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Regeneration

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04.08.2020
02:36 News-Medical.Net New biomarkers may identify people with Type 1 diabetes who could benefit from immunotherapy

Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively.

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30.07.2020
15:54 StemCellsPortal.coml “Self-Eating” Process of Stem Cells May Be the Key to New Regenerative Therapies

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28.07.2020
11:01 Technology.org “Self-eating” Process of Stem Cells May be the Key to New Regenerative Therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve

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09:25 News-Medical.Net Researchers show how aging can cause lung regeneration

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

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04:22 News-Medical.Net Researchers identify miRNA that could promote hair regeneration

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration.

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04:05 ScienceDaily.com How airway cells work together in regeneration and aging

Researchers have identified the process by which stem cells in the airways of the lungs switch between two distinct phases -- creating more of themselves and producing mature airway cells -- to regenerate lung tissue after an injury.

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27.07.2020
19:18 ScienceDaily.com Lego-inspired bone and soft tissue repair with tiny, 3D-printed bricks

A new, 3D-printed technology that was inspired by Lego block toys is designed to help heal broken bones, and could one day even lead to lab-made organs for human transplant.

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15:16 NYT Health A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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13:42 FightAging.Org Organoids Used to Identify NRG1 as a Regulator of Tissue Repair in the Intestine

The intestinal lining is an important tissue. Among its other functions, it protects the body from inflammation that can be generated by the actions of gut microbes. This barrier declines with age, and this is thought to be influential in the increased chronic inflammation observed in older people. Ways to spur greater maintenance and repair on the part of cell populations making up intestinal tissue would likely be of great benefit, given the importance of chronic inflammation as a driver of age-related disease. A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of microbes and harmful toxins present in our intestinal tract. This barrier is often damaged by infection and inflammation, which causes many painful symptoms. […]

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12:36 NYT Technology A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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12:22 NYT Science A Possible Weapon Against the Pandemic: Printing Human Tissue

Bioprinting could be used for testing potential treatments for Covid-19, cancer and other diseases.

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26.07.2020
18:37 ScienceDaily.com 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, researchers show.

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23.07.2020
21:05 Phys.org 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science.

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18.07.2020
21:38 News-Medical.Net Type 1 interferon deficiency as a biomarker for detecting patients at risk of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

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17.07.2020
19:32 ScienceDaily.com Type 1 interferon deficiency: Biomarker of patients at risk of severe COVID-19

Which patients are more likely to develop a severe form of COVID-19? In a new study, researchers describe a unique and unexpected immunological phenotype in severe and critical patients.

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12:31 Technology.org Two Projects Using Hydrogel Biomaterials to Stimulate Tissue Regeneration Move Forward with New Funding

Two innovative UCSF projects in hydrogel therapies to develop new salivary glands and restore muscle loss after facial

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13.07.2020
23:37 NewScientist.Com Lab-grown sperm could let infertile men have gene-edited children

The first reliable way of isolating and growing sperm stem cells could lead to new fertility treatments, including correcting mutations that block sperm production

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15:18 StemCellsPortal.coml Transplantable lab-grown organs move a step closer

LAUSANNE (CH), July 2020 — Biologists and bioengineers at Ecole Polytechnique Federale de Lausanne (EPFL) have designed a new method for growing simplified human mini-livers. Their process is a potentially important breakthrough in the quest for transplantable lab-grown tissues. In the shorter term, the miniaturized organs will serve as a platform for trialing treatments against non-alcoholic fatty liver disease, the most common liver disorder in the developed world. Their findings have been published in Nature Communications The EPFL scientists created a simplified tiny version of the organ, known as an organoid, using bipotent stem cells that occur naturally in the bile ducts connecting the liver to the gallbladder. But the real breakthrough lies in the fact that the researchers developed a new type of matrix that, like a scaffold,

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11:16 StemCellsPortal.coml Deciphering the Molecular Mechanisms Controlling Spinal Cord Regeneration

Review of “Injured adult neurons regress to an embryonic transcriptional growth state” from Nature by Stuart P. Atkinson The transplantation of spinal-cord-derived neural progenitor cells (NPCs) into sites of spinal cord injury can promote the regeneration of corticospinal axons and the restoration of forelimb function [1, 2]; however, we lack a general understanding of the molecular mechanisms involved in this process.  Now, researchers from the laboratories of Gunnar H. D. Poplawski and Mark H. Tuszynski (University of California San Diego, La Jolla, CA, USA) have profiled motor neurons of the mouse corticospinal tract to identify a ‘regenerative transcriptome’ after spinal cord injury and NPC grafting. In their new study, the team highlights a shift in the regenerating corticospinal motor neuron

