sign of a coherent explanation as to why beyond the sentiment that short-lived species are not useful models in this case. The […]

Скрыть анонс
11:01 News-Medical.NetStudy: All immature cells have potential to develop into stem cells

New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

Скрыть анонс
16.05.2019
23:03 TorqueNews.comMay Camaro of the Month: Mark Peterson's 1969 RS/SS Clone

The TorqueNews/Camaros Unlimited Camaro of the Month for May 2019 is this classic 1969 RS/SS clone with a modernized drivetrain, owned by Mark Peterson.

Скрыть анонс
22:56 ScienceDaily.comScientists find new type of cell that helps tadpoles' tails regenerate

Researchers have uncovered a specialized population of skin cells that coordinate tail regeneration in frogs. These 'Regeneration-Organizing Cells' help to explain one of the great mysteries of nature and may offer clues about how this ability might be achieved in mammalian tissues.

Скрыть анонс
21:10 Phys.orgScientists find new type of cell that helps tadpoles' tails regenerate

Researchers at the University of Cambridge have uncovered a specialised population of skin cells that coordinate tail regeneration in frogs. These 'Regeneration-Organizing Cells' help to explain one of the great mysteries of nature and may offer clues about how this ability might be achieved in mammalian tissues.

Скрыть анонс
20:58 Drugs.comLupus Takes Bigger Toll on Longevity for Blacks

THURSDAY, May 16, 2019 -- Lupus, a chronic autoimmune disease that attacks the skin, joints and organs, can shorten the lives of its victims, but new research shows it can shorten the lives of black patients the most. Health data from two counties...

Скрыть анонс
19:15 ScienceDaily.comSurprising research result: All immature cells can develop into stem cells

A new study challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy.

Скрыть анонс
17:06 Phys.orgNew power supply unit lets electrical devices live longer

From the charging unit for smartphones to the power supply of the laptop or washing machine to LED lights or charging stations of electric cars – switching power supplies are omnipresent in electrical devices. They convert the alternating current from the house line into the direct current needed by the device. The problem: power supplies are susceptible to errors, which also reduces the service life of end devices. Researchers of Karlsruhe Institute of Technology (KIT) have now developed a power supply unit with a significantly increased service life.

Скрыть анонс
16:15 AzoRobotics.comBiohybrid Robot Made from a Combination of Heart Tissue and 3D Printing

Taking inspiration from the toy shelf and biology, scientists at Thayer School of Engineering at Dartmouth College and City University of Hong Kong have built a swimming robot having a...

Скрыть анонс
16:10 ScienceDaily.comCancer drugs promote stem cell properties of colorectal cancer

Scientists have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses. The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.

Скрыть анонс
13:31 FightAging.OrgThe DNA Damage Response Falters in Old Stem Cells

Efficient DNA repair is necessary to prevent cells from becoming dysfunctional or senescent in response to stochastic nuclear DNA damage. This is particularly important in stem cell populations, as there is no outside source to replace their losses, or repair persistent dysfunction. Researchers here note that the DNA damage response fails to trigger sufficiently in old intestinal stem cell populations, and this may be an underlying contributing cause of higher levels of cellular senescence in these cells. Aging is related to disruption of tissue homeostasis, which increases the risks of developing inflammatory bowel diseases (IBDs), and colon cancer. However, the molecular mechanisms underlying this process are largely unknown. Various age-related dysfunctions of adult tissue-resident stem/progenitor cells (TSCs, also known as somatic stem cells) are associated […]

Скрыть анонс
13:19 FightAging.OrgAging, Metabolic Rate, and the Differences Between Birds and Mammals

There is a strong association in mammalian species between metabolic rate, size, and life span. When pulling in bird species to compare, however, it is observed that they tend to have higher metabolic rates and longer life spans at a given size. So the question here is what exactly is going on in bird metabolism that allows for this more heated operation of cellular metabolism, necessary to meet the demands of flight, without the consequences to life span observed in mammalian species. The open access paper here is illustrative of research in this part of the comparative biology of aging field. Is there anything in this ongoing work on metabolism and aging that might one day lead to methods of extending mammalian life? Perhaps, perhaps […]

Скрыть анонс
11:40 News-Medical.NetMediterranean diet shown to help prevent diabetes and protect the heart

Earlier this year, U.S. News & World Report issued its annual rankings of the best diets. This year's winner: the Mediterranean diet, a plant-based diet shown to help prevent diabetes and protect the heart.

