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Regeneration

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23.01.2018
14:13 News-Medical.NetScientists take tissue-engineering approach to improve healing related to skeletal system

"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the most easily injured.

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19.01.2018
18:17 AzoNano.comNanotubes Could Help Water Purification & Tissue Engineering

Materials scientists, headed by a team at the Department of Energy's Pacific Northwest National Laboratory, designed a small tube that rolls up and zips closed. These hollow nanotubes are...

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18.01.2018
20:11 Phys.orgInspired by biology, scientists created new tiny tubes that could help with water purification and tissue engineering

Materials scientists, led by a team at the Department of Energy's Pacific Northwest National Laboratory, designed a tiny tube that rolls up and zips closed.

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17.01.2018
16:29 Nature.ComScientists in China regenerate lens in human eye

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15.01.2018
19:46 CleanTechnica.comSuperMeat Secures $3 Million In Funding For Lab-Grown Chicken Meat

Israel-based biotech and food-tech startup SuperMeat has just secured a tasty $3 million in seed funding to help it on it mission to produce lab-grown ‘clean’ meat for the masses

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15:33 FightAging.OrgBMP4-Generating Endothelial Cells Spur Regeneration of the Thymus

The research community is interested in regeneration and tissue engineering of the thymus, as this could in principle resolve one of the causes of age-related decline in immune system function. It is worth keeping an eye on present efforts, such as the one noted here, at an early stage of exploration. The thymus is where cells of the adaptive immune system mature, and is thus one of two important gating factors determining the pace at which new immune cells enter the body, ready for action. The other is the quality and activity of the hematopoietic stem cell population in the bone marrow, where immune cells are created. The thymus is very active in childhood, but in early adulthood much of the specialized tissue - that […]

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13.01.2018
17:18 LiveScience.comScientists 3D-Printed Squishy, Brain-Like Tissue for the 1st Time

A new 3D-printing technique can create tissues as soft as a human's squishy brain or spongy lungs — something that has not been possible before.

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12.01.2018
23:08 ScienceDaily.comThe combination of two proteins exerts a regenerating effect in Parkinson's disease

Current therapies for Parkinson's disease are mainly of a replacement type and pose problems in the long term, so the challenge is to establish an early diagnosis and develop neuroprotective and neurorestorative therapies that will allow the symptoms of the disease to be slowed down or even reversed. Researcher have now documented the regenerative, neuroprotective effect of two neurotrophic factors when they are applied in a combined way.

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11.01.2018
14:41 FightAging.OrgStem Cells Enhanced with Platelet-Derived Coatings are More Effective at Cardiac Tissue Repair

The broad and well-funded field of regenerative medicine is giving rise many new and varied areas of development, one of which is the engineering of stem cells to make them perform more effectively following transplantation. This includes a range of additions that do not occur in nature. For example, in past years, researchers have enhanced stem cells with add-ons such as timed release packages of supportive molecules to steer their behavior and sustain their activities for longer in the patient. In the research presented here, scientists instead coat stem cells with particles based on the exterior of platelets, causing the cells to adhere to tissues in areas of damage, where they can do the most good via signaling and other mechanisms. In effect, it is […]

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06:44 ScienceDaily.comRobotic implants spur tissue regeneration inside the body

An implanted, programmable medical robot can gradually lengthen tubular organs by applying traction forces -- stimulating tissue growth in stunted organs without interfering with organ function or causing apparent discomfort, report researchers.

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10.01.2018
18:43 News-Medical.NetNew 3D printing technique allows researchers to replicate biological structures

A new 3D printing technique allows researchers to replicate biological structures, which could be used for tissue regeneration and replica organs.

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09.01.2018
06:11 News-Medical.NetOncologists discover cell type that gives rise to soft tissue cancer in children

St. Jude Children's Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children.

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00:27 StemCellsPortal.comlPhase III clinical trials begin for stem cell-based cartilage regeneration therapy

Researchers at Osaka University have developed a synthetic tissue for treating damaged cartilage, which had previously been incurable and had no effective therapies. Their method uses synovium-derived mesenchymal stem cells (MSCs) as the starting material.
In a Phase III clinical study to confirm the efficacy and safety of this therapy, surgery was successfully performed on the first patient. This is the first clinical trial of regenerative therapy in Japan using allogeneic stem cells and the commercial use of a stem cell bank at the Medical Center for Translational Research (MTR) of Osaka University. (In 2015, MTR established a stem cell bank to provide high-quality homologous cells for a consistent process from basic research to clinical application and commercialization.)
Articular cartilage does not have blood supply and, thus, has limited ability to heal itself. To date,

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05.01.2018
14:20 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Translating Regenerative Biology, Cord Blood Transplantation, Stem Cell Product Approval, and MSC Osteogenic Stimulation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Translating Regenerative Biology

The study of tissue regeneration in different mammalian models has provided evidence of a range of species-specific regenerative capabilities. A new review from Ashley W. Seifert and Jennifer Simkin (University of Kentucky, Kentucky, USA) highlight how an understanding of the various mechanisms at play in an injury microenvironment in various species may allow us to create advances in regenerative therapies in human patients. For what sounds like a

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03:37 News-Medical.NetPhase III clinical study of regenerative therapy for treating damaged cartilage has started

A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.

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04.01.2018
10:18 FinancialExpress.comBig boost for India, prevention of typhoid turns easier, Bharat Biotech vaccine gets WHO nod

The new vaccine was found to have given a longer immunity from typhoid than older vaccines and it required fewer doses for childhood immunisation.

