Techh.info/biomedtechnology hourly

Regeneration

headlines texts
13.09.2019
22:53 FightAging.OrgEmbedded 3D Printing Used to Assemble Tiny Organoids into Larger Vascularized Tissue Masses

For as long as I have been watching progress in tissue engineering, the primary and most important barrier to building organs to order has been the inability to construct vascular networks. A network of capillaries must exist for blood, and thus nutrients and oxygen necessary to cell survival, to reach more than a few millimeters into a tissue. In live tissues, hundreds of minuscule capillaries pass through every square millimeter, considered in cross-section. Replicating this level of capillary density in engineered tissue has yet to be accomplished, with even the more advanced technology demonstrations falling well short of this goal. Well funded initiatives such as the effort to produce genetically engineered pigs with organs that can be decellularized for transplantation into humans, or the application […]

Скрыть анонс
18:57 ScientificAmerican.ComLab-Grown Human Mini Brains Show Brainy Activity

As the little structures grow, their constituents specialize into different types of brain cells, begin to form connections and emit brain waves. They could be useful models for development and... -- Read more on ScientificAmerican.com

Скрыть анонс
17:58 ScientificAmerican.ComLab-Grown Human Minibrains Show Brainy Activity

As the little structures grow, their constituents specialize into different types of brain cells, begin to form connections and emit brain waves. They could be useful models for development and... -- Read more on ScientificAmerican.com

Скрыть анонс
13:17 FightAging.OrgSenolytic Treatment Reverses Age-Related Loss of Regenerative Capacity in the Liver

You might recall a paper published last year in which the authors reported that cellular senescence is a primary cause of declining capacity in liver regeneration with age. Here the obvious next step is taken, and a senolytic therapy is tested for its ability to restore the capacity of the aging liver to regenerate by clearing senescent cells. Improvement in all sorts of measures that normally decline with age is the expected result of senolytic treatment at this point, given the extensive evidence accumulated to date. Senescent cells are a cause of aging and age-related decline, they actively maintain a dysfunction state of metabolism via their secretions, and thus of course getting rid of them helps. Though, as noted in this paper, things are never […]

Скрыть анонс
12:07 Technology.orgTissue Type

The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have

Скрыть анонс
10.09.2019
21:55 ScienceDaily.comHow salamanders harness limb regeneration to buffer selves from climate change

Researchers have shown for the first time that salamanders inhabiting the Southern Appalachian Mountains use temperature rather than humidity as the best cue to anticipate changes in their environment. Significantly, they observed that these salamanders actually harness their unique ability to regenerate limbs to rapidly minimize the impact of hot temperatures. The findings may have implications for other animals and even plants.

Скрыть анонс
19:49 Phys.orgStudy shows how salamanders harness limb regeneration to buffer selves from climate change

Looking like a cross between a frog and a lizard, the gray cheek salamander has thin, smooth skin and no lungs. The amphibian breathes through its skin, and to survive it must keep its skin moist. As environmental conditions grow hotter or drier, scientists want to know whether and how these animals can acclimate.

Скрыть анонс
09.09.2019
21:41 DigitalTrends.comBiotech company 3D-prints a miniature human heart from stem cells

It's not science fiction anymore: 3D-printing a human heart is now a reality, which could help thousands who need a heart transplant.

Скрыть анонс
10:01 StemCellsPortal.comlThe Epigenetic Balancing Act of Liver Regeneration

Review of “Epigenetic Compensation Promotes Liver Regeneration” from Developmental Cell by Stuart P. Atkinson

Researchers from the laboratory of Kirsten C. Sadler (Icahn School of Medicine at Mount Sinai, New York, USA/New York University Abu Dhabi, UAE) recently sought to understand the epigenomic “balancing act” that is liver tissue regeneration [1, 2]; just how does the epigenome orchestrate the induction of the gene expression programs required to activate regeneration in hepatocytes [3, 4] while repressing the numerous and potentially deleterious transposable elements present throughout the genome [5]?

To answer this intriguing epigenetic question, Wang et al. analyzed the transcriptomic and epigenetic changes associated with liver regeneration in the well-characterized mouse partial hepatectomy (PH) model [6, 7]. Fascinatingly, this new study now reveals that that

Скрыть анонс
08.09.2019
17:23 SingularityHub.ComLab-Grown Minibrains Show Activity Similar to Babies’ Brains

Neurons are a collective bunch. Although each neuron receives, processes, and passes on information individually, the electrical spikes only make sense when melded together in waves of oscillating activity. Like an orchestra, the notes played from each neuron matter. But only when they synchronize in specific ways do single notes transform into the music of […]

Скрыть анонс
11:02 News-Medical.NetUAB researchers identify biomarker for early beta cell death in Type 1 diabetes

Beta cells in the pancreas produce insulin. Their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss.

Скрыть анонс
07.09.2019
02:21 ScienceDaily.comBiomarker identified for early beta cell death in Type 1 diabetes

Beta cells in the pancreas produce insulin. Their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. Researchers now have identified an early biomarker of Type 1 diabetes-associated beta-cell loss in humans -- microRNA-204. This biomarker may provide a much needed approach to assess early T1D-associated human beta-cell loss, even before onset of overt disease.

Скрыть анонс
06.09.2019
16:59 AzoNano.comThe Regeneration of Cartilage Using Graphene Oxide

Researchers from the University of Manchester have discovered that the inclusion of the 2D nanomaterial graphene oxide (GO) into 3D scaffolds, used to aid the regeneration of cartilage, has the...

