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Regeneration

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25.03.2019
17:52 ScienceDaily.comTissue engineering: Hydrogel for enhanced cell encapsulation and delivery

Cellulose nanofibers (CNF) hydrogel has great potential as a cell-encapsulation delivery carrier for sustained release of paracrine factors and for tissue regeneration, with unique versatility for injection, scaffolding, and 3D bioprinting.

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17:43 News-Medical.NetResearchers report new regenerative medicine approach for treating osteoarthritis of the knee

Researchers at Tokai University report in the journal npj Regenerative Medicine a regenerative medicine approach for treating osteoarthritis of the knee.

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22.03.2019
22:26 StemCellsPortal.comlThe Genetics of Regeneration

CAMBRIDGE, MA (US), March 2019 — When it comes to regeneration, some animals are capable of amazing feats — if you cut the leg off a salamander, for example, it will grow back. When threatened, some geckos drop their tails as a distraction and regrow them later.
Other animals take the process even further. Planarian worms, jellyfish and sea anemones can actually regenerate their entire bodies after being cut in half.
A team of researchers is shedding new light on how animals pull off the feat and uncovered a number of DNA switches that appear to control genes for whole-body regeneration. The study, led by Mansi Srivastava, Ph.D., assistant professor of organismic and evolutionary biology, is described in a March 15 paper in Science.
Using three-banded panther worms to test the process, Dr. Srivastava and Andrew Gehrke, a post-doctoral fellow working in her lab, found that a

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09:14 News-Medical.NetNanofibrous membrane could enhance periodontal tissue regeneration

According to the U.S. Centers for Disease Control and Prevention, about half of all Americans will have periodontal disease at some point in their lives.

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21.03.2019
19:57 StemCellsPortal.comlBlood Holds Key to Liver Regeneration

EAST LANSING, MI (US), March 2019 — The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn’t work.
A new Michigan State University study, published in the journal Blood, shows that the blood-clotting protein fibrinogen may hold the key as to why this happens.
“We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration,” said James Luyendyk, Ph.D., a professor of pathobiology in the College of Veterinary Medicine. “But if fibrinogen or platelets are inhibited, then regeneration is delayed.”
Platelets are blood cells that help form clots and stop bleeding. When they receive information

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18:11 News-Medical.NetTMJ disorders could be treated with tissue-engineered implants after successful animal study

It’s estimated that around 10 million Americans experience a temporomandibular joint (TMJ) disorder, with women being more susceptible than men. Affecting the jaw joint, TMJ disorders are characterized by pain around the jaw, ear, and temple, as well as difficulties in opening the mouth and significant clicking or grinding noises brought on by jaw movement.

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17:33 ScienceDaily.comEngineers aim to pioneer tissue-engineering approach to TMJ disorders

Here's something to chew on: One in four people are impacted by defects of the temporomandibular - or jaw - joint. Despite the pervasiveness of this affliction, treatments are lacking, and many sufferers resort to palliative measures to cope with the pain and debilitation it causes.

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13:33 FightAging.OrgChronic Inflammation as the Primary Cause of Declining Bone Regeneration with Age

Researchers here show that it is the chronic inflammation of aging that is the dominant contributing cause of loss of capacity in bone regeneration in later life. We should all feel a degree of relief whenever it turns out that chronic inflammation is the primary proximate cause of an age-related condition. Age-related inflammation is driven by senescent cells and immune system failure. Therapies to remove senescence cells are well advanced in clinical development, and there are many potential lines of work that will lead to ways to reverse the dysfunction of the aged immune system in years to come. The inflammatory profile of an old individual twenty years from now will look very different from the inflammatory profile of an old individual today. A new […]

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20.03.2019
23:40 NYT ScienceChop Up a Worm. It Will Regenerate. Scientists Figured Out Why.

Researchers identified the master control gene that enables worms to grow a new body, capturing the imagination of some humans looking for a fresh start.

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17:21 Phys.orgResearchers using tissue engineering to create lab-grown meat

Tissue engineering experts at the University of Bath are growing animal cells on blades of grass, as they play their part in helping the UK understand how to effectively scale up production of cultured meat.

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19.03.2019
19:06 Rejuvenation ResearchStem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice

Rejuvenation Research, Volume 22, Issue 1, Page 51-59, February 2019.

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15:26 Phys.orgGet ready for a menu of lab-grown steaks, "bleeding" plant burgers, and cricket smoothies

It takes about 90 seconds of flipping and stirring for Josh Hyman to whip up a skillet of fluffy, pale yellow scrambled eggs. He's in an industrial kitchen in San Francisco, and I'm 3,000 miles away on my farm in rural Tennessee, watching Hyman cook via Skype. He tips the craggy yellow mounds out of the pan and onto the plate, the eggs jiggling as they slide.

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15.03.2019
03:03 ScienceDaily.comStudy uncovers genetic switches that control process of whole-body regeneration

Researchers are shedding new light on how animals perform whole-body regeneration, and uncovered a number of DNA switches that appear to control genes used in the process.

