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Regeneration

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22.01.2020
21:54 News-Medical.NetStudy explores ways to stop cell death, induce regeneration to restore vision

Progress in research and technology is giving rise to an optimistic future for compensation and restoration of low vision, according to research in a special issue of Restorative Neurology and Neuroscience, published by IOS Press.

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21.01.2020
11:36 StemCellsPortal.comlVascularization for Regenerative Medicine – A Review

The promotion of blood vessel growth for therapeutic purposes remains a challenge both for the treatment of ischemia and the generation of functional tissue‐engineered grafts, as physiological angiogenesis represents an extraordinarily complex process. A deeper understanding of the mechanisms controlling vascular growth will provide the biological basis for the design of rational therapeutic approaches, and now, researchers led by Andrea Banfi (Basel University Hospital, Switzerland) overview some critical aspects of the biology of vascular endothelial growth factor (VEGF) and angiogenesis and discuss their therapeutic implications with a particular focus on approaches using gene therapy, genetically modified progenitors, and extracellular matrix engineering

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10.01.2020
19:59 ScienceDaily.comTransformative 3D printing approach established from insight into developmental biology

Engineers need to get more creative in their approach to design and additive manufacturing (AM) systems, by taking inspiration from the way humans grow and develop, say researchers.

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18:13 StemCellsPortal.comlRegenerative Potential of Pancreatic MSC Secretome

Mesenchymal stem cells (MSC) have been subcultured from various tissue, leading to a spectrum of MSCs displaying properties reflective of tissue microenvironment or developmental origin. As a result, MSCs possess a diverse range of therapeutic effects, including immunomodulatory, angiogenic, and tissue regenerative properties. In a new STEM CELLS study, researchers led by David A. Hess (Western University, London, ON, Canada) utilized label‐free mass spectrometry and functional analyses to characterize the proteome and secretome of MSC populations established from human pancreas tissue. Cooper et al. reported that pancreatic MSCs demonstrated a unique Vimentinhigh/Nestinhigh proteome restricted from adipogenesis, yet pancreatic MSCs

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07.01.2020
17:56 News-Medical.NetOlympus Launches Innovative Incubation Monitoring System with Cell Count and Confluency Analysis to Improve the Regenerative Medicine Workflow

The OLYMPUS Provi CM20 monitoring system* provides quantitative data about the health of cell cultures while they are in the incubator. The system periodically scans the cultures, counts the number of cells, determines confluency and wirelessly communicates the data to a tablet or PC. By using the CM20 system, you can acquire data that will help improve the reproducibility and stability of your cell culture process.

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11:15 StemCellsPortal.comlHair Follicle Regeneration - A Review

 While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human follicle neogenesis with patient-derived cells remains unreported. In the hope of driving this field forward, researchers led by Ana Rita Castro and Elsa Logarinho (Universidade do Porto, Porto, Portugal) provide a review on cell‐based hair follicle tissue engineering that systematically compiles emerging strategies and disclosing those obstacles that limit translation into the clinics. For all the details, see STEM CELLS Translational

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06.01.2020
22:53 StemCellsPortal.comlNew Protocol Could Signal Shift in Bone Regenerative Medicine

DURHAM, N.C. (JANUARY 06, 2020) - A new, safe and efficient way to coax stem cells into bone cells is reported in a recently published article from STEM CELLS Translational Medicine (SCTM). The protocol, developed by researchers at the University of Sydney, Australian Research Centre (ARC) for Innovative BioEngineering, could lead to a shift in the treatment of bone regenerative medicine.

Large bone defects and loss due to cancer or trauma can result in scar tissue that impairs the bones’ ability to repair and regenerate. The current gold standard therapy, autografting, has inherent drawbacks, including limited availability and donor site morbidity. This leaves researchers seeking an alternative source of bone cells — and makes bone tissue engineering a growing field with considerable translational potential.

“The success of induced

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21:37 ScienceDaily.comStep toward 'ink' development for 3-D printing a bioprosthetic ovary

For the first time, scientists identified and mapped the location of structural proteins in a pig ovary. Ongoing development of an 'ink' with these proteins will be used for 3-D printing an artificial (or bio-prosthetic) ovary that could be implanted and allow a woman to have a child.

