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Regeneration

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04.02.2019
15:31 Geek.comLab-Grown Insulin-Producing Cells Open Door to Type 1 Diabetes Cure

Scientists at the University of California San Francisco made a major breakthrough in the effort to cure diabetes mellitus type 1. For the first time, researchers transformed human stem cells into mature insulin-producing […]
The post Lab-Grown Insulin-Producing Cells Open Door to Type 1 Diabetes Cure appeared first on Geek.com.

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31.01.2019
17:46 Phys.orgBiophotonics: In situ printing liquid superlenses to image butterfly wings and nanobiostructures

Nanostructures and natural patterns have long fascinated researchers in bioinspired materials engineering. Biological samples can be imaged and observed at the nanoscale using sophisticated analytical tools in materials science, including scanning electron microscopy (SEM) and transmission electron microscopy (TEM). While imaging methods contribute to the understanding of structures by revealing material properties for biomimetic materials synthesis, they have often done so with the loss of photonic properties inherent to the materials.

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17:14 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Craniofacial Bone Defect Repair, Islet Regeneration, MSC Chondrogenic Potential, and Chronic Pancreatitis MSCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Dental Pulp Stem Cells Directly Participate in Calvaria Defect Repair

The osteogenic properties of dental pulp stem cells (DPSCs) have prompted research into their potential application in craniofacial bone repair. Now, a new STEM CELLS study from the lab of Anne Poliard (University Paris Descartes, Montrouge, France) has explored the repair process via studies in a mouse model of craniofacial bone defects. Interestingly, Collignon et al. establish the direct involvement of mouse DPSCs in repair via an

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17:13 Phys.orgFlatworms found to regenerate faster or slower when exposed to weak magnetic field

A team of researchers from Western Michigan University and the University of Colorado Boulder has found that the regeneration rate for planaria flatworms can be impacted by a weak magnetic field. In their paper published in the journal Science Advances, the group describes experiments they conducted with flatworms exposed to weak magnetic fields and what they found.

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30.01.2019
22:06 Phys.orgThe lamprey regenerates its spinal cord not just once—but twice

Spontaneous recovery from spinal cord injury is almost unheard of in humans and other mammals, but many vertebrates fare better. The eel-like lamprey, for instance, can fully regenerate its spinal cord even after it's been severed: Within 3 months the lamprey is swimming, burrowing, and flipping around again, as if nothing had happened.

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14:39 FightAging.OrgThe Importance of Macrophages in Kidney Regeneration

Macrophages are demonstrably important in tissue regeneration. The process of regeneration is an intricate dance of signaling and activity carried out between stem and progenitor cells, somatic cells of varying types, senescent cells, and immune cells such as macrophages. The research of recent years strongly suggests that differences in macrophage behavior are in some way fundamental to the exceptional regeneration exhibited by species as diverse as salamanders, zebrafish, and spiny mice. Can macrophage behavior in our species be beneficially adjusted to improve regenerative capacity? Comparatively simple approaches aiming to shift macrophage polarization from the inflammatory, aggressive M1 polarization to the pro-regenerative M2 polarization appear quite promising in early animal studies, but this is just the tip of the iceberg. Much is left to be explored, […]

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29.01.2019
16:33 DigitalTrends.comScientists identify key genes involved in salamander limb regeneration

In a huge step forward for regenerative medicine, scientists have sequenced the genome of the Axolotl, a giant Mexican salamander that is able to regenerate lost limbs on command.
The post Scientists identify key genes involved in salamander limb regeneration appeared first on Digital Trends.

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10:51 News-Medical.NetNew automated, high-throughput bioreactor system for lung regeneration analysis

New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.

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27.01.2019
17:31 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - CHD7 in Glioblastoma, Autophagy in Hyperglycemia, MSC Secretome in Corneal Healing, and CS-GAG in Bone Regeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Microenvironment and Angiogenic Properties of CHD7 in Glioblastoma

Recent research from the lab of Anita B. Hjelmeland (University of Alabama at Birmingham, Birmingham, AL, USA) sought to understand how the ischemic environment promotes the development of glioblastoma (GBM), the most common primary malignant brain tumor in adults. In their STEM CELLS paper, Boyd et al. identify the chromodomain helicase DNA binding protein 7 (CHD7) as a novel ischemia‐regulated gene whose expression decreases in brain

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25.01.2019
17:13 News-Medical.NetStratasys advanced FDM 3D printing helps Biodonostia to improve treatment for thoracic wall tumors

Founded in 2008, the Biodonostia Health Research Institute was the first institute for medical research in the Basque region of Spain. Facing difficult surgical challenges every day, it recently partnered with Tknika, a Research and Applied Innovation Centre for Vocational Education and Training in the Basque region, and Tecnun, a specialist division of Universidad de Navarra, to enable surgeons to harness the latest 3D printing technology as a tool to aid surgical preparedness.

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24.01.2019
21:09 ScienceDaily.com'Training gym' for lab-grown heart cells: Engineering researchers design new platform

Heart muscle cells need exercise -- even when they grow outside the human body. A new device uses a rigorous training regimen to grow small amounts of cardiac tissue and measure how strongly it beats. The platform is ideal for testing the effects of potential drug molecules, and could help bring personalized medicine closer to reality.

