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Regeneration

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19.11.2019
10:51 StemCellsPortal.comlHes1 Regulates HF Regeneration via Hedgehog Signaling

The adult hair follicle cycles through regression, resting, and growth phases and is maintained by hair follicle stem cells (HFSCs). During hair growth, progenitors and stem cells of the hair follicle activate and sustain the downward growth of hair follicles; however, our understanding of progenitor activation and stem cell maintenance during the hair cycle remains incomplete. Now, a new study from researchers led by Liang‐Tung Yang (National Health Research Institutes, Zhunan, Taiwan) report on the discovery of a potential link between Notch/Hes1 and Sonic Hedgehog pathways, in which Hes1 reinforces Hedgehog signaling at the onset of hair growth to expand the progenitors and replenish the stem cells to maintain the hair cycle homeostasis. For all the

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10:39 StemCellsPortal.comlHDAC7 Peptide Boosts Vascular Regeneration

Histone deacetylase 7 (HDAC7) plays a pivotal role in the maintenance of endothelial integrity, and while we know that short open reading frames (sORFs) exist within the 5′ terminal non‐coding area of Hdac7 mRNA, it remains unclear whether these sORFs contribute to HADC7 function. In a recent STEM CELLS study, researcher from the laboratories of Qian Wang (Southern Medical University, Guangzhou, China) and Lingfang Zeng (King's College London, UK) now report that a 7‐amino acid peptide translated from an HDAC7 sORF act as a phosphate group carrier, thereby forming a novel signal transduction pathway known as the MEKK1‐7A‐14‐3‐3γ pathway downstream of VEGF. Yang et al. believe that this novel signal pathway may be involved in vessel wall resident

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15.11.2019
23:29 DigitalTrends.comNew 3D-printing system can spit out custom-fitted bionic hands in under 10 hours

There have been some impressive 3D-printed powered prostheses. But getting them to the people who need them as quickly as possible is still something of a hurdle. That may be about to change.

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10:18 StemCellsPortal.comlCell-Based Therapies for Periodontal Regeneration

Cell‐based therapies have the potential to improve outcomes of orally-associated regenerative treatments; as an example, mesenchymal stem cells currently represent ideal candidates for adjuvant application for extraction sockets and challenging lateral/vertical bone defects requiring bone block grafts. However, a new review article from the laboratory of Federico Moreno Sancho  (UCL Eastman Dental Institute, London, UK) establishes that there exists insufficient evidence to identify best‐performing treatment modalities among the cell‐based techniques. The authors note that we must elucidate the clinical benefit of “substantial manipulation” of tissues and cells when compared with “minimal manipulation” and highlight the need for further research that

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00:55 News-Medical.NetNew type of bionic pacemaker

A new study published in the Journal of Physiology on November 14, 2019, reports the development of a radically different type of cardiac pacemaker which could change the prognosis of patients with heart failure.

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12.11.2019
22:33 News-Medical.NetCHLA researchers discover a mechanism of heart regeneration in zebrafish

One of the reasons coronary heart disease is so deadly is that fluid build-up and scarring can develop in the heart tissue. This prevents the heart from contracting properly, impacting its ability to supply the body with fresh blood. If scarring is extensive, heart failure can result.

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21:26 ScienceDaily.comAt the heart of regeneration: Scientists reveal a new frontier in cardiac research

Researchers uncover mechanisms in zebrafish heart regeneration that could lead to better treatments for babies in need of heart repair.

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11.11.2019
21:25 Technology.orgRegeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease

A newly-discovered molecular mechanism that allows damaged adult liver cells to regenerate could pave the way for drugs

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07.11.2019
23:19 FightAging.OrgCardiomyocytes Expressing SOX10 are Vital to Zebrafish Heart Regeneration

A few higher animal species, such as salamanders and zebrafish, are capable of regeneration of limbs and internal organs, regrowing lost and injured tissue without scarring or loss of function. Numerous research groups are engaged in investigating the biochemistry of proficient regeneration, attempting to find the specific differences between species that might explain how it happens and why adult mammals are largely incapable of such feats of regrowth. Today's open access research is an example of the type, in which the authors narrow down on a specific cell population that appear in zebrafish hearts during regeneration, but not in human tissues. It may be the case that the mechanisms and capacity for adult regeneration do still exist in mammals, but are suppressed in some way, […]

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13:32 Technology.orgLymphatic system found to play key role in hair regeneration

Given the amount of wear and tear it’s subjected to on a daily basis, the skin has a

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00:36 ScienceDaily.comNew technique lays foundation for regenerative cardiac therapies

Scientists have devised a technique to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. The method removes a significant roadblock to developing ways to regrow healthy cardiac muscle tissue, a feat not currently possible.