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14.03.2019
21:07 Phys.orgStudy uncovers genetic switches that control process of whole-body regeneration

When it comes to regeneration, some animals are capable of amazing feats—if you cut the leg off a salamander, it will grow back. When threatened, some geckos drop their tails as a distraction, and regrow them later.

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18:46 StemCellsPortal.comlBlood Holds Key to Liver Regeneration

EAST LANSING, MI (US), March 2019 — The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn’t work.
A new Michigan State University study, published in the journal Blood, shows that the blood-clotting protein fibrinogen may hold the key as to why this happens.
“We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration,” said James Luyendyk, Ph.D., a professor of pathobiology in the College of Veterinary Medicine. “But if fibrinogen or platelets are inhibited, then regeneration is delayed.”
Platelets are blood cells that help form clots and stop bleeding. When they receive information

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11.03.2019
10:12 News-Medical.NetBlood-clotting protein may hold the key to liver regeneration, shows study

The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn't work.

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10.03.2019
00:24 ScienceDaily.comBlood holds key to liver regeneration

The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn't work. A new study shows that the blood-clotting protein fibrinogen may hold the key as to why this happens.

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07.03.2019
18:55 Gizmag Dramatic regenerative abilities may have emerged relatively recently in some animals


Researchers have identified a number of marine worm species that have evolved the ability to completely regrow their heads and brains after having them severed, despite sharing a common ancestor that couldn't. The discovery could help scientists understand the traits that allow animals to dramatically regrow lost limbs.
.. Continue Reading Dramatic regenerative abilities may have emerged relatively recently in some animals Category: Biology Tags: Evolution Regeneration University of Maryland

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00:30 ScienceDaily.comScientists identify gene partnerships that promote spinal cord regeneration

Scientists have identified gene 'partners' in the axolotl salamander that, when activated, allow the neural tube and associated nerve fibers to functionally regenerate after severe spinal cord damage. Interestingly, these genes are also present in humans, though they are activated in a different manner.

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06.03.2019
20:27 FinancialExpress.comGrowing spine, literally! Gene ‘partners’ that promote spinal cord regeneration found

Researchers at the Marine Biological Laboratory (MBL) in the US identified gene "partners" in the axolotl salamander that allow the neural tube and associated nerve fibres to functionally regenerate after severe spinal cord damage.

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14:10 Phys.orgScientists identify gene partnerships that promote spinal cord regeneration

Researchers are one step closer to solving the mystery of why some vertebrates can regenerate their spinal cords while others, including humans, create scar tissue after spinal cord injury, leading to lifelong damage.

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05.03.2019
19:46 ScienceDaily.comElectrical signals kick off flatworm regeneration

Scientists report that electrical activity is the first known step in the tissue-regeneration process of planarian flatworms, starting before the earliest known genetic machinery kicks in and setting off the downstream activities of gene transcription needed to construct new heads or tails.

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19:06 Phys.orgElectrical signals kick off flatworm regeneration

Unlike most multicellular animals, planarian flatworms can regrow all their body parts after they are removed. This makes them a good model for studying the phenomenon of tissue regeneration. They are also useful for exploring fundamental questions in developmental biology about what underlies large-scale anatomical patterning.

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04:15 DigitalTrends.comMotif wants to supply the ingredients for lab-grown meat and dairy

Impossible Foods' Beyond Meat burger tastes a lot like real meat, but they had to spend a lot of money to get there. Motif Ingredients hopes to make that possible for companies large and small by becoming an ingredients supplier.
The post Motif wants to supply the ingredients for lab-grown meat and dairy appeared first on Digital Trends.

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04.03.2019
17:12 SeekingAlpha.comGeneral Mills commits to regenerative agriculture practices

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01.03.2019
23:40 FightAging.OrgUpregulation of Autophagy to Attenuate Age-Related Declines in Muscle Regeneration

As a companion piece to another recently published open access paper, noted earlier this week, today's review paper considers the therapeutic upregulation of autophagy as a possible approach to reduce the deleterious impact of aging on muscle regeneration. Autophagy is the name given to a collection of cellular housekeeping processes responsible for ensuring that excess and broken cellular components are transported to a lysosome for recycling. Lysosomes are membrane-bound vesicles packed with enzymes capable of breaking down near all structures and molecular waste they are likely to encounter. The remnant molecules are released back into the broader cell as raw materials. Autophagy is known to decline with age. Many of the approaches shown to slow aging in short-lived laboratory species either involve increased autophagy, or, […]

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21:45 News-Medical.NetNovel cell rejuvenation approach may open new avenues for regenerative medicine

Scientists from the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg and from the German Cancer Research Center have been able to rejuvenate stem cells in the brain of aging mice.

