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Regeneration

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27.06.2017
15:11 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Regenerating the Diabetic Heart, Tissue Repair with Stem Cell-EVs, ESC-Derived Dopaminergic Neurons, and Trialing ADRCs for Breast Cancer-Related Lymphedema!

A roundup of some the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond brought to you by the Stem Cells Portal!
Regenerating the Diabetic Heart: Reviewing the Challenges

Stem cell treatments to improve cardiac function are impaired in diabetic patients due to the progressive decline in the regenerative capacity of the stem cells themselves. Now, a new article from the labs of Rajesh Katare and Regis R Lamberts (University of Otago, Dunedin, New Zealand) aims to

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10:51 FinancialExpress.comHumans can regenerate their heart: Study

A team of researchers have discovered that communication between the heart genes may give rise to heart cells that can regenerate the human heart.
The post Humans can regenerate their heart: Study appeared first on The Financial Express.

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09:33 News-Medical.NetCarbon nanotubes show great potential to facilitate neuronal regeneration

Carbon nanotubes exhibit interesting characteristics rendering them particularly suited to the construction of special hybrid devices - consisting of biological issue and synthetic material - planned to re-establish connections between nerve cells, for instance at spinal level, lost on account of lesions or trauma.

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02:35 ScienceDaily.comCould humans ever regenerate a heart? A new study suggests the answer is 'yes'

A new study's findings point to potential for tweaking communication between human genes and advancing our ability to treat heart conditions and stimulate regenerative healing.

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26.06.2017
22:02 Phys.orgCould humans ever regenerate a heart? A new study suggests the answer is 'yes'

When Mark Martindale decided to trace the evolutionary origin of muscle cells, like the ones that form our hearts, he looked in an unlikely place: the genes of animals without hearts or muscles.

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21:37 StemCellsPortal.comlLab-grown human colons could change study of GI disease

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers at Cincinnati Children’s Hospital Medical Center who led the project.
The technology allows diseases of the colon to be studied in unprecedented detail in a human modeling system. It also comes with the potential to one day generate human gastrointestinal (GI) tract tissues for transplant into patients, according to James Wells, Ph.D., senior study investigator and director of the Cincinnati Children’s Pluripotent Stem Cell Center.
“Diseases affecting this region of the GI tract are quite prevalent and include ailments like colitis, colon cancer, irritable bowel

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23.06.2017
22:54 DigitalTrends.comMichelin’s new 3D-printed tire concept responds to terrain, regenerates tread

Unlike traditional tires, which must be replaced every few years, Michelin's new 3D printed tires will regenerate new tread -- and maybe even outlast your car.
The post Michelin’s new 3D-printed tire concept responds to terrain, regenerates tread appeared first on Digital Trends.

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15:01 IbTimes.co.uk How giant Burmese pythons regenerate their organs

They can double the size of their heart.

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22.06.2017
23:55 ScienceDaily.comLab grown human colons change study of GI disease

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to new research. The study is believed to be the first time human colon organoids have been successfully tissue engineered in this manner, according to researchers who led the project.

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20:05 ScienceDaily.comHow pythons regenerate their organs and other secrets of the snake genome

Snakes exhibit incredible evolutionary adaptations, including the ability to rapidly regenerate their organs and produce venom. Scientists studied these adaptations using genetic sequencing and advanced computing. Supercomputers helped the team identify a number of genes associated with organ growth in Burmese pythons, study secondary contact in related rattlesnake species, and develop tools to recognize evolutionary changes caused by natural selection.

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15:32 FightAging.OrgAltering Relative Macrophage Population Numbers to Enhance Nerve Regeneration

A good deal of evidence has accumulated to show that the immune cells called macrophages play important roles in regeneration. Further, there are several different classes of macrophage with quite different behaviors, and while all are essential in the bigger picture, one of them tends to hinder regeneration as a side-effect of the accomplishment of its other duties. Researchers have shown in a number of studies that adjusting the proportion of macrophages in a tissue, towards less of the hindering type, can significantly improve outcomes, and perhaps even produce regeneration that would normally not occur with any great reliability, such as regrowth of nerve tissue. This paper is a recent example of this area of research: After nerve trauma, the standard clinical operating procedure is […]

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21.06.2017
22:19 ScienceDaily.comNeurons that regenerate, neurons that die

Investigators report on a transcription factor that they have found that can help certain neurons regenerate, while simultaneously killing others.

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20.06.2017
03:54 News-Medical.NetScientists design bioactive nanomaterial that excels at stimulating bone regeneration

There hasn't been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.

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19.06.2017
12:05 FinancialExpress.comLab-grown mini-organs may help treat facial defects

Scientists are growing functioning mini-organs of the skull and face that may help treat facial deformities in newborns.
The post Lab-grown mini-organs may help treat facial defects appeared first on The Financial Express.

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17.06.2017
07:58 InsideEVs.comInvestigating Regenerative Braking Abilities Of Formula E Racers – Video

There is more technology in play in Formula E than in just about any other racing series. And one of the keys to putting a competitive team on the track in Formula E tick, is maximizing the regenerative braking abilities of the all-electric racers. Watch Marc Priestley take one of the cars and...

