Researchers have developed a new way to grow mineralized materials which could regenerate hard tissues such as dental enamel and bone.

UC San Francisco scientists used a process called synNotch signaling to create tissue structures from individual cells, in the hopes that the technology will eventually allow the generation of complex tissues and organs inside the body.

Avoiding dental caries typically begins with preventing the erosion of tooth enamel. Unfortunately, unlike other tissues of the body, enamel cannot regenerate once it is lost, which can lead to pain and tooth loss. These problems affect more than 50 percent of the world's population, and so finding ways to recreate enamel has long been a major need in dentistry. Now, investigators at Queen Mary University of London have developed a new way to grow mineralized materials which could regenerate hard tissues such as dental enamel and bone.        Findings from the new study were published today in Nature Communications through an article entitled “ Protein disorder-order interplay to guide the growth of hierarchical mineralized structures .” Discussing the new study, lead investigator Sherif Elsharkawy, Ph.D., a dentist, and researcher at Queen Mary's School of

Researchers at Queen Mary University of London have developed a new way to grow mineralized materials which could regenerate hard tissues such as dental enamel and bone.

Researchers have developed a new way to grow mineralised materials which could regenerate hard tissues such as dental enamel and bone.

Researchers at Queen Mary University of London have developed a new way to grow mineralised materials which could regenerate hard tissues such as dental enamel and bone.

They said they'd never do it, but De Beers has started selling lab-grown diamonds through a subsidiary called Lightbox Jewelry. And it's hilarious to watch how they're both selling and disparaging this new, far cheaper product line.
.. Continue Reading De Beers relents and starts shilling "not special, not real, not unique" lab-grown diamonds Category: Wearables Tags: Diamonds Related Articles: "Earrings from the Gods" fetch world record $56.3 million Diamond ring sold online for $412K The Icelink Snow 6 Timezone Watch Diamonds may be a titanium implant's best friend Strange space diamonds come from a large, long-lost planet Intense x-ray laser creates "diamond rain" in the lab

When it comes to building robots, why start from scratch when nature has already designed better materials and parts than our artificial ones? Japanese researchers have now developed a new way to integrate living muscle tissue onto a robotic skeleton, and make it move in a realistic way that takes some of the strain off.
.. Continue Reading Lab-grown living muscles help robots lift a finger Category: Robotics Tags: Cells Muscle Robotics University of Tokyo Related Articles: Cheap artificial muscles give soft robots lifting power Building a real-life Baymax 3D-printable synthetic muscle is three times stronger than you Shape-memory wire simulates muscle in high-precision artificial hand Working human muscle tissue grown from skin-derived stem cells Hydraulic muscle makes for tougher, stronger disaster-site robots

Wildfires are natural and even beneficial. We are not talking about huge forest fires ignited by some people

Scientists grafted human stem cells onto chicken embryos, but that doesn't mean the researchers are breeding "frankenfowl."

Environment It’ll be more efficient than the real thing, but that’s not saying much.
It’ll be more efficient than the real thing, but that’s not saying much. Here’s how lab-grown meat actually compares to available alternatives…

Engineers built a 3D printer that offers a sweet solution to making detailed structures that commercial 3D printers can't: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges. The water-soluble, biodegradable glassy sugar structures have multiple applications in biomedical engineering, cancer research and device manufacturing.

Origami - the Japanese art of folding paper into shapes and figures - dates back to the sixth century. At UMass Lowell, it is inspiring researchers as they develop a 21st-century solution to the shortage of tissue and organ donors.

Origami—the Japanese art of folding paper into shapes and figures—dates back to the sixth century. At UMass Lowell, it is inspiring researchers as they develop a 21st century solution to the shortage of tissue and organ donors.

Engineers built a 3-D printer that offers a sweet solution to making detailed structures that commercial 3-D printers can't: Rather than a layer-upon-layer solid shell, it produces a delicate network of thin ribbons of hardened isomalt, the type of sugar alcohol used to make throat lozenges.