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28.02.2019
16:16 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - MSC Homing, iPSC-MSC Misidentification, Attenuating T1D Bone Loss, and Coordinated Tissue Repair!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
CREKA Improves the Targeted Homing Ability of Mesenchymal Stem Cells

A team of researchers from Fudan University, Shanghai (China) recently sought to improve mesenchymal stem cell (MSC) homing to the injured myocardium to improve therapeutic outcomes. To this end, the authors modified MSCs with a homing peptide (cysteine-arginine-glutamic acid-lysine-alanine - CREKA) that targets fibrin, which is involved in the repair process of tissue injury. Overall, this STEM CELLS article establishes their CREKA-associated

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27.02.2019
18:50 StemCellsPortal.comlTwo cell types found in fat tissue may speed bone repair

BALTIMORE, MD (US), February 2019 — Research led by Johns Hopkins investigators has uncovered the roles of two types of cells found in the vessel walls of fat tissue and described how these cells may help speed bone repair.
The study found that one of these perivascular stem cell types, pericytes, induces growth of new blood vessels, while another type, adventicytes, induces the formation of bone cells called osteoblasts. In laboratory tests, researchers found that the two types of cells did a better job promoting bone repair in mice with skull defects when they were used together than when either type was used alone.
A description of the work was published online Jan. 7 in NPJ Regenerative Medicine.
Bone defects from trauma, cancer or congenital reasons are common, but beyond a certain size bone deficits cannot heal on their own, said senior study author Aaron James, M.D.,

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25.02.2019
11:07 Phys.orgIsraeli startups join firms making lab-grown 'clean meat'

Several Israeli start-ups have joined a handful of companies around the globe trying to develop lab-grown meat, something they see as a solution to the needs of the world's ever-growing population and burgeoning demand for food.

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21.02.2019
19:08 ReutersDe Beers says lab-grown diamond wholesale prices fall by up to 60 percent

Wholesale prices for lab-grown diamonds have fallen by up to 60 percent since De Beers began selling synthetic stones for jewelry in September, CEO Bruce Cleaver said on Thursday, adding margins for the sector would continue to fall.

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19:02 Yahoo.com BusinessDe Beers says lab-grown diamond wholesale prices fall by up to 60 percent

Wholesale prices for lab-grown diamonds have fallen by up to 60 percent since De Beers began selling synthetic stones for jewelry in September, CEO Bruce Cleaver said on Thursday, adding margins for the sector would continue to fall. De Beers, part of mining group Anglo American, shocked the diamond industry last year when it announced it was reversing a decades-old policy of selling natural diamonds only for jewelry and synthetic stones for industrial uses.

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03:23 ScienceDaily.comActivating tooth regeneration in mice

Most reptiles and fish have multiple sets of teeth during their lifetime. However, most mammals, such as humans, have only one set of replacement teeth and some mammals, like mice, have only a single set with no replacement. This diversity raises both evolutionary questions -- how did different tooth replacement strategies evolve? -- and developmental ones -- which mechanisms prevent replacement teeth in animals that lost them?

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20.02.2019
17:28 Phys.orgActivating tooth regeneration in mice

Most reptiles and fish have multiple sets of teeth during their lifetime. However, most mammals, such as humans, have only one set of replacement teeth and some mammals, like mice, have only a single set with no replacement. This diversity raises both evolutionary questions—how did different tooth replacement strategies evolve?—and developmental ones—which mechanisms prevent replacement teeth in animals that lost them?

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16:20 TechnologyReview.comLab-grown meat could be worse for the environment than beef

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16:08 News-Medical.NetStudy shows therapeutic potential of VEGF-A mRNA for regenerative angiogenesis in humans

An international team of researchers from academia and the biopharma industry has published a Phase 1a/b study, showing the therapeutic potential of mRNA encoding for vascular endothelial growth factor A (VEGF-A) for regenerative angiogenesis in humans.

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15:59 SeekingAlpha.comModerna up 4% premarket on positive early-stage data supporting potential of mRNA encoding as regenerative therapeutic

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07:35 News-Medical.NetResearchers develop new way to deliver treatment for cartilage regeneration

Researchers from Texas A&M University, led by Dr. Akhilesh K. Gaharwar, have developed a new way to deliver treatment for cartilage regeneration.

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04:15 CleanTechnica.comEVRT Middle East Put Three EVs Head To Head In The Regeneration Challenge

The Electric Vehicle Road Trip (EVRT) Middle East tested the limits of today's electric vehicles in a region of the world that would not be at the top of the list for EV adoption. This year, EVRT Middle East took participants up to the top of the highest peak in the United Arab Emirates (UAE) to put the participating vehicles to the test in the Regeneration Challenge

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19.02.2019
14:33 FightAging.OrgA Small Molecule NNMT Inhibitor Puts Aged Stem Cells Back to Work to Improve Muscle Regeneration in Old Mice

In old tissues, stem cell activity is much reduced relative to youthful activity. This is thought to be the most important contribution to loss of muscle mass and strength with age, leading to the condition known as sarcopenia. It also diminished the ability to regenerate after muscle injury. Numerous studies in the regenerative medicine community have demonstrated that while this loss of stem cell function may be a defense against cancer, reducing the activity of cells that may bear potentially dangerous molecular damage, there appears to be a fair amount of room to push the balance towards greater activity without large increases in cancer risk. In mice, anyway. Researchers here demonstrate a novel way of increasing muscle stem cell activity, to add to a number […]

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15.02.2019
16:36 GlobalConstructionReview.comLendlease to help develop £8bn Thamesmead regeneration project in London

Housing association Peabody has picked Lendlease as its partner for an £8bn, 11,500 home development ...