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05.11.2019
16:48 ScienceDaily.comRegeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease

Researchers have uncovered a novel molecular mechanism that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired.

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07:33 News-Medical.NetResearchers develop new type of transposase protein with improved biochemical properties

The team, comprising researchers from the European Molecular Biology Laboratory, the Universitätsklinikum Würzburg and the Paul-Ehrlich-Institut, managed to design a new variant of the Sleeping Beauty transposase with dramatically improved biochemical properties.

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04.11.2019
17:00 StemCellsPortal.comlLymphatic System Found to Play Key Role in Hair Regeneration

NEW YORK, NY (US), November 2019 — Given the amount of wear and tear it’s subjected to on a daily basis, the skin has a phenomenal ability to replenish itself. Spread throughout it are small reservoirs of stem cells, nested within supportive microenvironments called niches, which keep a tight rein on this repair process. Too much tissue might cause problems like cancer, while too little might accelerate aging.
Until now, scientists were uncertain whether the stem cells themselves could instruct other stem cells to form new skin by reshaping their niche. But new research in Science, led by Elaine Fuchs, Ph.D., of Rockefeller University and the Howard Hughes Medical Institute, indicates that stem cells can indeed influence tissue regeneration. The study identifies a molecular coordination tool used by stem cells to signal

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02.11.2019
03:15 ScienceDaily.comLymphatic system found to play key role in hair regeneration

To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.

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02:30 News-Medical.NetLymphatic system found to be involved in hair regeneration

Given the amount of wear and tear it's subjected to on a daily basis, the skin has a phenomenal ability to replenish itself.

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01:43 News-Medical.NetScientists propose new material for regenerative medicine capable of controlling immune response

Scientists of Tomsk Polytechnic University jointly with the University of Montana proposed a new promising material for regenerative medicine for recovery of damaged tissues and blood vessels.

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01.11.2019
17:49 Phys.orgA new material for regenerative medicine capable of controlling cell immune response

Scientists at Tomsk Polytechnic University jointly with the University of Montana (USA) proposed a promising new material for regenerative medicine for recovery of damaged tissues and blood vessels. This is a 3-D scaffold, made of biodegradable material and filled with special inhibitors, which were also obtained at TPU. They literally turn off the work of enzymes, responsible for the inflammation reaction, occurring in immune cells in response to external stimuli. In this case, such an irritant is a regenerative material.

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31.10.2019
18:43 News-Medical.NetREANIMA project may overturn paradigms that underlie regenerative cardiology research

Research into new endogenous mechanisms of tissue regeneration is an innovative research avenue in cardiac regeneration.

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30.10.2019
10:58 StemCellsPortal.comlRegeneration with Meniscus-derived Stem Cells

The results of a new study by researchers led by Weishan Chen and Weiliang Shen (Zhejiang University, Hangzhou, China) have demonstrated, for the first time, that meniscus‐derived stem cells (MeSCs) derived at earlier developmental stages may not be optimal for meniscus regeneration and articular cartilage protection when compared to MeSCs derived from day seven inner meniscus tissue. He et al. believe that their new findings could make a significant contribution to human meniscus tissue engineering in the future; for all the details, see STEM CELLS Translational Medicine.

 

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29.10.2019
00:47 ScienceDaily.comNew method promises advances in 3D printing, manufacturing and biomedical applications

In a development offering great promise for additive manufacturing, researchers have created a method to precisely create droplets using a jet of liquid. The technique allows manufacturers to quickly generate drops of material, finely control their size and locate them within a 3D space.

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25.10.2019
10:48 StemCellsPortal.comlEnhancing Bone Regeneration by Silencing Smurf1 in MSCs

The associated detrimental effects of the administration of high doses of bone morphogenetic proteins (BMPs) required to promote osteogenesis in orthopedic applications currently hinders many clinical applications. As a solution to this problem, researchers led by Flor María Pérez‐Campo (University of Cantabria, Santander, Spain) recently demonstrated that silencing of the Smurf1 gene in mesenchymal stem cells (MSCs) via antisense oligonucleotide expression significantly increases the susceptibility of MSCs to BMP‐2. García‐García et al. also report that the combination of MSCs expressing low levels of Smurf1 and biocompatible scaffolds that sustainably release small doses of BMP in a controlled manner may promote bone formation while avoiding the harmful

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24.10.2019
22:11 News-Medical.NetUA Little Rock receives $5.6 million DOD grant to advance bone regeneration technology

The U.S. Department of Defense has awarded the University of Arkansas at Little Rock a $5.6 million grant to advance the NuCress scaffold, a groundbreaking bone regeneration technology.