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12.07.2020
17:04 News-Medical.Net Biologists discover extraordinary regeneration of injured neurons in zebrafish

Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

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00:23 ScienceDaily.com Extraordinary regeneration of neurons in zebrafish

Biologists have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish. They studies the Mauthner cells, which are solely responsible for the escape behavior of the fish, and previously regarded as incapable of regeneration. However, their ability to regenerate crucially depends on the location of the injury.

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10.07.2020
15:38 Phys.org Scientists discover extraordinary regeneration of neurons

Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish. They studies the Mauthner cells, which are solely responsible for the escape behavior of the fish, and previously regarded as incapable of regeneration. However, their ability to regenerate crucially depends on the location of the injury. In central nervous systems of other animal species, such a comprehensive regeneration of neurons has not yet been proven beyond doubt. The scientists report their findings in the journal Communications Biology.

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09.07.2020
23:13 StemCellsPortal.coml Clinical Experience in Regenerative Medicine and Tissue Engineering: The Next Wave of Advanced Therapies

How do we move therapies from commercialization to industrialization, with tissue engineering being slightly less mature than cell and gene therapy? Chair Julie Allickson (Director, Regenerative Medicine Clinical Center, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA) Speakers Petter Björquist (CEO at VERIGRAFT, Gothenburg, Sweden)Laura Niklason (Yale University, New Haven, Connecticut, USA and Humacyte Inc., Durham, North Carolina, USA) Julie Allickson – Clinical Translation of Tissue Engineering in an Academic Facility To begin this session, Julie Allickson sought to introduce the Wake Forest Institute for Regenerative Medicine (WFIRM) and begin to answer an important question: how do we take a research idea through clinical trials and toward the industrial

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19:36 Nanowerk.com Regenerating the body from within using biomaterials

Materials to enhance the body's own regenerative capabilities.

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16:14 StemCellsPortal.coml Strategies for Commercialization Track Session—Clinical Experience in Regenerative Medicine and Tissue Engineering: The Next Wave of Advanced Therapies

How do we move therapies from commercialization to industrialization, with tissue engineering being slightly less mature than cell and gene therapy? Chair Julie Allickson (Director, Regenerative Medicine Clinical Center, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA) Speakers Petter Björquist (CEO at VERIGRAFT, Gothenburg, Sweden)Laura Niklason (Yale University, New Haven, Connecticut, USA and Humacyte Inc., Durham, North Carolina, USA) Julie Allickson – Clinical Translation of Tissue Engineering in an Academic Facility To begin this session, Julie Allickson sought to introduce the Wake Forest Institute for Regenerative Medicine (WFIRM) and begin to answer an important question: how do we take a research idea through clinical trials and toward the industrial scale. The challenges to this process abound: a viable supply chain can be complicated due to the temperature-sensitive nature of many of the

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15:43 StemCellsPortal.coml New technology improves effectiveness of stem cells in regenerative medicine

MADRID (SP), July 2020 — Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others. Researchers and stem cell pioneers Sir John B. Gurdon and Shinya Yamanaka received the Nobel Prize in Physiology and Medicine in 2012 for this idea. However, one of the main limitations in the application of these cell therapies is the quality of the stem cells that can be generated in the laboratory, which impedes their use for therapeutic purposes. Now, a team from the Cell Division and Cancer Group of the Spanish National Cancer Research

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06.07.2020
12:40 StemCellsPortal.coml Novel Cell Conversion Approach to Neural Regeneration and Hearing Loss Reversal

Review of “Lin28 reprograms inner ear glia to a neuronal fate” from STEM CELLS by Stuart P. Atkinson Researchers led by Albert S.B. Edge (Harvard Medical School, Boston, Massachusetts, USA) recently established that proteolipid protein 1 (Plp1)-expressing glial cells act as progenitors within the inner ear in that they spontaneously differentiate into neurons that grow neurites and form synapses [1-4]. Therefore, the team hypothesized that the in vivo induced conversion of Plp1-expressing glia into neurons might represent an exciting cell replacement approach in patients suffering from hearing loss due to the deficiency or functional impairment of auditory neurons. Given a wide range of studies linking the expression of the