University of Illinois engineers built a 3-D printer that offers a sweet solution to making detailed structures that

In a move that could one day lead to artificial transplant organs and sophisticated regenerative therapies, a UCLA team led by bioengineer Ali Khademhosseini has developed a new technique for printing complex bio-tissues using multiple materials. Using a specially modified 3D printer, it promises to one day create complex therapeutic biomaterials on demand.
.. Continue Reading Breakthrough 3D bio-printer puts artificial tissue on the table Category: 3D Printing Tags: 3D bioprinting UCLA Related Articles: 3D printing heart parts at 30,000 feet 3D printing of living tissues is easier and cheaper with BioBots L'Oréal plans to start testing cosmetics on 3D-printed skin 3D-printed ear, bone and muscle structures come to life after implantation in mice BioP3 technology could be an alternative to bioprinting organs Artificial blood vessels breath new life into root canal-treated teeth

Bioengineers have developed a technique that uses a specially adapted 3D printer to build therapeutic biomaterials from multiple materials. The advance could be a step toward on-demand printing of complex artificial tissues for use in transplants and other surgeries.

Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command —  simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.
The method, described in the May 18 issue of Science Advances, could be used for a number of research and clinical applications, including testing therapeutic drugs in more biologically relevant systems, developing use-specific drugs that are more precise and have fewer systemic effects and creating better medical devices, such as light-controlled pacemakers.
"When we first got this working in our lab, suddenly we had something

Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that

Missouri has become the first US state to officially pass a bill defining what products can and can't be classified as "meat." The legislation prohibits plant-based products from using the term and also removes the possibility of lab-grown meat hitting the market shelves in the future with the "meat" moniker.
.. Continue Reading Lab-grown meat not meat according to state of Missouri Category: Science Tags: Agriculture Biotechnology Food Food technology Related Articles: Big beef looms over definition of lab-grown meat Heat and light controlling smart window tech gets less-expensive, more flexible Meatless burger uses bloody special ingredient to replicate the real thing Cell to table: Device will let you start with plant cells, end with food Would you eat dog meat grown in a lab? Students create Frankenstein's monster of bacteria to detect toxic chemicals

Researchers have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command -- simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.

Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command—simply by shining a light on them and varying its intensity. The cells are grown on a material called graphene, which converts light into electricity, providing a more realistic environment than standard plastic or glass laboratory dishes.

Rutgers University-New Brunswick engineers have created a 3D-printed smart gel that walks underwater and grabs objects and moves them.

At a time when countries are pledging to restore millions of hectares of forest, new research argues that recent studies on forest regeneration techniques are flawed. Sites used to evaluate natural regeneration were secondary growth forests, whereas sites chosen to evaluate artificial regeneration ranged from abandoned coal mines to cattle-trampled fields. Authors of the new study suggest elements of both techniques should be considered, depending on the objectives for a site and its current state.

The U.S. Food and Drug Administration today approved Retacrit (epoetin alfa-epbx) as a biosimilar to Epogen/Procrit (epoetin alfa) for the treatment of anemia caused by chronic kidney disease, chemotherapy, or use of zidovudine in patients with HIV infection.

TUESDAY, May 15, 2018 -- Retacrit (epoetin alfa-epbx) has been approved by the U.S. Food and Drug Administration as the first "biosimilar" to the anemia drugs Epogen and Procrit. A biosimilar, derived from a living organism, has been proven to be...

TUESDAY, May 15, 2018 -- Retacrit (epoetin alfa-epbx) has been approved by the U.S. Food and Drug Administration as the first "biosimilar" to the anemia drugs Epogen and Procrit. A biosimilar, derived from a living organism, has been proven to be...