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21:03 Phys.orgSci-fi to reality: Superpowered salamander may hold the key to human regeneration

Regeneration is one of the most enticing areas of biological research. How are some animals able to regrow body parts? Is it possible that humans could do the same? If scientists could unlock the secrets that confer those animals with this remarkable ability, the knowledge could have profound significance in clinical practice down the road.

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23.01.2019
17:59 StemCellsPortal.comlDr. Yong-Beom Park’s Research in Cartilage Regeneration Earns Him Young Investigator Award

DURHAM, N.C. JANUARY 23, 2019 - Yong-Beom Park, M.D., Ph.D., is named the STEM CELLS Translational Medicine’s Young Investigator of 2018 for his research in cartilage regeneration in osteoarthritic patients. The award fosters advancements in the field of stem cells and regenerative medicine by honoring a young researcher who is principle author of an article published in SCTM that is deemed to have the most impact and to push the boundaries of novel and insightful research.
In this study, Dr. Park and his team collected stem cells from human umbilical cord blood (hUCB), mixed with a hyaluronic acid hydrogel composite and then implanted them in human knees with osteoarthritis. The results of their research showed promising efficacy in terms of durable cartilage regeneration in osteoarthritis, setting the foundation for

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18.01.2019
23:11 Gizmag Lab-grown human blood vessels promise breakthroughs in the fight against diabetes


Stem cell researchers at the University of British Columbia (UBC) have successfully managed to grow human blood vessels in the lab. The finding could mark a giant leap forward in the fight against vascular diseases such as Alzheimer's, cancer, and diabetes by allowing risk-free experimentation on live human tissue.
.. Continue Reading Lab-grown human blood vessels promise breakthroughs in the fight against diabetes Category: Science Tags: blood vessel Diabetes Stem Cells University of British Columbia

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17:28 ScienceDaily.comGene therapy promotes nerve regeneration

Researchers have shown that treatment using gene therapy leads to a faster recovery after nerve damage. By combining a surgical repair procedure with gene therapy, the survival of nerve cells and regeneration of nerve fibers over a long distance was stimulated. The discovery is an important step towards the development of a new treatment for people with nerve damage.

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17.01.2019
00:47 FightAging.OrgAccelerated Bone Regeneration via Transplant of Engineered Perivascular Stem Cells

Reprogramming stem or progenitor cells to adjust their behavior is growing in popularity as an approach to regenerative medicine. The large reductions in the cost of exploring cellular mechanisms achieved over the past twenty years mean that there is now a much greater understanding of relevant mechanisms, as well as a greater capacity to discover novel targets of interest for specific goals in altered cell behavior. The more straightforward outcome in this part of the field is simply to increase stem cell activity, to reduce the amount of time these cells spend quiescent rather than actively supplying tissue with new daughter somatic cells to assist in repair. As today's open access paper illustrates, there are certainly other options on the table, however. Many stem cell […]

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15.01.2019
17:18 InsideEVs.comBest And Worst Electric Cars For Regenerative Braking

Not all EV braking is created equal. When I drive an electric car for the first time, I’m always struck by how different it is from EVs that I previously experienced. More often than not, what separates them is not how they accelerate or handle – but how they brake. In the last couple of […]

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16:00 SeekingAlpha.comArray Bio up 11% premarket on positive late-stage data on triplet therapy for certain type of colorectal cancer

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11.01.2019
16:48 GlobalConstructionReview.comMajor Merseyside regeneration scheme to have hundreds of modular homes from Urban Splash

UK developer Peel Land and Property (Peel L&P) has contracted Urban Splash to erect 347 ...

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07.01.2019
18:03 SingularityHub.Com3D Printed Heads Can Unlock Phones. What Does that Mean for Biometric Security?

Facial recognition technology is likely not as safe as you may have thought. This was illustrated by a recent test where 3D printed busts of peoples’ heads were used to unlock smartphones. Out of five tested phones, only one refused to open when presented with the fake head. Other biometric security measures are also showing […]

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06.01.2019
19:05 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Appraising iPSC Clinical Translation, Reviewing Periodontal Regeneration, Knee Osteoarthritis MSC Trial, and Changing mESC Bioenergetics!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Reviewing the Clinical Translation of Induced Pluripotent Stem Cells

A new review article out of the laboratory of Nico Lachmann (Hannover Medical School, Germany) provides a brief overview of the recent developments and challenges faced during the progression of induced pluripotent stem cell (iPSC)-derived blood cells to clinical translation. While examples of the clinical transfer of iPSC‐derived hematopoietic cells remain few, this great new article from Haake et al. describes the advances made in hematopoietic

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03:42 Yahoo.com BusinessWhat Type Of Shareholder Owns Rhythm Biosciences Limited’s (ASX:RHY)?

The big shareholder groups in Rhythm Biosciences Limited (ASX:RHY) have power over the company. Insiders often own a large chunk of younger, smaller, companies while huge companies tend to have Read More...

