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18.08.2019
13:46 StemCellsPortal.comlEngineered Stem Cells for Targeted Cancer Therapy

Multiple stem cell types exhibit inherent cancer tropism, while engineered stem cells have been used as therapeutic agents to specifically target cancer cells. More recently, stem cells engineering has been employed to target multiple surface‐receptors on tumor cells, as well as endothelial and immune cells of the tumor microenvironment. In a new review published in STEM CELLS, researchers led by Sanam L. Kavari and Khalid Shah (Harvard Medical School, Boston, Massachusetts, USA) discuss the rationales and strategies of developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges that they hold as cancer therapeutics.


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17.08.2019
03:35 ScienceDaily.comRelaxing of regulations for regenerative medicines has cascading effect internationally

Countries that relax regulations for regenerative medicines, like stem cell 'treatments', could be causing a downward spiral in international standards.

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16.08.2019
18:10 News-Medical.NetDespite failed promises, stem cell advocates again want taxpayers to pony up billions

Californians voted in 2004 to shell out billions of dollars in taxpayer money to fund cutting-edge stem cell treatments.

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16:29 Technology.orgNew stem cell combination could help to repair damaged hearts

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed

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16:18 Technology.orgCambridge scientists reverse ageing process in rat brain stem cells

New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new

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14:21 News-Medical.NetMallinckrodt publishes results of StrataGraft regenerative tissue Phase 1b study

Mallinckrodt plc, a leading global biopharmaceutical company, today announced publication of results of its Phase 1b clinical trial of StrataGraft®, an investigational regenerative tissue, in Burns, the journal of the International Society for Burn Injuries.

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13:35 FightAging.OrgSenescent Cells Increase Risk of Colon Cancer via Secretion of GDF15

Cells that enter a senescent state have many purposes in the body. They are involved in both wound healing and cancer suppression, for example. Senescence also serves to remove somatic cells that reach the Hayflick limit on replication. Senescent cells secrete a potent mix of signals to rouse the immune system and encourage local tissue regrowth and remodeling. This is all useful in the short term, where senescent cells accomplish the immediate task at hand and then self-destruct or are destroyed by immune cells. Wounds are healed, and potentially cancerous cells destroyed. Yet cellular senescence is a cause of aging. The problems arise due to the tiny fraction of senescent cells that evade destruction and linger in the body in increasing numbers with advancing age. […]

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03:42 MedicalNewsToday.comMedical News Today: Rejuvenating brain stem cells may hold key to future MS treatments

Scientists have found a way to rejuvenate brain stem cells in rats. The finding offers clues on how to restore lost brain function in diseases such as MS.

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15.08.2019
22:30 FightAging.OrgStiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination

Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect between (a) increasing stiffness of the brain tissue that hosts niches where stem cells reside, (b) dysfunction of those stem cells mediated by the specific stiffness-sensing mechanism of Piezo1, a process that may exist in other stem cell populations as well, (c) the loss of myelin-generating cells normally produced by the stem cells, and (d) the consequent degradation of myelin and nervous system function. Without looking into underlying causes of increasing […]

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19:07 News-Medical.NetResearchers reverse stem cell aging process

Scientists have shown that older stem cells can be reverted to a younger state. The discovery has important implications for degenerative disease research.

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16:03 StemCellsPortal.comlImplantable 3D blastocyst-like embryonic structure generated from mouse stem cells

SAITAMA (JP), August 2019 — After an egg is fertilized, it begins to divide and passes through several stages. Cells in the two-cell stage are totipotent — they can become any type of cell. After many more cell divisions, the embryo turns into a blastocyst that is implanted in the womb where it differentiates and grows into a fetus. A blastocyst is like an almost hollow ball. Inside are pluripotent cells — cells that can become any type of cell in the body, but not the placenta — while the outer shell is made from trophoblasts — cells that eventually form the placenta.
For several years, scientists have been able to convert somatic cells, like skin cells, into pluripotent cells. However, nobody has been able to convert differentiated cells into totipotent cells.
In an earlier study conducted at Gladstone, authors Cody Kime, Ph.D., and Kiichiro Tomoda, Ph.D., were able to convert

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11:45 Nature.ComNiche stiffness underlies the ageing of central nervous system progenitor cells

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06:00 StemCellsPortal.comlHuman amniotic fluid stem cells show promise in treating severest type of spina bifida

DURHAM, N.C. AUGUST 14, 2019 - A study released today in STEM CELLS Translational Medicine provides compelling evidence of how an injection of human amniotic fluid stem cells can be used to protect the spinal cord of a fetus from myelomeningocele (MMC). The finding could lead to a new strategy for treating this debilitating birth defect that affects about 1 out of every 4,000 children born in the United States each year.

The most severe form of spina bifida, myelomeningocele results when the backbone and spinal canal do not close before birth. It can leave a child with many disabilities, including partial or full paralysis, difficulty with bowel and bladder control, hydrocephalus and developmental delay.