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03:14 FinancialExpress.comBharat Biotech’s typhoid vaccine receives WHO pre-qualification

The company now has an addressable traveller market opportunity of $2 bn globally.

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03.01.2018
15:53 FightAging.OrgMore on Efforts to Tissue Engineer Skin with Hair Follicles

Skin is one of the obvious initial targets for tissue engineering, as it is possible to grow in thin sheets without the need to solve the challenge of generating vascular networks to support larger, thicker tissue structures. Researchers have been making progress towards more complete, complex engineered skin, such as through the inclusion of functional hair follicles or sweat gland structures. The research noted here is an example of the type, though one should always be wary of publicity materials that claim researchers to be first to a specific goal in tissue engineering. It is more often the case that several different groups are in progress at at a similar stage for any given advance in this field. It is a very well funded and […]

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02.01.2018
23:47 DigitalTrends.comLab-grown SuperMeat may be the vegetarian option of the future

Thanks to companies like SuperMeat, even those who have sworn off of meat can still have the occasional piece of fried chicken. And it's not made of tofu or seitan or any other filler -- this chicken is grown in a lab.
The post Lab-grown SuperMeat may be the vegetarian option of the future appeared first on Digital Trends.

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18:37 VentureBeat.comSuperMeat raises $3 million for lab-grown chicken

Israeli biotech startup SuperMeat has announced a $3 million seed funding round to help bring its lab-grown meat products to market. Founded out of Tel Aviv in 2015, SuperMeat is one of a number of lab-made meat startups seeking to capitalize on the burgeoning sustainable food sector. The company’s so-called “clean meat” is created by […]

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16:12 SeekingAlpha.comBioTime up 6% on study identifying genes related to tissue regeneration

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28.12.2017
16:24 FightAging.OrgTissue Engineering of Better, More Correctly Structured Kidney Organoids

The research community continues to improve their ability to build structured and functional organ tissue from the starting point of a patient cell sample. The challenge of constructing blood vessel networks to support large tissue structures remains to be solved, but by the time it is, there will be a direct path to the manufacture of entire organs on demand. Work on kidney tissue is one of the leading areas from the point of view of technical capabilities in tissue engineering, as this research news demonstrates. In the embryonic kidney, three types of precursor cells, nephron progenitor cells, ureteric buds, and interstitial progenitor cells, interact to form three-dimensional structures of the kidney. Methods to induce nephron structures via nephron progenitor cells from mouse pluripotent stem […]

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12:55 Technology.orgSalamander genome gives clues about unique regenerative ability

This is the first time that an entire newt genome has been sequenced, an achievement that can give

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27.12.2017
19:12 Aps.org Editors' SuggestionsLinking biological and physical aging: Dynamical scaling of multicellular regeneration

Author(s): Yuting Lou, Jufeng Xia, Wei Tang, and Yu Chen Wound healing experiments suggest that biological aging can be defined in a similar way to physical aging in soft materials like glasses.
[Phys. Rev. E 96, 062418] Published Wed Dec 27, 2017

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13:04 News-Medical.NetNew approach to sticking bio-ink droplets together enables 3D printing of complex tissues

Printed replacement human body parts might seem like science fiction, but this technology is rapidly becoming a reality with the potential to greatly contribute to regenerative medicine. Before any real applications, "bioprinting" still faces many technical challenges.

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26.12.2017
17:51 GenEngNews.comSalamander Genome Sequencing May Provide Clues to Human Tissue Regeneration

Scientists at the Karolinska Institute have sequenced the genome of a salamander, the Iberian ribbed newt, which is a full six times larger than the human genome. Among the early findings is a family of genes that can provide clues to the unique ability of salamanders to rebuild complex tissue, even body parts. The team published its study (“Reading and Editing the Pleurodeles waltl Genome Reveals Novel Features of Tetrapod Regeneration” ) in Nature Communications and believes its findings may possibly lead to the development of new regenerative strategies for humans. “Salamanders exhibit an extraordinary ability among vertebrates to regenerate complex body parts. However, scarce genomic resources have limited our understanding of regeneration in adult salamanders. Here, we present the ~20 Gb genome and transcriptome of the Iberian ribbed newt Pleurodeles waltl , a tractable species suitable

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23.12.2017
07:04 News-Medical.NetResearchers sequence salamander genome to reveal unique features of regeneration

Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times greater than the human genome.

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22.12.2017
18:15 Phys.orgSalamander genome gives clues about unique regenerative ability

Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times greater than the human genome. Amongst the early findings is a family of genes that can provide clues to the unique ability of salamanders to rebuild complex tissue, even body parts. The study is published in Nature Communications.

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01:09 NewScientist.Com2018 preview: Bioelectricity tweak can regenerate missing limbs

A bold plan to regrow lost body parts in mammals could be realised by cracking the body’s bioelectric code

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20.12.2017
20:31 Geek.comAlways Remember When the Doctor Was You With Facebook Regeneration Effect

The Doctor may be reluctant to regenerate, but I’d sure like to try. BBC Worldwide Americas this week released a Doctor Who effect for Facebook camera users to experience the Time Lord transformation. […]
The post Always Remember When the Doctor Was You With Facebook Regeneration Effect appeared first on Geek.com.