Скрыть анонс
03:24 Electrek.coTesla is updating its battery software following a car fire, claims improve longevity

Several Tesla Model S vehicles have caught on fire seemingly on their own without any accident lately and now Tesla is updating its battery software following the latest incident. more…

Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast. https://youtu.be/ee5nKd7zjWo
The post Tesla is updating its battery software following a car fire, claims improve longevity appeared first on Electrek.

Скрыть анонс
15.05.2019
23:02 FightAging.OrgTowards Restoration of Neural Stem Cell Function in the Old

Every tissue in the body supported by its own specialized small stem cell populations. The vast majority of cells in the body, known as somatic cells, are limited in the number of times they can divide. Their telomeres shorten with each cell division, and they become senescent or self-destruct when reaching the Hayflick limit on replication, triggered by short telomeres. Stem cells have no such limitation, and use telomerase to maintain telomere length regardless of the number of divisions they undergo. They divide asymmetrically to generate daughter somatic cells with long telomeres that can replace lost somatic cells in order to maintain tissue function. This split between a small privileged cell population and a large, limited cell population most likely evolved because it greatly reduces […]

Скрыть анонс
20:20 Nature.ComTracing the origin of adult intestinal stem cells

Скрыть анонс
16:16 Nature.ComStem-cell and genetic therapies make a healthy marriage

Скрыть анонс
12:14 GizmagScientists discover self-defense "switch" for stem cells


With the power to turn themselves into any other cell in the body, stem cells have a future as a key treatment for a range of diseases and injuries. The problem is, they lack some of the self-defense mechanisms that other cells have, leaving them open to attack from viruses and other threats. Now, researchers from the University of Edinburgh may have found a way to switch this mechanism back on, making stem cell treatments more effective.
.. Continue Reading Scientists discover self-defense "switch" for stem cells Category: Biology Tags: Molecules Protein Stem Cells The Immune System University of Edinburgh Virus

Скрыть анонс
11:23 News-Medical.NetImmune system discovery could inform the development of new stem cell therapies

A discovery of how stem cells are protected from viruses could inform the development of therapies for use in medicine, research suggests.

Скрыть анонс
09:30 News-Medical.NetExploring the contributions of health care to longevity

A widely cited statistic suggests that health care services account for only a small percentage of the variation in American life expectancy. However, the methodology supporting the finding has been challenged.

Скрыть анонс
14.05.2019
23:17 News-Medical.NetOxidative stress acts directly on telomeres to hasten cellular aging, study reveals

The same sources thought to inflict oxidative stress on cells- pollution, diesel exhaust, smoking and obesity- also are associated with shorter telomeres, the protective tips on the ends of the chromosomal shoelace.

Скрыть анонс
22:49 ScienceDaily.comImmune system discovery could aid quest for stem cell therapies

Scientists have discovered how stem cells can develop resistance against viruses, a finding that could aid the development of stem cell therapies.

Скрыть анонс
18:14 Yahoo Science Zombie cells buildup in your body may play role in aging

NEW YORK (AP) — Call them zombie cells — they refuse to die.

Скрыть анонс
18:01 StemCellsPortal.comlStem cells make more ‘cargo’ packets to carry cellular aging therapies

Baltimore, MD (US), May 2019 —Johns Hopkins University scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny “cargo packets” able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.
Extracellular vesicles are naturally abundant in many types of cells, which use the cargo-containing spheres to communicate with other cells. They are about one 100th the diameter of a cell and can carry anything from fats and proteins to nucleic acids. When a cell releases an extracellular vesicle, other cells nearby slurp up the tiny packet and its contents, making it an attractive

Скрыть анонс
13:39 FightAging.OrgAn Analysis of Six Decades of Change in the Variability of Human Life Span