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04.01.2019
18:12 FierceBiotech.comA vaccine for Type 1 diabetes? Provention Bio says a human trial is in sight

Type 1 diabetes is caused by genetic susceptibility and environmental factors, researchers believe. Startup Provention Bio is trying to reduce the environmental risk by way of a vaccine scientists believe can prevent up to 50% of new Type 1 diabetes cases.

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01.01.2019
20:04 Teslarati.comFirst living tissue 3D printed in space aboard International Space Station

Using the “Organaut”, a 3D bioprinter designed for microgravity, Russia has become the first country to print living tissue in space. After a December 3rd cargo delivery to the International Space Station (ISS), cosmonaut Oleg Kononenko completed an experiment with the machine in the Russian sector of the station, successfully producing human cartilage tissue and […]
The post First living tissue 3D printed in space aboard International Space Station appeared first on TESLARATI.com.

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31.12.2018
12:41 StemCellsPortal.comlMacrophages: The Missing Ingredient of Functional 3D Tissue-engineered Muscle Constructs?

Review of “Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration” from Nature Biomedical Engineering by Stuart P. Atkinson 

Muscle satellite cells (MuSCs) activate in response to damage and asymmetrically divide to both self-renew and generate proliferative myogenic precursor cells that promote skeletal muscle regeneration [1]. However, in cases such as severe muscle loss or chronic degenerative diseases, insufficiencies in the natural regeneration process have prompted the development of three-dimensional (3D) tissue-engineered muscle constructs as an alternative treatment strategy.

Researchers from the laboratory of Nenad Bursac (Duke University, Durham, NC, USA) aimed to develop advanced 3D tissue-engineered muscle constructs by not only considering the physical interactions between the MuSCs, myofibers, and

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28.12.2018
08:26 News-Medical.NetStudy explains effects of aging on endothelial health and vascular regenerative capacity

The endothelium plays an important role in cardiovascular regulation, from blood flow to platelet aggregation, immune cell infiltration and demargination.

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00:45 DigitalTrends.comScientists create a way to make more breathable 3D-printed tissues

A team of researchers at Pennsylvania State University found a new way to 3D print lab-made porous tissues, such as bone and cartilage. Here's what makes their advance so exciting.
The post Scientists create a way to make more breathable 3D-printed tissues appeared first on Digital Trends.

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24.12.2018
20:55 StemCellsPortal.comlCRISPR-activation of SOX2 Promotes Corneal Endothelial Cell-mediated Wound Healing and Regeneration

Review of “SOX2 Activation Using CRISPR/dCas9 Promotes Wound Healing in Corneal Endothelial Cells” from STEM CELLS by Stuart P. Atkinson

Other than corneal transplants [1], there currently exist no effective treatments for corneal endothelial dysfunction/disease [2]. While corneal endothelial cells (CECs) may seem to represent an obvious choice for the development of novel regenerative therapies, they do not proliferate in vivo even when in an injured state [3]. As wounded CECs express the pluripotency- and eye development-associated SOX2 transcription factor [4], researchers from the laboratory of Young Joo Shin (Hallym University, Seoul, Korea) sought to harness the power of CRISPR-activation technology [5, 6] to promote the overexpression of SOX2 in CECs in the hope of enhancing wound healing of the corneal

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20:44 StemCellsPortal.comlFirst Isolation of Human Skeletal Stem Cells: The Key to Regenerative Approaches for Skeletal Disorder Treatment?

Review of “Identification of the Human Skeletal Stem Cell” from Cell by Stuart P. Atkinson 

Recent lineage-tracing and clonal analysis studies provided evidence for the existence of a mouse skeletal stem cell (mSSC) that exhibits the exclusive ability to generate bone, cartilage, and bone marrow stroma [1-3]. However, the relative absence of reliable cell-surface markers and related protocols and assays has hampered the discovery of putative human SSCs (hSSCs).

However, researchers from the laboratory of Michael T. Longaker (Stanford Medicine, Stanford, CA, USA) have published a new article in Cell in which they describe the isolation, regenerative activity, and cross-species comparison of a self-renewing hSSC with bone, cartilage, and stroma differentiation potential [4]. Is this new study by Chan et al. the key to regenerative approaches for skeletal disorder

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21.12.2018
10:56 ReutersLab-grown diamond prices slide as De Beers fights back

Since De Beers abandoned its decades-old policy of refusing to sell lab-grown diamonds as jewelery, the price gap between man-made stones and natural gems has widened - and the difference is set to get even bigger.

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20.12.2018
19:55 SeekingAlpha.comMustang Bio's MB-102 an Orphan Drug in U.S. for rare type of blood cancer; shares up 1%

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14:41 FightAging.OrgReviewing GDF11 as a Basis for Regenerative Therapy

I think it fair to say that GDF11 was the first concrete target to emerge from the modern reinvention of parabiosis research, in which the circulatory systems of an old mouse and a young mouse are joined. The old mouse rejuvenates a little, and the young mouse is aged a little, most of which seems to emerge from effects on inflammation and stem cell activity. Researchers thereafter started looking for specific signals carried in the bloodstream that might mediate this effect. There has been no shortage of debate in this part of the field, such as over whether or not it is possible that beneficial factors from young blood can exist, given the evidence. Or whether the early work on GDF11 holds up at all. […]

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19.12.2018
21:45 MedicalNewsToday.comMedical News Today: Multiple sclerosis: Could this be why myelin fails to regenerate?