“Despite the poor prognosis associated with MMC, the options

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04:41 GizmagCambridge study reverses aging of key brain stem cells in rodents


New research, led by a team of scientists from the University of Cambridge, has demonstrated a way to rejuvenate old, dysfunctional brain stem cells, making them act young again. The technique points to potential new treatments for multiple sclerosis (MS), but also broader ways to reverse general age-related brain changes.
.. Continue Reading Cambridge study reverses aging of key brain stem cells in rodents Category: Medical Tags: Aging Brain Cambridge University Multiple Sclerosis Neuroscience Stem Cells

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02:12 ScienceDaily.comScientists reverse aging process in rat brain stem cells

Scientists say the results have far reaching implications for how we understand the aging process, and how we might develop much-needed treatments for age-related brain diseases.

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14.08.2019
22:21 FightAging.OrgTargeting NKG2D Ligands on the Surface of Persistent Senescent Cells Enables their Destruction by the Immune System

A harmful accumulation of lingering senescent cells occurs in all tissues over the course of aging. A cell entering a senescent state ceases to replicate and begins to generate an mix of signals known as the senescence-associated secretory phenotype (SASP). These signals drive chronic inflammation, remodel the surrounding tissue structure, and encourage nearby cells to also become senescent. This can be helpful in the short term, such as following injury, where it can aid in regeneration. When sustained over the long term, it is a cause of aging and age-related disease, however. Cells become senescent constantly, largely somatic cells reaching the Hayflick limit on cellular replication, but also potentially cancerous, damaged cells. Near all senescent cells either self-destruct via the process of apoptosis or are […]

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19:22 StemCellsPortal.comlβ-Cell Mass Formation in Stem Cell-Derived Implants

A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al. describe the optimization steps used to enhance this protocol in a STEM CELLS Translational Medicine study. The authors investigated the formation of a β‐cell mass inside the device to identify the underlying mechanisms and conditions that reduce variability and, in doing so, elucidated a protocol that resulted in the more consistent formation of a glucose‐controlling β‐cell mass.


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18:58 StemCellsPortal.comlPerspectives: Translation of Stem Cell Research: Points to Consider in Designing Preclinical Animal Studies

Summary Stem cell‐based therapies hold tremendous promise for the treatment of serious diseases and injuries. Although hematopoietic stem cell transplantation is routinely used as part of the treatment regime for some malignancies and genetic diseases, most stem cell‐based therapeutic products are investigational and still require preclinical and clinical studies to support their many novel therapeutic uses. Because of the multiple sources of stem cells, the plethora of potential applications, and the novel mechanism of action of stem cell‐based therapies, there is no single set of universal guidance documents that can be used to inform the preclinical development path for these therapeutics. Specific technical issues relating to the transplantation of human cells in animals, new delivery procedures, and laborious methods to characterize

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17:28 StemCellsPortal.comlHuman amniotic fluid stem cells show promise in treating severest type of spinal bifida

The most severe form of spinal bifida, myelomeningocele results when the backbone and spinal canal do not close before birth. It can leave a child with many disabilities, including partial or full paralysis, difficulty with bowel and bladder control, hydrocephalus and developmental delay.

“Despite the poor prognosis

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17:16 StemCellsPortal.comlPerspectives: The Alpha Stem Cell Clinic: A Model for Evaluating and Delivering Stem Cell-Based Therapies

Summary Cellular therapies require the careful preparation, expansion, characterization, and delivery of cells in a clinical environment. There are major challenges associated with the delivery of cell therapies and high costs that will limit the companies available to fully evaluate their merit in clinical trials, and will handicap their application at the present financial environment. Cells will be manufactured in good manufacturing practice or near‐equivalent facilities with prerequisite safety practices in place, and cell delivery systems will be specialized and require well‐trained medical and nursing staff, technicians or nurses trained to handle cells once delivered, patient counselors, as well as statisticians and database managers who will oversee the monitoring of patients in relatively long‐term follow‐up studies.

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16:31 StemCellsPortal.comlProfiles: California Institute for Regenerative Medicine: Accelerating Stem Cell Therapies in California and Beyond


Among the most prolific funders of stem cell research today is the California Institute for Regenerative Medicine (CIRM). CIRM was established in 2004 by Proposition 71 to accelerate the development of new therapies for chronic disease and injury by funding stem cell research programs throughout the state of California. Its mission is to support and advance stem cell research and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury. Renowned stem cell and in vitro fertilization expert Dr. Alan Trounson has been president of CIRM since 2008. He shares the organization's goals and strategies as well as its successes.
 
Introduction The California Institute for Regenerative Medicine (CIRM)

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16:16 News-Medical.NetNanotechnology could boost stem cell transplantation research

Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.

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14:01 Nanowerk.comNew nanotechnology platform could aid stem cell transplantation research

People with neurodegenerative diseases and central nervous system injuries could benefit.

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13:37 FightAging.OrgFibroblast Growth Factors in Skin Aging

This open access review examines what is known of the role of fibroblast growth factors in mechanisms relevant to skin aging, such as loss of collagen and elastin from the extracellular matrix. This type of paper always makes for an interesting read, and fully mapping the cellular metabolism of aging is the right goal from a fundamental science perspective. When it comes to near term intervention in the aging process, this sort of examination is less helpful, however. Yes, growth factor expression levels change in aging skin cells, and that has consequential effects. But this is in and of itself far removed from the underlying causes of degenerative aging. It is itself a consequence and not a cause. The most efficient way forward is to […]

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13:28 Phys.orgNew nanotechnology could aid stem cell transplantation research

Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.