Inequality is something of a fixation these days; all too many people think that addressing inequality via forced reallocation of the wealth that exists is more important than generating more wealth for all through technological progress. That way lies only ruins. The growth of capabilities and wealth provided by technological progress must be the most important goal, above all others, particularly if we are to develop and benefit from rejuvenation biotechnologies. Still, all too many people focus on inequality to the exclusion of progress, and inequality, not progress, is the hot button topic of the moment. Thus this paper on variability of human life span over time is presented as a discussion on inequality. Nonetheless, after skipping the rhetoric, the data is quite interesting. The […]

Скрыть анонс
13:26 FightAging.OrgEvidence for the Mutation Accumulation Hypothesis of the Origin of Aging

Researchers here examine the growing vaults of genomic data for evidence to support the theory that aging evolves because evolutionary selection is inefficient when it comes to genes variants that have harmful effects in later life. Selection acts most readily on variants that aid reproductive success in early life. Thus variants that are damaging in late life accumulate, reinforcing an age-related decline of health and robustness. This is closely related to the concept of antagonistic pleiotropy, which refers to genes and biological systems that are beneficial in youth but become harmful in later life. These will tend to be selected for, with all of the attendant unpleasant consequences for individual members of the species. Medawar's mutation accumulation hypothesis explains aging by the declining force of […]

Скрыть анонс
01:39 News-Medical.NetCoffee and longevity – debate continues

There have been studies saying coffee drinking increases longevity and general health and also studies to the contrary.

Скрыть анонс
00:21 MoneyMorning.comThis Small-Cap Stock Is Making Life Better for 3 Million Aging Americans

It's no secret that aging demographics are fueling growth in the healthcare sector.
But this small-cap stock is helping people stay mobile and healthy at an affordable price.
And the stock itself is available at a bargain if you grab it now.
Read more here...
Tags: Stocks
To get full access to all Money Morning content, click here
About Money Morning: Money Morning gives you access to a team of ten market experts with more than 250 years of combined investing experience – for free. Our experts – who have appeared on FOXBusiness, CNBC, NPR, and BloombergTV – deliver daily investing tips and stock picks, provide analysis with actions to take, and answer your biggest market questions. Our goal is to help our millions of e-newsletter subscribers and Moneymorning.com visitors become smarter, more confident investors.
Disclaimer: © 2019 Money Morning and Money Map Press.

Скрыть анонс
00:17 Medscape.ComHow Much Does Healthcare Influence Longevity?

Healthcare plays a minor role in determining life span in the US; behavioral and social factors play a much bigger role, data suggest. The numbers indicate US health spending priorities are out of alignment.

Скрыть анонс
13.05.2019
22:07 NYT ScienceStem Cell Treatments Flourish With Little Evidence That They Work

The F.D.A. has taken an industry-friendly approach toward companies using unproven cell cocktails to treat people desperate for relief from aging or damaged joints.

Скрыть анонс
21:54 NYT HealthStem Cell Treatments Flourish With Little Evidence That They Work

The F.D.A. has taken an industry-friendly approach toward companies using unproven cell cocktails to treat people desperate for relief from aging or damaged joints.

Скрыть анонс
20:33 StemCellsPortal.comlChronic Pancreatitis Patient Mesenchymal Stem Cells Can Support Islet Grafting

Review of “Mesenchymal Stem Cells from Chronic Pancreatitis Patients Show Comparable Potency Compared to Cells from Healthy Donors” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Recent research from the laboratory of Hongjun Wang (Medical University of South Carolina, USA) established that cotransplantation of syngeneic mouse islet with mesenchymal stem cells (MSCs) derived from patients suffering from chronic pancreatitis, a long‐standing inflammatory condition associated with endocrine and exocrine dysfunction [1, 2], fostered enhanced islet survival and function [3]. Furthermore, recent data from a pilot clinical trial of autologous islet cotransplantation for human patients undergoing total pancreatectomy also established the potential protective effects of chronic pancreatitis MSCs on islet

Скрыть анонс
20:09 Drugs.comInjured Lungs Can Be Regenerated for Transplant: Study

MONDAY, May 13, 2019 -- Severely damaged lungs can be regenerated to be suitable for transplantation, researchers say. A transplant is the only lifesaving treatment for people with end-stage lung disease, but donor organs are in short supply. Up to...