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14:26 FightAging.OrgThe Advanced Regenerative Manufacturing Institute Works Towards the Mass Production of Organs

It seems that more members of the high profile entrepreneur segment are starting to consider mass manufacture of tissue engineered organs as an area to put time and effort into. The publicity article here offers one example. While the research community has yet to produce a robust means of creating the microvasculature needed to sustain larger tissue sections, that absence is really the only serious roadblock standing between the state of the science today and a manufactured, patient-matched kidney or liver a few years from now. It is high time to consider moving the technology from laboratory to manufactory. Even lacking the ability to lace tissue with tiny blood vessels, researchers can still create small organoids that exhibit the correct structure and function of their […]

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10:15 Phys.orgXSEDE supercomputer allocations on Stampede1 and Comet help sample protein folding in bone regeneration study

Some secrets to repair our skeletons might be found in the silky webs of spiders, according to recent experiments guided by supercomputers. Scientists involved say their results will help understand the details of osteoregeneration, or how bones regenerate.

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19.12.2017
21:15 IbTimes.co.uk A Christmas miracle! Reindeer antlers could hold the secret to human skin regeneration

Reindeer antlers are covered in velvet – a type of fuzzy, hairy skin – which has the ability to "almost perfectly" regenerate.

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15:18 ScientificAmerican.ComLab-Grown Meat Is On the Way

It's good for the planet, and surveys show that significant numbers of people would be willing to give it a try -- Read more on ScientificAmerican.com

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14.12.2017
17:55 Phys.orgLab-grown meat could let humanity ignore a serious moral failing

Lab-grown meat is being hailed as the solution to the factory farming of animals. The downside of factory farming for the cows, chickens and pigs themselves is obvious enough. But it is also bad for human health, given the amount of antibiotics pumped into the animals, as well as for the environment, given the resources required to provide us with industrial quantities of meat.

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08.12.2017
20:53 ScienceDaily.comInhibiting TOR boosts regenerative potential of adult tissues

Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers discovered that TOR, a nutrient sensing pathway which is central to the aging process, drives the loss of adult stem cells. Treating mice with the TOR-inhibitor rapamycin prevented this loss and could reverse age-related loss of stem cells in mouse trachea.

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10:38 FinancialExpress.comSay goodbye to stinking train loos! Indian Railways to roll out aircraft-type bio-vacuum toilets

Stinking and non-functioning toilets on Indian Railways -- one of the world's largest rail networks -- may soon become a thing of the past.
The post Say goodbye to stinking train loos! Indian Railways to roll out aircraft-type bio-vacuum toilets appeared first on The Financial Express.

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04.12.2017
14:05 DnaIndia.com'Living materials' 3D-printed using bio ink

Scientists have printed three- dimensional (3D) 'living materials' using bacteria-loaded inks. The new printing material called "Flink", which stands for "functional living ink", has been developed by scientists at ETH Zurich in Switzerland.

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30.11.2017
14:02 Phys.orgWound healing or regeneration—the environment decides?

An earthworm cut in two parts can survive and regenerate. For humans, the loss of limbs is a severe problem that can only be treated by complex surgery. However, among animals, there are numerous examples of self-healing mechanisms, especially among invertebrates. How these regeneration mechanisms function genetically and biochemically is one of the most exciting research questions in developmental biology and medicine.

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11:27 Technology.orgResearchers Develop an Injectable Gel that Helps Heart Muscle Regenerate after a Heart Attack

In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not

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29.11.2017
22:23 ScienceDaily.cominjectable gel helps heart muscle regenerate after heart attack

Researchers have used mouse models to demonstrate a new approach to restart cardiomyocyte replication after a heart attack: an injectable gel that slowly releases short gene sequences known as microRNAs into the heart muscle.

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22:13 Nature.ComOrthogonal muscle fibres have different instructive roles in planarian regeneration

The ability to regenerate missing body parts exists throughout the animal kingdom. Positional information is crucial for regeneration, but how it is harboured and used by differentiated tissues is poorly understood. In planarians, positional information has been identified from study of phenotypes caused by RNA interference in which the wrong tissues are regenerated. For example, inhibition of the Wnt signalling pathway leads to regeneration of heads in place of tails. Characterization of these phenotypes has led to the identification of position control genes (PCGs)—genes that are expressed in a constitutive and regional manner and are associated with patterning. Most PCGs are expressed within planarian muscle; however, how muscle is specified and how different muscle subsets affect regeneration is unknown. Here we show that different muscle fibres have distinct regulatory roles during

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21:21 ScienceDaily.comWound healing or regeneration -- the environment decides?

For humans, the loss of limbs is almost always an irreversible catastrophe. Many animals, however, are not only able to heal wounds but even to replace whole body parts. Biologists have now been able to prove for the first time that comb jellyfish can switch between two completely different self-healing processes depending on the environmental conditions.

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19:13 StemCellsPortal.comlScientists find key to regenerating blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.
"Our research shows that the formation of fully functional blood vessels requires activation of protein kinase Akt by a protein called R-Ras, and this mechanism is necessary for the formation of the hallow structure, or lumen, of a blood vessel." said Masanobu Komatsu, Ph.D., associate professor at SBP's Lake Nona, Florida, campus. "The findings are important because they shed new light on the biological process needed to increase blood flow in ischemic tissues."
Previous efforts to treat

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19:13 StemCellsPortal.comlSurprising roles for muscle in tissue regeneration, study finds

A team of researchers has illuminated an important role for different subtypes of muscle cells in orchestrating the process of tissue regeneration. In a paper published in the November 22 issue of Nature, they reveal that a subtype of muscle fibers in flatworms is required for triggering the activity of genes that initiate the regeneration program. Notably, in the absence of these muscles, regeneration fails to proceed.
Another type of muscle, they report, is required for giving regenerated tissue the proper pattern – for example, forming one head instead of two.
"One of the central mysteries in organ and tissue regeneration is, how do animals initiate all of the cellular and molecular steps that lead to regeneration?" said senior author Peter Reddien, Ph.D., a member of Whitehead Institute for Biomedical Research at MIT and investigator with the Howard Hughes Medical Institute.