A study finds a previously unknown mechanism that quietens adult stem cells and could be a disruptor of myelin repair in inflammatory diseases, such as MS.

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08:36 News-Medical.NetFDA supports C-Path's Type 1 Diabetes Consortium to pursue biomarker qualification

Critical Path Institute (C-Path) announced today that its Type 1 Diabetes (T1D) Consortium has received a positive response to its Letter of Intent (LOI) from the U.S. Food and Drug Administration (FDA) detailing the FDA's decision to accept the consortium's Biomarker Initiative project into the Center for Drug Evaluation and Research (CDER) Biomarker Qualification Program (BQP).

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18.12.2018
17:26 Phys.orgSearching for the source of planarians' regenerative powers

Using a technique that involves analyzing thousands of single cells, scientists have figured out a new way to capture a stem cell that underlies flatworm regeneration.

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13:06 CleanTechnica.comRegenerative Cities: An Urban Concept Whose Time Has Come!

The regenerative city vision needs to be driven by strong political leadership capable of setting ambitious yet realistic goals, able to gather momentum across society and mobilize different stakeholders towards such a common vision

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17.12.2018
11:37 StemCellsPortal.comlComparing the Regenerative Potential of SVF and MFAT - Which Adipose Tissue Preparation Comes out Top?

Review of “Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

A recent STEM CELLS Translational Medicine article established the safety, feasibility, and potential effectiveness of single intra‐articular injections of micro‐fragmented adipose tissue (MFAT) [1, 2] as a treatment strategy for osteoarthritis when tested in a canine model [3]. As opposed to the enzymatic dissociation of adipose tissue followed by removal of adipocytes and collection of the remaining stromal vascular fraction (SVF) for regenerative applications, MFAT employs mechanical dissociation of adipose tissue to generate blood- and free lipid-free submillimeter cell clusters that have

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16.12.2018
12:59 Financial TimesFinancial pressures haunt Battersea regeneration

Malaysian owners’ refinancing arrangement delayed for third time as costs climb

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15.12.2018
07:44 News-Medical.NetA new type of 'painless' adhesive for biomedical applications

Pulling off a Band-Aid may soon get a lot less painful. Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences and Xi'an Jiaotong University in China have developed a new type of adhesive that can strongly adhere wet materials -- such as hydrogel and living tissue -- and be easily detached with a specific frequency of light.

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14.12.2018
23:15 Geek.comFirst Lab-Grown Steak Gives Foodies a Taste of the Future

Arby’s doesn’t have “the meats” anymore: A startup just unveiled its new lab-grown steak, which it claims is the world’s first ever cell-grown beef product. On Wednesday, Aleph Farms announced that it developed […]
The post First Lab-Grown Steak Gives Foodies a Taste of the Future appeared first on Geek.com.

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11:41 Technology.orgResearchers use zinc to target insulin-producing cells with regenerative drug

An insulin injection can manage diabetes symptoms, but actually curing the disease would mean healing cells in the

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04:11 Nanowerk.comInexpensive 3-D-printed microfluidics device quickly tests drugs on tumor tissue

Re searchers have 3-D printed a novel microfluidic device that simulates cancer treatments on biopsied tumor tissue - and keeps the tissue alive for days - so clinicians can better examine how individual patients will respond to different therapeutics.

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13.12.2018
23:40 DigitalTrends.comThere’s a new lab-grown meat startup on the block — and it has a secret weapon

Aleph Farms is developing lab-grown steaks with the same flavor, shape, texture, and structure as the real thing using beef cells isolated from living cows. Coming soon to a store near you?
The post There’s a new lab-grown meat startup on the block — and it has a secret weapon appeared first on Digital Trends.

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15:56 Phys.orgScientists develop a cellulose biosensor material for advanced tissue engineering

I.M. Sechenov of First Moscow State Medical University teamed up with Irish colleagues to develop a new imaging approach for tissue engineering. The team produced hybrid biosensor scaffold materials based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. These materials enable visualization of the metabolism and other important biomarkers in engineered artificial tissues by microscopy. The results of the work were published in the Acta Biomaterialia journal.

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14:31 FightAging.OrgMacrophages Could Improve Heart Regeneration, but Arrive Too Late Following Injury

Macrophages of the innate immune system play an important role in coordinating the intricate dance of cell populations that takes place during regeneration from injury. Differences in macrophage behavior may be key to the exceptional regenerative capacities of species such as salamanders that can regrow entire organs, and possibly also in the few mammalian species and genetically altered lineages capable of noteworthy feats of regeneration. Researchers here make a most interesting discovery, finding that in mice there are populations of macrophages capable of coordinating greater than normal regeneration following injury to the heart, such as that resulting from a heart attack. This regeneration doesn't take place because the macrophages arrive too late to prevent the formation of scar tissue; regeneration is already well advanced by […]

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08:15 News-Medical.NetResearch identifies new therapeutic target for cancer treatment and tissue regeneration

Research led by the University of Plymouth and Technische Universität Dresden has identified a new therapeutic target for cancer treatment and tissue regeneration - a protein called Prominin-1.