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03:09 Phys.orgPinpointing the molecular mechanisms of ageing

Although each and every one of us goes through it, ageing is a poorly understood process. Researchers have used a biomarker called the epigenetic clock to identify a gene that is closely linked to ageing in humans. The study, published in Genome Biology, shows that the epigenetic clock could be a good tool for improving our understanding of the molecular mechanisms behind ageing.

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13.08.2019
23:35 FightAging.OrgReviewing Potential Strategies for the Rejuvenation of Stem Cell Populations

Every type of tissue is supported by its own dedicated stem cell population, delivering a supply of daughter somatic cells that replace losses and maintain tissue function. Unfortunately, stem cell function declines with age. This has numerous causes, all of which descend from the underlying accumulation of molecular damage outlined in the SENS research proposals for rejuvenation biotechnologies. Downstream of those causes, stem cells become less active due to some combination of internal damage, damage to their niche of supporting cells, and changes in the signaling environment. The latter two classes of issue appear more influential in the best studied stem cell populations, such as the satellite cells of muscle tissue. Thus most research and development intended to restore stem cell function is presently focused […]

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21:09 Drugs.comTight Blood Pressure Control Could Help Save Aging Brains

TUESDAY, Aug. 13, 2019 -- Staying sharp and warding off dementia might rely, in part, on doing your best to keep high blood pressure at bay. So finds a new study that suggests strict control of hypertension may help prevent dementia. In the study,...

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13:32 FightAging.OrgA Review of HDAC Inhibitors as a Category of Drugs that Modestly Slow Aging

HDAC inhibitors are a comparatively poorly understood category of drugs that act to modestly slow aging in short-lived laboratory species. As such, they most likely function through some form of upregulation of cellular stress responses, thus activating cellular maintenance processes that lead to improved cell and tissue function. That said, the chain of cause and effect leading from the known mechanism of action to that stress response upregulation is not clearly mapped. As for all approaches that slow aging via stress response mechanisms, we should remember that the effects on life span in short-lived species are much larger, relatively speaking, than those in long-lived species such as our own, even when the short term effects on the operation of metabolism are quite similar. Calorie restriction […]

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13:13 Yahoo.com BusinessDoes Sensys Gatso Group (STO:SENS) Have A Healthy Balance Sheet?

David Iben put it well when he said, 'Volatility is not a risk we care about. What we care about is avoiding the...

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12:22 BBC HealthInside the village that caters for its ageing population

Pescueza in Extremadura, western Spain, is adapting to provide for the needs of its older population.

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12:00 News-Medical.NetTooth repair using stem cells may soon be a reality

A team of researchers including those from Biotechnology Center of the TU Dresden (BIOTEC), have found that stem cells could be used for several forms of tissue engineering including tooth repair.

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12.08.2019
22:40 StemCellsPortal.comlNovel dual stem cell therapy improving cardiac regeneration

HONG KONG, August 2019 — As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team of scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells.
The findings give hope to develop a new treatment for repairing MI heart, as an alternative to the existing complex and risky heart transplant for seriously ill patients.
MI is a fatal disorder caused by a shortage of coronary blood supply to the myocardium. It leads to permanent loss of heart muscle cells (cardiomyocytes) and scar tissue formation, resulting in irreversible damage to cardiac function or even

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21:52 FightAging.OrgJim Mellon Interviewed by Adam Ford at Undoing Aging 2019

Adam Ford of Science, Technology, and the Future carried out a number of interviews while at Undoing Aging in Berlin earlier this year. The interview materials are steadily being processed and uploaded, and that just recently included this interview with Jim Mellon, billionaire investor and philanthropist, cofounder of Juvenescence, and a very down to earth fellow who is interested in improving the human condition by targeting aging with new biotechnologies. Accordingly, he has used his resources to put himself into a position to talk up the longevity industry, move research forward, and attract a great deal more funding for the next stage in the process of guiding the first treatments to slow and reverse aspects of aging from the laboratory to the clinic. These are […]

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19:21 StemCellsPortal.comlXeno-free Culture Reagents Improves Bone Generation by Periosteum‐derived Stem Cells

Review of “Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture” from STEM CELLS Translational Medicineby Stuart P. Atkinson

The translation of basic stem cell research into clinically relevant therapies will require xeno‐free culture components used as part of highly efficient and scalable in vitro expansion and differentiation approaches. Researchers from the laboratory of Ioannis Papantoniou (KU Leuven, Leuven, Belgium) previously established the potential of expanding and differentiating human periosteum‐derived stem cells (hPDCs), crucial to bone fracture healing in vivo [1], in microcarrier‐containing bioreactors [2] as a means to develop sources of cells with osteogenic or chondrogenic potential for in vivo transplantation. 
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18:48 Benzinga.comCellect Shares Rally After Lead Stem Cell Program Receives Clearance For Midstage Study

The thinly traded nano-cap penny stock CELLECT BIOTECH/S ADR (NASDAQ: APOP) was soaring Monday.
read more

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18:03 Drugs.comDepression, Alzheimer's Might Be Part of Same Process in Some Aging Brains: Study

MONDAY, Aug. 12, 2019 -- New research is untangling the complex relationship between symptoms of depression and losses in memory and thinking that often emerge together with Alzheimer's disease. In fact, the new data suggests that "depression...