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14.02.2019
17:30 Phys.orgSkin wound regeneration with bioactive glass-gold nanoparticles ointment

Healing is a complex process in adult skin impairments, requiring collaborative biochemical processes for onsite repair. Diverse cell types (macrophages, leukocytes, mast cells) contribute to the associated phases of proliferation, migration, matrix synthesis and contraction, coupled with growth factors and matrix signals at the site of the wound. Understanding signal control and cellular activity at the site could help explain the process of adult skin repair beyond mere patching up and more as regeneration, to assess biomechanics and implement strategies for accelerated wound repair in regenerative medicine.

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13.02.2019
20:01 Nature.ComBiological sex shapes tumour evolution across cancer types

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12.02.2019
23:52 FightAging.OrgBetter Understanding the Origins of Fibroblasts Found in Healing Wounds Might Lead to Regeneration Without Scarring

Scarring is an unfortunate fact of mammalian life, both following injury and throughout inner organs in old age, when the processes of regeneration and tissue maintenance run awry. Wound healing, or indeed any form of regeneration, is enormously complex. It is a dance of signals and actions carried out between numerous cell populations: various stem cells and progenitor cells; immune cells; somatic cells. These processes are similar at the high level in different tissues, but the details vary. It is far from completely mapped by the research community, as is true of most of cellular metabolism, particularly when multiple cell types are coordinating with one another. Today's research is a good illustration of the complexities of regenerative biochemistry. When focusing down on even one class […]

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11.02.2019
22:11 ScienceDaily.comResearchers 3D bio-print a model that could lead to improved anticancer drugs and treatments

Researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3D in vitro model (i.e., in a culture dish rather than in a human or animal).

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21:50 MedicalNewsToday.comMedical News Today: Simple drug formula regenerates brain cells

Scientists have shown how a drug cocktail of four compounds can convert glia, or support cells, next to damaged neurons into new working neurons.

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17:43 Phys.orgRegenerative agriculture can make farmers stewards of the land again

For years, "sustainable" has been the buzzword in conversations about agriculture. If farmers and ranchers could slow or stop further damage to land and water, the thinking went, that was good enough. I thought that way too, until I started writing my new book, "One Size Fits None: A Farm Girl's Search for the Promise of Regenerative Agriculture."

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10.02.2019
21:39 CNBC technologyRanchers said to lobby states to outlaw use of the label 'meat' on plant, lab-grown products

Plant-based and lab-grown meat substitutes like the Impossible Burger have become a billion-dollar industry, and cattle ranchers are trying to head off the competition.

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21:31 CNBC.comRanchers said to lobby states to outlaw use of the label 'meat' on plant, lab-grown products

Plant-based and lab-grown meat substitutes like the Impossible Burger have become a billion-dollar industry, and cattle ranchers are trying to head off the competition.

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15:53 FinancialExpress.comIndian Railways gets first ‘Make in India’ electric locomotive with regenerative braking; what’s special

Meanwhile, under the Make in India initiative, Prime Minister Narendra Modi is set to launch three big Indian Railways projects this month.

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06.02.2019
17:11 Nature.ComSizzling interest in lab-grown meat belies lack of basic research

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04.02.2019
15:31 Geek.comLab-Grown Insulin-Producing Cells Open Door to Type 1 Diabetes Cure

Scientists at the University of California San Francisco made a major breakthrough in the effort to cure diabetes mellitus type 1. For the first time, researchers transformed human stem cells into mature insulin-producing […]
The post Lab-Grown Insulin-Producing Cells Open Door to Type 1 Diabetes Cure appeared first on Geek.com.

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31.01.2019
17:46 Phys.orgBiophotonics: In situ printing liquid superlenses to image butterfly wings and nanobiostructures

Nanostructures and natural patterns have long fascinated researchers in bioinspired materials engineering. Biological samples can be imaged and observed at the nanoscale using sophisticated analytical tools in materials science, including scanning electron microscopy (SEM) and transmission electron microscopy (TEM). While imaging methods contribute to the understanding of structures by revealing material properties for biomimetic materials synthesis, they have often done so with the loss of photonic properties inherent to the materials.

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17:14 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Craniofacial Bone Defect Repair, Islet Regeneration, MSC Chondrogenic Potential, and Chronic Pancreatitis MSCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Dental Pulp Stem Cells Directly Participate in Calvaria Defect Repair

The osteogenic properties of dental pulp stem cells (DPSCs) have prompted research into their potential application in craniofacial bone repair. Now, a new STEM CELLS study from the lab of Anne Poliard (University Paris Descartes, Montrouge, France) has explored the repair process via studies in a mouse model of craniofacial bone defects. Interestingly, Collignon et al. establish the direct involvement of mouse DPSCs in repair via an

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17:13 Phys.orgFlatworms found to regenerate faster or slower when exposed to weak magnetic field

A team of researchers from Western Michigan University and the University of Colorado Boulder has found that the regeneration rate for planaria flatworms can be impacted by a weak magnetic field. In their paper published in the journal Science Advances, the group describes experiments they conducted with flatworms exposed to weak magnetic fields and what they found.