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16:13 ScienceDaily.comBy cutting out one gene, researchers remove a tadpole's ability to regenerate

Tadpoles that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution.

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13:57 Phys.orgSpecial cells contribute to regenerate the heart in zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group led by Prof. Nadia Mercader of the University of Bern now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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23.10.2019
21:31 ScienceDaily.comSpecial cells contribute to regenerate the heart in Zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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20:43 News-Medical.NetNew study on zebrafish may have possible relevance for heart regeneration in humans

In mammals, including humans, the heart muscle has a very limited capacity to recover after injury. After an acute myocardial infarction, millions of cardiac muscle cells, named cardiomyocytes, die, and are replaced by a scar.

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16:38 News-Medical.NetPolymerized estrogen can protect nervous system cells and promote regeneration

Spinal cord damage that causes paralysis and reduced mobility doesn't always stop with the initial trauma, but there are few treatment options to halt increased deterioration -- and there is no cure.

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22.10.2019
21:01 DigitalTrends.comCotton candy machines inspired this potential breakthrough in lab-grown meat

Lab-grown meat is the future. But for it to take off, it's going to have to taste like the real thing. Scientists at at Harvard recently developed a breakthrough approach that could help.

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20:06 Nanowerk.com3D-printing, bioinks create implantable blood vessels

A modified triple-coaxial 3D cell printing technique allows fabrication of multilayer blood vessels that have the unique biomolecules needed to transform into functional blood vessels when they are implanted.

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19:02 Phys.org3-D printing, bioinks create implantable blood vessels

A biomimetic blood vessel was fabricated using a modified 3-D cell printing technique and bioinks, which were formulated from smooth muscle cells from a human aorta and endothelial cells from an umbilical vein. The result is a fully functional blood vessel with a dual-layer architecture that outperforms existing engineered tissue and brings 3-D-printed blood vessels several fundamental steps closer to clinical use.

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19:02 Phys.orgBy cutting out one gene, researchers remove a tadpole's ability to regenerate

Tadpoles of frogs that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution. The work appears October 22 in the journal Cell Reports.

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16:31 Phys.orgResearchers identify functions of key genes responsible for liver regeneration

Researchers of the RUDN Medical Institute have identified the genes controlling the process of liver regeneration—they "instruct" hepatocyte cells, which comprise 80 percent of the liver, to divide. The results of the study will contribute to the development of new methods of liver regeneration in patients with chronic hepatitis, sclerosing cholangitis, as well as those who had liver resection for cancer or other conditions. The article is published in Cell Biology International.

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21.10.2019
17:55 Nanowerk.comBioprinting: Living cells in a 3D printer

With a new process, living cells can be integrated into fine structures created in a 3D printer - extremely fast and with very high resolution.

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17:49 ScienceDaily.comBioprinting: Living cells in a 3D printer

A high-resolution bioprinting process has been developed: Cells can now be embedded in a 3D matrix printed with micrometer precision -- at a printing speed of one meter per second, orders of magnitude faster than previously possible. Tissue growth and the behavior of cells can be controlled and investigated particularly well by embedding the cells in a delicate 3D framework. This is achieved using so called 'bioprinting' techniques.

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16:34 ScienceDaily.comReal texture for lab-grown meat

Researchers have grown rabbit and cow muscles cells on edible gelatin scaffolds that mimic the texture and consistency of meat, demonstrating that realistic meat products may eventually be produced without the need to raise and slaughter animals.

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12:48 Nanowerk.comReal texture for lab-grown meat

Researchers grow muscle cells on edible fibers.

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12:08 Phys.orgLab-grown meat: Researchers grow muscle cells on edible fibers

Lab-grown or cultured meat could revolutionize food production, providing a greener, more sustainable, more ethical alternative to large-scale meat production. But getting lab-grown meat from the petri dish to the dinner plate requires solving several major problems, including how to make large amounts of it and how to make it feel and taste more like real meat.