Скрыть анонс
13:18 News-Medical.NetUA receives $37.5 million NIH grant to research potential regenerative therapy for Alzheimer's

The University of Arizona Center for Innovation in Brain Science has received a $37.5 million grant from the National Institutes of Health to research a potential regenerative therapy for Alzheimer's disease.

Скрыть анонс
05.09.2019
22:48 FightAging.OrgAttempting a Unified View of Aging and Loss of Regenerative Capacity

Today's open access paper from the AgeX Therapeutics folk discusses a conceptual framework for looking at aging and loss of regeneration in a unified way across: (a) evolutionary differences between highly regenerative lower species such as hydra and less regenerative higher species such as mammals, (b) the loss of regenerative capacity over the course of embryonic development, and (c) the loss of regenerative capacity that occurs with aging in individuals. It covers a lot of ground, and even the summaries could do with a shorter summary. In essence this all ties back to the work being done at AgeX Therapeutics and elsewhere on the potential uses of induced pluripotency to produce regenerative therapies. The discovery that cells can be reprogrammed into what are essentially embryonic […]

Скрыть анонс
04.09.2019
16:43 StemCellsPortal.comlScientists Uncover Key New Molecules That Could Help Tackle Tooth Loss and Regeneration

PLYMOUTH (UK), September 2019 — Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.
Now new research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament, which helps keep the tooth stable in the jawbone. This improved understanding will also help scientists work toward regenerating the tissues that support teeth.
The study, led by the Universities of Plymouth and Geneva, shows how a signaling pathway called Notch, which is known to be activated in stem cells and cancer, is important for periodontal ligament development.
A signaling pathway describes how a group of molecules in a cell work together to control one or more cell functions, such as cell division or cell death. After the first molecule in

Скрыть анонс
30.08.2019
22:15 News-Medical.NetNew molecules that could help tackle tooth loss and regeneration discovered

Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.

Скрыть анонс
18:58 ScienceDaily.comScientists uncover key new molecules that could help to tackle tooth loss and regeneration

New research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament, which helps keep the tooth stable in the jawbone. This improved understanding will help scientists work towards regenerating the tissues that support teeth. This is a peer-reviewed, observational study conducted in rodent teeth and human cells.

Скрыть анонс
18:29 Phys.orgResearch team aims to reduce cost of drug development using 3-D-printed living tissues

Thomas E. Angelini, Ph.D., Associate Professor in the Department of Mechanical & Aerospace Engineering at the University of Florida and his research group, the Soft Matter Engineering lab have successfully fabricated living micro-beams from glioblastoma cells and extra-cellular material (ECM) embedded in a packed microgel support medium. They subsequently characterized the physical properties of the beams and compared their results against traditional mechanical engineering models. To their surprise, these microscopic, delicate structures behave a lot like the massive beams used in everyday building construction. "We were pleased and excited to see that our micro-beams, only 50 to 200 µm in diameter, acted in accordance with the mechanical principles for other models such as large steel beams," said S. Tori Ellison. Ellison is a Mechanical & Aerospace Engineering Ph.D. student who is mentored

Скрыть анонс
11:01 News-Medical.NetLab-grown brain organoids and the brains of preemie babies generate similar electrical impulses

Brain organoids — also called mini-brains — are 3D cellular models that represent aspects of the human brain in the laboratory. Brain organoids help researchers track human development, unravel the molecular events that lead to disease and test new treatments.

Скрыть анонс
29.08.2019
21:06 Yahoo ScienceHuman-like neural activity detected in lab grown mini brains

Scientists reported Thursday they had picked up human-like electrical activity in lab-grown brains for the first time, paving the way to model neurological conditions and answer fundamental questions on how our gray matter develops. "If you had asked me five years ago 'Would you think that a brain organoid would ever have a sophisticated network able to generate a brain oscillation?' I would say no," Alysson Muotri, a biologist at the University of California San Diego, told AFP. A paper published by Muotri and his colleagues in the journal Cell Press said that two factors were responsible for the breakthrough.

Скрыть анонс
20:19 Yahoo ScienceIn first, brain waves detected in lab grown mini-brains

Scientists have picked up electrical activity in pea-sized, lab-grown brains for the first time, paving the way to model neurological conditions and answer fundamental questions on how our gray matter develops. "If you had asked me five years ago would you think that a brain organoid would ever have a sophisticated network able to generate a brain oscillation, I would say no," Alysson Muotri, a biologist at the University of California San Diego, told AFP. A paper published by Muotri and colleagues in the journal Cell Press on Thursday said that part of the breakthrough was the result of a better procedure to grow stem cells, including optimizing the culture medium formula.

Скрыть анонс
18:05 ScientificAmerican.ComLab-Grown "Mini Brains" Can Now Mimic the Neural Activity of a Preterm Infant

The so-called organoids are not capable of complex thought but could be used to study neurological diseases -- Read more on ScientificAmerican.com

Скрыть анонс
28.08.2019
18:31 Phys.orgSkateboarding's DIY ethos is kick-starting a new wave of urban regeneration

In less than a year, skateboarding will make its debut in the Olympic Games in Tokyo. It's an international sport with an estimated 50m participants—but, more than that, skateboarding's DIY ethos and strong ties with art, music and the built environment make it an unlikely asset for cities.