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30.01.2019
22:06 Phys.orgThe lamprey regenerates its spinal cord not just once—but twice

Spontaneous recovery from spinal cord injury is almost unheard of in humans and other mammals, but many vertebrates fare better. The eel-like lamprey, for instance, can fully regenerate its spinal cord even after it's been severed: Within 3 months the lamprey is swimming, burrowing, and flipping around again, as if nothing had happened.

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14:39 FightAging.OrgThe Importance of Macrophages in Kidney Regeneration

Macrophages are demonstrably important in tissue regeneration. The process of regeneration is an intricate dance of signaling and activity carried out between stem and progenitor cells, somatic cells of varying types, senescent cells, and immune cells such as macrophages. The research of recent years strongly suggests that differences in macrophage behavior are in some way fundamental to the exceptional regeneration exhibited by species as diverse as salamanders, zebrafish, and spiny mice. Can macrophage behavior in our species be beneficially adjusted to improve regenerative capacity? Comparatively simple approaches aiming to shift macrophage polarization from the inflammatory, aggressive M1 polarization to the pro-regenerative M2 polarization appear quite promising in early animal studies, but this is just the tip of the iceberg. Much is left to be explored, […]

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29.01.2019
16:33 DigitalTrends.comScientists identify key genes involved in salamander limb regeneration

In a huge step forward for regenerative medicine, scientists have sequenced the genome of the Axolotl, a giant Mexican salamander that is able to regenerate lost limbs on command.
The post Scientists identify key genes involved in salamander limb regeneration appeared first on Digital Trends.

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10:51 News-Medical.NetNew automated, high-throughput bioreactor system for lung regeneration analysis

New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.

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27.01.2019
17:31 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - CHD7 in Glioblastoma, Autophagy in Hyperglycemia, MSC Secretome in Corneal Healing, and CS-GAG in Bone Regeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Microenvironment and Angiogenic Properties of CHD7 in Glioblastoma

Recent research from the lab of Anita B. Hjelmeland (University of Alabama at Birmingham, Birmingham, AL, USA) sought to understand how the ischemic environment promotes the development of glioblastoma (GBM), the most common primary malignant brain tumor in adults. In their STEM CELLS paper, Boyd et al. identify the chromodomain helicase DNA binding protein 7 (CHD7) as a novel ischemia‐regulated gene whose expression decreases in brain

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25.01.2019
17:13 News-Medical.NetStratasys advanced FDM 3D printing helps Biodonostia to improve treatment for thoracic wall tumors

Founded in 2008, the Biodonostia Health Research Institute was the first institute for medical research in the Basque region of Spain. Facing difficult surgical challenges every day, it recently partnered with Tknika, a Research and Applied Innovation Centre for Vocational Education and Training in the Basque region, and Tecnun, a specialist division of Universidad de Navarra, to enable surgeons to harness the latest 3D printing technology as a tool to aid surgical preparedness.

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24.01.2019
21:09 ScienceDaily.com'Training gym' for lab-grown heart cells: Engineering researchers design new platform

Heart muscle cells need exercise -- even when they grow outside the human body. A new device uses a rigorous training regimen to grow small amounts of cardiac tissue and measure how strongly it beats. The platform is ideal for testing the effects of potential drug molecules, and could help bring personalized medicine closer to reality.

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21:03 Phys.orgSci-fi to reality: Superpowered salamander may hold the key to human regeneration

Regeneration is one of the most enticing areas of biological research. How are some animals able to regrow body parts? Is it possible that humans could do the same? If scientists could unlock the secrets that confer those animals with this remarkable ability, the knowledge could have profound significance in clinical practice down the road.

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23.01.2019
17:59 StemCellsPortal.comlDr. Yong-Beom Park’s Research in Cartilage Regeneration Earns Him Young Investigator Award

DURHAM, N.C. JANUARY 23, 2019 - Yong-Beom Park, M.D., Ph.D., is named the STEM CELLS Translational Medicine’s Young Investigator of 2018 for his research in cartilage regeneration in osteoarthritic patients. The award fosters advancements in the field of stem cells and regenerative medicine by honoring a young researcher who is principle author of an article published in SCTM that is deemed to have the most impact and to push the boundaries of novel and insightful research.
In this study, Dr. Park and his team collected stem cells from human umbilical cord blood (hUCB), mixed with a hyaluronic acid hydrogel composite and then implanted them in human knees with osteoarthritis. The results of their research showed promising efficacy in terms of durable cartilage regeneration in osteoarthritis, setting the foundation for

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18.01.2019
23:11 Gizmag Lab-grown human blood vessels promise breakthroughs in the fight against diabetes


Stem cell researchers at the University of British Columbia (UBC) have successfully managed to grow human blood vessels in the lab. The finding could mark a giant leap forward in the fight against vascular diseases such as Alzheimer's, cancer, and diabetes by allowing risk-free experimentation on live human tissue.
.. Continue Reading Lab-grown human blood vessels promise breakthroughs in the fight against diabetes Category: Science Tags: blood vessel Diabetes Stem Cells University of British Columbia

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17:28 ScienceDaily.comGene therapy promotes nerve regeneration

Researchers have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated. The discovery is an important step towards the development of a new treatment for people with nerve damage.