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11:45 StemCellsPortal.comlNew Developments Towards Thymic Regeneration via Organoid Technology

Review of “Gene modification and 3D scaffolds as novel tools to allow the use of post-natal thymic epithelial cells for thymus regeneration approaches” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Thymic dysfunction renders patients vulnerable to infections, malignancies, and autoimmune diseases [1, 2]; however, stimulating thymic regeneration and thymus transplantation both present with significant problems. The generation of thymic organoids based on three-dimensional cultures of thymic epithelial cells (TECs) may represent a new solution to this problem [3, 4]. Now, a new STEM CELLS Translational Medicine article from laboratory of Marita Bosticardo (IRCCS San Raffaele Scientific Institute, Milan, Italy) reports on the growth of Oct4-“rejuvenated” adult mouse TECs in three-dimensional (3D)

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14.10.2019
12:06 Technology.orgU of T researcher develops nanosystem that promotes regeneration after root canals

A novel nanosystem developed by Anil Kishen, a professor in the University of Toronto’s Faculty of Dentistry, shows promising results

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11.10.2019
01:59 News-Medical.NetHuman regenerative capacity discovered

Move over, salamanders, we humans can also regrow some of our body tissues. At least, this is what a new study published on October 9, 2019, in the journal Science Advances, reports. Using a mechanism quite similar to that by which amphibians like salamanders, and some zebrafish, grow back lost body parts, human joint cartilage can also regenerate itself.

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09.10.2019
23:52 News-Medical.Netβ-blockers could regenerate infant heart muscle, mitigate effects of congenital heart disease

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure throughout the rest of their lives. Yet, according to a Science Translational Medicine study published today by UPMC Children's Hospital of Pittsburgh researchers, β-blockers could supplement surgery to regenerate infant heart muscle and mitigate the lasting effects of congenital heart disease.

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16:46 News-Medical.NetLab-grown, testosterone-producing cells could help treat hypogonadism

Researchers have managed to grow human, testosterone-producing cells, which could lead to improved treatment options for low testosterone levels.

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08.10.2019
15:55 Phys.orgResearchers discover how water is regenerated on asteroids

Scientists have discovered how water molecules can be regenerated on asteroids moving through space, in an exciting breakthrough that could extend to other bodies such as the moon.

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07.10.2019
23:38 News-Medical.NetNew device can accelerate bone regeneration in difficult cases

Within minutes of breaking a bone, the body begins to repair itself.

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12:03 StemCellsPortal.comlASC Therapy Promotes Bone Regeneration After Bacterial Infection

Review of “Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Decreased bone regeneration due to inflammatory processes after severe bacterial infections remains a common problem in orthopedic surgery and previous studies from researchers led by Björn Behr (Ruhr-Universität Bochum, Germany) found that dysregulated inflammatory responses hindered bone regeneration after debridement following bacterial infection [1, 2]. Specifically, the authors observed reduced levels of osteoblastogenesis and increased levels of osteoclastogenesis and elevated B‐cell activity. 

Now the team returns with a STEM CELLS Translational Medicine study that investigates the

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11:27 StemCellsPortal.comlRegenerating the Aged and Damaged Intestine by Saying “No” to Notum

Review of “Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium” from Nature by Stuart P. Atkinson

A Paneth cell-containing niche supports the active cycling of intestinal stem cells (ISCs) [1, 2]; however, increased levels of complications observed in the gastrointestinal system with age suggest a reduction in both ISC activity and stem cell niche function. Fascinatingly, a recent Nature study by a team led by Pekka Katajisto (University of Helsinki, Helsinki, Finland) confirmed this hypothesis and established the production of Notum, an extracellular Wnt inhibitor, in aged Paneth cells as a crucial factor in the reduced regenerative potential of the intestinal epithelium that functions by targeting ISC function [3]. However, Pentinmikko et al. also highlight the pharmacological

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05.10.2019
16:08 News-Medical.NetResearchers develop new way of 3D printing soft biomaterials

A new way of 3D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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12:53 Phys.orgCommonwealth targets climate change with regeneration projects

The Commonwealth on Friday launched an ideas-sharing network to tackle the effects of climate change through replicable regeneration projects.