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03:16 Gizmag Aleph Farms serves up world's first lab-grown steak


Israel-based startup Aleph Farms has just unveiled the world's first lab-grown steak. This milestone on the road to bringing a cruelty-free meat product to the market demonstrates, for the first time, the technology's ability to imitate the flavor, shape, texture and structure of a classic beef steak.
.. Continue Reading Aleph Farms serves up world's first lab-grown steak Category: Environment Tags: Clean meat Food Food technology Lab grown meat

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12.12.2018
14:24 FightAging.OrgCan Peripheral Nervous System Regenerative Mechanisms be Introduced into the Central Nervous System?

The nervous system in general is not particularly regenerative, but peripheral nervous system tissue is more capable of repair than central nervous system tissue. Focusing on neurons that link these two parts of the nervous system, researchers here report on mechanisms involved in repair of nervous system cells, and propose that it might be possible to make central nervous system cells act more like peripheral nervous system cells in this regard. Whether or not this can be achieved safely is another question, however; this is very early stage work, too early to answer many questions about safety and plausibility. Neurons in the central nervous system - the brain and spinal cord - and the peripheral nervous system are very similar except in their ability to […]

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11.12.2018
12:14 News-Medical.NetNew review focuses on electrospinning techniques used in musculoskeletal tissue engineering

The rotator cuff is a group of four muscles and tendons that stabilizes the shoulder joint. It also helps in the motion of the shoulder. Rotator cuff tear is the most common condition involving ailing shoulders. It happens due to normal muscle tissue wear and tear by repeating the same motion again and again, without resting the muscles.

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10:23 News-Medical.NetCartilage tissue engineering brings good news for patients with cartilage defects

Chondral defect is a kind of defect which refers to focal area damage to the articular cartilage. This defect also damages the bone which is lying underneath the cartilage.

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10.12.2018
17:09 StemCellsPortal.comlResearchers Evaluate pMSCs Sheets for Engineered Repair and Regeneration of Heart Tissue

BOSTON, MA (US), December 2018 — The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds.
Congenital heart disease is the leading cause of birth-defect-related illness and death. The placenta can be readily collected at birth and the cells harvested for pediatric reparative procedures, as described in the study published recently in Tissue Engineering, Part A.
Sitaram Emani, M.D., Breanna Piekarski, R.N., and Sirisha Emani, Children's Hospital, Boston, and Erin Roberts, Kevin Huang and Joyce Wong, Ph.D., Boston University, participated in the study. They evaluated MSCs independent of their source, demonstrated

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08:02 News-Medical.NetStudy evaluates placental mesenchymal stem cell sheets for myocardial repair and regeneration

The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. Congenital heart disease is the leading cause of birth-defect-related illness and death.

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04:11 BBC HealthBionic 3D-printed arm 'gives confidence' to young amputees

Open Bionics has developed the world's first medically-certified 3D-printed artificial arm

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07.12.2018
21:37 ScienceDaily.com3D-printed glucose biosensors

A 3D-printed glucose biosensor for use in wearable monitors has been created. The work could lead to improved glucose monitors for millions of people who suffer from diabetes.

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17:55 FierceBiotech.comRegenerating insulin-producing cells with zinc could tackle the underlying cause of diabetes

The ability to regenerate insulin-producing cells in the pancreas would do the job, but that has so far proven to be an elusive target. A team of Stanford University scientists is now searching for a solution in a common nutrient: zinc.

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14:31 FightAging.OrgA Macrophage-Derived Factor from Young Mice Speeds Bone Regeneration in Older Mice

The innate immune cells called macrophages are known to be important coordinators of regeneration, in addition to their role in protecting tissues from invading pathogens. In recent years, researchers have investigated the altered behavior of macrophages with aging, and linked this to a range of age-related conditions. In older individuals, macrophages are more likely to be inflammatory and aggressive rather than acting to assist tissue regeneration, and the consequence is a much reduced capacity for tissue maintenance. If the methods by which macrophages act to induce greater regenerative activity on the part of other cell populations can be deciphered, boiled down to a set of signal molecules, then this may open the door to the development of comparatively straightforward therapies that incrementally enhance healing and […]

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06.12.2018
19:01 Phys.orgResearchers use zinc to target insulin-producing cells with regenerative drug

An insulin injection can manage diabetes symptoms, but actually curing the disease would mean healing cells in the pancreas that produce insulin, a hormone that regulates the amount of sugar in blood.

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05.12.2018
17:10 Phys.orgStudy describes the dynamics of chromatin during organ and tissue regeneration

Researchers from the Department of Genetics, Microbiology and Statistics and the Institute of Biomedicine of the University of Barcelona (UB), in collaboration with the Centre for Genomic Regulation (CRG), have described the genes and regulatory elements of gene expression that are required during the process of tissue and organ regeneration. The study, published in Genome Research, combines classic genetic analysis with new study techniques for chromatin through next-generation sequencing.