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13:38 FightAging.OrgAssessing Retrotransposon Activity and Senescent Cell Burden in Mice by Age and Tissue

Retrotransposons are genetic sequences that can copy themselves to new locations in the genome. This activity increases with age, for reasons that are still poorly understood, and it is an open question as to the degree to which this is important as a cause of tissue dysfunction with aging. The arguments for and against are much the same as those for stochastic mutation of nuclear DNA to be a meaningful contribution to degenerative aging, with the most compelling model being the one in which mutations in stem or progenitor cells can spread widely in a tissue through their descendant somatic cells. This open access paper is focused on assessing the growth in retrotransposon activity and the increasing burden of senescent cells with advancing age, the […]

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09:27 GizmagHarvard team grows cyborg mini-organs out of stem cells


Scientists could almost build a whole mini-body out of the mini-organs that have been grown over the last few years. But cell development has traditionally been tricky to study, thanks largely to the difficulty in getting sensors in there without damaging the organs. Now, researchers from Harvard have developed a way to create "cyborg organoids" by integrating nanoelectronics into cell cultures.
.. Continue Reading Harvard team grows cyborg mini-organs out of stem cells Category: Biology Tags: Artificial organs Cells Cyborg Electronic Harvard Medication Stem Cells

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06:34 GizmagNewly-discovered group of dental stem cells could patch up cavities


The dentist's drill is a sound that sends shudders down the spines of many people, so it sure would be nice if teeth could just repair themselves. Thankfully that's not as far-fetched as it sounds – researchers from the University of Plymouth have found a new population of stem cells in mice that are in charge of repairing tooth tissue and could be recruited to help us patch up cavities.
.. Continue Reading Newly-discovered group of dental stem cells could patch up cavities Category: Medical Tags: Dental Health Regenerative Medicine Stem Cells Teeth University of Plymouth

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11.08.2019
14:26 FightAging.OrgFight Aging! Newsletter, August 12th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents An Interview with Reason at Undoing Aging 2019 The Potential of Senolytic Therapies to Treat Chronic Kidney Disease The Implications of Greater Amounts of Remnant Cholesterol in the Bloodstream Reviewing Progress Towards Regenerative

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02:55 News-Medical.NetResearchers seek to understand the regenerative potential of newborn mammalian hearts

Unlike lower vertebrates, mammals are unable to repair their adult hearts after injuries that include heart attacks. This inability in humans leads to heart failure -- a deadly and costly disease that affects more than 5 million Americans.

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10.08.2019
17:40 ScienceDaily.comNovel dual stem cell therapy improving cardiac regeneration

Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

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01:12 Reuters.com HealthMediterranean diet tied to lower risk of gestational diabetes

(Reuters Health) - Pregnant women at high risk for developing gestational diabetes may be less likely to experience this complication when they switch to a Mediterranean diet instead of sticking with their usual eating habits, a recent experiment suggests.

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09.08.2019
23:30 FightAging.OrgThe Present Popularity of Epigenetic Reprogramming to Treat Aging

A fair number of research groups are presently working on ways to force large numbers of cells in the body to adopt more youthful epigenetic profiles. Much of this research is an outgrowth of the discovery of induced pluripotency, the ability to reprogram any cell into a pluripotent stem cell that is largely indistinguishable from an embryonic stem cell, capable of generating any of the cell types in the body. This process also happens to reset many of the epigenetic markers of age that are found in cells in old tissues, alongside restoring mitochondrial function by clearing out damaged mitochondria, and a few other interesting changes. The article here focuses on one representative project, but readers here might be more familiar with the work of […]

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17:02 News-Medical.NetResearchers identify epigenetic mechanism that may strongly influence healthy aging

Researchers at the Max Delbrueck Center for Molecular Medicine have identified an epigenetic mechanism that appears to strongly influence healthy aging.

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16:34 ScienceDaily.comA genetic chaperone for healthy aging?

Researchers have identified an epigenetic mechanism that appears to strongly influence healthy aging. It's a protein that controls muscle integrity, lifespan and levels of an essential sugar. How does one protein have that much power?

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14:24 Phys.orgEpigenetic mechanism appears to strongly influence healthy aging

Researchers at the Max Delbrueck Center for Molecular Medicine (MDC) have identified an epigenetic mechanism that appears to strongly influence healthy aging. It's a protein that controls muscle integrity, lifespan and levels of an essential sugar. How does one protein have that much power?

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10:23 Reuters.com HealthAstraZeneca's Tagrisso helps lung cancer patients live longer: study

AstraZeneca Plc said on Friday a late-stage study showed its top-selling drug, Tagrisso, had significantly helped patients with a type of lung cancer live longer without the disease worsening.

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07:58 News-Medical.NetTreatment with both targeted cancer therapy and MS drug halts glioblastoma stem cells

Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery.