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14:24 FightAging.OrgThe State of Tissue Engineering for Hair Restoration

Research into the application of regenerative medicine techniques to regrowth of hair has been ongoing for some time. In principle, the hair follicle is a structure that could be engineered and implanted, or existing follicles induced to restored activity in some way. In practice this is challenging, and most forms of progressive hair loss are far from fully understood at the level of cellular biochemistry in the hair follicle: there is no great guarantee that generating or providing new follicles would have the desired effect, given the surrounding environment and its signaling. Up to date, treatments for hair loss (alopecia) include pharmacological and surgical (autologous hair transplant) interventions. Although hair restoration surgery is nowadays the most effective method, donor hair follicles (HFs) scarcity is often […]

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30.12.2019
13:20 StemCellsPortal.comlIdentifying an Optimal Meniscus‐derived Stem Cell Population for Regenerative Approaches

Review of “Characterization and comparison of post-natal rat meniscus stem cells at different developmental stages” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Injury to or removal of the meniscus, the cartilage that cushions the contact between the femur and tibia, can lead to the accelerated onset of long‐term degenerative joint changes, such as osteoarthritis, thereby highlighting the need for new therapies that preserve or repair the damaged meniscus [1]. Mesenchymal stem cells have been posited by many as a possible treatment option, although most sources associate with donor site morbidity and ectopic bone formation.

Researchers led by Weishan Chen and Weiliang Shen (Zhejiang University School of Medicine, Zhejiang Province, China) proposed the application of meniscus‐derived MSCs

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27.12.2019
08:17 News-Medical.NetLab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it.

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22.12.2019
21:16 ScienceDaily.comFiltered coffee helps prevent type 2 diabetes, show biomarkers in blood samples

Coffee can help reduce the risk of developing type 2 diabetes -- but only filtered coffee, rather than boiled coffee. New research show that the choice of preparation method influences the health effects of coffee.

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20.12.2019
14:32 FightAging.OrgDelivering Adenosine to a Bone Injury Accelerates Regeneration

A very large number of tissue-specific signals are involved in the mechanisms of regeneration, an intricate dance between many different cell types. It has long been the goal of the research community to identify the most important signals in this enormous repertoire and amplify them in a targeted way in order to enhance regeneration from injury or reverse age-related loss of tissue maintenance capacity. The work here is an example of the former goal, in which researchers find that adenosine can be delivered to bone injuries in a targeted way in order to accelerate healing. Researchers have found that the body naturally floods the area around a new bone injury with the pro-healing adenosine molecules, but those locally high levels are quickly metabolized and don't […]

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19.12.2019
16:42 ScienceDaily.comWatered down biodiversity: Sample type is critical in environmental DNA studies for biomonitoring

A new study looking at macroinvertebrate diversity in shallow, open-water wetlands found that sample choice is a critical factor for a comprehensive assessment of biodiversity. This study has major impacts for informing large-scale freshwater biomonitoring projects.

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18.12.2019
20:08 Phys.orgWatered down biodiversity: Sample type is critical in environmental DNA studies for biomonitoring

DNA-based biomonitoring relies on species-specific segments of organisms DNA for their taxonomic identification and is rapidly advancing for monitoring invertebrate communities across a variety of ecosystems. The analytical approaches taken vary from single-species detection to bulk environmental sample analysis, depending largely on the focus of data generation. However, for freshwater systems, there is often a lack of consideration as to the optimal sample type for maximising detection of macroinvertebrates.

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12:26 Nanowerk.comBiocompatible hydrogel printing for soft robotic systems made easy

Researchers have developed a facile and versatile strategy to directly print hydrogels into biomimetic soft robots. Hydrogel materials possess intrinsic softness and they also exhibit other favorable properties that make them a perfect fabrication material for biomimetic soft robots: stretchability, biocompatibility, permeability, and stimuli-adaptability. The team harnesses biocompatible alginate as a rheological modifier to manufacture 3D freeform architectures of both chemically and physically cross-linked hydrogels using the direct-inkwrite printing.

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13.12.2019
03:33 News-Medical.NetResearch could pave way for regenerative TBI-IV therapy

A team of researchers from the University of Georgia's Regenerative Bioscience Center has found that neural exosomes- "cargo" molecules within the nervous system that carry messages to the brain- can minimize or even avert progression of traumatic brain injury when used as part of a new cell-to-cell messaging technology.

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00:18 News-Medical.NetPromising new light-based sensor to study lab-grown tissue

Someday, doctors would like to grow limbs and other body tissue for soldiers who have lost arms in battle, children who need a new heart or liver, and many other people with critical needs.

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12.12.2019
21:09 ScienceDaily.comTracking lab-grown tissue with light

Someday, doctors would like to grow limbs and other body tissue for soldiers who have lost arms in battle, children who need a new heart or liver, and many other people with critical needs. Scientists are supporting this field of research by developing a promising new kind of light-based sensor to study tissue growth in the lab.