OnLume, a spinoff from the University of Wisconsin–Madison, is continuing to develop its system for identifying tissue types

Device could help advance regenerative medicine A UCLA bioengineer has developed a technique that uses a specially adapted

Review of “Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells” from Stem Cell Reports by Stuart P. Atkinson

Long-term calorie restriction (CR) represents an effective means of prolonging healthy lifespan in many different species and may function by preserving tissue-resident stem and progenitor cell function. While long-term CR is “unappetizing” for many, studies in young and healthy animals have established that shorter-term CR enhances recovery from injuries to tissues such as the intestine [1, 2]. However, the specific stem cell-types involved in CR-promoted intestinal regeneration remained unidentified until the publication of a new Stem Cell Reports study by researchers from the laboratory of Christopher J. Lengner (University of Pennsylvania, Philadelphia, PA, USA) [3]. 

House appropriations bill suggests that USDA oversee products of “cellular agriculture”

Stem cell scientists are to join forces with doctors to investigate methods of promoting tissue repair in the liver, lungs and joints.

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

PS Audio is aiming directly for the audiophile set with its new DirectStream Power Plant power regenerators, which massage your A/C current for the cleanest, distortion-free audio possible.
The post PS Audio’s new regenerators clean up your A/C power for audio perfection appeared first on Digital Trends.

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As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine.
This age-related loss of stem cell function can be reversed by a 24-hour fast, according to a new study from Massachusetts Institute of Technology (MIT) biologists. The researchers found that fasting dramatically improves stem cells’ ability to regenerate, in both aged and young mice.
In fasting mice, cells begin breaking down fatty acids instead of glucose, a change that stimulates the stem cells to become more regenerative. The researchers found that they could also boost regeneration with a molecule that activates the same metabolic switch.
Such an intervention could potentially help older people

Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice.

Researchers here outline a method of pushing stem cells in several different tissues into greater activity, thereby accelerating regeneration from injury and potentially improving ongoing tissue maintenance. Given a few more decades of development, regenerative medicine will probably bear little resemblance to today's approaches of cell transplantation, and will instead rely upon a combination of (a) delivering signal molecules or otherwise controlling cell behavior, and (b) repairing damage that accumulates in important cell populations, such as stem cells. If stem cells are kept in a well maintained state, and can be directed to perform as needed, then a major component of the progression of aging will be eliminated. This is, of course, a very large project. There are hundreds of types of cell in the […]

Arguably the most reliable of first generation stem cell therapies is the transplantation of mesenchymal stem cells. The cells don't last long in the recipient, which is a problem characteristic of all such cell therapies, but the signals they secrete while still alive act to change native cell behavior and suppress inflammation for an extended period of time. Since chronic inflammation degrades tissue maintenance and regeneration, this respite can allow some degree of healing that wouldn't have otherwise occurred - though that benefit is much less reliable than the initial suppression of inflammation. In the study reported here, researchers turn this set of mechanisms towards regeneration from spinal injury, demonstrating improvements in rats. This is still a long way from comprehensive repair, and much of […]

New research published in The Journal of Physiology has indicated a potential new stem cell treatment following a heart attack, by encouraging the regeneration of heart muscle cells. The low retention and survival rate of stem cells implanted in the heart had previously proven a sticking point for stem cell therapy following a heart attack.

Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. The scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human organ tissues from a person's own cells for regenerative therapy, say study investigators.

Very shortly after birth, mammals are capable of far greater feats of regeneration than is the case for older individuals. The research community has put a fair amount of effort into determining why this is the case, though far less progress has been made here than in investigations of the biochemistry of highly regenerative species such as salamanders and zebrafish. This popular science article captures some of the present state of knowledge and uncertainty. Near future advances in medicine arising from this line of research seem unlikely at the present time, as by the look of it there is further to go yet in building a foundation of understanding sufficient to start talking about therapies. Newborn mice are able to repair damaged heart tissue better […]

Age-related declines in stem cell function can be reversed by a 24-hour fast, according to a new study. Biologists found fasting dramatically improves stem cells' ability to regenerate, in both aged and young mice.