Скрыть анонс
27.08.2019
22:44 News-Medical.NetU of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

Скрыть анонс
17:00 ScienceDaily.comResearchers engineer antibodies that unlock body's regenerative potential

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

Скрыть анонс
02:46 News-Medical.NetUltrafast 3D printing technique for artificial tissues

Scientists have come up with a very rapid 3D printing technique for producing the most complex tissue forms in hydrogels which are loaded with stem cells, and then generating the growth of blood vessels in the resulting tissue mass.

Скрыть анонс
26.08.2019
16:09 Phys.org3-D printed salt template for bioresorbable bone implants

With the help of a 3-D printed salt template, ETH researchers have succeeded in producing magnesium scaffolds with structured porosity that are suitable for bioresorbable bone implants.

Скрыть анонс
13:35 FightAging.OrgEstradiol Accelerates Liver Regeneration in Mice

The liver is the most regenerative organ in mammals, capable of regrowing lost sections, albeit imperfectly in comparison to the capabilities of highly regenerative species such as salamanders. Researchers here demonstrate that the sex hormone estradiol is involved in the regulation of liver regeneration, and that regeneration can be accelerated via artificially increased levels of estradiol. This is particularly interesting in the context of recent work showing that loss of estradiol with aging is involved in loss of muscle mass, due to effects on stem cell activity. One might wonder if this sort of mechanism will show up in other tissues as well. The endogenous hormone estradiol is widely recognized as a stress signaling molecule. It is mainly produced by the ovary, and its production […]

Скрыть анонс
25.08.2019
11:13 StemCellsPortal.comlSIRT1 Promotes Beta-cell Regeneration

As calorie restriction can induce β cell regeneration, researchers led by Po Sing Leung (Chinese University of Hong Kong, Shatin, New Territories, Hong Kong) recently evaluated a role for sirtuin 1 (SIRT1), a calorie restriction mimic, in the stimulation of β‐cell regeneration. Writing in STEM CELLS, Wu et al. demonstrate that SIRT1 activation promotes β‐cell regeneration via the enhanced activation of endocrine progenitors and the promotion of endocrine progenitor differentiation via a mechanism that involves AMPK signaling‐regulated fatty acid oxidation. The authors hope that their findings will promote the development of new strategies for β‐cell restoration as well as for β‐cell production for islet transplantation in patients with diabetes.


Скрыть анонс
23.08.2019
16:20 News-Medical.NetNew mechanisms to enable regeneration of injured nerve fibers

Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate.

Скрыть анонс
16:01 GlobalConstructionReview.comTokyo starts “massive” regeneration scheme with country’s tallest tower and Heatherwick parks

Japanese developer Mori Building Co has begun work on a $5.4bn, three-tower urban regeneration scheme, ...

Скрыть анонс
13:24 FightAging.OrgInduced Pluripotent Stem Cells for Regenerative Medicine

This review paper looks over the technology of induced pluripotency in the context of its ability to advance the state of regenerative medicine. A little over a decade ago, it was discovered that expression just a few genes in any adult cell reprogrammed it to become an induced pluripotent stem cell, near identical to an embryonic stem cell. Such pluripotent cells are capable of forming any type of cell in the body, given the research and development needed to establish the right recipe of stimuli and signals. This technology is not just interesting as a way to potentially produce supplies of any cell and tissue type needed for regenerative therapies, but also for the fact that reprogrammed cells restore lost mitochondrial function and reverse their […]

Скрыть анонс
22.08.2019
13:23 FightAging.OrgActin as a Potential Target to Spur Regeneration of Axons in the Adult Nervous System

Adult neurons retain the developmental infrastructure to be able to regrow damaged axons, in principle, but this capability is repressed after early development ends. Researchers here explore the details of the controlling mechanism. The goal at the end of the day is to produce the means to unlock regrowth in adult nerve tissue, particularly the spinal column. A great deal of research and development in regenerative medicine is of this nature, a search for ways to reenable the processes of regulated growth that took place during early development. It is commonly accepted that neurons of the central nervous system shut down their ability to grow when they no longer need it; this occurs normally after they have found their target cells and established synapses. However, […]

Скрыть анонс
21.08.2019
13:04 Yahoo ScienceCould Stem Cells Be the Key to Organ Regeneration?

GettyBy Tobias Deuse, Professor of Surgery, University of California, San FranciscoMany of the most common diseases, like heart failure, liver failure, Type 1 diabetes and Parkinson’s disease, occur when cells or whole organs fail to do their job. Wouldn’t it be fantastic if it were possible to replace cells in these defunct organs? That is exactly what physician-scientists in the field of regenerative medicine are trying to do.I am a surgeon and stem cell scientist and am interested in regenerating failing organs with stem cells—because for many diseases we don’t have good treatment options yet.In a recent paper, my colleagues and I figured out why stem cells derived from a patient’s own tissue are sometimes rejected by their own immune systems. We also developed a solution that we think may solve the problem:

Скрыть анонс
08:28 Yahoo ScienceStem Cells Could Regenerate Organs – But Only If the Body Won’t Reject Them

Many of the most common diseases, like heart failure, liver failure, Type 1 diabetes and Parkinson’s disease, occur when cells or whole organs fail to do their job. Wouldn’t it be fantastic if it were possible to replace cells in these defunct organs? That is exactly what physician-scientists in the field of regenerative medicine are trying to do.I am a surgeon and stem cell scientist and am interested in regenerating failing organs with stem cells – because for many diseases we don’t have good treatment options yet.In a recent paper, my colleagues and I figured out why stem cells derived from a patient’s own tissue are sometimes rejected by their own immune systems. We also developed a solution that we think may solve the problem: stem cells that are stripped of their immune features and can’t trigger rejection.The