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04.10.2019
16:33 StemCellsPortal.comlAdult Fly Intestine Could Help Understand Intestinal Regeneration

BRISTOL (UK), September 2019 — Intestinal epith,elial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the universities of Bristol, Heidelberg and the German Cancer Research Center (DKFZ) have found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.
The research, published in Nature Communications, used the adult fly intestine, which is remarkably like a human intestine, to understand how IECs sense stress or damage, defend themselves and promote epithelial regeneration.
Stress-sensing pathways are activated upon a variety of stresses in fly IECs, but how these pathways are activated and how they promote IEC resilience and intestinal regeneration are not known.
The

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13:27 FightAging.OrgA Profile of Tissue Engineering Efforts at LyGenesis

LyGenesis is the company founded to develop the technique of implanting organoid tissue into lymph nodes in order to allow it to survive and grow in the body. Some organs can carry out much or all of their function more or less regardless of location in the body, such as the liver and thymus. Thus any viable transplant strategy that leads to functional tissue thriving in the body should help patients. LyGenesis is initially focused on restoring liver function via this approach, but the thymus is next in line, with an eye to reversing some of the age-related decline in immune function. Let's spend a little bit of time talking about your therapy. Let's say I hop into a time machine and go to the […]

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12:10 NYT HealthRegeneration: A Miracle, Against the Odds

Months after I’d shaved my head for cancer treatment, my old hair dropped out of the sky.

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08:17 News-Medical.Net3D printer could help expedite repair or replace damaged tissues for injured warfighters

The ability to 3D print a variety of healthcare-related products in deployment zones would greatly benefit the nation's warfighters.

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03.10.2019
19:49 ScienceDaily.comPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers have devised a fully print-in-place technique for printable electronics that is gentle enough to work on delicate surfaces ranging from paper to human skin. This can be accomplished without additional steps to bake, wash or powder-coat materials. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages with patient-specific biosensors.

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18:26 News-Medical.NetPrinted electronics show promise for personalized biosensors, embedded electronic tattoos

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin.

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15:34 Nanowerk.comPrinted electronics open way for electrified tattoos and personalized biosensors

The first demonstration of a fully print-in-place electronics technique is gentle enough to work on surfaces as delicate as human skin and paper.

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15:10 Phys.orgPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages tricked out with patient-specific biosensors.

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02.10.2019
17:11 Phys.orgNew 3-D printing technique for biomaterials

A new way of 3-D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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16:09 Nanowerk.comNew 3D printing technique for biomaterials

A new way of 3D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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01.10.2019
05:12 News-Medical.NetOptoceutics technique opens up new horizons for regenerative medicine

Using light to facilitate the formation of new blood vessels: it is the breakthrough outcome of a research study carried out by researchers at Istituto Italiano di Tecnologia in Milan (Italy). The study was published in Science Advances.

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05:01 News-Medical.NetNew optoceutics technique opens up new horizons for regenerative medicine

Using light to facilitate the formation of new blood vessels: it is the breakthrough outcome of a research study carried out by researchers at Istituto Italiano di Tecnologia in Milan (Italy). The study was published in Science Advances.

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30.09.2019
22:03 Nanowerk.comNew biofabrication method creates one scaffold to guide regeneration of multiple tissues

Scientists present a new 3D printing platform to fabricate multi-component scaffolds that 'steal from Nature' to engineer tissues organized like native tissues.

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20:57 ScienceDaily.comNew biofabrication method creates one scaffold to guide regeneration of multiple tissues

Scientists have taken a major step to address the challenge of engineer tissues organized like native tissues. They have demonstrated a new method to fabricate scaffolds presenting spatially organized cues to control cell behavior locally within one material.

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26.09.2019
23:19 FightAging.OrgApoE Levels Rise with Age and Degrade the Ability to Regenerate Bone

ApoE is a important protein in lipid metabolism, one of those responsible for transporting cholesterols and other lipids around the body. In today's open access research, the authors present evidence for rising levels of ApoE with aging to degrade the ability of bone to regenerate. This is unfortunate, because it will not be straightforward to just reduce ApoE levels. The protein is vital; a number of serious inherited conditions involve ApoE mutation that leads to greatly increased lipid levels on the bloodstream and organs. Bone regeneration, and normal tissue maintenance of bone for that matter, is a balance between constant creation and destruction of extracellular matrix structures. Osteoblast cells build bone, and osteoclasts tear it down. Age-related loss of bone density and strength is the […]

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12:51 Technology.orgAdult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but

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01:53 ScienceDaily.comAdult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research has found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.

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25.09.2019
00:45 News-Medical.NetTapeworms need their head for stem cell-driven regeneration

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.