Скрыть анонс
20:06 News-Medical.Net3D-printed tissue scaffolds could help improve nipple reconstruction

Nipple and areola reconstruction is a common breast reconstruction technique, especially for breast cancer patients after mastectomy.

Скрыть анонс
13:41 FightAging.OrgMicroRNA-199 Produces Significant Heart Regeneration in Pigs

This is one of the more promising animal studies of heart regeneration that I recall seeing in recent years, particularly given that it is accomplished in pigs, which are a good match in size for human tissues. The heart is one of the least regenerative organs in the mammalian body, and damage, such as that resulting from a heart attack, results in scar tissue and loss of function rather than healing. Here, researchers used a microRNA in order to provoke native cells into regenerative activities that would not normally take place. One of the major goals of the regenerative medicine community over the past two decades has to been to find ways to either deliver cells capable of regrowth or to deliver instructions to native […]

Скрыть анонс
12:16 Technology.orgStem cells provide information about neuron resilience in ALS

Researchers at Karolinska Institutet in Sweden have developed a stem cell based model in order to study the

Скрыть анонс
10:15 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Retinal Ganglion Cell Repair, Human Platelet Lysate, Female Germline Stem Cells, and Metabolic Reprogramming of iPSCs!

Retinal Ganglion Cell Repair by iPSC-Derived Müller Glia

The transplantation of Müller glial cells may represent a beneficial treatment for glaucoma, one of the leading causes of blindness. In an encouraging advance, researchers led by Karen Eastlake and G. Astrid Limb (UCL Institute of Ophthalmology, Moorfields Eye Hospital, London, UK) recently described the isolation of Müller glia from retinal organoids formed by human induced pluripotent stem cells (iPSCs) in a STEM CELLS Translational Medicine article. The team demonstrated how these cells partially restored visual function in rats depleted of retinal ganglion cells and may, therefore, represent an attractive means

Скрыть анонс
08:19 News-Medical.NetResearchers reveal ebb and flow of gene expression that may awaken neural stem cells

The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells -- neurons -- have limited ability to regenerate.

Скрыть анонс
12.05.2019
16:46 FightAging.OrgFight Aging! Newsletter, May 13th 2019

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being […]

Скрыть анонс
10.05.2019
23:45 Yahoo.com Business10-Year-Old Hears Mom Say 'I Love You' For the First Time After Getting a Cochlear Implant

Grab the tissues: This beautiful video will have you crying happy tears just in time for Mother's Day.

Скрыть анонс
19:28 ScienceDaily.comPrince Charming's kiss unlocking brain's regenerative potential?

Researchers find that 'waves' of Hes1 and Ascl1 gene expression control the quiescent and active state of adult neural stem cells. Hes1 expression promotes quiescence and suppresses Ascl1, and knocking out Hes1 increases Ascl1 expression and subsequent adult neural stem cell activation.

Скрыть анонс
19:28 ScienceDaily.comNative plants regenerate on their own after invasive shrubs are removed

Invasive shrubs have become increasingly prevalent in the deciduous forests of eastern North America -- often creating a dense understory that outcompetes native plants. Many land managers would like to remove the invaders, but worry about whether a costly remediation program will be needed to help the native plant community rebound.

Скрыть анонс
18:10 Phys.orgStudy shows native plants regenerate on their own after invasive shrubs are removed

Invasive shrubs have become increasingly prevalent in the deciduous forests of eastern North America—often creating a dense understory that outcompetes native plants. Many land managers would like to remove the invaders, but worry about what happens afterwards. Will they need to launch a costly remediation program to reestablish native plant communities?

Скрыть анонс
16:59 Yahoo.com BusinessSenseonics Holdings, Inc. (SENS) Q1 2019 Earnings Call Transcript

SENS earnings call for the period ending March 31, 2019.

Скрыть анонс
First← Previous12345678910Previous →Last