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12:26 StemCellsPortal.coml Transcriptional Study Paves the Way for Novel Heart Regeneration Strategy

Review of “Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity” from Nature Communications by Stuart P. Atkinson The Myc basic helix-loop-helix–leucine zipper transcription factor functions principally as a transcriptional activator to coordinate those programs underpinning normal cell function; furthermore, Myc also controls tissue-specific tissue regeneration programs [1-3]. Myc regulates the expression of a large proportion of genes and binds at virtually all promoters with an open chromatin architecture; therefore, the observed tissue-specific variations in Myc activity [4, 5] might derive from the engagement of specific, pre-configured resident cellular transcriptional programs. Recently, researchers led by Gerard I. Evan and Catherine H. Wilson (University of Cambridge, Cambridge,

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02.07.2020
17:49 News-Medical.Net New technology can increase the quality of stem cells used in regenerative medicine

Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others.

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17:06 ScienceDaily.com Long-term culture of human pancreatic slices reveals regeneration of beta cells

Scientists have developed a method allowing for the long-term culture of 'pancreatic slices' to study the regeneration of the human pancreas in real time.

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03:59 News-Medical.Net Extended culture of human pancreatic slices as a model to study regeneration of beta cells

Scientists from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.

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01.07.2020
19:36 Phys.org Sustainable biomedical device for use in regenerative medicine

UPV/EHU researchers have developed a biomedical device consisting of byproducts from the food industry and which displays excellent properties for use in regenerative medicine. The novel device comprises soy protein and chitin, which form a matrix with a porous, interconnected microarchitecture similar to that of certain body tissues. The work has been published in the June issue of Green Chemistry.

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17:53 News-Medical.Net Researchers develop biomedical device for use in regenerative medicine

The UPV/EHU-University of the Basque Country has developed a sustainable biomedical device from food industry by-products for use in regenerative medicine

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30.06.2020
22:47 ScienceDaily.com Plant tissue engineering improves drought and salinity tolerance

After several years of experimentation, scientists have engineered thale cress, or Arabidopsis thaliana, to behave like a succulent, improving water-use efficiency, salinity tolerance and reducing the effects of drought. The tissue succulence engineering method devised for this small flowering plant can be used in other plants to improve drought and salinity tolerance with the goal of moving this approach into food and bioenergy crops.

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20:35 News-Medical.Net Researchers find new therapy for stimulating myocardial regeneration

Ischemic heart disease has maintained its rank as one of the worldwide leading causes of mortality outweighing the burden from all malignancies combined.

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19:43 Phys.org Plant tissue engineering improves drought and salinity tolerance

After several years of experimentation, scientists have engineered thale cress, or Arabidopsis thaliana, to behave like a succulent, improving water-use efficiency, salinity tolerance and reducing the effects of drought. The tissue succulence engineering method devised for this small flowering plant can be used in other plants to improve drought and salinity tolerance with the goal of moving this approach into food and bioenergy crops.

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18:43 ScienceDaily.com Lab-grown 'mini-brains' suggest COVID-19 virus can infect human brain cells

Researchers have found that organoids known as 'mini-brains' can be infected by the SARS-CoV-2 virus that causes COVID-19.

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18:16 ScienceDaily.com Promising therapy for cardiac regeneration

New research gives information in order to understand safety, efficacy and mechanisms of action of a new cardiac therapy.

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17:39 News-Medical.Net A potential treatment for cardiac regeneration

New research gives information in order to understand safety, efficacy and mechanisms of action of a new cardiac therapy.

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27.06.2020
00:28 ScienceDaily.com These muscle cells are guideposts to help regenerative flatworms grow back their eyes

If anything happens to the eyes of the tiny, freshwater-dwelling planarian Schmidtea mediterranea, they can grow them back within just a few days. New research provides insight about how the worms accomplish this feat: researchers have identified a new type of cell that likely serves as a guidepost to help route axons from the eyes to the brain as the worms complete the difficult task of regrowing their neural circuitry.

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23.06.2020
11:09 Technology.org Bayer to Test New Drugs Using Human Heart Tissues 3D-Printed at TAU

Ramot at Tel Aviv University has signed a collaboration agreement with Bayer to develop and validate a platform for in vitro cardiotoxicity screening,

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02:17 News-Medical.Net Insight into merits and limitations of direct reprogramming strategies for cardiac regeneration

Direct reprogramming or Transdifferentiation is a way of inducing changes in the cell type from one lineage into another lineage, bypassing pluripotency.