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24.09.2019
19:15 Phys.orgTapeworms need to keep their head to regenerate

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.

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23.09.2019
23:25 FightAging.OrgConversion of Glial Cells into Neurons as an Approach to Regeneration in the Brain

The authors of today's research report on success in use of a gene therapy to convert glial cells into neurons in a living mouse brain, and thereby improve the normally limited recovery that takes place following brain injury, such as that caused by a stroke. A number of research groups are investigating this class of approach to enhance regeneration in the brain, an organ that has little capacity to repair itself. The capacity that does exist is generated by neural stem cells that, arguably, continue to produce new neurons at some pace throughout life. As for all stem cell populations, activity declines with age, however. An increased supply of new neurons, provided that they are capable of correctly maturing and integrating into neural circuits, should […]

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15:24 Phys.orgBiochemists reveal insights into extraordinary regenerative ability

Planarians are flatworms with the extraordinary ability to restore wounded or missing parts of their body. It has long been known that a particular group of proteins—known as PIWI proteins—are essential for this ability to regenerate. A team of researchers at the University of Bayreuth led by biochemist Dr. Claus Kuhn now reveals insights into the mode of action of these proteins in more detail. In the journal Genes & Development, the scientists present their research results, which promise to advance the molecular understanding of regeneration processes.

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20.09.2019
17:12 News-Medical.NetSponge-like action of circular RNA aids tissue repair after heart attack

The human genetic blueprint is like a string of code. To follow it, the code, or DNA, is transcribed into shorter strings of RNA.

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13.09.2019
22:53 FightAging.OrgEmbedded 3D Printing Used to Assemble Tiny Organoids into Larger Vascularized Tissue Masses

For as long as I have been watching progress in tissue engineering, the primary and most important barrier to building organs to order has been the inability to construct vascular networks. A network of capillaries must exist for blood, and thus nutrients and oxygen necessary to cell survival, to reach more than a few millimeters into a tissue. In live tissues, hundreds of minuscule capillaries pass through every square millimeter, considered in cross-section. Replicating this level of capillary density in engineered tissue has yet to be accomplished, with even the more advanced technology demonstrations falling well short of this goal. Well funded initiatives such as the effort to produce genetically engineered pigs with organs that can be decellularized for transplantation into humans, or the application […]

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18:57 ScientificAmerican.ComLab-Grown Human Mini Brains Show Brainy Activity

As the little structures grow, their constituents specialize into different types of brain cells, begin to form connections and emit brain waves. They could be useful models for development and... -- Read more on ScientificAmerican.com

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17:58 ScientificAmerican.ComLab-Grown Human Minibrains Show Brainy Activity

As the little structures grow, their constituents specialize into different types of brain cells, begin to form connections and emit brain waves. They could be useful models for development and... -- Read more on ScientificAmerican.com

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13:17 FightAging.OrgSenolytic Treatment Reverses Age-Related Loss of Regenerative Capacity in the Liver

You might recall a paper published last year in which the authors reported that cellular senescence is a primary cause of declining capacity in liver regeneration with age. Here the obvious next step is taken, and a senolytic therapy is tested for its ability to restore the capacity of the aging liver to regenerate by clearing senescent cells. Improvement in all sorts of measures that normally decline with age is the expected result of senolytic treatment at this point, given the extensive evidence accumulated to date. Senescent cells are a cause of aging and age-related decline, they actively maintain a dysfunction state of metabolism via their secretions, and thus of course getting rid of them helps. Though, as noted in this paper, things are never […]

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12:07 Technology.orgTissue Type

The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have

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10.09.2019
21:55 ScienceDaily.comHow salamanders harness limb regeneration to buffer selves from climate change

Researchers have shown for the first time that salamanders inhabiting the Southern Appalachian Mountains use temperature rather than humidity as the best cue to anticipate changes in their environment. Significantly, they observed that these salamanders actually harness their unique ability to regenerate limbs to rapidly minimize the impact of hot temperatures. The findings may have implications for other animals and even plants.

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19:49 Phys.orgStudy shows how salamanders harness limb regeneration to buffer selves from climate change

Looking like a cross between a frog and a lizard, the gray cheek salamander has thin, smooth skin and no lungs. The amphibian breathes through its skin, and to survive it must keep its skin moist. As environmental conditions grow hotter or drier, scientists want to know whether and how these animals can acclimate.