A new comparative study showed the advantages of using donor decellularized muscle to promote functional tissue regeneration at the site of bulk skeletal muscle loss due to trauma or surgery.

Today I'll point out a demonstration of one of the many ways in which calorie restriction and fasting improve matters in our biology, in this case via improved stem cell function. As always it is worth bearing in mind that while forms of calorie restriction produce useful short term and long term healthy benefits in humans, they don't have anywhere near the same size of effect on life span as occurs in short-lived species such as mice. We didn't evolve to react as strongly to famines, as famines are typically a much shorter fraction of our life span in comparison to that of a mouse. Stem cell populations, of different types for each variety of tissue in the body, support surrounding tissue by providing a […]

Researchers at The University of Texas at Arlington have developed a highly elastic biodegradable hydrogel for bio-printing of materials that mimic natural human soft tissues.

After mice fasted for 24 hours, they removed intestinal stem cells and grew them in a culture dish, allowing them to determine whether the cells can give rise to "mini-intestines" known as organoids.

As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are

Property developer Peel has released new images of its redesigned £5bn ($6.8bn) Liverpool Waters scheme, ...

By studying a rare liver disease called Alagille syndrome, scientists from Cincinnati Children's and the University of California San Francisco (UCSF) have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.

Research on ungulates in the limestone forests of northern Guam has yielded surprising results.

Human activity continues to shape environmental systems around the world creating novel ecosystems that are increasingly prevalent in what some scientists call the Anthropocene (the age of humans). The island of Guam is well known as a textbook case for the devastating effects of invasive species on island ecosystems with the extirpation of most of the forest dwelling birds due to brown tree snake predation. The loss of native birds has resulted in a loss of forest seed dispersers. Recent research conducted by lead author Ann Marie Gawel, based on her University of Guam master's thesis, has found an unlikely forest ally, feral pigs.

First generation stem cell therapies largely achieve their results through brief signaling changes, not through any lasting work on the part of the transplanted cells. Those cells in fact die quite rapidly, but the signals they secrete while still alive change the behavior of native cells. This produces benefits such as reduced inflammation or improved regenerative capacity. Given this, why not deliver the signals instead of the cells? It could in principle be an easier, less complex task. Much of cell signaling involves the exchange of extracellular vesicles, tiny membrane-bound packages of molecules. Numerous groups are presently engaged in animal studies of vesicle-based approaches to regenerative therapy, and the one noted here is representative of the type. The adult human heart cannot regenerate itself after […]

Donor age does not appear to influence the functionality of stem cells derived from adult body tissues, concludes a new review. The analysis of research on induced pluripotent stem cells (iPSCs) finds that not only are typical signs of aging reversed in iPSCs, but cells derived from both older and younger donors show the same ability to differentiate into mature body cells.

Researchers have incorporated therapeutic microRNAs (miRNAs) into bioresorbable, silk-based medical devices such as screws and plates to achieve local delivery of factors that can improve bone growth and mineralization at the site of bone repair. The study, which demonstrated the promise of silk-based orthopedic devices combined with bioactive miRNA-based therapeutics, is published in Tissue Engineering, Part A.

Ever since the first Toyota Prius rolled off the line over 20 years ago, the concept of regenerative braking has become fairly well-known as a method of increasing range in hybrid and electric vehicles. But did you know that regenerative braking isn’t only limited to electric cars? These days, you can find it in everything from electric bicycles and skateboards to electric scooters.
Join us as we take a deep dive into regenerative braking and its effectiveness in various electric vehicles. more…

Cancer that has spread, or metastasized, from its original site to other tissues and organs in the body is a leading cause of cancer death.