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16:56 Technology.orgResilient reefs offer hope for regeneration

Just three per cent of the Great Barrier Reef’s corals may hold the key to regenerating reefs damaged after

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08:08 ScienceDaily.comResilience of Great Barrier Reef offers opportunities for regeneration

New research has found that, despite the extensive damage to coral in recent events, there are still 100 reefs on the Great Barrier Reef that are well suited to promoting the regional recovery of the ecosystem after major disturbances.

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28.11.2017
22:08 Phys.orgResilience of Great Barrier Reef offers opportunities for regeneration

New research has found that, despite the extensive damage to coral in recent events, there are still 100 reefs on the Great Barrier Reef that are well suited to promoting the regional recovery of the ecosystem after major disturbances. The results publishing 28 November in the open access journal PLOS Biology by Dr Karlo Hock, Prof Peter Mumby, and colleagues from the University of Queensland, CSIRO, the Australian Institute of Marine Science, and the University of Sheffield, suggest that these reefs not only appear to be less at risk of being exposed to damaging effects of bleaching and starfish predation, but are also well connected to other downstream reefs by ocean currents, and therefore possess the potential to provide coral larvae to support the recovery of other reefs.

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23.11.2017
22:05 Technology.orgMuscle plays surprising role in tissue regeneration

Researchers at the Whitehead Institute have illuminated an important role for different subtypes of muscle cells in orchestrating the

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19:38 ScienceDaily.comKey to regenerating blood vessels discovered

A signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels, has been discovered by researchers. The findings may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.

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22.11.2017
21:57 ValueWalk.comFord’s MoDe Flex eBike Will Have Regenerative Braking As Well Reveals A Recent Patent

Ford recently has filed a patent application for its hi-tech bicycle MoDe Flex eBike which it revealed first in June 2015. It is considered to be one of the high tech bikes ever designed. The patent discloses Ford’s endeavors to […]
The post Ford’s MoDe Flex eBike Will Have Regenerative Braking As Well Reveals A Recent Patent appeared first on ValueWalk.

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21:51 ScienceDaily.comSurprising roles for muscle in tissue regeneration, study finds

Researchers have illuminated an important role for different subtypes of muscle cells in orchestrating the process of tissue regeneration. Notably, in the absence of these muscles, regeneration fails to proceed.

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15:52 SeekingAlpha.comPluristem granted key U.S. patent for Skeletal Muscle Regeneration

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20.11.2017
23:36 ScienceDaily.comPhotocrosslinkable, thermoreversible, type-I collagen bioink for photolithographic printing

Biomedical engineers have leveraged a unique combination of properties of methacrylated collagen to demonstrate its potential as a bioink capable of simple, photolithographic printing of 3D scaffolds for tissue engineering and regenerative medicine. Type-I collagen is the most ubiquitous protein in the human body. Chief among the fibril forming collagens, type-I collagen gives many soft tissues strength and structure. Type-I collagen is also easily extracted from tissues, and it is frequently used as a 2D or 3D substrate for in vitro studies. Its ability to self-assemble hierarchically into strong and flexible fibers and its excellent biocompatibility across species also make it a popular biomaterial for applications in tissue engineering. However, its fibrillar, higher order structure also complicates collagen's use as a bioink for 3D printing, which would otherwise be an increasingly

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18:35 GenEngNews.comFDA Issues Final and Draft Regenerative Medicine Guidance Documents

The FDA has issued two final guidances and two draft guidances, all designed to articulate the agency’s approach to developing and overseeing novel cellular therapies and other regenerative medicine products. The agency said its suite of four guidance documents constituted a risk-based and science-based policy framework approach designed to support innovative product development while clarifying the FDA’s authority, its enforcement priorities against products deemed to raise potential significant safety concerns. The two final guidances are designed to clarify the FDA’s interpretation of the risk-based criteria manufacturers must use to determine whether a product is subject to the FDA’s premarket review. The first guidance is intended to spell out more clearly when cell and tissue-based products are excepted from the established regulations if they are removed from and implanted into the

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18:25 GenEngNews.comFDA Issues Final and Draft Regenerative Medicine Guidances

The FDA has issued two final guidances and two draft guidances, all designed to articulate the agency’s approach to developing and overseeing novel cellular therapies and other regenerative medicine products. The agency said its suite of four guidance documents constituted a risk-based and science-based policy framework approach designed to support innovative product development while clarifying the FDA’s authority, its enforcement priorities against products deemed to raise potential significant safety concerns. The two final guidances are designed to clarify the FDA’s interpretation of the risk-based criteria manufacturers must use to determine whether a product is subject to the FDA’s premarket review. The first guidance is intended to spell out more clearly when cell and tissue-based products are excepted from the established regulations if they are removed from and implanted into the

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18:25 Phys.orgPhotocrosslinkable, thermoreversible, type-I collagen bioink for photolithographic printing

A group of biomedical engineers from Rutgers, The State University of New Jersey have leveraged a unique combination of properties of methacrylated collagen to demonstrate its potential as a bioink capable of simple, photolithographic printing of 3D scaffolds for tissue engineering and regenerative medicine. Type-I collagen is the most ubiquitous protein in the human body. Chief among the fibril forming collagens, type-I collagen gives many soft tissues strength and structure. Type-I collagen is also easily extracted from tissues, and it is frequently used as a 2D or 3D substrate for in vitro studies. Its ability to self-assemble hierarchically into strong and flexible fibers and its excellent biocompatibility across species also make it a popular biomaterial for applications in tissue engineering. However, its fibrillar, higher order structure also complicates collagen's use as a bioink for