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07:25 Financial TimesBirmingham regeneration plans start to pay dividends

Second city growth driven by metro mayor, low rents and local tech talent

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08.08.2019
23:33 FightAging.OrgReviewing Progress Towards Regenerative Therapies for Age-Related Hearing Loss

Today's open access paper is a review of present progress towards regenerative therapies that can reverse hearing loss. Progressive hearing loss is pervasive in old age, and accelerates considerable in the later stages of life. Hearing loss correlates with cognitive decline, and while it is plausible that this is because of degeneration of central nervous system function, there is also the consideration that loss of hearing isolates people and deprives them of interactions that stimulate brain activity. It is well demonstrated in mice that environment richness has a strong impact on the brain and its pace of aging. Much of the research into age-related hearing loss is focused on the sensory hair cells of the inner ear. These detect the pressure waves of sound and […]

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22:12 StemCellsPortal.comlTargeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

SEATTLE, WA (US), August 2019 — Researchers at Fred Hutchinson Cancer Research Center have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.
It's the first time that scientists have specifically edited the genetic makeup of a specialized subset of adult blood stem cells that are the source of all cells in the blood and immune system.
The proof-of-principle study, published July 31 in Science Translational Medicine, suggests that efficient modification of targeted stem cells could reduce the costs of gene-editing treatments for blood disorders and other diseases while decreasing the risks of unwanted effects that can occur with a less discriminating approach.
"By demonstrating how this select group of cells can be efficiently edited for one type of

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19:35 ScienceDaily.comImplantable 3D blastocyst-like embryonic structure generated from mouse stem cells

Researchers have generated 3D blastocyst-like structures from stem cells. The study shows that the blastocyst-like structures very closely resemble actual blastocysts, and even induce proper changes in the uterus after being implanted in pseudo-pregnant mice.

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17:51 Yahoo.com BusinessRich, Aging Boomers Poised to Keep Millennials Out of Housing

(Bloomberg) -- A growing cohort of rich, aging baby boomers will contribute to even tighter housing supply for younger generations in Toronto over the next decade, according to a new report.Seniors have traditionally downsized or switched to rentals and retirement homes, which has freed up supply for younger homeowners. Rising employment and income among older generations along with growing social-support services has turned that trend on its head, the Canada Mortgage & Housing Corp. said in report Thursday.“Rising home-ownership rate among seniors may continue, which will translate into less supply being freed up for younger generations,” the country’s housing agency said.A quarter of homes in Toronto were owned by seniors age 65 and over in 2016, up 4.5 percentage points from 2006, the CMHC said. The share of

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17:39 Benzinga.comBayer To Buyout Stem Cell Therapy Company BlueRock For Up To $600M

Biotech M&A has been on a roll this year, with companies striking up both mid- and large-sized deals. 
read more

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16:42 Yahoo.com BusinessSenseonics Holdings, Inc. (SENS) Q2 2019 Earnings Call Transcript

SENS earnings call for the period ending June 30, 2019.

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14:50 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

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14:39 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

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14:27 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

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14:23 ReutersBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline.

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14:15 TechnologyReview.comHas this scientist finally found the fountain of youth?

Editing the epigenome, which turns our genes on and off, could be the “elixir of life”.

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13:40 FightAging.OrgDGCR8 Overexpression Attenuates the Accumulation of Senescent Cells with Age

Given the newfound acceptance of cellular senescence as an important cause of aging, many more research groups are assessing the impact of senescent cells in their research into aging. Here, the focus is on chromatin organization, a collection of nuclear structures and processes in the cell that appear to have some influence over the pace of aging over a lifetime. The researchers discover that the gene DGCR8 accelerates the appearance of senescent cells and dysfunction when mutated, and thus producing broken protein machinery, but slows the accumulation of lingering senescent cells when overexpressed in its correct form. This touches on some of the same machinery of the cell as the mir-122 findings discussed a few days ago, and that work is worth comparing with the […]

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13:40 FightAging.OrgCytomegalovirus in the Immunology of Aging

The open access editorial noted here serves as an introduction to some of the current thinking on the role of cytomegalovirus (CMV) in the age-related decline of the immune system. CMV infection is pervasive throughout the population, particularly in the old. This persistent viral infection cannot be effectively cleared by the immune system, and an ever greater percentage of immune cells become uselessly specialized to fight CMV. This leaves ever fewer immune cells ready to tackle other threats. This seems an important component of immune dysfunction, one that can perhaps be addressed by selectively destroying these immune cells to free up space for replacements. The research community is by no means unified on this view of CMV, however, as illustrated here. Aging represents a paradox […]

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08:21 News-Medical.NetNew method to enhance heart-attack repair using stem cell-derived cardiomyocytes

The heart cannot regenerate muscle tissue after a heart attack has killed part of the muscle wall. That dead tissue can strain surrounding muscle, leading to a lethal heart enlargement.

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07:16 CNBC technologyMobile games may be Nintendo's answer to waning sales of its aging handheld devices

Mobile games could be the answer for Nintendo as interest in its portable devices such as the 3DS wanes, according to Niko Partners' Daniel Ahmad.

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00:27 SeekingAlpha.comU.S. Stem Cell reports Q2 results

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07.08.2019
20:34 NYT HealthAnother Baseball Mystery: Why Do Players Seem to Live Longer?