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19.06.2020
13:38 StemCellsPortal.coml Wnt/β‐catenin Signaling Controls Regeneration by Lung Progenitors

The field of regenerative lung biology lacks a general understanding of those mechanisms regulating lung progenitor behavior under conditions of homeostasis and chronic disease. Now, a new study from researchers led by Melanie Koenigshoff (University of Colorado, Aurora, Colorado, USA) demonstrates a distinct, broad, Wnt‐responsive cellular landscape in the lung. In their new STEM CELLS study, Hu et al. reveal previously undescribed nuances in Wnt signaling dynamics during organoid formation demonstrate, for the first time, the impairment of distal lung epithelial progenitor cell function in a mouse model of chronic lung disease. Overall, the authors believe that their findings will advance the field, contributing to our

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16.06.2020
06:21 News-Medical.Net A new technology to print 3D tissues directly in the body

In the TV series Westworld, human body parts are built on robotic frames using 3D printers. While still far from this scenario, 3D printers are being increasingly used in medicine.

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15.06.2020
11:15 Technology.org Researchers develop 3D-printable material that mimics biological tissues

Biological tissues have evolved over millennia to be perfectly optimized for their specific functions. Take cartilage as an

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13.06.2020
05:54 News-Medical.Net RCSI scientists develop new biomaterial with potential to accelerate bone regeneration

Scientists at RCSI University of Medicine and Health Sciences have developed a new biomaterial that has the potential to accelerate bone regeneration by promoting an immune response that encourages repair and lowers the risk of inflammation.

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12.06.2020
08:07 News-Medical.Net A protein that helps treat viruses can later interfere with lung tissue repair

Researchers at the Francis Crick Institute have found that a protein which is initially helpful in the body’s immune response to a virus, can later interfere with the repair of lung tissue.

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11.06.2020
15:26 Nature.Com Lab-grown cells mimic crucial moment in embryo development

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11:55 AzoNano.com 2D Nanosheets can Advance Regenerative Medicine, Cancer Treatment

Scientists in the Department of Biomedical Engineering at Texas A&M University are developing new ways to advance the field of regenerative medicine and cancer treatment. They are developing a 2D...

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10.06.2020
08:43 Nanowerk.com Researchers develop 3D-printable material that mimics biological tissues

Scientists 3D-printed a complex, porous lattice structure using liquid crystal elastomers creating devices that can finally mimic cartilage and other biological tissues.

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09.06.2020
22:44 ScienceDaily.com 3D-printable material that mimics biological tissues

Researchers have 3D printed a complex, porous lattice structure using liquid crystal elastomers creating devices that can mimic cartilage and other biological tissues.

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18:40 TechnologyReview.com Lab-grown mini-lungs could reveal why covid-19 kills

Inside the biosafety level 4 lab at the National Emerging Infectious Diseases Laboratories (NEIDL) in Boston, researchers wear three sets of gloves and breathe air piped into moon suits through snaking tubes. Before them, under a plastic shield, are human lung-sac cells grown from organoids, blobs of cells that mimic organs. Now it’s time to…

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08.06.2020
22:07 Phys.org Scientists engineer one protein to fight cancer and regenerate neurons

Our lungs, bones, blood vessels and other major organs are made up of cells, and one way our bodies keep us healthy is by using protein messengers known as ligands that bind to receptors on the surfaces of cells to regulate our biological processes. When those messages get garbled, it can make us ill with a host of different diseases.

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17:58 StemCellsPortal.coml Stem cell treatments 'go deep' to regenerate sun-damaged skin

RIO DE JANEIRO (BZ), June 2020 — For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they've been getting good results, it's been unclear exactly how these treatments – using adult stem cells harvested from the patient's own body – work to rejuvenate "photoaged" facial skin. A new microscopic-level study provides the answer: Within a few weeks, stem cell treatment eliminates the sun-damaged elastin network and replaces it with normal, undamaged tissues and structures, even in the deeper layers of skin. Injection of the patient's own mesenchymal stem cells (MSCs) is "appropriate, competent and sufficient to elicit the full structural regeneration of the sun-aged skin," according to the report by Luis Charles-de-Sá, M.D. (of Universidade Federal do Rio de Janeiro, Brazil), Natale Gontijo-Amorim, M.D. and Gino Rigotti, M.D. (of Verone-Italy University) and colleagues. Their study appears in the June issue of Plastic

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16:24 News-Medical.Net Scientists create 3D-printable material that mimics cartilage, biological tissues

Biological tissues have evolved over millennia to be perfectly optimized for their specific functions. Take cartilage as an example. It's a compliant, elastic tissue that's soft enough to cushion joints, but strong enough to resist compression and withstand the substantial load bearing of our bodies: key for running, jumping, and our daily wear and tear.