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12:09 StemCellsPortal.comlPreventing Transplant Rejection with Endometrial Regenerative Cell-Therapy and SDF-1

Review of “Stromal Cell-Derived Factor-1 Mediates Cardiac Allograft Tolerance Induced by Human Endometrial Regenerative Cell-Based Therapy” from STEM CELLS Translational Medicine by Stuart P. Atkinson

While the long-term success of organ transplantation currently still depends on the delicate balance between under- and over-immunosuppression [1, 2], research teams across the globe still hope to encounter a more efficient strategy. Several studies have harnessed the immunomodulatory powers of mesenchymal stromal cells (MSCs); however, the optimal source for MSCs remains an unanswered, yet heavily studied, question. 

The research team of Hao Wang (Tianjin Medical University General Hospital, PR China) believes that endometrial regenerative cells (ERCs), mesenchymal-like stromal cells non-invasively obtained

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19.11.2017
23:25 Yahoo ScienceWhat Causes Mental Illness? Scientists Hope Lab-Grown Mini Brains Will Help Them Find Out

Psychiatric research is full of complex problems and the appeal of new technologies to untangle them is high. A new study in Translational Psychiatry aimed to do just that: By growing cerebral organoids, or mini brains, derived from the cells of a group of patients with schizophrenia, Michal Stachowiak’s group from the University at Buffalo claimed to be one step closer to understanding the cause of this chronic and severe mental disorder. Schizophrenia is typically understood as an illness that starts in the brain at a very early stage of development. Stachowiak’s researchers sought to test this older hypothesis using the latest technology—growing miniature organs that mimic the real brain at the earliest stages of fetal development.

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17.11.2017
16:28 FierceBiotech.comBuilding on Cures Act, FDA lays out cell therapy fast track in regenerative medicine framework

The FDA has created a policy framework for cellular therapies and other regenerative medicines by releasing two draft and two final guidance documents. Publication of the texts builds on the 21st Century Cures Act by setting criteria for the new Regenerative Medicine Advanced Therapy (RMAT) designation and outlining the benefits of the regulatory status.

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16.11.2017
23:19 KoreaITTtimes.comMainland-Hong Kong synergy in life sciences underscored in 3rd Stem Cell & Regenerative Medicine Conference co-hosted by HKSTP and GIBH

Friday, November 17th, 2017  
HONG KONG, Nov. 16, 2017 /PRNewswire/Korea IT times-- Hong Kong Science and Technology Parks Corporation ("HKSTP") and Guangzhou Institutes of Biomedicine and Health ("GIBH") co-hosted the third Hong Kong and Guangzhou International Conference on Stem Cell and Regenerative Medicine, held at Hong Kong Science Park on 9 November. The event was attended by high-profile guests, including Mr Nicholas Yang, Secretary for Innovation and Technology of the HKSAR Government; and Mr Cao Jinghua, Director General, Bureau of International Cooperation, Chinese Academy of Sciences (CAS).
Mr Nicholas Yang, Secretary for Innovation and Technology of the HKSAR Government (3rd from the left, first row), Mr Cao Jing-hua, Director General, Bureau of International Cooperation, Chinese Academy of Sciences (3rd from the right, first row), Mr Albert Wong, CEO of HKSTP

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23:19 KoreaITTtimes.comMainland-Hong Kong synergy in life sciences underscored in 3rd Stem Cell & Regenerative Medicine Conference co-hosted by HKSTP and GIBH

Friday, November 17th, 2017  
HONG KONG, Nov. 16, 2017 /PRNewswire/Korea IT times-- Hong Kong Science and Technology Parks Corporation ("HKSTP") and Guangzhou Institutes of Biomedicine and Health ("GIBH") co-hosted the third Hong Kong and Guangzhou International Conference on Stem Cell and Regenerative Medicine, held at Hong Kong Science Park on 9 November. The event was attended by high-profile guests, including Mr Nicholas Yang, Secretary for Innovation and Technology of the HKSAR Government; and Mr Cao Jinghua, Director General, Bureau of International Cooperation, Chinese Academy of Sciences (CAS).
Mr Nicholas Yang, Secretary for Innovation and Technology of the HKSAR Government (3rd from the left, first row), Mr Cao Jing-hua, Director General, Bureau of International Cooperation, Chinese Academy of Sciences (3rd from the right, first row), Mr Albert Wong, CEO of HKSTP

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21:47 Drugs.comFDA Seeks to Speed Development of 'Regenerated' Organs for Medical Use

THURSDAY, Nov. 16, 2017 -- Using stem cells to grow new heart tissue, and even whole organs, used to be the stuff of science fiction. But the field of "regenerative medicine" is a reality now -- and the U.S. Food and Drug Administration has its eye...

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21:05 News-Medical.NetCommon ingredient in laundry detergents may help build bioartificial pancreas to cure type 1 diabetes

Two oxygen-producing compounds – including one that boosts performance in some laundry detergents – might one day play a key role in helping scientists successfully build a bioartificial pancreas in the lab to cure type 1 diabetes.

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15.11.2017
21:33 Nature.ComRegeneration of the entire human epidermis using transgenic stem cells

Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving patients with JEB develop chronic wounds to the skin and mucosa, which impair their quality of life and lead to skin

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19:14 AzoRobotics.comNew Bioengineered Robotic Hand Regenerates the Sensation of Touch

The sense of touch is frequently taken for granted. Losing that sense of touch can be devastating for someone without a hand or limb. While greatly sophisticated prostheses with complex moving joints...