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19:44 Phys.orgTracking lab-grown tissue with light

Someday, doctors would like to grow limbs and other body tissue for soldiers who have lost arms in battle, children who need a new heart or liver, and many other people with critical needs. Today, medical professionals can graft cells from a patient, deposit them onto a tissue scaffold, and insert the scaffold into the body to encourage the growth of bone, cartilage and other specialized tissue. But researchers are still working toward building complex organs that can be implanted into patients.

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19:31 Nanowerk.comTracking lab-grown tissue with light

New proof-of-concept photonic pH sensor could advance studies of tissue regeneration.

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09.12.2019
18:11 SingularityHub.ComWill Cultured Bacon Be Delicious? A Dutch Startup Is Developing the First Lab-Grown Pork

The food chain has always worked roughly like this: sunlight feeds plants. Plants feed insects. Insects and plants feed animals. Plants and animals feed people. Then eventually—not to get too morbid here—people feed the Earth. Nothing like the circle of life, eh? But the traditional food chain’s getting shaken up. For starters, more and more […]

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08.12.2019
20:12 News-Medical.NetThe role of adenosine in neurodegeneration and brain regeneration

The role of adenosine in neurodegeneration and neuroregeneration has led to growing attention on adenosine receptors as potential drug targets in a range of brain disorders, including neuroregenerative therapy and treatment for amyotrophyic lateral sclerosis.

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06.12.2019
20:55 Phys.orgGenetic typing of a bacterium with biotechnological potential

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p.—the ability of the bacterium to infect its host and inflict a disease—is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs. Now, Kohei Ogura from Kanazawa University and colleagues have performed gene sequencing for various P. putida isolates originating from both environmental and clinical sites.

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18:50 AzoRobotics.comAmputee Bonds with Son Thanks to 3D Printed Bionic Hand

For 21 years, Danny Florence has lived with one hand. But when he became a father, he decided to apply for an Open Bionics Hero Arm. With the help of the maxon driven prosthesis he can now build a...

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17:17 Phys.orgNovel bioprinter shows potential to speed tissue engineering

The dream of tissue engineering is a computer-controlled manufacturing of complex and functional human tissue for potential organ regeneration or replacement.

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16:35 News-Medical.NetUAB bioprinter shows potential to accelerate tissue engineering

The dream of tissue engineering is a computer-controlled manufacturing of complex and functional human tissue for potential organ regeneration or replacement.

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10:01 Nanowerk.comNovel bioprinter shows potential to speed tissue engineering (w/video)

Engineered tissue from a bioprinter has promise for organ regeneration or replacement.

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05.12.2019
19:20 Reuters.com HealthFDA declines to approve Enzyvant regenerative therapy on manufacturing concerns

Privately held drug developer Enzyvant said on Thursday the U.S. Food and Drug Administration declined to approve its regenerative tissue therapy for a rare immunodeficiency disorder and raised concerns about its manufacturing.

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19:06 Reuters.com HealthFDA declines to approve Enzyvant's regenerative tissue therapy

Privately held drug developer Enzyvant said on Thursday the U.S. Food and Drug Administration declined to approve its regenerative tissue therapy for a rare immunodeficiency disorder and raised concerns about its manufacturing.

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17:17 Phys.orgWith cellular blueprint for lungs, researchers look ahead to organ regeneration

Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung that will make it easier to understand the design principles behind lung function and disease—and to bioengineer new lungs.

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11:07 Technology.orgWith cellular blueprint for lungs, Yale researchers look ahead to organ regeneration

Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung

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10:41 StemCellsPortal.comlBMP Signaling and Club Cell Regeneration

Markers for cub cells, airways stem cells that can self‐renew and differentiate into other cells, and the signaling pathways involved in their stem cell activities remain poorly understood. However, a new STEM CELLS article from the lab of Huijuan Liu (Shanghai Jiao Tong University, Shanghai, China) has reported, for the first time, the essential nature of the BMPR1A-mediated Tak1‐p38MAPK pathway for club cell regeneration and the repair of the bronchiolar epithelium. Furthermore, Shafiquzzaman et al. identify Prrx1 as a marker for club cells in the adult mouse lung.


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04.12.2019
21:05 Nature.ComThe integrative biology of type 2 diabetes

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03.12.2019
21:53 News-Medical.NetIsolated components of Saussurea have positive effect on bone tissue regeneration

Saussurea controversa is a perennial herbaceous plant that has been traditionally used by the people of the Far East, Siberia, Tibet, and Mongolia to treat liver, kidney, digestive tract, and locomotive diseases. Its dried leaves are sold in pharmacies because their decoction is widely used as a medicine against cold and bronchitis. To understand what substances this plant owes its medicinal properties to, a team of scientists from Siberian State Medical University and Tomsk Polytechnic University extracted individual components from the plant and determined their composition.