A new study suggests professional baseball players live longer than other athletes and American men in general. The reasons could be complex.

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13:38 FightAging.OrgThe Inflammatory Feedback Loop Produced by Senescent Cells in the Aging Heart

Senescent cells are an important cause of degenerative aging. Lingering senescent cells accumulate over time and disrupt tissue function and immune function via their secretions. An insidious part of this is that the signals secreted by senescent cells cause other nearby cells to be more likely to become senescent. Thus once they start to accumulate the result is an accelerating feedback loop of dysfunction and degeneration. There are many such feedback loops in aging, which is why the process starts slow and then speeds up considerably in later life. Aging is a major risk factor in the development of chronic diseases, especially cardiovascular diseases. Age-related organ dysfunction is strongly associated with the accumulation of senescent cells. Cardiac mesenchymal stromal cells (cMSCs), deemed part of the […]

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13:16 FightAging.OrgComparing the Metabolomic Signature of Aging in Mice and Naked Mole-Rats

Naked mole-rats live something like ten times longer than similarly sized mice, show few signs of aging until very late life, and are near immune to cancer. These two species are used as models by researchers to try to understand how, in detail, differences in metabolism can lead to the observed large differences in life span across mammalian species. Since metabolism is ferociously complex, this is very much a work in progress; in the grand scheme of things, only small inroads and starting points have been established. I fully expect investigations of the detailed interactions of metabolism and aging to be ongoing and nowhere near complete thirty years from now, when rejuvenation therapies based on repair of the well-known root causes of aging are a […]

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12:17 Nature.ComWind-down of stem-cell institute leaves a void

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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10:53 Yahoo ScienceAstraZeneca s Lynparza helps prostate cancer patients live longer: study

The British drugmaker said the treatment met the main goal in a late-stage study of patients with metastatic castration-resistant prostate cancer and BRCA1/2 or ATM gene mutations. BRCA and ATM genes are responsible for producing proteins that repair damaged DNA, but can cause cancer growth if the genes mutate. "This will be a big extension to Lynparza's market potential and will be seen as good news.

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10:51 Reuters.com HealthAstraZeneca's Lynparza helps prostate cancer patients live longer: study

AstraZeneca said on Wednesday its cancer drug, Lynparza, was successful in helping patients with metastatic prostate cancer and certain genetic mutations live longer without the disease worsening, compared with the standard of care.

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06.08.2019
21:52 Yahoo.com Business3 Stocks for an Aging Population

These three companies are creating ways to take care of our rapidly aging population.

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20:56 StemCellsPortal.comlNeural Stem Cells from Neuroepithelial Stem Cells

A recent study from the labs of Philipp Koch (University of Heidelberg/Medical Faculty Mannheim) and Oliver Brüstle (University of Bonn, Germany) explored whether stable neuroepithelial stem (NESCs) derived from human pluripotent stem cells can give rise to neural stem cells with radial glia‐like properties. Ostermann et al. now report on the in vitro transition of human NESCs into radial glia‐like NSCs, define the developmental relationship between in vitro propagated human NSC systems, and provide a matrix for the relationship between pluripotent stem cell‐derived populations and their native counterparts in the brain. For all the exciting details, see STEM CELLS now!


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16:28 StemCellsPortal.comlComputer modeling predicts best stem cell donors and therapies for kids with heart disease

Durham, NC – A study released today in STEM CELLS Translational Medicine (SCTM) identifies a computational modeling system that could have far-reaching implications for personalized medicine, especially when seeking treatments for children with heart failure. The system, called partial least squares regression (PLSR), is able to predict which stem cell donors and manipulation methods might yield the best therapies for these patients.
According to the March of Dimes, nearly one out of every 100 babies born in the United States each year has a heart defect — a quarter of them critical, with symptoms including severe right ventricular heart failure (RVHF).The SCTM study team, made up of researchers from Emory University and Georgia Institute of Technology, had alreadyshown that aggregated c-kit+

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13:16 FightAging.OrgMicroRNA miR-122 is Important in Improved Mitochondrial Function Resulting from Calorie Restriction

Calorie restriction improves near all measures of metabolic health, mitochondrial function included. Mitochondria are the power plants of the cell, and they accumulate damage and dysfunction with age, in part because the processes of quality control intended to remove worn and broken mitochondria falter. Calorie restriction improves the situation, but, characteristically, does so in a very broad way that makes it challenging to pick out the important mechanisms from the many other sweeping changes in cellular activity. Researchers here suggest that upregulation of miR-122 is noteworthy, but it is just one of many changes noted in the paper. Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains mitochondrial proteostasis in mammals remains elusive. MicroRNAs (miRNAs) are well known for […]

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09:18 GizmagGiving stem cells some support helps heal damaged hearts


Considering how important an organ it is, it's a shame that the heart is so bad at repairing itself. One heart attack is rarely the end of the problem, as scarring prevents healing and often leads to further attacks. Stem cells are an emerging solution, and now researchers at the Universities of Cambridge and Washington have combined heart muscle cells and supportive cells to help mend broken hearts.
.. Continue Reading Giving stem cells some support helps heal damaged hearts Category: Medical Tags: Cambridge University Cells Heart Heart attack Heart Disease Stem Cells University of Washington

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05.08.2019
23:23 Reuters.com HealthEpilepsy patients may live longer with specialist care

People with epilepsy who receive care from specialists may be less likely to die prematurely than their counterparts who don't, a Canadian study suggests.