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12.11.2017
21:04 Yahoo ScienceLab-Grown Skin Saves Dying Boy with Rare Disease

A boy who nearly died from a rare skin disease has recovered thanks to an experimental treatment, his doctors announced this week. The young boy, named Hassan, was 7 years old when he was admitted to the Children's Hospital at Ruhr University in Bochum, Germany, in June 2015. At that time, a genetic disease called epidermolysis bullosa (EB) had destroyed about 60 percent of his skin.

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11.11.2017
18:17 Geek.comLab-Grown Mosquitoes Get EPA Okay

Mosquitos are kinda the bane of human existence. Even more so than other people, mosquitos have been responsible for more dead people than any other species on earth. So, naturally, scientists have been […]
The post Lab-Grown Mosquitoes Get EPA Okay appeared first on Geek.com.

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10.11.2017
19:29 SingularityHub.ComThe Dream of Regenerative Medicine Is Alive and Well

To Bob Hariri, the body is a machine. Hariri is a surgeon, entrepreneur, and biomedical scientist. But perhaps it’s his time flying jets that most strongly lends itself to such thinking. “I’ve been flying longer than anything I’ve done in my life,” Hariri said in an interview with Peter Diamandis this week at Singularity University’s […]

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14:07 Technology.orgGene shown to induce undifferentiated cells during tadpole tail regeneration

A group of researchers at the University of Tokyo found that a particular gene, interleukin-11, functions as a key

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00:44 Gizmag To almost match spider silk, scientists regenerate silkworm silk


Pound for pound, spider silk is among the strongest known materials. Unfortunately, though, farming spiders for their silk is highly impractical. While some researchers are pursuing synthetic spider silk, scientists at MIT and Tufts University have taken another approach … they've devised a method of using silkworm silk to produce fibers that are almost as stiff as spider silk.
.. Continue Reading To almost match spider silk, scientists regenerate silkworm silk Category: Materials Tags: MIT Silk Spiders Tufts University Related Articles: Dangerous spider spins deadly-strong silk Graphene-fed spiders spin bionic silk Large quantities of synthetic spider silk spun on demand Spider silk bridges the gap between busted nerves Cambridge scientists spin hydrogel into synthetic spider silk Spider silk might make for more sensitive hearing aids

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09.11.2017
19:32 LiveScience.comLab-Grown Skin Saves Dying Boy with Rare Disease

Scientists created fully functional skin for a 7-year-old boy with a genetic skin disease. Here's how they accomplished the medical feat.

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19:20 ScienceMag.orgLab-grown minibrains are revealing what makes humans special

New tools offer clues to how the human brain takes shape

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16:50 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Hematopoietic Regulation and Regeneration, Restoration of Dysfunctional Endothelial Progenitor Cells, and the Production of Mature Heart Muscle!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Reviewing the Epigenetic Regulation of Hematopoiesis

The title for this Stem Cells Buzz article says it all! Straight out of the lab of Annarita Miccio (Imagine Institute, Paris, France) comes a summary of recent epigenetic and genetic studies in hematopoietic cells that have provided fresh insight into human hematopoiesis and have stimulated the construction of novel therapeutic approaches. For all the details on this new article from Antoniani et al., scoot on over to STEM CELLS

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08.11.2017
22:01 Nature.ComSkin regeneration with insights

A feat in stem-cell therapy highlights what can be achieved when basic and clinical research combine to advance biological understanding and treatment.

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21:58 IbTimes.co.uk Seven-year-old with deadly skin disease saved after surgeons regenerate 80% of boy's skin

Junctional Epidermolysis Bullosa is a genetically inherited disease that can severely affect quality of life, and often leads to death.

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21:37 StemCellsPortal.comlStem cells conduct cartilage regeneration but are not directly involved

Therapy with mesenchymal stem cells, the so-called progenitor cells of connective tissue, holds great promise for the regeneration of cartilage tissue. But how stem cell therapy contributes to the healing of damaged connective tissue has been unclear. Debate has centered on whether the injected cells promote regeneration or stimulate the body's own cells to proliferate.
A new strategy has now enabled researchers from the Department of Biomedical Sciences at the University of Veterinary Medicine (Vetmeduni), Vienna, to solve the question.
The problem was that a marker protein was recognized by the immune system of the recipient as a non-self protein, leading to the rejection of the injected stem cells. The Vetmeduni scientists were able to overcome this limitation and show that progenitor cells do not participate directly in cartilage regeneration, but serve to "animate" the

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15:11 FierceBiotech.comAmgen makes regenerative medicine play, backing $25M Fortuna round to move neural stem cells into the clinic

Amgen’s VC wing has invested in Fortuna Fix to help move autologous neural stem cells into the clinic. The $25 million series B sets regenerative medicine startup Fortuna up to move candidates against Parkinson’s disease and spinal cord injury into the clinic next year. 