Скрыть анонс
20.08.2019
23:29 Benzinga.comSun+Earth Certified Issues Regenerative Organic Farming, Fair Labor Standards For Cannabis Cultivation

This week, Sun+Earth announced the launch of its organic certification program for outdoor cannabis, which goes beyond the organic standards set by the U.S. Department of Agriculture, and includes fair labor standards for cannabis farm workers.
read more

Скрыть анонс
19.08.2019
22:01 Phys.orgCommon origin identified could bring tooth regeneration potential closer

A common origin shared by teeth and taste buds in a fish that has regenerative abilities has been identified by a team of researchers from the UK and the States. Regulated by the BMP signalling pathway, the results suggest that the oral organs have surprising regenerative capabilities and can be manipulated to express characteristics of different tissue types.

Скрыть анонс
17.08.2019
03:35 ScienceDaily.comRelaxing of regulations for regenerative medicines has cascading effect internationally

Countries that relax regulations for regenerative medicines, like stem cell 'treatments', could be causing a downward spiral in international standards.

Скрыть анонс
16.08.2019
14:21 News-Medical.NetMallinckrodt publishes results of StrataGraft regenerative tissue Phase 1b study

Mallinckrodt plc, a leading global biopharmaceutical company, today announced publication of results of its Phase 1b clinical trial of StrataGraft®, an investigational regenerative tissue, in Burns, the journal of the International Society for Burn Injuries.

Скрыть анонс
14.08.2019
16:31 StemCellsPortal.comlProfiles: California Institute for Regenerative Medicine: Accelerating Stem Cell Therapies in California and Beyond


Among the most prolific funders of stem cell research today is the California Institute for Regenerative Medicine (CIRM). CIRM was established in 2004 by Proposition 71 to accelerate the development of new therapies for chronic disease and injury by funding stem cell research programs throughout the state of California. Its mission is to support and advance stem cell research and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury. Renowned stem cell and in vitro fertilization expert Dr. Alan Trounson has been president of CIRM since 2008. He shares the organization's goals and strategies as well as its successes.
 
Introduction The California Institute for Regenerative Medicine (CIRM)

Скрыть анонс
12.08.2019
22:40 StemCellsPortal.comlNovel dual stem cell therapy improving cardiac regeneration

HONG KONG, August 2019 — As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team of scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells.
The findings give hope to develop a new treatment for repairing MI heart, as an alternative to the existing complex and risky heart transplant for seriously ill patients.
MI is a fatal disorder caused by a shortage of coronary blood supply to the myocardium. It leads to permanent loss of heart muscle cells (cardiomyocytes) and scar tissue formation, resulting in irreversible damage to cardiac function or even

Скрыть анонс
11.08.2019
02:55 News-Medical.NetResearchers seek to understand the regenerative potential of newborn mammalian hearts

Unlike lower vertebrates, mammals are unable to repair their adult hearts after injuries that include heart attacks. This inability in humans leads to heart failure -- a deadly and costly disease that affects more than 5 million Americans.

Скрыть анонс
10.08.2019
17:40 ScienceDaily.comNovel dual stem cell therapy improving cardiac regeneration

Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

Скрыть анонс
09.08.2019
07:25 Financial TimesBirmingham regeneration plans start to pay dividends

Second city growth driven by metro mayor, low rents and local tech talent

Скрыть анонс
08.08.2019
23:33 FightAging.OrgReviewing Progress Towards Regenerative Therapies for Age-Related Hearing Loss

Today's open access paper is a review of present progress towards regenerative therapies that can reverse hearing loss. Progressive hearing loss is pervasive in old age, and accelerates considerable in the later stages of life. Hearing loss correlates with cognitive decline, and while it is plausible that this is because of degeneration of central nervous system function, there is also the consideration that loss of hearing isolates people and deprives them of interactions that stimulate brain activity. It is well demonstrated in mice that environment richness has a strong impact on the brain and its pace of aging. Much of the research into age-related hearing loss is focused on the sensory hair cells of the inner ear. These detect the pressure waves of sound and […]

Скрыть анонс
05.08.2019
16:13 SeekingAlpha.comProvention Bio's PRV-031 Breakthrough Therapy for individuals at risk type 1 diabetes

Скрыть анонс
14:25 News-Medical.NetFDA announces new policy framework for development of regenerative medicine products

Today the U.S. Food and Drug Administration announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies.

Скрыть анонс
14:15 Phys.orgNew knowledge in history: Evaluating seven decades of ex situ seed regeneration

The Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben has been promoting the transition of gene banks into bio-digital resource centres—the aim is the preparation and collation of the phenotypic and genetic information for all stored accessions. As an important step for the further development of the Federal Ex situ Gene Bank, which is being hosted by the IPK in Gatersleben, researchers have been evaluating the historical data which has been accrued by the gene bank over the last 70 years. Not only is the resulting published data an important new resource for researchers and plant breeders, the publications also provide blueprint strategies for the preparation of correlated datasets from which other gene banks and research facilities will be able to draw.