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02.12.2019
17:58 Yahoo ScienceAre lab-grown diamonds the real deal?

Are lab-grown diamonds the real deal? originally appeared on goodmorningamerica.comShopping for a diamond for a special someone?Before you make your purchase, you may want to learn more about lab-grown diamonds.This option has grown in popularity and been seen on celebs such as Bindi Irwin. View this post on Instagram July 24th 2019 ❤️ On my birthday I said ‘yes’ and ‘forever’ to the love of my life. Chandler, close to 6 years ago I fell in love with you and every day since has been a whirlwind of adventure and true happiness. ...

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29.11.2019
14:21 AzoRobotics.comInvestor Tej Kohli Expands ‘Venture Philanthropy’ Into 3D-Printed Bionic Arms

Investor Tej Kohli is to fund the purchase of ten bionic arms for children with limb differences in the UK. The Tej Kohli Foundation hopes that its commitment to fund arms for ten children over the...

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28.11.2019
10:11 Technology.orgCoral ecology and robot technology combine to combat bleaching and regenerate reef

Coral experts have scaled up their advanced technological approach to restoring baby corals on damaged areas of the

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02:43 News-Medical.NetResearch findings provide novel therapeutic space to induce scarless regenerative healing

Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix.

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27.11.2019
17:22 Technology.orgHitachi Developed Automation Technology of 3D Culture to Expand Regenerative Medicine Business

Hitachi, Ltd. has announced that Hitachi developed a new automation technology of 3D culture(2), solving problems of the

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26.11.2019
11:14 StemCellsPortal.comlKLF2 Enhances Bone Regeneration by MSCs and ECs

A team of researchers led by Mengfei Yu and Huiming Wang (Zhejiang University, Hangzhou, China) recently investigated KLF2 as a novel in vitro marker for mesenchymal stem cells (MSCs) to investigate osteogenesis and angiogenesis following the interaction between KLF2+ MSCs and endothelial cells (ECs). Zhou et al. demonstrated the improved formation of blood vessels via the secretion of angiogenic factors like ANG1 by KLF2-expressing MSCs and the differentiation of MSCs into pericytes through the PDGF‐BB/PDGFR‐ß signaling pathway. Mature ECs, in turn, synergistically enhanced the osteogenesis of KLF2-expressing MSCs through the efficient up‐regulation of VEGF. For more on how synergism between MSCs and ECs can have a profound impact on vascular network

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11:14 StemCellsPortal.comlTissue Repair Brakes - A Review

The state of differentiation of a given cell is not carved in stone; cell identity can be modulated by inhibitory signals from the cellular environment. Therefore, cell identity maintenance represents an active process of inhibition of a natural trend to change, and not an intrinsic or passive state of differentiation. Now, researchers led by Pedro L. Herrera (University of Geneva, Switzerland) review the literature regarding brakes to changes of cell identity and thus to tissue regeneration as described in different experimental models. Cigliola et al. note how the modulation of these inhibitory signals, by helping specialized cells to foster regeneration could prove crucial for treating pathologies due to massive or inappropriate cell death. For more on this

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19.11.2019
10:51 StemCellsPortal.comlHes1 Regulates HF Regeneration via Hedgehog Signaling

The adult hair follicle cycles through regression, resting, and growth phases and is maintained by hair follicle stem cells (HFSCs). During hair growth, progenitors and stem cells of the hair follicle activate and sustain the downward growth of hair follicles; however, our understanding of progenitor activation and stem cell maintenance during the hair cycle remains incomplete. Now, a new study from researchers led by Liang‐Tung Yang (National Health Research Institutes, Zhunan, Taiwan) report on the discovery of a potential link between Notch/Hes1 and Sonic Hedgehog pathways, in which Hes1 reinforces Hedgehog signaling at the onset of hair growth to expand the progenitors and replenish the stem cells to maintain the hair cycle homeostasis. For all the

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10:39 StemCellsPortal.comlHDAC7 Peptide Boosts Vascular Regeneration

Histone deacetylase 7 (HDAC7) plays a pivotal role in the maintenance of endothelial integrity, and while we know that short open reading frames (sORFs) exist within the 5′ terminal non‐coding area of Hdac7 mRNA, it remains unclear whether these sORFs contribute to HADC7 function. In a recent STEM CELLS study, researcher from the laboratories of Qian Wang (Southern Medical University, Guangzhou, China) and Lingfang Zeng (King's College London, UK) now report that a 7‐amino acid peptide translated from an HDAC7 sORF act as a phosphate group carrier, thereby forming a novel signal transduction pathway known as the MEKK1‐7A‐14‐3‐3γ pathway downstream of VEGF. Yang et al. believe that this novel signal pathway may be involved in vessel wall resident

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15.11.2019
23:29 DigitalTrends.comNew 3D-printing system can spit out custom-fitted bionic hands in under 10 hours

There have been some impressive 3D-printed powered prostheses. But getting them to the people who need them as quickly as possible is still something of a hurdle. That may be about to change.