Why can species such as salamanders regrow organs and limbs while mammals cannot? This proficiency even extends to portions of the central nervous system, such as the spinal cord. In recent years, researchers have made good progress in understanding exceptional regeneration, finding that, for example, differences in the behavior of immune cells called macrophages are essential to regrowth. In the central nervous system, glial cells are somewhat analogous to macrophages in other tissues, and in the research noted here, scientists report on evidence for an equivalent importance in mammalian versus salamander regenerative capacities. Given the macrophage and glial cell connection, this area of comparative biology is moving of late from speculative to relevant to clinical development. Numerous research groups are investigating the alteration of macrophage […]

Fish and amphibians such as newts can perfectly regenerate tissue without scar tissue in the event that they lose organs such as their limbs. Studying the mechanisms of regeneration and homeostasis of tissues has potential for application in human regenerative medicine. Not much has been known about the mechanism and the source of cells involved in the regeneration of tissue.

Heart disease is a major global health problem--myocardial infarction annually affects more than one million people in the U.S. alone, and there is still no effective treatment.

But platelets also release so-called growth factors that help repair soft tissues – blood vessels, skin, muscle, tendons

The meat industry, a major contributor to CO2 emissions and deforestation, is facing competition.

Researchers have succeeded in observing the behavior of epidermal cells for the regeneration of smooth skin without remaining scar tissue using their model animal, the zebrafish.

Digital Trends recently paid a fascinating visit to the Swedish headquarters of Cellink, one of the most exciting companies working on 3D bioprinted organs. Here's what we found out.

Digital Trends recently paid a fascinating visit to the Swedish headquarters of Cellink, one of the most exciting companies working on 3D bioprinted organs. Here's what we found out.
The post Inside Cellink, the Swedish company building 3D printers for living tissue appeared first on Digital Trends.

A UNLV scientist and her team have found that frog embryos can fully regrow their eyes after injuries, a breakthrough that may lead one day to the ability to orchestrate tissue regeneration in humans.

A UNLV scientist and her team have found that frog embryos can fully regrow their eyes after injuries, a breakthrough that may lead one day to the ability to orchestrate tissue regeneration in humans.

The authors of this open access paper consider the potential for regenerative medicine to treat Alzheimer's disease, such as by increasing production of new neurons, or delivering neurons via transplantation. While there has been something of an exodus from the amyloid hypothesis of late, given the litany of failure in clinical trials aiming to reduce amyloid in the brain, it still seems clear that protein aggregates (amyloid and tau) occupy a central position in the progression of neurodegeneration. Spurring greater brain tissue maintenance via generation of neurons is a beneficial goal in and of itself, but as a compensatory treatment, it can't be enough on its own to turn back neurodegeneration primarily caused by factors such as metabolic waste and chronic inflammation. Alzheimer's disease (AD) […]

Leanna Garfield / Business Insider: TechThe battle between the beef industry and Silicon Valley’s lab-grown meat startups is heating up - * In February, the US Cattlemens Association (USCA) filed a petition to the USDA arguing that lab-grown meat startups should not be able to call their products meat, since they do not come from slaughtered animals. But this week, the National Cattlemens Beef Association (NCBA) asked the USDA to regulate ...

The human airway is a system of branching tubes that connects the nose and mouth with the lungs and allows us to inhale air, extract the vital oxygen, and exhale the waste product carbon dioxide.

In adult mammals, the liver is the most regenerative organ, capable of significant regrowth following injury. Why is this the case? Researchers here point to a small subset of liver cells in mice that are distinguished by telomerase expression, and while mice and humans have quite different telomerase and telomere dynamics, indirect evidence suggests that a similar population may exist in our species. Significant telomerase expression is the characteristic of stem cells that allows for unlimited replication: telomerase acts lengthen telomeres, the caps at the ends of chromosomes that shorten with each cell division. When too short, cells enter senescence or destroy themselves. Lacking telomerase, the vast majority of cells can only divide a set number of times. This segregation between a few privileged stem […]