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15:06 Phys.org Researchers develop 3-D-printable material that mimics biological tissues

Biological tissues have evolved over millennia to be perfectly optimized for their specific functions. Take cartilage as an example. It's a compliant, elastic tissue that's soft enough to cushion joints, but strong enough to resist compression and withstand the substantial load bearing of our bodies: key for running, jumping, and our daily wear and tear.

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13:17 FightAging.Org Transplantion of Glial Progenitor Cells Regenerates Myelin in a Mouse Model of Multiple Sclerosis

Disabling conditions result when the myelin sheathing of nerves is sufficiently degraded, such as via a malfunctioning immune system attacking the body's own tissues, as is the case for multiple sclerosis. All of us suffer loss of myelin with aging to some degree however, due to damage and dysfunction in the oligodendrocyte cell populations responsible for maintaining myelin. There is evidence for this specific issue to contribute to age-related cognitive decline. Thus treatments that focus on boosting remyelination are of general interest: if safe, they should probably be applied to every older person, not just those with conditions such as multiple sclerosis. Glial cells play several key roles in the central nervous system, including supplying oxygen to neurons and forming myelin - the protective, fatty […]

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04.06.2020
03:36 ScienceDaily.com Hairy, lab-grown human skin cell model could advance hair loss research

A new, hair-sprouting dollop of human skin created in the lab might one day help prevent hair loss. An article describes the hairy creation as the first hair-baring human skin organoid made with pluripotent stem cells, or the master cells present during early stages of embryonic development that later turn into specific cell types.

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03.06.2020
18:14 Nature.Com Regenerative medicine could pave the way to treating baldness

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02.06.2020
09:30 Technology.org Biomedical engineering and mechanics postdoc and students adapt lab spaces and resources to 3D print PPE parts

The philosophy of the Verbridge Laboratory of Integrated Tumor Ecology, led by associate biomedical engineering and mechanics professor Scott Verbridge, goes

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30.05.2020
05:52 News-Medical.Net C-DOCTOR receives $30-million grant from NIDCR for tissue and organ regeneration research

The initiative aims to propel USC forward as the epicenter of tissue and organ regeneration research.

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29.05.2020
22:18 DigitalTrends.com Lab-grown meat? Peasant food. Say hello to lab-grown foie gras

A cruelty-free version of the delicacy is coming soon

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20:39 News-Medical.Net NIH funding supports research on first therapeutic drug to regenerate heart tissue

With funding from the National Institutes of Health, University of Arkansas researchers hope to develop the first therapeutic drug that can regenerate heart tissue.

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05:31 News-Medical.Net Stem cell treatments elicit full structural regeneration of the sun-aged skin

For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they've been getting good results, it's been unclear exactly how these treatments - using adult stem cells harvested from the patient's own body - work to rejuvenate "photoaged" facial skin.

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28.05.2020
15:34 Phys.org Study investigates Atlantic Rainforest regeneration in the state of S o Paulo

The Atlantic Rainforest has been so savagely clearcut and burned over several centuries that only approximately 12% now remains. Nevertheless, it is still one of the planet's largest repositories of biodiversity, and counter to a process that appeared irreversible, forest cover in the biome has begun to recover in recent decades.

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13:29 News-Medical.Net SCN study outlines impacts of targeted skills training on Canada’s regenerative medicine sector

Today, Canada’s Stem Cell Network (SCN) released a study entitled, Training Tomorrow’s Research Leaders, outlining the impacts of nearly 20 years of targeted skills training on Canada’s emergent regenerative medicine sector.

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12:48 News-Medical.Net AXT offer Fluicell’s innovative range of tissue engineering systems in Australia & NZ

AXT are proud to announce that they have just expanded their life science product portfolio with the addition of Fluicell’s innovative tissue engineering systems. The new agreement will see AXT exclusively distribute their Biopixlar and BioPen product lines in Australia and New Zealand.

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27.05.2020
08:55 News-Medical.Net Updates on stem cell therapeutics and regenerative medicine

Stem cell and regenerative medicine research is an important area of clinical research which promises to change the face of medicine as it will be practiced in the years to come.