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10:18 StemCellsPortal.comlCell-Based Therapies for Periodontal Regeneration

Cell‐based therapies have the potential to improve outcomes of orally-associated regenerative treatments; as an example, mesenchymal stem cells currently represent ideal candidates for adjuvant application for extraction sockets and challenging lateral/vertical bone defects requiring bone block grafts. However, a new review article from the laboratory of Federico Moreno Sancho  (UCL Eastman Dental Institute, London, UK) establishes that there exists insufficient evidence to identify best‐performing treatment modalities among the cell‐based techniques. The authors note that we must elucidate the clinical benefit of “substantial manipulation” of tissues and cells when compared with “minimal manipulation” and highlight the need for further research that

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00:55 News-Medical.NetNew type of bionic pacemaker

A new study published in the Journal of Physiology on November 14, 2019, reports the development of a radically different type of cardiac pacemaker which could change the prognosis of patients with heart failure.

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12.11.2019
22:33 News-Medical.NetCHLA researchers discover a mechanism of heart regeneration in zebrafish

One of the reasons coronary heart disease is so deadly is that fluid build-up and scarring can develop in the heart tissue. This prevents the heart from contracting properly, impacting its ability to supply the body with fresh blood. If scarring is extensive, heart failure can result.

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21:26 ScienceDaily.comAt the heart of regeneration: Scientists reveal a new frontier in cardiac research

Researchers uncover mechanisms in zebrafish heart regeneration that could lead to better treatments for babies in need of heart repair.

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11.11.2019
21:25 Technology.orgRegeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease

A newly-discovered molecular mechanism that allows damaged adult liver cells to regenerate could pave the way for drugs

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07.11.2019
23:19 FightAging.OrgCardiomyocytes Expressing SOX10 are Vital to Zebrafish Heart Regeneration

A few higher animal species, such as salamanders and zebrafish, are capable of regeneration of limbs and internal organs, regrowing lost and injured tissue without scarring or loss of function. Numerous research groups are engaged in investigating the biochemistry of proficient regeneration, attempting to find the specific differences between species that might explain how it happens and why adult mammals are largely incapable of such feats of regrowth. Today's open access research is an example of the type, in which the authors narrow down on a specific cell population that appear in zebrafish hearts during regeneration, but not in human tissues. It may be the case that the mechanisms and capacity for adult regeneration do still exist in mammals, but are suppressed in some way, […]

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13:32 Technology.orgLymphatic system found to play key role in hair regeneration

Given the amount of wear and tear it’s subjected to on a daily basis, the skin has a

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00:36 ScienceDaily.comNew technique lays foundation for regenerative cardiac therapies

Scientists have devised a technique to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. The method removes a significant roadblock to developing ways to regrow healthy cardiac muscle tissue, a feat not currently possible.

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05.11.2019
16:48 ScienceDaily.comRegeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease

Researchers have uncovered a novel molecular mechanism that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired.

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07:33 News-Medical.NetResearchers develop new type of transposase protein with improved biochemical properties

The team, comprising researchers from the European Molecular Biology Laboratory, the Universitätsklinikum Würzburg and the Paul-Ehrlich-Institut, managed to design a new variant of the Sleeping Beauty transposase with dramatically improved biochemical properties.

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04.11.2019
17:00 StemCellsPortal.comlLymphatic System Found to Play Key Role in Hair Regeneration

NEW YORK, NY (US), November 2019 — Given the amount of wear and tear it’s subjected to on a daily basis, the skin has a phenomenal ability to replenish itself. Spread throughout it are small reservoirs of stem cells, nested within supportive microenvironments called niches, which keep a tight rein on this repair process. Too much tissue might cause problems like cancer, while too little might accelerate aging.
Until now, scientists were uncertain whether the stem cells themselves could instruct other stem cells to form new skin by reshaping their niche. But new research in Science, led by Elaine Fuchs, Ph.D., of Rockefeller University and the Howard Hughes Medical Institute, indicates that stem cells can indeed influence tissue regeneration. The study identifies a molecular coordination tool used by stem cells to signal

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02.11.2019
03:15 ScienceDaily.comLymphatic system found to play key role in hair regeneration

To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.

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02:30 News-Medical.NetLymphatic system found to be involved in hair regeneration

Given the amount of wear and tear it's subjected to on a daily basis, the skin has a phenomenal ability to replenish itself.