Скрыть анонс
11:45 GizmagStem cell map shows how immortal invertebrate regenerates itself


Our bodies do a decent enough job of repairing themselves, able to patch up wounds, fight off infections and even heal broken bones. But that only applies up to a certain point – lose a limb, for example, and it's not coming back short of a prosthesis. Other creatures have mastered this skill though, and now scientists at the University of California Davis (UC Davis) and Harvard have sequenced the RNA transcripts for the immortal hydra and figured out how it manages to do just that.
.. Continue Reading Stem cell map shows how immortal invertebrate regenerates itself Category: Biology Tags: Animals Genetics Harvard Regeneration Regenerative Medicine RNA Stem Cells UC Davis

Скрыть анонс
11:11 StemCellsPortal.comlA Step Towards Diaphragmatic Regeneration with Engineered Muscle Constructs

Review of “Generation of a Functioning and Self-Renewing Diaphragmatic Muscle Construct” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Researchers from the laboratories of Martina Piccoli and Michela Pozzobon (Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy) recently reported that an extracellular matrix (ECM) biologic scaffold obtained from decellularized mouse diaphragm recruited host muscle precursor cells (MPCs) when implanted into a mouse model [1]. As this scaffold displayed many of the properties of the native diaphragm [2], a complex muscle organ that supports respiration, the researchers believed that seeding such an ECM scaffold with human MPCs [3, 4] may allow the in vitro generation of a diaphragmatic muscle construct that can be potentially transplanted to treat

Скрыть анонс
03.08.2019
17:40 Technology.orgScientists found a way to improve regeneration of intestine tissue

Time is not good for us. As we age, condition of our bodies start to decline right to

Скрыть анонс
02.08.2019
23:21 FightAging.OrgGarfish as a Model for Limb Regeneration

Exceptional regeneration can be found in some higher animals, such as zebrafish and salamanders. These species are capable of completely regenerating non-lethal injuries and large loss of tissue from internal organs and limbs, producing an organ that is indistinguishable in function from the original, and doing so repeatedly. In mammals, with very few exceptions that occur in only a few species and a few tissues, such injuries only scar with no proficient regeneration. Why is this case? That is the question that many research groups seek to answer, as finding a way to spur regeneration of organs and limbs in our species is obviously a very desirable goal. The authors of today's paper argue for the use of garfish as an animal model for the […]

Скрыть анонс
19:26 ScienceDaily.comFinding new knowledge in history: Evaluating seven decades of ex situ seed regeneration

Biologist have been promoting the transition of gene banks into bio-digital resource centers - the aim is the preparation and collation of the phenotypic and genetic information for all stored accessions.

Скрыть анонс
17:17 Yahoo.com BusinessWhat Type Of Shareholder Owns Marinomed Biotech AG s (VIE:MARI)?

Every investor in Marinomed Biotech AG (VIE:MARI) should be aware of the most powerful shareholder groups. Large...

Скрыть анонс
30.07.2019
16:55 Phys.orgBone tissue engineering—nano-glue polymer membranes for robust bone regeneration

In a new study now published on NPG Asia Materials, bioengineers report the development of a new fibrous membrane with stem cells to repair bone defects in the skulls of mice. For this, they incorporated mussel-inspired polydopamine protein as a promising compound to tether biological substances to the membrane surfaces, much like adhesive proteins in mussels. In the work, Yi Deng and a research team in the interdisciplinary departments of chemical engineering, mechanical engineering, materials technology, center for future materials and regenerative medicine in China and Australia, coated the biocompatible membranes with polydopamine nanoparticles to form many topological sites for calcium attachment and bone defect repair.

Скрыть анонс
16:22 GlobalConstructionReview.comMadrid gives green light to “largest regeneration project in Europe”

A €7.3bn plan to redevelop 2.7 million sq m of northern Madrid has been approved ...

Скрыть анонс
29.07.2019
23:46 ScienceDaily.comFish reveal limb-regeneration secrets

What can fish teach scientists about limb regeneration? Quite a bit, as it turns out. In the current issue of Proceedings of the National Academy of Sciences, Michigan State University scientists show that gar, a toothy, freshwater fish, can reveal many evolutionary secrets - even possible genetic blueprints for limb regeneration in people.

Скрыть анонс
20:12 News-Medical.NetFreshwater fish can reveal evolutionary secrets for limb regeneration

What can fish teach scientists about limb regeneration? Quite a bit, as it turns out.

Скрыть анонс
18:39 Phys.orgFish reveal limb-regeneration secrets

What can fish teach scientists about limb regeneration? Quite a bit, as it turns out.

Скрыть анонс
15:22 Phys.orgScientists look to synthetic biology and 3-D printing for life support in space

As NASA gears up to send humans back to the moon or even to Mars, they'll need to figure out how to keep these humans healthy and safe, far away from the resource-abundant Earth.

Скрыть анонс
26.07.2019
10:32 Technology.orgMapping Cells in the Immortal Regenerating Hydra

The tiny hydra, a freshwater invertebrate related to jellyfish and corals, has an amazing ability to renew its

Скрыть анонс
25.07.2019
23:10 ScienceDaily.comMapping cells in the 'immortal' regenerating hydra

The tiny hydra, a freshwater invertebrate related to jellyfish and corals, has an amazing ability to renew its cells and regenerate damaged tissue. Cut a hydra in half, and it will regenerate its body and nervous system in a couple of days. Researchers have now traced the fate of hydra's cells, revealing how three lines of stem cells become nerves, muscles or other tissues.

Скрыть анонс
08:00 News-Medical.NetNanoparticles foster regenerative healing process after spinal cord injury

Paralyzing damage in spinal cord injury is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.