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09.09.2019
21:41 DigitalTrends.comBiotech company 3D-prints a miniature human heart from stem cells

It's not science fiction anymore: 3D-printing a human heart is now a reality, which could help thousands who need a heart transplant.

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10:01 StemCellsPortal.comlThe Epigenetic Balancing Act of Liver Regeneration

Review of “Epigenetic Compensation Promotes Liver Regeneration” from Developmental Cell by Stuart P. Atkinson

Researchers from the laboratory of Kirsten C. Sadler (Icahn School of Medicine at Mount Sinai, New York, USA/New York University Abu Dhabi, UAE) recently sought to understand the epigenomic “balancing act” that is liver tissue regeneration [1, 2]; just how does the epigenome orchestrate the induction of the gene expression programs required to activate regeneration in hepatocytes [3, 4] while repressing the numerous and potentially deleterious transposable elements present throughout the genome [5]?

To answer this intriguing epigenetic question, Wang et al. analyzed the transcriptomic and epigenetic changes associated with liver regeneration in the well-characterized mouse partial hepatectomy (PH) model [6, 7]. Fascinatingly, this new study now reveals that that

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08.09.2019
17:23 SingularityHub.ComLab-Grown Minibrains Show Activity Similar to Babies’ Brains

Neurons are a collective bunch. Although each neuron receives, processes, and passes on information individually, the electrical spikes only make sense when melded together in waves of oscillating activity. Like an orchestra, the notes played from each neuron matter. But only when they synchronize in specific ways do single notes transform into the music of […]

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11:02 News-Medical.NetUAB researchers identify biomarker for early beta cell death in Type 1 diabetes

Beta cells in the pancreas produce insulin. Their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss.

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07.09.2019
02:21 ScienceDaily.comBiomarker identified for early beta cell death in Type 1 diabetes

Beta cells in the pancreas produce insulin. Their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. Researchers now have identified an early biomarker of Type 1 diabetes-associated beta-cell loss in humans -- microRNA-204. This biomarker may provide a much needed approach to assess early T1D-associated human beta-cell loss, even before onset of overt disease.

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06.09.2019
16:59 AzoNano.comThe Regeneration of Cartilage Using Graphene Oxide

Researchers from the University of Manchester have discovered that the inclusion of the 2D nanomaterial graphene oxide (GO) into 3D scaffolds, used to aid the regeneration of cartilage, has the...

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13:18 News-Medical.NetUA receives $37.5 million NIH grant to research potential regenerative therapy for Alzheimer's

The University of Arizona Center for Innovation in Brain Science has received a $37.5 million grant from the National Institutes of Health to research a potential regenerative therapy for Alzheimer's disease.

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05.09.2019
22:48 FightAging.OrgAttempting a Unified View of Aging and Loss of Regenerative Capacity

Today's open access paper from the AgeX Therapeutics folk discusses a conceptual framework for looking at aging and loss of regeneration in a unified way across: (a) evolutionary differences between highly regenerative lower species such as hydra and less regenerative higher species such as mammals, (b) the loss of regenerative capacity over the course of embryonic development, and (c) the loss of regenerative capacity that occurs with aging in individuals. It covers a lot of ground, and even the summaries could do with a shorter summary. In essence this all ties back to the work being done at AgeX Therapeutics and elsewhere on the potential uses of induced pluripotency to produce regenerative therapies. The discovery that cells can be reprogrammed into what are essentially embryonic […]

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04.09.2019
16:43 StemCellsPortal.comlScientists Uncover Key New Molecules That Could Help Tackle Tooth Loss and Regeneration

PLYMOUTH (UK), September 2019 — Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.
Now new research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament, which helps keep the tooth stable in the jawbone. This improved understanding will also help scientists work toward regenerating the tissues that support teeth.
The study, led by the Universities of Plymouth and Geneva, shows how a signaling pathway called Notch, which is known to be activated in stem cells and cancer, is important for periodontal ligament development.
A signaling pathway describes how a group of molecules in a cell work together to control one or more cell functions, such as cell division or cell death. After the first molecule in

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30.08.2019
22:15 News-Medical.NetNew molecules that could help tackle tooth loss and regeneration discovered

Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.

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18:58 ScienceDaily.comScientists uncover key new molecules that could help to tackle tooth loss and regeneration

New research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament, which helps keep the tooth stable in the jawbone. This improved understanding will help scientists work towards regenerating the tissues that support teeth. This is a peer-reviewed, observational study conducted in rodent teeth and human cells.