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01:43 News-Medical.NetScientists propose new material for regenerative medicine capable of controlling immune response

Scientists of Tomsk Polytechnic University jointly with the University of Montana proposed a new promising material for regenerative medicine for recovery of damaged tissues and blood vessels.

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01.11.2019
17:49 Phys.orgA new material for regenerative medicine capable of controlling cell immune response

Scientists at Tomsk Polytechnic University jointly with the University of Montana (USA) proposed a promising new material for regenerative medicine for recovery of damaged tissues and blood vessels. This is a 3-D scaffold, made of biodegradable material and filled with special inhibitors, which were also obtained at TPU. They literally turn off the work of enzymes, responsible for the inflammation reaction, occurring in immune cells in response to external stimuli. In this case, such an irritant is a regenerative material.

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31.10.2019
18:43 News-Medical.NetREANIMA project may overturn paradigms that underlie regenerative cardiology research

Research into new endogenous mechanisms of tissue regeneration is an innovative research avenue in cardiac regeneration.

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30.10.2019
10:58 StemCellsPortal.comlRegeneration with Meniscus-derived Stem Cells

The results of a new study by researchers led by Weishan Chen and Weiliang Shen (Zhejiang University, Hangzhou, China) have demonstrated, for the first time, that meniscus‐derived stem cells (MeSCs) derived at earlier developmental stages may not be optimal for meniscus regeneration and articular cartilage protection when compared to MeSCs derived from day seven inner meniscus tissue. He et al. believe that their new findings could make a significant contribution to human meniscus tissue engineering in the future; for all the details, see STEM CELLS Translational Medicine.

 

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29.10.2019
00:47 ScienceDaily.comNew method promises advances in 3D printing, manufacturing and biomedical applications

In a development offering great promise for additive manufacturing, researchers have created a method to precisely create droplets using a jet of liquid. The technique allows manufacturers to quickly generate drops of material, finely control their size and locate them within a 3D space.

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25.10.2019
10:48 StemCellsPortal.comlEnhancing Bone Regeneration by Silencing Smurf1 in MSCs

The associated detrimental effects of the administration of high doses of bone morphogenetic proteins (BMPs) required to promote osteogenesis in orthopedic applications currently hinders many clinical applications. As a solution to this problem, researchers led by Flor María Pérez‐Campo (University of Cantabria, Santander, Spain) recently demonstrated that silencing of the Smurf1 gene in mesenchymal stem cells (MSCs) via antisense oligonucleotide expression significantly increases the susceptibility of MSCs to BMP‐2. García‐García et al. also report that the combination of MSCs expressing low levels of Smurf1 and biocompatible scaffolds that sustainably release small doses of BMP in a controlled manner may promote bone formation while avoiding the harmful

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24.10.2019
22:11 News-Medical.NetUA Little Rock receives $5.6 million DOD grant to advance bone regeneration technology

The U.S. Department of Defense has awarded the University of Arkansas at Little Rock a $5.6 million grant to advance the NuCress scaffold, a groundbreaking bone regeneration technology.

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16:13 ScienceDaily.comBy cutting out one gene, researchers remove a tadpole's ability to regenerate

Tadpoles that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution.

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13:57 Phys.orgSpecial cells contribute to regenerate the heart in zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group led by Prof. Nadia Mercader of the University of Bern now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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23.10.2019
21:31 ScienceDaily.comSpecial cells contribute to regenerate the heart in Zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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20:43 News-Medical.NetNew study on zebrafish may have possible relevance for heart regeneration in humans

In mammals, including humans, the heart muscle has a very limited capacity to recover after injury. After an acute myocardial infarction, millions of cardiac muscle cells, named cardiomyocytes, die, and are replaced by a scar.

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16:38 News-Medical.NetPolymerized estrogen can protect nervous system cells and promote regeneration

Spinal cord damage that causes paralysis and reduced mobility doesn't always stop with the initial trauma, but there are few treatment options to halt increased deterioration -- and there is no cure.

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22.10.2019
21:01 DigitalTrends.comCotton candy machines inspired this potential breakthrough in lab-grown meat

Lab-grown meat is the future. But for it to take off, it's going to have to taste like the real thing. Scientists at at Harvard recently developed a breakthrough approach that could help.

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20:06 Nanowerk.com3D-printing, bioinks create implantable blood vessels

A modified triple-coaxial 3D cell printing technique allows fabrication of multilayer blood vessels that have the unique biomolecules needed to transform into functional blood vessels when they are implanted.