Скрыть анонс
24.07.2019
23:40 FightAging.Orgp53, Hsp90β, and Cellular Senescence in Muscle Regeneration and Muscle Aging

Senescent cells are a mechanism of aging, but also a mechanism of regeneration. When entering a senescent state, a cell shuts down replication and begins to secrete a mix of inflammatory and other signals, rousing the immune system and altering the behavior of surrounding cells. In addition to the other ways in which cells become senescent, in response to the Hayflick limit on cellular replication, or to potentially cancerous DNA damage, senescent cells also arise in response to injury. Their secretions help to guide the complicated dance of immune cells, stem cells, and somatic cells that takes place during the consequent regeneration. Afterwards, the senescent cells self-destruct via apoptosis, or are destroyed by the immune system. Unfortunately, it is never the case that all senescent […]

Скрыть анонс
16:20 Technology.orgNew Multi-Material 3D Nano-Printing Technique Promises a Revolution in Optics, Photonics, and Biomedicine

A group of engineers from the University of Maryland (UMD) have developed a new technique for printing multi-material

Скрыть анонс
08:11 News-Medical.NetClinical study demonstrates potential of regenerative therapy for hypoplastic left heart syndrome

A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.

Скрыть анонс
22.07.2019
21:33 News-Medical.NetCHLA researcher receives NIH grant to study repair and regeneration mechanisms in the gut

Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue.

Скрыть анонс
19.07.2019
09:48 StemCellsPortal.comlStem Cell Extracellular Vesicles Mediate Corneal Regeneration

Researchers led by James L. Funderburgh (University of Pittsburgh, Pittsburgh, Pennsylvania, USA) recently sought to understand the mechanisms by which corneal stromal stem cells enhance corneal wounding by assessing extracellular vesicles. In their new STEM CELLS Translational Medicine article, Shojaati et al. report that the delivery of miRNA to ocular tissues by extracellular vesicles leads to corneal regeneration. The authors hope that their findings will lead to the development of a rapid and inexpensive means of treating corneal blindness for millions of individuals who have no further options for treatment.


Скрыть анонс
09:48 StemCellsPortal.comlTonsil-derived MSCs in Tissue Regeneration

A recent concise review article in STEM CELLS from the laboratory of Inho Jo (Ewha Womans University, Seoul, Republic of Korea) summarizes the differentiation capacities of tonsil‐derived mesenchymal stem cells (MSCs) and their therapeutic competencies. Oh et al. believe that tonsil-derived MSCs could be an attractive choice for clinical applications because of their non‐invasive collection, relatively high proliferation rate, low allogenicity and their ability to differentiate into mesodermal, endodermal, and ectodermal lineages.


Скрыть анонс
18.07.2019
14:47 MedicalNewsToday.comMedical News Today: Scientists discover pathway to skin regeneration

A new study in human volunteers and mice identifies which danger signaling molecules lie at the heart of skin rejuvenation pathways.

Скрыть анонс
15.07.2019
16:42 Reuters.com ScienceOn the menu soon: lab-grown steak for eco-conscious diners

Diners in some upmarket restaurants will soon be able to tuck into laboratory-grown steak, thanks to an Israeli startup that seeks to tap into consumer concerns about health, the environment and animal welfare.

Скрыть анонс
16:30 Reuters.com HealthOn the menu soon: lab-grown steak for eco-conscious diners

Diners in some upmarket restaurants will soon be able to tuck into laboratory-grown steak, thanks to an Israeli startup that seeks to tap into consumer concerns about health, the environment and animal welfare.

Скрыть анонс
16:20 Yahoo ScienceOn the menu soon: lab-grown steak for eco-conscious diners

While lab-grown hamburgers and chicken are already in development around the world, Israel's Aleph Farms claims to be the first company to have developed steak in a laboratory and is in talks with some high-end restaurants in the United States, Europe and Asia to have it on the market in 2021. It plans initially to offer minute steak developed from a small number of cells taken from a cow, avoiding the need to slaughter the animal in the process or use antibiotics which can be harmful to meat eaters. Aleph Farms hopes to have its product on a limited number of restaurant menus from 2021 in a trial phase, aiming for an official launch in 2023, first in restaurants and then in stores.

Скрыть анонс
13:57 SeekingAlpha.comMotif Bio submits Type B meeting request to FDA

© seekingalpha.com. Use of this feed is limited to personal, non-commercial use and is governed by Seeking Alpha's Terms of Use (https://seekingalpha.com/page/terms-of-use). Publishing this feed for public or commercial use and/or misrepresentation by a third party is prohibited.

Скрыть анонс
09:48 StemCellsPortal.comlCarbon Dot-mediated Inhibition of Inflammation Boosts Cartilage Regeneration by MSCs

Review of “Bioconjugated Carbon Dots for Delivery of siTnfα to Enhance Chondrogenesis of Mesenchymal Stem Cells by Suppression of Inflammation” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

The chronic inflammation associated with cartilage injury can dampen the effectiveness of mesenchymal stem cell (MSC) therapy by impairing their chondrogenic potential. As studies have implicated the proinflammatory cytokine tumor necrosis factor‐α (TNFα) in this process [1, 2], researchers from the laboratory of Maolin He, Jinmin Zhao, and Li Zheng (Guangxi Medical University, Nanning, China) sought to explore whether silencing TNFα may facilitate MSC-based therapy of cartilage injury.