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14:15 FightAging.OrgCellular Senescence Contributes to Impaired Heart Regeneration

This paper is a preprint, meaning it hasn't gone through peer review yet, so apply the appropriate multiple to its chances of containing significant errors. The authors outline evidence for the age-related accumulation of senescent cells to impair heart regeneration. I'd have to say that this is an expected outcome of cellular senescence, given what is presently known of senescent cells, and in particular the ways in which their potent mix of inflammatory signaling disrupts normal tissue function. Of course the scientific community still has to provide satisfactory proof for that to be the case for the heart specifically, and join the dots between the underlying mechanisms. Since a number of senolytic therapies exist, treatments capable of selectively removing 25-50% of senescent cells from various […]

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10:17 News-Medical.NetScientists support original theory about pancreas regeneration

A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

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04.12.2018
19:14 ScienceDaily.comDynamics of chromatin during organ and tissue regeneration

The researchers, who conducted the analysis with Drosphila melanogaster, discovered a group of genes involved in regeneration and which are kept in different species.

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14:31 FightAging.OrgManipulating Energy Generation in Kidney Cells Can Enhance Regeneration

There are multiple distinct mechanisms by which cells can generate the energy needed for operations. Since everything is connected to everything else inside a cell, these various mechanisms are also tied in to the regulation of cell behavior, such as whether or not cells are actively assisting in tissue regeneration. Thus ways to change the balance of energy generation in cells might be a viable path towards enhanced regeneration for damaged organs. Researchers here provide evidence for this approach to be useful in the kidney, at least in mice. Researchers have discovered a pathway for enhancing the self-repair efforts of injured kidneys. This involves reprogramming the body's own metabolism in order to save damaged kidneys. Normally, a process called glycolysis converts glucose from food into […]

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03.12.2018
13:06 Technology.orgTiny Mexican tetra fish may be holding secrets to successful heart regeneration

Heart disease kills millions every year. It is one of the leading causes of death, because of how

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01.12.2018
02:11 ScienceDaily.comCellular gene signatures for heart muscle regeneration

A research team has used a transcriptomic approach -- studying what genes are expressed -- to identify gene signatures of cell subpopulations identified as atrial-like or ventricular-like. This understanding could lead to regenerative therapy discoveries for the millions of people living with damaged heart muscle caused by heart attacks or other chronic heart conditions.

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30.11.2018
20:26 ScienceDaily.comSwitch for the regeneration of nerve cell insulation

An international research team has discovered a mechanism that regulates the regeneration of the insulating layer of neurites. This insulation coating, also referred to as myelin sheath, is crucial for rapid signal transmission among cells. Damages to the myelin sheath, such as are caused by multiple sclerosis, can considerably inhibit the function of the nervous system.

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29.11.2018
01:04 LiveScience.comLab-Grown Miniplacentas Resemble the Real Thing So Much, They Fooled a Pregnancy Test

Miniature placentas grown in a laboratory behave much like real placentas.

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23.11.2018
08:52 Gizmag Highly adhesive hydrogel sticks to the task of tissue regeneration


Researchers from all corners of medical science are hoping to harness advanced hydrogels to help repair damaged hearts, regrow brain tissues, or quickly shut down bleeding wounds, to name just a few examples. Scientists in Switzerland have now developed a new form of the material they say has unparalleled adhesive properties, a characteristic that could prove particularly useful in trying to repair cartilage and meniscus.
.. Continue Reading Highly adhesive hydrogel sticks to the task of tissue regeneration Category: Medical Tags: EPFL Healing Hydrogels Regenerative Medicine

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00:41 FightAging.OrgDelivering Klotho to Old Mice Partially Reverses Loss of Muscle Regenerative Capacity

Klotho is one of the better known longevity-associated genes. More klotho improves function and slows measures of aging in mice, and there is suggestive evidence for the same to be true to some degree in humans. The effect on life span is likely to be smaller in our comparatively long-lived species, unfortunately. This is true of all of the approaches to slowing aging for which there is data in both mice and humans to directly compare. Changes to the operation of metabolism that influence the pace of aging are subject to a long history of evolutionary pressures that lead to much greater plasticity of lifespan in response to environmental circumstances in short-lived species. Consider seasonal famines for example; a season is a sizable fraction of […]

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00:34 DigitalTrends.comTime for test-tube turkey? Everything you need to know about lab-grown meat

Lab-grown meat is big business. A handful of enterprising startups have raised and invested hundreds of millions of dollars into nascent technology, banking on breakthroughs in biotech to revolutionize the food industry.
The post Time for test-tube turkey? Everything you need to know about lab-grown meat appeared first on Digital Trends.

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21.11.2018
22:50 ScienceMag.orgWatch these tissue-engineered spinal disks mimic the real thing

Goats and rats respond well to implants

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21:28 News-Medical.Net'Longevity protein' restores muscle regeneration after injury in older animals

One of the downsides to getting older is that skeletal muscle loses its ability to heal after injury. New research from the University of Pittsburgh implicates the so-called "longevity protein" Klotho, both as culprit and therapeutic target.

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20.11.2018
10:42 News-Medical.NetScientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord.