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19:02 Phys.org3-D printing, bioinks create implantable blood vessels

A biomimetic blood vessel was fabricated using a modified 3-D cell printing technique and bioinks, which were formulated from smooth muscle cells from a human aorta and endothelial cells from an umbilical vein. The result is a fully functional blood vessel with a dual-layer architecture that outperforms existing engineered tissue and brings 3-D-printed blood vessels several fundamental steps closer to clinical use.

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19:02 Phys.orgBy cutting out one gene, researchers remove a tadpole's ability to regenerate

Tadpoles of frogs that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution. The work appears October 22 in the journal Cell Reports.

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16:31 Phys.orgResearchers identify functions of key genes responsible for liver regeneration

Researchers of the RUDN Medical Institute have identified the genes controlling the process of liver regeneration—they "instruct" hepatocyte cells, which comprise 80 percent of the liver, to divide. The results of the study will contribute to the development of new methods of liver regeneration in patients with chronic hepatitis, sclerosing cholangitis, as well as those who had liver resection for cancer or other conditions. The article is published in Cell Biology International.

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21.10.2019
17:55 Nanowerk.comBioprinting: Living cells in a 3D printer

With a new process, living cells can be integrated into fine structures created in a 3D printer - extremely fast and with very high resolution.

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17:49 ScienceDaily.comBioprinting: Living cells in a 3D printer

A high-resolution bioprinting process has been developed: Cells can now be embedded in a 3D matrix printed with micrometer precision -- at a printing speed of one meter per second, orders of magnitude faster than previously possible. Tissue growth and the behavior of cells can be controlled and investigated particularly well by embedding the cells in a delicate 3D framework. This is achieved using so called 'bioprinting' techniques.

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16:34 ScienceDaily.comReal texture for lab-grown meat

Researchers have grown rabbit and cow muscles cells on edible gelatin scaffolds that mimic the texture and consistency of meat, demonstrating that realistic meat products may eventually be produced without the need to raise and slaughter animals.

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12:48 Nanowerk.comReal texture for lab-grown meat

Researchers grow muscle cells on edible fibers.

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12:08 Phys.orgLab-grown meat: Researchers grow muscle cells on edible fibers

Lab-grown or cultured meat could revolutionize food production, providing a greener, more sustainable, more ethical alternative to large-scale meat production. But getting lab-grown meat from the petri dish to the dinner plate requires solving several major problems, including how to make large amounts of it and how to make it feel and taste more like real meat.

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11:45 StemCellsPortal.comlNew Developments Towards Thymic Regeneration via Organoid Technology

Review of “Gene modification and 3D scaffolds as novel tools to allow the use of post-natal thymic epithelial cells for thymus regeneration approaches” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Thymic dysfunction renders patients vulnerable to infections, malignancies, and autoimmune diseases [1, 2]; however, stimulating thymic regeneration and thymus transplantation both present with significant problems. The generation of thymic organoids based on three-dimensional cultures of thymic epithelial cells (TECs) may represent a new solution to this problem [3, 4]. Now, a new STEM CELLS Translational Medicine article from laboratory of Marita Bosticardo (IRCCS San Raffaele Scientific Institute, Milan, Italy) reports on the growth of Oct4-“rejuvenated” adult mouse TECs in three-dimensional (3D)

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14.10.2019
12:06 Technology.orgU of T researcher develops nanosystem that promotes regeneration after root canals

A novel nanosystem developed by Anil Kishen, a professor in the University of Toronto’s Faculty of Dentistry, shows promising results

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11.10.2019
01:59 News-Medical.NetHuman regenerative capacity discovered

Move over, salamanders, we humans can also regrow some of our body tissues. At least, this is what a new study published on October 9, 2019, in the journal Science Advances, reports. Using a mechanism quite similar to that by which amphibians like salamanders, and some zebrafish, grow back lost body parts, human joint cartilage can also regenerate itself.

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09.10.2019
23:52 News-Medical.Netβ-blockers could regenerate infant heart muscle, mitigate effects of congenital heart disease

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure throughout the rest of their lives. Yet, according to a Science Translational Medicine study published today by UPMC Children's Hospital of Pittsburgh researchers, β-blockers could supplement surgery to regenerate infant heart muscle and mitigate the lasting effects of congenital heart disease.

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16:46 News-Medical.NetLab-grown, testosterone-producing cells could help treat hypogonadism

Researchers have managed to grow human, testosterone-producing cells, which could lead to improved treatment options for low testosterone levels.

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08.10.2019
15:55 Phys.orgResearchers discover how water is regenerated on asteroids

Scientists have discovered how water molecules can be regenerated on asteroids moving through space, in an exciting breakthrough that could extend to other bodies such as the moon.