A previous study from the authors reported that while small interfering (si)RNAs transfected using fluorescent quantum

Скрыть анонс
11.07.2019
21:57 StemCellsPortal.comlRegenerating human retinal ganglion cells in the dish to inform glaucoma treatment

OMAHA, NB (US), July 2019 — The capacity of the human central nervous system to regenerate after injury or illness is limited, and the resulting functional impairments carry a vast societal and personal burden. In glaucoma, degeneration of retinal ganglion cells (RGCs) — the axons of which form the optic nerve connecting the retina to the brain — leads to permanent blindness. There is currently no effective treatment for RGC degeneration.
Now, University of Nebraska Medical Center researcher Iqbal Ahmad, Ph.D., and colleagues show that human RGCs can be regenerated in an in vitro setting helped by lessons learned in rodent models. The discovery is detailed in Development.
"This finding could lead to new methods of screening for drugs and genes impacted by glaucoma to help treat and possibly reverse vision loss in people suffering from the disease," said Dr. Ahmad, a professor in the

Скрыть анонс
19:49 Yahoo.com BusinessWhat Type Of Shareholder Owns Entera Bio Ltd. s (NASDAQ:ENTX)?

If you want to know who really controls Entera Bio Ltd. (NASDAQ:ENTX), then you'll have to look at the makeup of its...

Скрыть анонс
07:16 News-Medical.NetStudy finds new way to enhance regenerative potential of aged intestine

Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age.

Скрыть анонс
10.07.2019
20:31 Nature.ComNotum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Скрыть анонс
16:27 News-Medical.NetUGR scientists design new hydrogel that aids in cartilage regeneration

Cartilage degeneration and damage treatment remain a major challenge in today's society; hence, tissue engineering strategies are being developed to investigate new alternatives based on a combination of cell therapy and 3D scaffolds to support cartilage cells

Скрыть анонс
09.07.2019
19:23 Reuters.com ScienceThe $280,000 lab-grown burger could be a more palatable $10 in two years

Lab-grown meat, first introduced to the world six years ago in the form of a $280,000 hamburger, could hit supermarket shelves at $10 a patty within two years, European start-ups told Reuters.

Скрыть анонс
19:01 Yahoo.com BusinessThe $280,000 lab-grown burger could be a more palatable $10 in two years

MADRID/ZURICH (Reuters) - Lab-grown meat, first introduced to the world six years ago in the form of a $280,000 hamburger, could hit supermarket shelves at $10 a patty within two years, European start-ups told Reuters. Consumers concerned about climate change, animal welfare and their own health are fueling interest in so-called clean meat, with the number of associated business start-ups climbing from four at the end of 2016 to more than two dozen two years later, according to the Good Food Institute market researcher. Plant-based meat alternatives are also booming.

Скрыть анонс
18:57 ReutersThe $280,000 lab-grown burger could be a more palatable $10 in two years

Lab-grown meat, first introduced to the world six years ago in the form of a $280,000 hamburger, could hit supermarket shelves at $10 a patty within two years, European start-ups told Reuters.

Скрыть анонс
05.07.2019
13:39 FightAging.OrgInvestigating the Molecular Triggers for Heart Regeneration Following Injury

Zebrafish are a highly regenerative species, capable of completely regrowing lost heart tissue. This is not the case in mammals, where the heart regenerates very poorly, with injury leading to scar tissue and loss of function. Thus researchers are exploring the mechanisms of regeneration in zebrafish and other highly regenerative species, such as salamanders, in search of important differences that might become the basis for regenerative therapies. The research here is an example of this sort of work. In any case where trigger mechanisms for regeneration are better mapped, there is the possibility that regeneration might be enhanced via intervention at one of the triggers. Heart muscle cells called cardiomyocytes hold on to the capacity to reprogram themselves and alter their fate in response to […]

Скрыть анонс
03.07.2019
17:18 SingularityHub.ComCould Lab-Grown Brains Develop Consciousness?

There’s a very un-sexy view of consciousness: our rich, meaningful inner experience of self and other is nothing but electrical and chemical chattering inside our brains. If you, like many scientists, subscribe to this theory, then a difficult question naturally follows: at what point does electro-chemical activity in dissected brain-like tissue become conscious? Yes, I’m […]

Скрыть анонс
09:18 News-Medical.NetNational effort to document intricate cell types and states in breast cancer tissues

University of California, Irvine researchers will lead an unprecedented national effort to document the intricate cell types and states in breast tissue that underlie cancer.

Скрыть анонс
02.07.2019
08:35 News-Medical.NetBioSA team aims to develop improved bone regeneration scaffold design

Millions of patients all over the world undergo surgical procedures related to bone defect repair every year.

Скрыть анонс
29.06.2019
11:18 DigitalTrends.comGrub’s up? Lab-grown insect meat could be the future of food production

Would you switch to a lab-grown insect flesh diet for the good of our planet? Researchers from Tufts University believe this may be one way to solve some of our food production problems.

Скрыть анонс
27.06.2019
15:47 StemCellsPortal.coml3D printed tissues and organs without the scaffolding

CHICAGO, IL (US), June 2019 — Engineered tissues and organs have been grown with various degrees of success in labs for many years. Many of them have used a scaffolding approach where cells are seeded onto biodegradable supportive structures that provide the underlying architecture of the organ or tissue desired.
But scaffolds can be problematic — ultimately, they should degrade and disappear, but timing that decomposition to coincide with the maturation of the organ is tricky, and sometimes degradation byproducts can be toxic. Scaffolds also can interfere with the development of cell-to-cell connections, which are important for the formation of functional tissues.
Now, a research team led by Eben Alsberg, Ph.D., professor of bioengineering and orthopedics at the University of Illinois at Chicago, has developed a process that enables 3D printing of biological tissues without scaffolds