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26.05.2020
17:58 News-Medical.Net Rejuvenated fibroblasts could be used in regenerative medicine, stem cell engineering

Fibroblasts are the most common connective tissue cells. They produce the structural framework for animal tissues, synthesize the extracellular matrix and collagen, and play a critical role in wound healing.

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22.05.2020
22:44 StemCellsPortal.coml Regenerative Resources

Place Holder   1 Start 2 Complete Name * Full Name Email *

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10:55 Nanowerk.com 3D-printing functional bone tissues with nanoengineered bioink

A novel printable bioink could be used to create anatomical-scale functional tissues.

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20.05.2020
03:25 News-Medical.Net Texas A&M lab produces 3D-bioprinted bone tissue to benefit bone regeneration

Dr. Akhilesh K. Gaharwar, associate professor, has developed a highly printable bioink as a platform to generate anatomical-scale functional tissues. This study was recently published in the American Chemical Society's Applied Materials and Interfaces.

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19.05.2020
15:02 Rejuvenation Research Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin

Rejuvenation Research, Ahead of Print.

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05:44 News-Medical.Net CU researchers identify new way that nerve cells regenerate and repair after damage

Researchers from the University of Colorado School of Medicine have identified a new way that cells in the central nervous system regenerate and repair following damage.

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18.05.2020
17:26 StemCellsPortal.coml New Research Into Stem Cell Mutations Could Improve Regenerative Medicine

SHEFFIELD (UK), May 2020 — Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring. The findings, published in Stem Cell Reports, show that pluripotent stem cells are particularly susceptible to DNA damage and mutations compared to other cells, and this could cause genetic mutations. Pluripotent stem cells are able to develop into any cell type in the body, and there is considerable interest in using them to produce cells to replace diseased or damaged tissues in applications referred to as regenerative medicine. One concern for the safety of this is that these cells often acquire recurrent mutations, which might lead to safety issues if used in patients. The researchers have found that these mutations are more likely to occur in a certain point during their cell cycle and have suggested ways of growing the cells to dramatically reduce the

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13:21 FightAging.Org Lin28 as a Target for Nerve Regeneration

Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondrial function, thus providing additional energy for cellular growth and replication. Researchers here employ a viral vector to deliver Lin28 to mice, which is a first step on the long road towards clinical applications. Practical therapies remain years in the future, however. "Our findings show that Lin28 is a major regulator of axon regeneration and a promising therapeutic target for central nervous system injuries. We became interested in Lin28 as a target for neuron regeneration because it acts as a gatekeeper of stem cell […]

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16.05.2020
22:01 ScienceDaily.com New research into stem cell mutations could improve regenerative medicine

Research has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

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14.05.2020
03:05 News-Medical.Net C-Path, Provention Bio collaborate to improve scientific community's insight into type 1 diabetes

The Critical Path Institute and Provention Bio, Inc. are proud to announce their collaboration to significantly improve the scientific community's insight into type 1 diabetes through Provention's contribution of data from the Phase III Protégé study of teplizumab to the T1D Trial Outcome Measures Initiative integrated database.

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12.05.2020
13:07 StemCellsPortal.coml Wnt7b-Sox11 Axis Mediates BM-MSC Bone Regeneration

In a new STEM CELLS study led by Ling Ye (Sichuan University, People's Republic of China), Yu et al. report, for the first time, that the Wnt7b‐induced Sox11 signaling axis governs the self-renewal and osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). The Wnt7b‐induced Sox11 signaling axis manipulates the expression of crucial fate‐decisive genes to support the long‐term amplification and lineage commitment of BM-MSCs, which finally contributes to enhanced bone formation and regeneration. Overall, these results provide evidence that the modulation of Wnt7b‐Sox11 signaling in BM-MSCs may represent a means to develop viable bone anabolic therapies.