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07.10.2019
23:38 News-Medical.NetNew device can accelerate bone regeneration in difficult cases

Within minutes of breaking a bone, the body begins to repair itself.

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12:03 StemCellsPortal.comlASC Therapy Promotes Bone Regeneration After Bacterial Infection

Review of “Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Decreased bone regeneration due to inflammatory processes after severe bacterial infections remains a common problem in orthopedic surgery and previous studies from researchers led by Björn Behr (Ruhr-Universität Bochum, Germany) found that dysregulated inflammatory responses hindered bone regeneration after debridement following bacterial infection [1, 2]. Specifically, the authors observed reduced levels of osteoblastogenesis and increased levels of osteoclastogenesis and elevated B‐cell activity. 

Now the team returns with a STEM CELLS Translational Medicine study that investigates the

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11:27 StemCellsPortal.comlRegenerating the Aged and Damaged Intestine by Saying “No” to Notum

Review of “Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium” from Nature by Stuart P. Atkinson

A Paneth cell-containing niche supports the active cycling of intestinal stem cells (ISCs) [1, 2]; however, increased levels of complications observed in the gastrointestinal system with age suggest a reduction in both ISC activity and stem cell niche function. Fascinatingly, a recent Nature study by a team led by Pekka Katajisto (University of Helsinki, Helsinki, Finland) confirmed this hypothesis and established the production of Notum, an extracellular Wnt inhibitor, in aged Paneth cells as a crucial factor in the reduced regenerative potential of the intestinal epithelium that functions by targeting ISC function [3]. However, Pentinmikko et al. also highlight the pharmacological

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05.10.2019
16:08 News-Medical.NetResearchers develop new way of 3D printing soft biomaterials

A new way of 3D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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12:53 Phys.orgCommonwealth targets climate change with regeneration projects

The Commonwealth on Friday launched an ideas-sharing network to tackle the effects of climate change through replicable regeneration projects.

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04.10.2019
16:33 StemCellsPortal.comlAdult Fly Intestine Could Help Understand Intestinal Regeneration

BRISTOL (UK), September 2019 — Intestinal epith,elial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the universities of Bristol, Heidelberg and the German Cancer Research Center (DKFZ) have found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.
The research, published in Nature Communications, used the adult fly intestine, which is remarkably like a human intestine, to understand how IECs sense stress or damage, defend themselves and promote epithelial regeneration.
Stress-sensing pathways are activated upon a variety of stresses in fly IECs, but how these pathways are activated and how they promote IEC resilience and intestinal regeneration are not known.
The

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13:27 FightAging.OrgA Profile of Tissue Engineering Efforts at LyGenesis

LyGenesis is the company founded to develop the technique of implanting organoid tissue into lymph nodes in order to allow it to survive and grow in the body. Some organs can carry out much or all of their function more or less regardless of location in the body, such as the liver and thymus. Thus any viable transplant strategy that leads to functional tissue thriving in the body should help patients. LyGenesis is initially focused on restoring liver function via this approach, but the thymus is next in line, with an eye to reversing some of the age-related decline in immune function. Let's spend a little bit of time talking about your therapy. Let's say I hop into a time machine and go to the […]

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12:10 NYT HealthRegeneration: A Miracle, Against the Odds

Months after I’d shaved my head for cancer treatment, my old hair dropped out of the sky.

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08:17 News-Medical.Net3D printer could help expedite repair or replace damaged tissues for injured warfighters

The ability to 3D print a variety of healthcare-related products in deployment zones would greatly benefit the nation's warfighters.

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03.10.2019
19:49 ScienceDaily.comPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers have devised a fully print-in-place technique for printable electronics that is gentle enough to work on delicate surfaces ranging from paper to human skin. This can be accomplished without additional steps to bake, wash or powder-coat materials. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages with patient-specific biosensors.

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18:26 News-Medical.NetPrinted electronics show promise for personalized biosensors, embedded electronic tattoos

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin.

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15:34 Nanowerk.comPrinted electronics open way for electrified tattoos and personalized biosensors

The first demonstration of a fully print-in-place electronics technique is gentle enough to work on surfaces as delicate as human skin and paper.

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15:10 Phys.orgPrinted electronics open way for electrified tattoos and personalized biosensors

Electrical engineers at Duke University have devised a fully print-in-place technique for electronics that is gentle enough to work on delicate surfaces including paper and human skin. The advance could enable technologies such as high-adhesion, embedded electronic tattoos and bandages tricked out with patient-specific biosensors.

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02.10.2019
17:11 Phys.orgNew 3-D printing technique for biomaterials

A new way of 3-D printing soft materials such as gels and collagens offers a major step forward in the manufacture of artificial medical implants.

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