Скрыть анонс
13:20 FightAging.OrgTemporary β-catenin Inhibition Attenuates Effects of Aging on Bone Regeneration

For all that it reports a success, the open access paper here is an excellent example of the prevalent, inferior approach to the development of therapies for age-related conditions. Instead of looking for causes of the problem in question, the slow and dysfunction regeneration of bone fractures in older individuals, the scientists find a way to tinker with the dysfunctional state of aged metabolism, overriding one of the detrimental regulatory changes to some degree. As a strategy this will always be far less effective than tackling the underlying root causes of age-related dysfunction: trying to tinker a damaged engine into continued operation without fixing the damage is always going to be a challenging task. Nonetheless, this strategy remains much more popular in the research community, […]

Скрыть анонс
26.06.2019
16:28 News-Medical.NetZebrafish offers new clues to regenerating damaged cardiac tissue

Research into the hearts of zebrafish, a pet shop staple marked by their eponymous stripes, has shed light on ways the human heart muscle could be healed following damage.

Скрыть анонс
25.06.2019
23:00 FightAging.OrgMir-294 Awakens an Embryonic Proliferation Behavior in Heart Cells, Spurring Regeneration Following Heart Attack

That microRNA-294 (mir-294) beneficially affects heart regeneration was discovered via its presence in embryonic stem cell exosomes. Exosomes are extracellular vesicles, membrane-bound packages of molecules that cells pass between one another. They are interesting to the research community because it is in principle much easier to construct a therapy based on delivery of exosomes harvested from stem cells than it is to deliver those same stem cells. Thus most of the present generation of stem cell therapies may well be replaced in the near future by the delivery of extracellular vesicles, and many research groups are testing exosomes from stem cells to see how well they work to spur greater regeneration. Most vesicles contain a wide variety of molecules, but in the case of embryonic […]

Скрыть анонс
13:24 FightAging.OrgEfficiently Reprogramming Fibroblasts into Cardiomyocytes for Heart Regeneration

The heart regenerates only very poorly, and responds to injury by producing scar tissue, a process that involves fibroblast cells. Additionally, the age-related disruption of regenerative processes produced by senescent cells and chronic inflammation tends to empower fibroblasts to produce fibrosis in the heart even in the absence of injury. One potential approach to the challenge of poor heart regeneration and growing fibrosis is to reprogram the fibroblasts of scar tissue into functional heart muscle cells, cardiomyocytes. Given recent demonstrations of in situ cell reprogramming, it is plausible to think that this can be accomplished. The challenge is to do so without disrupting the vital structural and electrical properties of heart tissue. A heart attack leaves damaged scar tissue on the heart and limits its […]

Скрыть анонс
24.06.2019
13:17 FightAging.OrgMesenchymal Stem Cells Improve Heart Regeneration via Macrophage Polarization

It is well known that the most commonly available forms of stem cell therapy produce benefits via signaling on the part of the transplanted cells, which soon die, rather than via any sort of integration of these cells into tissues. These treatments use varieties of what are called mesenchymal stem cells, which is actually a poorly defined, broad category. One clinic's mesenchymal stem cells are usually meaningfully different from those of the next. Nonetheless, these therapies fairly reliably reduce chronic inflammation. This can allow for improved regeneration in patients, but that outcome is much less reliable in practice. The innate immune cells known as macrophages are important in the complex dance of tissue regeneration. In recent years researchers have become increasingly interested in deciphering and […]

Скрыть анонс
23.06.2019
20:45 News-Medical.NetIntroduction of very small RNA molecule promotes heart cell regeneration, study shows

By adulthood, the heart is no longer able to replenish injured or diseased cells. As a result, heart disease or an event like a heart attack can be disastrous, leading to massive cell death and permanent declines in function.

Скрыть анонс
22.06.2019
18:46 ScienceDaily.comUnlocking the secrets of liver regeneration

Researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing 'jumping genes' (i.e. transposable elements), other epigenetic marks were redistributed.

Скрыть анонс
21.06.2019
17:07 SingularityHub.ComLab-Grown Dairy: The Next Food Frontier

Lab-grown meat is getting a lot of attention along with plant-based meat substitutes. Technology is driving the industry toward providing alternatives to conventionally produced food products. Dairy proteins may be the next product produced in a lab, for use in fluid “milk” production and processed dairy products like yogurt and cheese, to name a few. […]

Скрыть анонс
18.06.2019
13:10 News-Medical.NetNew process enables 3D printing of biological tissues without scaffolds

Engineered tissues and organs have been grown with various degrees of success in labs for many years. Many of them have used a scaffolding approach where cells are seeded onto biodegradable supportive structures that provide the underlying architecture of the organ or tissue desired.

Скрыть анонс
09:38 StemCellsPortal.comlASCs Restore Bone Regeneration After Infection

Previous research from the lab of Björn Behr (University Hospital Bergmannsheil Bochum, Germany) demonstrated diminished healing capacity following bone infections, mainly due to reduced osteoblastogenesis, increased osteoclastogenesis, and elevated B‐cell activity. In their new STEM CELLS Translational Medicine article, the team evaluated bone regeneration following treatment with adipose‐derived stem cells (ASCs) in an established murine animal model of bone infection. Interestingly, Wagner et al. discovered that ASC treatment prompted the restoration of bone healing via the elevation of osteoblastogenesis and downregulation of both osteoclastogenesis and B‐cell number. Could ASC therapy represent a novel treatment approach?

Скрыть анонс

First← Previous123456Previous →Last