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17.01.2019
00:47 FightAging.OrgAccelerated Bone Regeneration via Transplant of Engineered Perivascular Stem Cells

Reprogramming stem or progenitor cells to adjust their behavior is growing in popularity as an approach to regenerative medicine. The large reductions in the cost of exploring cellular mechanisms achieved over the past twenty years mean that there is now a much greater understanding of relevant mechanisms, as well as a greater capacity to discover novel targets of interest for specific goals in altered cell behavior. The more straightforward outcome in this part of the field is simply to increase stem cell activity, to reduce the amount of time these cells spend quiescent rather than actively supplying tissue with new daughter somatic cells to assist in repair. As today's open access paper illustrates, there are certainly other options on the table, however. Many stem cell […]

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15.01.2019
17:18 InsideEVs.comBest And Worst Electric Cars For Regenerative Braking

Not all EV braking is created equal. When I drive an electric car for the first time, I’m always struck by how different it is from EVs that I previously experienced. More often than not, what separates them is not how they accelerate or handle – but how they brake. In the last couple of […]

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16:00 SeekingAlpha.comArray Bio up 11% premarket on positive late-stage data on triplet therapy for certain type of colorectal cancer

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11.01.2019
16:48 GlobalConstructionReview.comMajor Merseyside regeneration scheme to have hundreds of modular homes from Urban Splash

UK developer Peel Land and Property (Peel L&P) has contracted Urban Splash to erect 347 ...

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07.01.2019
18:03 SingularityHub.Com3D Printed Heads Can Unlock Phones. What Does that Mean for Biometric Security?

Facial recognition technology is likely not as safe as you may have thought. This was illustrated by a recent test where 3D printed busts of peoples’ heads were used to unlock smartphones. Out of five tested phones, only one refused to open when presented with the fake head. Other biometric security measures are also showing […]

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06.01.2019
19:05 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Appraising iPSC Clinical Translation, Reviewing Periodontal Regeneration, Knee Osteoarthritis MSC Trial, and Changing mESC Bioenergetics!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Reviewing the Clinical Translation of Induced Pluripotent Stem Cells

A new review article out of the laboratory of Nico Lachmann (Hannover Medical School, Germany) provides a brief overview of the recent developments and challenges faced during the progression of induced pluripotent stem cell (iPSC)-derived blood cells to clinical translation. While examples of the clinical transfer of iPSC‐derived hematopoietic cells remain few, this great new article from Haake et al. describes the advances made in hematopoietic

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03:42 Yahoo.com BusinessWhat Type Of Shareholder Owns Rhythm Biosciences Limited’s (ASX:RHY)?

The big shareholder groups in Rhythm Biosciences Limited (ASX:RHY) have power over the company. Insiders often own a large chunk of younger, smaller, companies while huge companies tend to have Read More...

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04.01.2019
18:12 FierceBiotech.comA vaccine for Type 1 diabetes? Provention Bio says a human trial is in sight

Type 1 diabetes is caused by genetic susceptibility and environmental factors, researchers believe. Startup Provention Bio is trying to reduce the environmental risk by way of a vaccine scientists believe can prevent up to 50% of new Type 1 diabetes cases.

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01.01.2019
20:04 Teslarati.comFirst living tissue 3D printed in space aboard International Space Station

Using the “Organaut”, a 3D bioprinter designed for microgravity, Russia has become the first country to print living tissue in space. After a December 3rd cargo delivery to the International Space Station (ISS), cosmonaut Oleg Kononenko completed an experiment with the machine in the Russian sector of the station, successfully producing human cartilage tissue and […]
The post First living tissue 3D printed in space aboard International Space Station appeared first on TESLARATI.com.

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31.12.2018
12:41 StemCellsPortal.comlMacrophages: The Missing Ingredient of Functional 3D Tissue-engineered Muscle Constructs?

Review of “Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration” from Nature Biomedical Engineering by Stuart P. Atkinson 

Muscle satellite cells (MuSCs) activate in response to damage and asymmetrically divide to both self-renew and generate proliferative myogenic precursor cells that promote skeletal muscle regeneration [1]. However, in cases such as severe muscle loss or chronic degenerative diseases, insufficiencies in the natural regeneration process have prompted the development of three-dimensional (3D) tissue-engineered muscle constructs as an alternative treatment strategy.

Researchers from the laboratory of Nenad Bursac (Duke University, Durham, NC, USA) aimed to develop advanced 3D tissue-engineered muscle constructs by not only considering the physical interactions between the MuSCs, myofibers, and

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28.12.2018
08:26 News-Medical.NetStudy explains effects of aging on endothelial health and vascular regenerative capacity

The endothelium plays an important role in cardiovascular regulation, from blood flow to platelet aggregation, immune cell infiltration and demargination.