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07.11.2017
15:40 FightAging.OrgInvestigating the Cellular Biochemistry of Spinal Regeneration in Geckos

A broadening collection of research groups are investigating various highly regenerative species - zebrafish, salamanders, spiny mice, and in this case geckos - in order to understand what exactly how they achieve regrowth of lost limbs and organs. The answers will probably be at least slightly different in each case. It remains to be seen as to whether or not the basis for a near-term therapy for human medicine is there to be uncovered, a way to make a comparatively small adjustment to our biochemistry that leads to similar outcomes. Maybe so, maybe not. Many lizards can detach a portion of their tail to avoid a predator and then regenerate a new one. Unlike in mammals, the lizard tail includes part of the spinal cord. […]

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06.11.2017
11:19 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? – Inflammatory Cycling in MSCs, Slimming-down MSCs with Vesicles, Boosting Bone and Cartilage Regeneration, and Trialing Autologous Cord Blood!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
MSCs-EVs Caught in an Inflammatory Cycle

A new study by the lab of Matthew T. Harting (University of Texas McGovern Medical School, USA) has suggested that mesenchymal stem cells (MSCs) and secreted extracellular vesicles (EVs) may be caught in an inflammatory cycle! Specifically, their new STEM CELLS study demonstrates that inflammatory stimulation of MSCs results in the release of EVs with enhanced anti-inflammatory effects, attributed in part to COX2/PGE2

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04.11.2017
00:48 KoreaITTtimes.comElucidation of Bone Regeneration Mechanism

Saturday, November 4th, 2017 TOKYO, Nov. 3, 2017 /PRNewswire/Korea IT times -- Fish have the extraordinary ability to regenerate lost fins and other appendages containing cartilage and bone. The cells responsible for the regeneration offer new clues on how to regenerate tissues in humans. Researchers at Tokyo Institute of Technology (Tokyo Tech) have found a dormant progenitor cell population in zebrafish that regenerates bone cells, or osteoblasts. The study can be read in Developmental Cell.
OPC in the niche of fin joint: OPCs marked in green, osteocyte-lineage marker, Zns5, in red, and cell nuclei in blue. OPCs that are dormant in the niche have a unique shape with dendrites. (PRNewsfoto/Tokyo Institute of Technology)
How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. According to Atsushi Kawakami, an Associate

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03.11.2017
21:06 News-Medical.NetNew study elucidates osteoblast production during bone regeneration

How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. According to Atsushi Kawakami, an Associate Professor who specializes in tissue regeneration and led the study, scientists disagree on how these cells are made.

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17:04 GlobalConstructionReview.comLendlease in €2bn Milan regeneration scheme

Property and infrastructure group Lendlease has entered into a project development agreement for the second ...

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16:52 ScienceDaily.comElucidation of bone regeneration mechanism

Fish have the extraordinary ability to regenerate lost fins and other appendages containing cartilage and bone. The cells responsible for the regeneration offer new clues on how to regenerate tissues in humans. Researchers have found a dormant progenitor cell population in zebrafish that regenerates bone cells, or osteoblasts.

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06:21 KoreaITTtimes.comElucidation of Bone Regeneration Mechanism

Friday, November 3rd, 2017 TOKYO, Nov. 3, 2017 /PRNewswire/ Korea IT Times-- Fish have the extraordinary ability to regenerate lost fins and other appendages containing cartilage and bone. The cells responsible for the regeneration offer new clues on how to regenerate tissues in humans. Researchers at Tokyo Institute of Technology (Tokyo Tech) have found a dormant progenitor cell population in zebrafish that regenerates bone cells, or osteoblasts. The study can be read in Developmental Cell.
How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. According to Atsushi Kawakami, an Associate Professor who specializes in tissue regeneration and led the study, scientists disagree on how these cells are made.
The new study uses genetically engineered transgenic zebrafish to show that a population of progenitor cells marked by high

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02.11.2017
14:58 GenEngNews.comTissue-Engineered Blood Vessels Offer Hope to Kidney Dialysis Patients

University of Minnesota scientists say they have created a lab-grown blood vessel replacement composed of biological materials, but without living cells at implantation. The vessel, that could be used as an off-the-shelf graft for kidney dialysis patients, showed positive results in a recent study with nonhuman primates, according to the researchers. It reportedly is the first-of-its-kind nonsynthetic, decellularized graft that becomes repopulated with cells by the recipient's own cells when implanted. The grafts not only have applications in kidney dialysis but could be adapted for use as coronary and peripheral bybass blood vessels and tubular heart valves. The study (“A completely biological “off-the-shelf” arteriovenous graft that recellularizes in baboons”) is published in  Science Translational Medicine. “Prosthetic arteriovenous grafts (AVGs) conventionally used for

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12:07 Technology.orgNew tissue-engineered blood vessel replacements closer to human trials

Researchers at the University of Minnesota have created a new lab-grown blood vessel replacement that is composed completely

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31.10.2017
20:26 News-Medical.NetStem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process.

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18:53 ScienceDaily.comStem cells conduct cartilage regeneration but are not directly involved

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process. Researchers have been able to resolve this issue by tracking the effects in a new, natural model. After injection, stem cells orchestrate the healing effect of endogenous cells but are not responsible for cartilage regeneration. The breakthrough was enabled by preventing the normal immune response to the molecule required to trace the injected cells.

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30.10.2017
10:07 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Distal Limb Wound Healing, Dentin-Pulp Tissue Regeneration, Report from the ISCBI, and MSCs Requirement for Survivin!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
MSC-mediated Healing of Distal Limb Wounds

Both humans and horses may benefit from allogeneic mesenchymal stem cell (MSC) therapy for distal extremity wounds. To assess the potential benefits of this treatment option, researchers from the laboratory of Dori L. Borjesson (UC Davis, California, USA) assessed gross, histologic, and transcriptional features of healing in a horse model. Encouragingly, Textor et al. discovered that direct injection of MSCs into the wound margin correlated to smaller wound area and improved histologic outcomes and the authors hope that

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27.10.2017
16:25 Phys.org3-D printing with a biobased polymer for CO2-neutral manufacturing

In our modern world, eliminating plastics is inconceivable. Unfortunately, they do have disadvantages, including the formation of CO2 in both production and combustion, depletion of fossil feedstocks, and growth of landfills. In the journal Angewandte Chemie, Russian researchers introduce a new way forward, a polymer made entirely from biomass that can easily and inexpensively be used in 3-D printing. Objects produced in this way are of high quality, easily recyclable, and highly solvent-resistant.