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19.11.2018
20:13 StemCellsPortal.comlRogue Cells Found Lurking in lab-grown Kidney Organoids

ST. LOUIS, MO (US), November 2018 — Scientists hoping to develop better treatments for kidney disease have turned their attention to growing clusters of kidney cells in the lab. One day, so-called organoids – grown from human stem cells – may help repair damaged kidneys in people or be used to test drugs developed to fight kidney disease.
But new research from Washington University School of Medicine in St. Louis has identified rogue cells – namely brain and muscle cells – lurking within kidney organoids. Such cells make up only 10 to 20 percent of an organoid’s cells, the scientists found, but their presence indicates that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types.
While at first glance the discovery might be viewed as a setback for using kidney organoids as stand-ins for human kidneys, there’s still promise. The

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11:08 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Immunomodulatory MSCs, MSC Single-Cell Transcriptomics, OSC-mediated Facial Nerve Regeneration, and Islet Transplant in T1D!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Immunomodulatory Mesenchymal Stem Cells in Humanized Mice

Contradictory clinical trial data and our incomplete grasp of immunosuppressive mechanisms represent significant obstacles in the widespread therapeutic application of human mesenchymal stem cells (MSCs). Now, a review article from the lab of Vera J. Mehler (NIBSC, South Mimms, UK) discusses humanized mice as a tool to develop a better comprehension of the mode of action of MSCs in mitigating the immune response in an in-vivo environment that closely resembles

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16.11.2018
15:39 LiveScience.comLab-Grown Mini Kidneys 'Go Rouge,' Sprout Brain and Muscle Cells

Miniature kidneys produced in the lab were hiding something from the researchers that grew them.

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15.11.2018
21:57 Nature.ComLab-grown ‘mini brains’ produce electrical patterns that resemble those of premature babies

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18:00 News-Medical.NetNicoya designate the Institute for Stem Cell Biology and Regenerative Medicine as the OpenSPR Centre of Excellence

Currently in India, there are over 200,000 researchers working on numerous applications to better understand diseases and advance drug discovery. To support their discoveries, we are thrilled to announce the opening of the OpenSPR Centre of Excellence in Bangalore, India!

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03:36 Teslarati.comBio-tech firm develops 3D printed replacement cornea for human eyes

After successfully transplanting the first 3D-printed cornea in an animal, North Carolina company Precise Bio has recently announced the launch of a dedicated business for creating marketable, 3D-printed products for human eyes. Founded by scientists from the Wake Forest Institute of Regenerative Medicine, this company is developing bio-fabrication printers that can restore cells, tissues, and […]
The post Bio-tech firm develops 3D printed replacement cornea for human eyes appeared first on TESLARATI.com.

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13.11.2018
19:19 Nanowerk.comA step closer to 'design on demand' scaffolds for tissue regeneration

New research on cross-linked polymer interactions' impact on gel structure could improve tailoring of implantable scaffolds to regrow tissue.

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12.11.2018
23:17 DigitalTrends.comThis lab-grown heart tissue beats just like the real thing

A team of researchers in Germany have used stem cells to create a lab-grown human heart tissue which actually beats, as well as responding to drugs in the same way as the real thing.
The post This lab-grown heart tissue beats just like the real thing appeared first on Digital Trends.

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20:41 Phys.orgA step closer to 'design on demand' scaffolds for tissue regeneration

The structure of cross-linked polymeric gels is very similar to soft tissue—which is one reason that understanding this material is so critical, according to Kelly Schultz, assistant professor in the Department of Chemical and Biomolecular Engineering at Lehigh University.

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07.11.2018
20:41 News-Medical.NetRegenerative medicine scientist receives $1.3 million to study stem cell therapy for liver failure

Currently, the only therapy for metabolic liver disease is an organ transplant. Tracy Grikscheit, MD, an attending physician and regenerative medicine scientist at Children's Hospital Los Angeles, hopes to change that reality.

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16:34 Nanowerk.com3D-printed bionic mushrooms fuse nanotech, bacteria and fungi

Researchers take an ordinary white button mushroom and supercharge it with clusters of tightly-packed cyanobacteria and swirls of graphene nanoribbons to make electricity.

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01:54 ScienceDaily.comBioreactor device helps frogs regenerate their legs

Scientists havedesigned a device that can induce partial hindlimb regeneration in adult aquatic African clawed frogs (Xenopus laevis) by 'kick-starting' tissue repair at the amputation site. Their findings introduce a new model for testing 'electroceuticals,' or cell-stimulating therapies.

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06.11.2018
20:25 ScienceDaily.comRegeneration in the digestive tract

The human gut is teeming with billions of beneficial bacteria. Therapies that use antibiotics often destroy most of them. Whether and how the intestinal flora will subsequently recover has been investigated by a research team.

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19:08 SingularityHub.ComCustom-Grown Bones and Other Wild (But Real) Advances in Regenerative Medicine

The human body has always been an incredible machine, from the grand feats of strength and athleticism it can accomplish down to the fine details of each vein, nerve, and cell. But the way we think about the body has changed over time, as has our level of understanding of it. In Nina Tandon’s view, […]

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19:01 Phys.orgBioreactor device helps frogs regenerate their legs

A team of scientists designed a device that can induce partial hindlimb regeneration in adult aquatic African clawed frogs (Xenopus laevis) by "kick-starting" tissue repair at the amputation site. Their findings, appearing November 6 in the journal Cell Reports, introduce a new model for testing "electroceuticals," or cell-stimulating therapies.