Over the years numerous research groups have claimed the existence of novel stem cell or stem cell like populations in various tissues. Stem cells spend much of their time dormant, but with the right signals or other form of control, it is plausible that they could be directed to greater activity, enhancing tissue regeneration. This is a slow process of discovery, however, usually accompanied by debates over whether or not cells of a claimed type actually exist, whether the research methodologies used in published studies are sound, and so forth. It is wise not to become too excited over any specific claim, but the prevalence of this sort of research suggests that there may be something there. The results noted here are an example of […]

Just a few weeks ago I noted the results from an early trial of a form of retinal patch, in which the patients involved showed striking signs of improved vision, considering their age and the degree to which their macular degeneration had advanced. Today another set of clinical trial results were published by a separate group using a similar approach - human embryonic stem cells are used to derive sufficient retinal pigment epithelium cells to create a structured patch, resembling retinal tissue in at least some aspects. The patch is then implanted into the retina, and sufficient cells survive and integrate to restore some function to areas damaged by the progression of age-related macular degeneration. That two teams are seeing positive outcomes from this type […]

Liver stem cells that express high levels of telomerase, a protein often associated with resistance to aging, act in mice to regenerate the organ during normal cellular turnover or tissue damage, according to a new study.

Scientists have coaxed a minibrain into growing blood vessels and capillaries.

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Amniotic Membrane as a Substrate for Limbal Epithelial Cells

A new review article out of the lab of Amer Sehic (University of Oslo, Norway) discusses the rationale behind employing altered versus unaltered amniotic membrane (AM) as a culture substrate for the ex vivo expansion of the limbal epithelial cells (LECs) used to treat limbal stem cell deficiency

Researchers have developed a low-cost 3-D bioprinter by modifying a standard desktop 3-D printer, and they have released the breakthrough designs as open source so that anyone can build their own system.

Researchers have developed a low-cost 3-D bioprinter by modifying a standard desktop 3-D printer, and they have released the breakthrough designs as open source so that anyone can build their own system.

Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a

Review of “Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments” from STEM CELLS Translational Medicine by Stuart P. Atkinson

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1]. 

To solve this vexing problem and boost the regenerative potential of cord blood, researchers from the laboratories of Shay Soker and Graça Almeida-Porada (Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA) shifted from two dimensions to three dimensions in a recent STEM CELLS

On the morning of March 20, eye surgeon Jason Comander injected viruses carrying lab-grown genes into the eyes of a boy whose vision had been gradually disappearing. If all goes as planned, the 13-year-old patient — who lives with an inherited genetic defect that causes blindness — will experience an improvement in eyesight in about a month. After a series of tests, the U.S. Food and Drug Administration (FDA) approved this gene-therapy treatment, called Luxturna, in December 2017.  SEE ALSO: Doctors find virus in a pond, use it to destroy antibiotic-resistant bacteria in man's heart Three months later, the procedure Comander performed at Massachusetts Eye and Ear served as the first time an FDA-approved gene therapy was used on a person living with an inherited, and incurable, genetic disease. There are no other

Imagine being able to print out healthy tissue with just a sample of a patient's own cells. While printed replacement human body parts might seem like science fiction, the use of 3D printing technologies for medical applications is a relatively new but rapidly expanding research field, although still quite a way from clinical application for treating patients. However, currently available bioinks cannot 3D print self-sustaining anatomic-size structures containing live cells. To overcome the limitations of existing bioinks, researchers have developed a highly printable bioink for fabricating large scale, cell-laden, bioactive scaffolds.

Bill Gates and Richard Branson invested in Memphis Meats, a start-up that makes lab-grown meat.

The ability to robustly and predictably regenerate dental, oral and craniofacial (DOC) tissues through tissue engineering and/or regenerative medicine strategies is a major goal for clinicians. While many technologies have shown proof of principle in small animals, few have made it into the clinic.

Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice. The findings point to potential therapies for controlling inflammation and slowing progression of rare retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD).