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18:29 Phys.orgResearch team aims to reduce cost of drug development using 3-D-printed living tissues

Thomas E. Angelini, Ph.D., Associate Professor in the Department of Mechanical & Aerospace Engineering at the University of Florida and his research group, the Soft Matter Engineering lab have successfully fabricated living micro-beams from glioblastoma cells and extra-cellular material (ECM) embedded in a packed microgel support medium. They subsequently characterized the physical properties of the beams and compared their results against traditional mechanical engineering models. To their surprise, these microscopic, delicate structures behave a lot like the massive beams used in everyday building construction. "We were pleased and excited to see that our micro-beams, only 50 to 200 µm in diameter, acted in accordance with the mechanical principles for other models such as large steel beams," said S. Tori Ellison. Ellison is a Mechanical & Aerospace Engineering Ph.D. student who is mentored

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11:01 News-Medical.NetLab-grown brain organoids and the brains of preemie babies generate similar electrical impulses

Brain organoids — also called mini-brains — are 3D cellular models that represent aspects of the human brain in the laboratory. Brain organoids help researchers track human development, unravel the molecular events that lead to disease and test new treatments.

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29.08.2019
21:06 Yahoo ScienceHuman-like neural activity detected in lab grown mini brains

Scientists reported Thursday they had picked up human-like electrical activity in lab-grown brains for the first time, paving the way to model neurological conditions and answer fundamental questions on how our gray matter develops. "If you had asked me five years ago 'Would you think that a brain organoid would ever have a sophisticated network able to generate a brain oscillation?' I would say no," Alysson Muotri, a biologist at the University of California San Diego, told AFP. A paper published by Muotri and his colleagues in the journal Cell Press said that two factors were responsible for the breakthrough.

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20:19 Yahoo ScienceIn first, brain waves detected in lab grown mini-brains

Scientists have picked up electrical activity in pea-sized, lab-grown brains for the first time, paving the way to model neurological conditions and answer fundamental questions on how our gray matter develops. "If you had asked me five years ago would you think that a brain organoid would ever have a sophisticated network able to generate a brain oscillation, I would say no," Alysson Muotri, a biologist at the University of California San Diego, told AFP. A paper published by Muotri and colleagues in the journal Cell Press on Thursday said that part of the breakthrough was the result of a better procedure to grow stem cells, including optimizing the culture medium formula.

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18:05 ScientificAmerican.ComLab-Grown "Mini Brains" Can Now Mimic the Neural Activity of a Preterm Infant

The so-called organoids are not capable of complex thought but could be used to study neurological diseases -- Read more on ScientificAmerican.com

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28.08.2019
18:31 Phys.orgSkateboarding's DIY ethos is kick-starting a new wave of urban regeneration

In less than a year, skateboarding will make its debut in the Olympic Games in Tokyo. It's an international sport with an estimated 50m participants—but, more than that, skateboarding's DIY ethos and strong ties with art, music and the built environment make it an unlikely asset for cities.

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27.08.2019
22:44 News-Medical.NetU of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

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17:00 ScienceDaily.comResearchers engineer antibodies that unlock body's regenerative potential

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

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02:46 News-Medical.NetUltrafast 3D printing technique for artificial tissues

Scientists have come up with a very rapid 3D printing technique for producing the most complex tissue forms in hydrogels which are loaded with stem cells, and then generating the growth of blood vessels in the resulting tissue mass.

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26.08.2019
16:09 Phys.org3-D printed salt template for bioresorbable bone implants

With the help of a 3-D printed salt template, ETH researchers have succeeded in producing magnesium scaffolds with structured porosity that are suitable for bioresorbable bone implants.

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13:35 FightAging.OrgEstradiol Accelerates Liver Regeneration in Mice

The liver is the most regenerative organ in mammals, capable of regrowing lost sections, albeit imperfectly in comparison to the capabilities of highly regenerative species such as salamanders. Researchers here demonstrate that the sex hormone estradiol is involved in the regulation of liver regeneration, and that regeneration can be accelerated via artificially increased levels of estradiol. This is particularly interesting in the context of recent work showing that loss of estradiol with aging is involved in loss of muscle mass, due to effects on stem cell activity. One might wonder if this sort of mechanism will show up in other tissues as well. The endogenous hormone estradiol is widely recognized as a stress signaling molecule. It is mainly produced by the ovary, and its production […]

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