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02.11.2018
19:45 Phys.orgRegeneration may cause isolation for older people, study finds

A study by an academic from The University of Manchester has found that urban regeneration in poor neighbourhoods can actually backfire, and lead to older people feeling isolated.

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01.11.2018
18:07 Phys.orgLaser-activated silk sealants outperform sutures for tissue repair

NIBIB funded researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection.

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08:05 News-Medical.NetResearchers discover biomarker for most common type of heart failure

A team led by a Cedars-Sinai physician-scientist has discovered a biomarker--a protein found in the blood--for the most common type of heart failure, a new study published today in JAMA Cardiology shows.

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31.10.2018
21:10 Nature.ComTDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

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20:19 Phys.orgSalvage logging, planting not necessary to regenerate Douglas firs after Klamath fires

Researchers at Portland State University and Oregon State University looking at the aftermath of wildfires in southwestern Oregon and northern California found that after 20 years, even in severely burned areas, Douglas fir grew back on its own without the need for salvage logging and replanting.

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19:00 Technology.orgLooking for promising silvicultural treatments to regenerate boreal forests

Clearcutting is the dominant harvesting method in boreal forests of North America and Scandinavia, but today there is

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18:51 StemCellsPortal.coml"Cellular Dust" Provides New Hope for Regenerative Medicine

PARIS, (FR), October 2018 — While stem cells have the most therapeutic potential, the benefits of regenerative medicine may best be mobilized using extracellular vesicles (EVs. A team of researchers from CNRS, AP-HP, INSERM and Paris Descartes and Paris Diderot Universities have tested these vesicles for the first time in a porcine model for the treatment of post-operative digestive fistulas. Their results, which yielded a 100 percent success rate, open the door to testing in humans and broader possibilities for applications.
Extracellular vesicles are matter that is released by cells. Seen for many years as not having any value, this “cellular dust” has been studied and presents therapeutic properties similar to their mother cells, without their disadvantages. They do not divide, limiting the risk of cancer, and do not differentiate, thus preventing the development of poor function.

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17:32 Nanowerk.comLaser-activated silk nanosealants outperform sutures for tissue repair

Researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection.

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08:49 News-Medical.NetFirst shared Swiss platform to promote regenerative medicine launched in Bern

Regenerative Medicine is one of the fastest growing sectors in biomedical research – replacing diseased cells, tissues or organs.

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30.10.2018
21:57 StemCellsPortal.comlHelping Blood Cells Regenerate After Radiation Therapy

CAMBRIDGE, MA (US), October 2018 — Patients with blood cancers such as leukemia and lymphoma are often treated by irradiating their bone marrow to destroy the diseased cells. After the treatment, patients are vulnerable to infection and fatigue until new blood cells grow back. MIT researchers have now devised a way to help blood cells regenerate faster. Their method involves stimulating a particular type of stem cell to secrete growth factors that help precursor cells differentiate into mature blood cells.
Using a technique known as mechanopriming, the researchers grew mesenchymal stem cells (MSCs) on a surface whose mechanical properties are very similar to that of bone marrow. This induced the cells to produce special factors that help hematopoietic stem and progenitor cells (HSPCs) differentiate into red and white blood cells, as well as platelets and other blood cells.
“You can

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21:57 StemCellsPortal.comlSkeletal Stem Cells Regress when Tasked with Extensive Regeneration

STANFORD, CA (US), October 2018 — Adult mouse skeletal stem cells in the jaw revert to a more developmentally flexible state when called upon to regenerate large portions of bone and tissue, according to a study by researchers at the Stanford University School of Medicine. 
The finding is the first to show that mammalian adult stem cells can march backward along the developmental timeline in a process called de-differentiation to become more primitive in response to environmental signals. In particular, the cells appeared to regress to a cell type that normally occurs within weeks of conception in humans and that give rise to the bones, cartilage and connective tissue of the head and face. 
The results suggest the possibility of using naturally occurring adult stem cells, which are usually restricted to generate only a limited panel of closely related progeny, to carry out

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29.10.2018
17:30 SeekingAlpha.comFDA clears Bio-Rad semi-automated blood typing instrument

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16:02 StemCellsPortal.comlHelping Blood Cells Regenerate After Radiation Therapy

CAMBRIDGE, MA (US), October 2018 — Patients with blood cancers such as leukemia and lymphoma are often treated by irradiating their bone marrow to destroy the diseased cells. After the treatment, patients are vulnerable to infection and fatigue until new blood cells grow back. MIT researchers have now devised a way to help blood cells regenerate faster. Their method involves stimulating a particular type of stem cell to secrete growth factors that help precursor cells differentiate into mature blood cells.
Using a technique known as mechanopriming, the researchers grew mesenchymal stem cells (MSCs) on a surface whose mechanical properties are very similar to that of bone marrow. This induced the cells to produce special factors that help hematopoietic stem and progenitor cells (HSPCs) differentiate into red and white blood cells, as well as platelets and other blood cells.
“You can

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