The trial results announced here represent a promising step forward in efforts to regenerate an age-damaged retina, particularly because the patients were in an advanced stage of their degenerative condition and nonetheless achieved a meaningful degree of restored sight. Macular degeneration has a number of different manifestations, and here the wet form was treated, which involves excessive growth of blood vessels in the retina and consequent death of the retinal cells necessary for vision. Researchers have established an approach involving the generation of a patch of engineered retinal cells that can be implanted to restore some of the lost retinal function. Given the details, it is interesting to speculate on the degree to which the transplanted cells are helping by integrating into the retina versus […]

With military conflicts continue to rage on in many regions of the globe, understanding how tissues regenerate and heal is an area of research that has come to the forefront in recent years. Additionally, as one of the largest segments of the population move into their six and seventh decades, advance healthcare initiatives focused on wound healing are imperative to improve quality of life and help keep seniors active. Now, investigators from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering have developed new wound dressings that dramatically accelerate healing and improve tissue regeneration. The researchers found that naturally-occurring proteins in plants and animals can promote healing and regrow tissue. Findings from the latest study—published today in Biomaterials through an article entitled “

Fungi grown in bioreactors might give dogs a vegan lifestyle, but we don’t know if it will be a healthy one

A team of researchers has identified biological variations in lung tissue samples that for the first time can help identify people with mild asthma from those with moderate or severe asthma.

Waseda University researchers recently elucidated the regenerative processes by neural stem cells using a stab injury model in the optic tectum, a less studied area of the brain, of adult zebrafish. This study has brought them a step closer to shedding light on how an injured, human central nervous system (CNS) could be restored.
"Unlike mammals, zebrafish have superior abilities to generate new neurons and to regenerate tissues in the brain after an injury, but surprisingly their genes are said to be very similar to humans and mice," explained Toshio Ohshima, M.D., Ph.D., professor of molecular neurobiology at Waseda. "There have even been reports on how the mechanism of zebrafish's regenerative abilities could be applied to mice. This means that there is a possibility in which this same mechanism could be applied to humans as well."
The study was recently published online in

Some of Brazil's most important rivers, including the Xingu, Tocantins, Araguaia, São Francisco, Parnaíba, Gurupi, Jequitinhonha, Paraná and Paraguay, rise in the Cerrado, the only savanna in the world with perennial rivers. This biome is at risk owing to rapid conversion to pasture and cropland, in conjunction with inadequate management of preserved areas, despite its tremendous importance as a natural resource to a country with the world's third-largest technically usable hydroelectric potential and where hydropower accounts for 77.2 percent of the total supply of electricity.

According to study, after being converted to pastures, areas of the so-called 'Cerrado' become closed forest with poor biodiversity if not appropriately managed. This biome works as the source for much of Brazil's main river basins, and boasts biodiversity levels higher than tropical forests at the microscale.

To investigate the mechanism behind skeletal muscle growth and regeneration, researchers bombarded zebrafish with chemical mutagen and screened for larvae with defective skeletal muscle structure. Using genetic mapping, they found that zebrafish larvae with a mutation in DDX27 showed reduced muscle growth and impaired regeneration.

Researchers in Sweden and the U.S. report new insights into how the human body sets its target blood glucose level—the glycemic set point—and say their findings could have implications for ongoing diabetes research and the development of regenerative therapies. Every animal species has its own signature glycemic set point, and a normal glucose level for one species may be life threatening to another. What hasn’t been known until now, however, is which organ is responsible for defining that glycemic set point in each species. Karolinska Institutet researchers, led by Per-Olof Berggren, Ph.D., have now shown that transplanting the islets from different species into mice resulted in the recipient animals taking on the glycemic set point of the donor species. “We found that the engrafted islets transferred the glycemic levels of the donor species,” comments Dr. Berggren, a researcher at the

Cell-based biosensors have the ability to reproduce the effect of different substances (for example, drugs) on the human body in the lab. Yet, based on the measuring principle, it is very costly to...