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21:21 9to5mac.comUSB-C dual-bay HDD and SSD dock offers offline cloning and more

Orico is out today with a new dual-bay HDD and SSD dock that offers USB-C, 2.5- and 3.5-inch drive compatibility, the option to clone a drive without a computer or internet connection, and more.
more…
The post USB-C dual-bay HDD and SSD dock offers offline cloning and more appeared first on 9to5Mac.

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21:17 FightAging.OrgAn Interview with Reason at Undoing Aging 2019

Much of the proceedings at Undoing Aging in Berlin earlier this year were recorded, but of course it takes a few months for everything to process through the queue. I briefly escaped from the conference for an ad hoc, unstructured discussion with Adam Ford of Science, Technology, and the Future, who, like the Life Extension Advocacy Foundation folk, was interviewing as many people as he could during the event. It wound up a monologue on topics that were at the top of my mind at the time, particularly the present state of funding and the transformation of our community from a primary focus on advocacy and academic research to one in which a great deal of important work is now carried out in startup companies, […]

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17:32 FierceBiotech.comStem cell combo repairs damaged hearts in rats

Scientists in the U.K. and U.S. worked together on a study showing that a combination of cardiac muscle cells and epicardial cells derived from stem cells could restore both damaged heart muscle and blood vessel cells in rat models of heart attack. They believe the combo could be key to improving stem-cell treatments for people with heart failure.

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16:13 SeekingAlpha.comProvention Bio's PRV-031 Breakthrough Therapy for individuals at risk type 1 diabetes

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15:49 StemCellsPortal.comlNew stem cell combination could help to repair damaged hearts

LONDON (UK), August 2019 — A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed treatment for heart failure, according to new research published in Nature Biotechnology.
Researchers have found that, by transplanting an area of damaged tissue with a combination of both heart muscle cells and supportive cells taken from the outer layer of the heart wall, they may be able to help the organs recover from the damage caused by a heart attack.
Scientists have been trying to use stem cells to repair damaged hearts for a number of years. Efforts have been unsuccessful so far, mainly because the vast majority of transplanted cells die within a few days.
Now, Sanjay Sinha, M.D., Ph.D., and his team at the University of Cambridge, in collaboration with researchers at the University of Washington, have used supportive epicardial

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14:36 FightAging.OrgThe Gut Microbiome Changes Over the Course of Aging

This short open access review is a good introduction to what is known of the changes to the microbial population of the gut that take place over the course of aging. Collectively, the activity of gut microbes is influential on health, arguably to a similar degree as exercise, though far less well quantified at this time. Altering the distribution of bacterial populations in older animals, to better resemble what is observed in young animals, leads to benefits to health, for example. Some of the specific mechanisms by which beneficial gut microbes improve health are being uncovered, such as the secretion of propionate, a compound now being developed as a dietary supplement. Much more remains to be established, of course; this is a part of the […]

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14:25 News-Medical.NetFDA announces new policy framework for development of regenerative medicine products

Today the U.S. Food and Drug Administration announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies.

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14:15 Phys.orgNew knowledge in history: Evaluating seven decades of ex situ seed regeneration

The Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben has been promoting the transition of gene banks into bio-digital resource centres—the aim is the preparation and collation of the phenotypic and genetic information for all stored accessions. As an important step for the further development of the Federal Ex situ Gene Bank, which is being hosted by the IPK in Gatersleben, researchers have been evaluating the historical data which has been accrued by the gene bank over the last 70 years. Not only is the resulting published data an important new resource for researchers and plant breeders, the publications also provide blueprint strategies for the preparation of correlated datasets from which other gene banks and research facilities will be able to draw.

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13:17 News-Medical.NetSuperstar athletes popularize unproven stem cell procedures

Baseball superstar Max Scherzer — whose back injury has prevented him from pitching for the Washington Nationals since he last played on July 25 — is the latest in a long list of professional athletes to embrace unproven stem cell injections in an attempt to accelerate their recovery.

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11:45 GizmagStem cell map shows how immortal invertebrate regenerates itself


Our bodies do a decent enough job of repairing themselves, able to patch up wounds, fight off infections and even heal broken bones. But that only applies up to a certain point – lose a limb, for example, and it's not coming back short of a prosthesis. Other creatures have mastered this skill though, and now scientists at the University of California Davis (UC Davis) and Harvard have sequenced the RNA transcripts for the immortal hydra and figured out how it manages to do just that.
.. Continue Reading Stem cell map shows how immortal invertebrate regenerates itself Category: Biology Tags: Animals Genetics Harvard Regeneration Regenerative Medicine RNA Stem Cells UC Davis

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11:11 StemCellsPortal.comlA Step Towards Diaphragmatic Regeneration with Engineered Muscle Constructs