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11.05.2020
12:15 StemCellsPortal.coml Transcriptional Analysis of Fetal Mesangioblasts May Boost Muscle Regeneration Strategies

Review of “Human fetal mesoangioblasts reveal tissue-dependent transcriptional signatures” from STEM CELLS Translational Medicine by Stuart P. Atkinson  Mesoangioblasts, a subpopulation of pericytes or vessel‐associated stem/progenitor cells, can self‐renew and differentiate into skeletal and cardiac muscle [1]; therefore, they represent a therapeutically relevant cell source for the treatment of conditions such as muscular dystrophies or myocardial infarction. While mesoangioblasts can be readily obtained from postnatal vessels of skeletal muscle and heart of humans [2] and possess huge expansion potential during in vitro culture, their clinical application [3] suffers from problems related to poor engraftment,

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09.05.2020
04:32 News-Medical.Net Tissue engineering can play an important role during COVID-19 pandemic

Tissue engineering has a unique set of tools and technologies for developing preventive strategies, diagnostics, and treatments that can play an important role during the ongoing COVID-19 pandemic.

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08.05.2020
12:36 AzoNano.com Piezoelectric Properties Found in Lab-Grown, 2D Molybdenum Dioxide

Rice University researchers have found evidence of piezoelectricity in lab-grown, two-dimensional flakes of molybdenum dioxide. Their investigation showed the surprise electrical properties are due...

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07.05.2020
15:37 StemCellsPortal.coml Neurons Regenerated in Mice With Spinal Cord Injury and Optic Nerve Damage

PHILADELPHIA, PA (US), May 2020 — Like power lines in an electrical grid, long wiry projections that grow outward from neurons — structures known as axons — form interconnected communication networks that run from the brain to all parts of the body. But unlike an outage in a power line, which can be fixed, a break in an axon is permanent. Each year thousands of patients confront this reality, facing life-long losses in sensation and motor function from spinal cord injury and related conditions in which axons are badly damaged or severed. New research by scientists at the Lewis Katz School of Medicine Temple University (LKSOM) shows, however, that gains in functional recovery from these injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth. In a study published online in Molecular Therapy, the Temple researchers describe the ability of Lin28 — when expressed above its usual levels —  to fuel axon regrowth in mice with spinal cord injury or

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06.05.2020
18:56 News-Medical.Net Study identifies protein vital for liver restoration and regeneration after transplant

Researchers from the Faculty of Medicine of the University of Barcelona and the CELLEX Biomedical Research Centre from IDIBAPS have identified in a study with mice a protein which is fundamental to guarantee the restoration and regeneration of the liver after a transplant or hepatic surgery.

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04.05.2020
16:51 Phys.org Biofabrication: 3-D printing, sonic tweezers, and the creation of neurons in microscopic cages

Microscopically small cages have been produced at TU Wien (Vienna) with grid openings only a few micrometers in size, making them ideal for holding cells and allowing living tissue to grow in a very specific shape. This new field of research is called biofabrication.

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16:23 AzoNano.com Nanostimulators Boost Stem Cells' Regenerative Powers

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells. In a new study published...

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16:23 FierceBiotech.com Repairing spinal cord injuries with a protein that regulates axon regeneration

Temple University researchers discovered that boosting levels of a protein called Lin28 in injured spinal cords of mice prompts the regrowth of axons and repairs communication between the brain and body. They believe the discovery could be used to develop new treatments for both spinal cord and optic nerve injuries.

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03.05.2020
23:04 News-Medical.Net Nanostimulators can amp up stem cells' regenerative powers for muscle repair

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells.

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01.05.2020
06:02 ScienceDaily.com Scientists regenerate neurons in mice with spinal cord injury and optic nerve damage

Each year thousands of patients face life-long losses in sensation and motor function from spinal cord injury and related conditions in which axons are badly damaged or severed. New research in mice shows, however, that gains in functional recovery from these injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth.

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27.04.2020
13:45 StemCellsPortal.coml Can Targeting Cardiomyocyte Metabolism Improve Cardiac Regeneration?

Review of “Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression” from Nature Metabolism by Stuart P. Atkinson The neonatal mammalian heart displays robust regenerative potential in the period just after birth; however, a metabolic shift from anaerobic glycolysis to mitochondrial oxidative phosphorylation during development,  particularly towards fatty-acid use [1, 2], coincides with the loss of this ability. Fatty acid metabolism causes the cardiac mitochondria to produce elevated rates of reactive oxygen species (ROS) [3-5], and researchers led by Alisson C. Cardoso and Hesham A. Sadek (University of Texas Southwestern Medical Center, Dallas, TX, USA) recently established that these ROS can induce a DNA damage response in the early postnatal heart, thereby prompting the cell cycle

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24.04.2020
13:42 FightAging.Org A Cardiac Patch Without Cells Improves Regeneration Following Heart Attack