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00:45 DigitalTrends.comScientists create a way to make more breathable 3D-printed tissues

A team of researchers at Pennsylvania State University found a new way to 3D print lab-made porous tissues, such as bone and cartilage. Here's what makes their advance so exciting.
The post Scientists create a way to make more breathable 3D-printed tissues appeared first on Digital Trends.

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24.12.2018
20:55 StemCellsPortal.comlCRISPR-activation of SOX2 Promotes Corneal Endothelial Cell-mediated Wound Healing and Regeneration

Review of “SOX2 Activation Using CRISPR/dCas9 Promotes Wound Healing in Corneal Endothelial Cells” from STEM CELLS by Stuart P. Atkinson

Other than corneal transplants [1], there currently exist no effective treatments for corneal endothelial dysfunction/disease [2]. While corneal endothelial cells (CECs) may seem to represent an obvious choice for the development of novel regenerative therapies, they do not proliferate in vivo even when in an injured state [3]. As wounded CECs express the pluripotency- and eye development-associated SOX2 transcription factor [4], researchers from the laboratory of Young Joo Shin (Hallym University, Seoul, Korea) sought to harness the power of CRISPR-activation technology [5, 6] to promote the overexpression of SOX2 in CECs in the hope of enhancing wound healing of the corneal

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20:44 StemCellsPortal.comlFirst Isolation of Human Skeletal Stem Cells: The Key to Regenerative Approaches for Skeletal Disorder Treatment?

Review of “Identification of the Human Skeletal Stem Cell” from Cell by Stuart P. Atkinson 

Recent lineage-tracing and clonal analysis studies provided evidence for the existence of a mouse skeletal stem cell (mSSC) that exhibits the exclusive ability to generate bone, cartilage, and bone marrow stroma [1-3]. However, the relative absence of reliable cell-surface markers and related protocols and assays has hampered the discovery of putative human SSCs (hSSCs).

However, researchers from the laboratory of Michael T. Longaker (Stanford Medicine, Stanford, CA, USA) have published a new article in Cell in which they describe the isolation, regenerative activity, and cross-species comparison of a self-renewing hSSC with bone, cartilage, and stroma differentiation potential [4]. Is this new study by Chan et al. the key to regenerative approaches for skeletal disorder

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21.12.2018
10:56 ReutersLab-grown diamond prices slide as De Beers fights back

Since De Beers abandoned its decades-old policy of refusing to sell lab-grown diamonds as jewelery, the price gap between man-made stones and natural gems has widened - and the difference is set to get even bigger.

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20.12.2018
19:55 SeekingAlpha.comMustang Bio's MB-102 an Orphan Drug in U.S. for rare type of blood cancer; shares up 1%

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14:41 FightAging.OrgReviewing GDF11 as a Basis for Regenerative Therapy

I think it fair to say that GDF11 was the first concrete target to emerge from the modern reinvention of parabiosis research, in which the circulatory systems of an old mouse and a young mouse are joined. The old mouse rejuvenates a little, and the young mouse is aged a little, most of which seems to emerge from effects on inflammation and stem cell activity. Researchers thereafter started looking for specific signals carried in the bloodstream that might mediate this effect. There has been no shortage of debate in this part of the field, such as over whether or not it is possible that beneficial factors from young blood can exist, given the evidence. Or whether the early work on GDF11 holds up at all. […]

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19.12.2018
21:45 MedicalNewsToday.comMedical News Today: Multiple sclerosis: Could this be why myelin fails to regenerate?

A study finds a previously unknown mechanism that quietens adult stem cells and could be a disruptor of myelin repair in inflammatory diseases, such as MS.

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08:36 News-Medical.NetFDA supports C-Path's Type 1 Diabetes Consortium to pursue biomarker qualification

Critical Path Institute (C-Path) announced today that its Type 1 Diabetes (T1D) Consortium has received a positive response to its Letter of Intent (LOI) from the U.S. Food and Drug Administration (FDA) detailing the FDA's decision to accept the consortium's Biomarker Initiative project into the Center for Drug Evaluation and Research (CDER) Biomarker Qualification Program (BQP).

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18.12.2018
17:26 Phys.orgSearching for the source of planarians' regenerative powers

Using a technique that involves analyzing thousands of single cells, scientists have figured out a new way to capture a stem cell that underlies flatworm regeneration.

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13:06 CleanTechnica.comRegenerative Cities: An Urban Concept Whose Time Has Come!

The regenerative city vision needs to be driven by strong political leadership capable of setting ambitious yet realistic goals, able to gather momentum across society and mobilize different stakeholders towards such a common vision

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17.12.2018
11:37 StemCellsPortal.comlComparing the Regenerative Potential of SVF and MFAT - Which Adipose Tissue Preparation Comes out Top?