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26.10.2017
16:23 GenEngNews.comCell Surprise Prepares the Way for Nerve Regeneration

Studies by researchers in the U.S. have overturned previous models of how immune cells clear up the debris associated with damaged peripheral nerve cells, suggesting potential new targets for promoting nerve regeneration. Prior models have assumed that macrophages take on this key job of removing debris around the sites of nerve cell damage. The new studies, headed Richard Zigmond, Ph.D., professor of neurosciences, neurosurgery and pathology at Case Western Reserve University School of Medicine, suggest that it is neutrophils, and not macrophages, which carry out this clean-up role. “This finding is quite surprising and raises an important question: do neutrophils play a significant role in nerve disorders?” professor Zigmond comments. The studies are reported in the Journal of Neuroscience , in a paper entitled, “ Neutrophils are critical for myelin removal in a peripheral nerve injury

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05:15 News-Medical.NetScientists discover how immune cells clear the way for nerve regeneration after injury

Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury.

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24.10.2017
17:24 StemCellsPortal.comlStudy shows how growth factor aids stem cells’ ability to regenerate damaged teeth

In a new study published in STEM CELLS Translational Medicine, researchers used a type of platelet-derived growth factor called PDGF-BB that enhances cells’ ability to regenerate dentin-pulp complex.

Many in the medical community view stem cell therapy as a promising new strategy for repairing teeth once thought to be irreversibly damaged by tooth decay or dental injuries. The benefits of human dental pulp stem cells (hDPSCs), isolated from the living connective tissue in the tooth’s center, on such damage have been well documented in studies.

However, previous studies also revealed several problems with this type of treatment, including limitations on how much mineralized tissue can be formed when scaffolds with hDPSCs alone were implanted in nude mice. More importantly, the narrow root canal of a tooth

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19.10.2017
16:45 GenEngNews.comFDA Approves Gilead CAR-T Therapy Yescarta, Plans Regenerative Medicine Policy 'Soon'

Gilead Sciences’ Kite subsidiary has won FDA approval for Yescarta™ (axicabtagene ciloleucel), the second time in less than two months that the agency has authorized a chimeric antigen receptor T-cell (CAR-T) treatment for a form of cancer. As with the first-approved CAR-T therapy , Novartis’ Kymriah (tisagenlecleucel), the FDA acted more than a month ahead of schedule. The agency had set a Prescription Drug User Fee Act (PDUFA) target decision date for Yescarta of November 29, 2017. The Yescarta approval came 15 days after Gilead completed its approximately $11.9 billion acquisition of Kite (formerly Kite Pharma), a deal announced August 28, two days before Kymriah was approved. “We believe this is only the beginning for CAR T therapies,” Arie Belldegrun, MD, FACS, founder of Kite, said in a statement. “The FDA approval of Yescarta is a landmark for patients with relapsed or refractory large

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18.10.2017
13:35 BBC.comRedcar SSI site regeneration plan 'may create 20,000 jobs'

Redevelopment over the next 25 years would make the area a "national asset", say planners.

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16.10.2017
17:48 GenEngNews.comDeep Survey of Genome Regulation Spans Tissue Types, Highlights Role of Local Genetic Variation

Despite the complexities inherent in the human genome, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases. That is the takeaway from a collection of new studies completed by participants in the Genotype-Tissue Expression (GTEx) consortium. These studies present findings from the deepest survey of gene expression across multiple tissues and individuals to date, encompassing 7,051 samples from 449 donors across 44 human tissues. One of the studies, by Barbara Engelhardt and colleagues, characterized the relationship between genetic variation and gene expression. This study appeared October 11 in the journal Nature, in an article entitled “Genetic effects on gene expression across human tissues.” It indicated that most genes are regulated by genetic variation near to the affected gene. “We find

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15.10.2017
18:07 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Enhanced RGC Generation, Bladder Tissue Engineering, Placental MSC-Treatment of Cardiomyopathy, and MSC-EVs Enhance Survival after Irradiation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Enhanced Generation of Human Retinal Ganglion Cells

A new report from the labs of Donald J. Zack (Johns Hopkins University School of Medicine, Maryland, USA) and Derek S. Welsbie (University of California, USA) describes a novel means to efficiently differentiate and purify retinal ganglion cells (RGC) from pluripotent stem cells (PSCs). Employing

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12.10.2017
21:07 Phys.orgThe sea cucumber genome points to genes for tissue regeneration

A new high-definition genome sequence of the sea cucumber provides molecular insights into its ability to regenerate, according to a new study publishing 12 October in the open access journal PLOS Biology by Xiaojun Zhang, Lina Sun, Hongsheng Yang and Jianhai Xiang, of the Institute of Oceanology, Chinese Academy of Sciences, and colleagues. The genome sequence also helps explain why the sea cucumber has such a radically different skeletal structure from other members of the echinoderm phylum, and may be useful for understanding evolution of the animal kingdom.

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18:18 FierceBiotech.comNew stem cell type expands R&D, regenerative medicine possibilities

Scientists from the Wellcome Trust Sanger Institute have created a new type of stem cell that retains the ability to develop into any type of cell. Derived from embryos in the earliest stage of development, these stem cells open the doors to disease research and the development of regenerative treatments.

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