It is a sad truth that near all transplanted cells in near all cell therapies die quickly, and do not integrate with tissues to improve function. The benefits that do occur result from the signals secreted by the transplanted cells before they die. The research community has been undertaking a range of strategies to address this issue. One is to produce a scaffold material that mimics tissue sufficiently well to give cells the support they need to survive, populate it with suitable cells, and then transplant the resulting structure. This can produce 10% survival of transplanted cells, an enormous improvement over delivery of cells alone. One manifestation of this approach is a heart patch, a thin structure that is placed onto the surface of an […]

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13:27 FightAging.Org GDF11 in the Regeneration and Aging of Skin

GDF11 was identified in parabiosis studies as beneficially influencing stem cell and tissue function. Levels of GDF11 decline with age. There was some debate over whether or not the early research was correct, but GDF11 is presently in clinical development as a basis for regenerative therapies for the old. Researchers here outline a role of GDF11 in the regeneration and tissue maintenance of skin, focusing on its anti-inflammatory role. The chronic inflammation of aging is present in all tissues, skin included, and is detrimental to health and tissue function. Anti-inflammatory effects are likely important in the observed benefits from upregulation of GDF11 in old animals. GDF11 regulates essential cell differentiation and proliferation responses and is expressed in numerous tissues, including the skin, heart, skeletal muscle, […]

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15.04.2020
02:03 ScienceDaily.com Keratin scaffolds could advance regenerative medicine and tissue engineering for humans

Researchers have developed a simple method for preparing 3D keratin scaffold models which can be used to study the regeneration of tissue.

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14.04.2020
22:25 News-Medical.Net Researchers develop synthetic scaffolds for tendon and ligament regeneration

Australia's love of sport means it has one of the highest rates of knee anterior cruciate ligament (ACL) injury and reconstruction in the world.

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13.04.2020
13:55 StemCellsPortal.coml Deciphering How Stress Influences Stem Cells and Tissue Regeneration

Review of “Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells” from Nature by Stuart P. Atkinson While the greying of our hair has long since been linked to elevated levels of stress [1, 2], we currently have little insight into the mechanisms involved and the potential involvement of the hair follicle stem cells and melanocyte stem cells that support the production of pigmented hair [3, 4]. This situation led researchers from the laboratory of Ya-Chieh Hsu (Harvard University/Harvard Stem Cell Institute, Cambridge, MA, USA.) to investigate the melanocyte lineage to understand how stress influences tissue regeneration [5].  Excitingly, Zhang et al. now report that model mice undergoing acute stress suffer from the rapid loss of melanocyte stem cells and the appearance of har

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09.04.2020
18:40 Nanowerk.com 3D printed corals could improve bioenergy and help coral reefs

Researchers have designed bionic 3D-printed corals that could help energy production and coral reef research.

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16:44 ScienceDaily.com 3D-printed corals could improve bioenergy and help coral reefs

Researchers have designed bionic 3D-printed corals that could help energy production and coral reef research.

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12:11 Phys.org 3-D-printed corals could improve bioenergy and help coral reefs

Researchers from Cambridge University and University of California San Diego have 3-D printed coral-inspired structures that are capable of growing dense populations of microscopic algae. Their results, reported in the journal Nature Communications, open the door to new bio-inspired materials and their applications for coral conservation.

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08.04.2020
10:17 Phys.org 3-D printing, biology research make the journey back to earth aboard SpaceX's Dragon

On March 9, 2020, a Dragon cargo spacecraft arrived at the International Space Station carrying dozens of scientific experiments as a part of SpaceX's 20th cargo resupply mission. Now, Dragon heads home. On April 7, it is scheduled to undock from station, bringing samples, hardware and data from completed investigations back to Earth on its return trip.

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06.04.2020
15:45 StemCellsPortal.coml CRISPR-approach May Decipher Axolotl Limb Regeneration

Review of “Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls” from eLife by Stuart P. Atkinson The axolotl can regenerate their limbs, tails, and gills through the formation of a mass of proliferating dedifferentiated cells and pre-existing progenitor and stem cells known as the blastema [1-3]. In a previous attempt to better understand the regeneration process, researchers led by Craig M. Crews (Yale University, New Haven, USA) employed the next-generation sequencing-based tracking of mutant alleles in primary and secondary limbs to demonstrate that high-fidelity limb regeneration involved the replication of small cell populations present in the original limb in the regenerated limb [4]. Furthermore, recent single-cell sequencing of the axolotl limb blastema provided evidence of a shared

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