Review of “Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

A recent STEM CELLS Translational Medicine article established the safety, feasibility, and potential effectiveness of single intra‐articular injections of micro‐fragmented adipose tissue (MFAT) [1, 2] as a treatment strategy for osteoarthritis when tested in a canine model [3]. As opposed to the enzymatic dissociation of adipose tissue followed by removal of adipocytes and collection of the remaining stromal vascular fraction (SVF) for regenerative applications, MFAT employs mechanical dissociation of adipose tissue to generate blood- and free lipid-free submillimeter cell clusters that have

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16.12.2018
12:59 Financial TimesFinancial pressures haunt Battersea regeneration

Malaysian owners’ refinancing arrangement delayed for third time as costs climb

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15.12.2018
07:44 News-Medical.NetA new type of 'painless' adhesive for biomedical applications

Pulling off a Band-Aid may soon get a lot less painful. Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences and Xi'an Jiaotong University in China have developed a new type of adhesive that can strongly adhere wet materials -- such as hydrogel and living tissue -- and be easily detached with a specific frequency of light.

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14.12.2018
23:15 Geek.comFirst Lab-Grown Steak Gives Foodies a Taste of the Future

Arby’s doesn’t have “the meats” anymore: A startup just unveiled its new lab-grown steak, which it claims is the world’s first ever cell-grown beef product. On Wednesday, Aleph Farms announced that it developed […]
The post First Lab-Grown Steak Gives Foodies a Taste of the Future appeared first on Geek.com.

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11:41 Technology.orgResearchers use zinc to target insulin-producing cells with regenerative drug

An insulin injection can manage diabetes symptoms, but actually curing the disease would mean healing cells in the

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04:11 Nanowerk.comInexpensive 3-D-printed microfluidics device quickly tests drugs on tumor tissue

Re searchers have 3-D printed a novel microfluidic device that simulates cancer treatments on biopsied tumor tissue - and keeps the tissue alive for days - so clinicians can better examine how individual patients will respond to different therapeutics.

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13.12.2018
23:40 DigitalTrends.comThere’s a new lab-grown meat startup on the block — and it has a secret weapon

Aleph Farms is developing lab-grown steaks with the same flavor, shape, texture, and structure as the real thing using beef cells isolated from living cows. Coming soon to a store near you?
The post There’s a new lab-grown meat startup on the block — and it has a secret weapon appeared first on Digital Trends.

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15:56 Phys.orgScientists develop a cellulose biosensor material for advanced tissue engineering

I.M. Sechenov of First Moscow State Medical University teamed up with Irish colleagues to develop a new imaging approach for tissue engineering. The team produced hybrid biosensor scaffold materials based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. These materials enable visualization of the metabolism and other important biomarkers in engineered artificial tissues by microscopy. The results of the work were published in the Acta Biomaterialia journal.

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14:31 FightAging.OrgMacrophages Could Improve Heart Regeneration, but Arrive Too Late Following Injury

Macrophages of the innate immune system play an important role in coordinating the intricate dance of cell populations that takes place during regeneration from injury. Differences in macrophage behavior may be key to the exceptional regenerative capacities of species such as salamanders that can regrow entire organs, and possibly also in the few mammalian species and genetically altered lineages capable of noteworthy feats of regeneration. Researchers here make a most interesting discovery, finding that in mice there are populations of macrophages capable of coordinating greater than normal regeneration following injury to the heart, such as that resulting from a heart attack. This regeneration doesn't take place because the macrophages arrive too late to prevent the formation of scar tissue; regeneration is already well advanced by […]

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08:15 News-Medical.NetResearch identifies new therapeutic target for cancer treatment and tissue regeneration

Research led by the University of Plymouth and Technische Universität Dresden has identified a new therapeutic target for cancer treatment and tissue regeneration - a protein called Prominin-1.

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03:16 Gizmag Aleph Farms serves up world's first lab-grown steak


Israel-based startup Aleph Farms has just unveiled the world's first lab-grown steak. This milestone on the road to bringing a cruelty-free meat product to the market demonstrates, for the first time, the technology's ability to imitate the flavor, shape, texture and structure of a classic beef steak.
.. Continue Reading Aleph Farms serves up world's first lab-grown steak Category: Environment Tags: Clean meat Food Food technology Lab grown meat

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12.12.2018
14:24 FightAging.OrgCan Peripheral Nervous System Regenerative Mechanisms be Introduced into the Central Nervous System?

The nervous system in general is not particularly regenerative, but peripheral nervous system tissue is more capable of repair than central nervous system tissue. Focusing on neurons that link these two parts of the nervous system, researchers here report on mechanisms involved in repair of nervous system cells, and propose that it might be possible to make central nervous system cells act more like peripheral nervous system cells in this regard. Whether or not this can be achieved safely is another question, however; this is very early stage work, too early to answer many questions about safety and plausibility. Neurons in the central nervous system - the brain and spinal cord - and the peripheral nervous system are very similar except in their ability to […]

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11.12.2018
12:14 News-Medical.NetNew review focuses on electrospinning techniques used in musculoskeletal tissue engineering

The rotator cuff is a group of four muscles and tendons that stabilizes the shoulder joint. It also helps in the motion of the shoulder. Rotator cuff tear is the most common condition involving ailing shoulders. It happens due to normal muscle tissue wear and tear by repeating the same motion again and again, without resting the muscles.

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