Review of “Generation of a Functioning and Self-Renewing Diaphragmatic Muscle Construct” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Researchers from the laboratories of Martina Piccoli and Michela Pozzobon (Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy) recently reported that an extracellular matrix (ECM) biologic scaffold obtained from decellularized mouse diaphragm recruited host muscle precursor cells (MPCs) when implanted into a mouse model [1]. As this scaffold displayed many of the properties of the native diaphragm [2], a complex muscle organ that supports respiration, the researchers believed that seeding such an ECM scaffold with human MPCs [3, 4] may allow the in vitro generation of a diaphragmatic muscle construct that can be potentially transplanted to treat

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10:59 StemCellsPortal.comlA Role for hnRNP‐K in Regulating Open Chromatin in Embryonic Stem Cells

Review of “hnRNP-K targets open chromatin in mouse embryonic stem cells in concert with multiple regulators” from STEM CELLS by Stuart P. Atkinson

While the expression of the OCT4 transcription factor characterizes pluripotent stem cells, we still have an incomplete picture of the initiation of OCT4 gene expression and its maintenance during development. Researchers from the laboratory of Alexey N. Tomilin (Russian Academy of Sciences, St. Petersburg, Russia) recently sought to explore a role of hnRNP‐K in OCT4 gene expression, given several reports describing a role for hnRNP‐K in pluripotent stem cells and development [1-4]. hnRNP‐K itself is a KH‐domain poly(C)‐binding protein family member characterized by high‐affinity interactions with polycytosine strands in DNA and RNA [5].

In a new STEM CELLS article,

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07:11 DigitalTrends.comPlayStation 4 destroyed to protest The Legend of Zelda: Breath of the Wild clone

A man destroyed a PlayStation 4 Pro at ChinaJoy 2019 in protest against Genshin Impact, which is being criticized as a clone of The Legend of Zelda: Breath of the Wild. The game's similarities were apparent in a new trailer.

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04.08.2019
16:17 FightAging.OrgFight Aging! Newsletter, August 5th 2019

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Impaired Monocyte to Macrophage Transition Implicated in Cardiovascular Disease Overexpression of Proteasome β5 Subunit in Neurons Slows Aging in Flies Cells with Stem Cell Properties Identified in the Adult Liver ATGL-1 is a Central

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03.08.2019
18:03 CryptoCoinsNews.comAngry Fan Smashes PS4, SLAMS Sony's Zelda 'Clone' Genshin Impact

Today at the Chinese gaming expo ChinaJoy, a devoted fan destroyed a PlayStation 4 in protest at what a cluster of onlookers saw as Sony's promotion of shameless The Legend of Zelda: Breath of the Wild ''clone'' Genshin Impact. When Mihoyo unveiled Genshin Impact for PS4, many noted the game was inspired by BOTW. Some […]
The post Angry Fan Smashes PS4, SLAMS Sony's Zelda 'Clone' Genshin Impact appeared first on CCN Markets

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17:40 Technology.orgScientists found a way to improve regeneration of intestine tissue

Time is not good for us. As we age, condition of our bodies start to decline right to

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03:57 Rejuvenation ResearchRe: “Regulation of S-Nitrosylation in Aging and Senescence” by Larrick and Mendelsohn (Rejuvenation Res 2019;22:171–174)

Rejuvenation Research, Ahead of Print.

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02.08.2019
23:21 FightAging.OrgGarfish as a Model for Limb Regeneration

Exceptional regeneration can be found in some higher animals, such as zebrafish and salamanders. These species are capable of completely regenerating non-lethal injuries and large loss of tissue from internal organs and limbs, producing an organ that is indistinguishable in function from the original, and doing so repeatedly. In mammals, with very few exceptions that occur in only a few species and a few tissues, such injuries only scar with no proficient regeneration. Why is this case? That is the question that many research groups seek to answer, as finding a way to spur regeneration of organs and limbs in our species is obviously a very desirable goal. The authors of today's paper argue for the use of garfish as an animal model for the […]

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22:39 Yahoo.com BusinessThe secret to slowing down aging? Tickling, a new study suggests

Scientists at the University of Leads 'tickled' patients' ears with a tiny electric current- they found it could slow aging effects.

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22:13 StemCellsPortal.comlStudy looks at stem cells for answers to how a type of autism develops

CHICAGO, IL (US), July 2-19 — Researchers have discovered how the genetic defect in fragile X syndrome — a type of autism — delays production of neurons (nerve cells) at a critical time in the embryo's brain development. In a study published in Cell Reports, Yongchao Ma, Ph.D., and colleagues describe a previously unknown regulatory mechanism controlling how stem cells differentiate into neurons.
They identified early disruptions in this process in fragile X syndrome, the most common inherited intellectual disability in children.By investigating the earliest stages in development of fragile X syndrome, researchers hope to identify new targets for potential treatments.
"During embryonic brain development, the right neurons have to be produced at the right time and in the right numbers," said Dr. Ma, senior author and researcher at Ann & Robert H. Lurie Children's Hospital of

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21:24 News-Medical.NetNew stem cell combination may help repair damage caused by heart attack

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed treatment for heart failure, according to new research part-funded by the British Heart Foundation (BHF) and published in Nature Biotechnology.

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