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16.06.2017
11:30 Technology.orgSpace-traveling flatworms help scientists enhance understanding of regenerative health

Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists

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15.06.2017
22:58 CARandDriver.comMichelin Reveals Another Airless Wheel/Tire Concept, But This One Is Biodegradable and 3D Printed

  While gamers are losing their minds at the Electronic Entertainment Expo in Las Vegas this week, Movin’On—formerly known as the Michelin Challenge Bibendum—is going down in Montreal. The global summit explores topics of sustainability, mobility, and how to effectively and efficiently blend the two. It was the perfect and obvious place for Michelin to unveil its […]

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22:46 CARandDriver.comMichelin Reveals Another Airless Wheel/Tire Concept, But This One Is Biodegradable and 3D Printed

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03:18 News-Medical.NetSLU scientists discover nuclear receptor that appears to play key role in muscle regeneration

Saint Louis University researchers report in Molecular Metabolism new findings that the nuclear receptor REV-ERB appears to play a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries.

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01:59 FightAging.OrgRecent Examples of the Road to Pharmacological Enhancement of Muscle Regeneration

Numerous research teams are interested in finding ways to enhance muscle regeneration, and below find the publicity materials for a couple of different lines of research along these lines - researchers in search of specific mechanisms that might be amenable to change, and thus the potential foundation for a drug discovery program and therapies in the clinic. Enhanced muscle regeneration encompasses more than just faster and more comprehensive recovery from injury, as much the same set of mechanisms are also involved in the normal maintenance and growth of muscles. As I'm sure the audience here is well aware, muscle tissue weakens and diminishes with age, a condition known as sarcopenia. Researchers hope that enhancements to the processes of muscle repair will be able to at […]

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00:56 ScienceDaily.comKey to muscle regeneration discovered

The nuclear receptor REV-ERB plays a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries.

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14.06.2017
22:17 AutoBlog.comMichelin unveils Vision 3D-printed, recyclable, biodegradable concept tire

Filed under: Design/Style,Green,Videos,Emerging Technologies,Technology
Made from sustainable materials and inspired by nature, it's a futuristic wheel and tire in one. Continue reading Michelin unveils Vision 3D-printed, recyclable, biodegradable concept tire

Michelin unveils Vision 3D-printed, recyclable, biodegradable concept tire originally appeared on Autoblog on Wed, 14 Jun 2017 15:01:00 EDT. Please see our terms for use of feeds.
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20:28 Nature.ComTissue engineering: NIH competition to create 'eye in a dish'

The National Eye Institute of the US National Institutes of Health (NIH) has launched a competition to develop a working model of the human retina from stem cells — namely, the 3-D Retina Organoid Challenge (see www.nei.nih.gov/3droc). This will help to clarify the mechanisms

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06:09 News-Medical.NetStudy: Seal oil holds potential to help promote nerve regeneration in patients with Type 1 diabetes

A research team at the Krembil Neuroscience Centre in Toronto has published a paper that suggests seal oil has the potential to help promote nerve regeneration in patients with Type 1 diabetes.

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13.06.2017
17:18 ScienceDaily.cominflammatory molecule essential to muscle regeneration in mice, researchers find

A molecule released as part of an inflammatory response after muscle injury or rigorous exercise activates muscle stem cells responsible for repairing the damage, according to a study.

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15:54 GenEngNews.comLab-Grown Cartilage May Serve as Effective Treatments for Joint Diseases

University of California-Davis researchers say they have created a lab-grown tissue similar to natural cartilage. The tissue, grown under tension but without a supporting scaffold, shows similar mechanical and biochemical properties to natural cartilage, according to the scientists, who published their study ("Tension stimulation drives tissue formation in scaffold-free systems") in Nature Materials . The investigators explain that articular cartilage provides a smooth surface for joints to move, but it can be damaged by trauma, disease or overuse. Once damaged, it does not regrow and is difficult to replace. Artificial cartilage that could be implanted into damaged joints would have great potential to help people regain mobility, the researchers point out. Natural cartilage is formed by chondrocytes that stick together and produce a matrix of proteins and other molecules that solidifies

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15:40 FightAging.OrgAnother Potential Approach to the Creation of Tissue Engineered Cartilage

Cartilage is a comparatively simple, homogeneous tissue, and the medical community has a great deal of experience in treating cartilage injuries, so it is an obvious place to start for tissue engineers. Creating cartilage that has the correct load-bearing characteristics has proven to be a challenge, however: you can't just put cartilage cells into a bioreactor on their own and expect to obtain anything other than a sloppy gel at the end of the day. Fortunately, a number of groups have made progress in recent years on this front, finding approaches to convince the cells involved to generate the suitably structured extracellular matrix needed to form a solid, high-strength tissue. The method described here is one of the more straightforward ones: Biomedical engineers have created […]

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13:15 News-Medical.NetUC Davis biomedical engineers create lab-grown tissue similar to natural cartilage

Biomedical engineers at the University of California, Davis, have created a lab-grown tissue similar to natural cartilage by giving it a bit of a stretch.

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12.06.2017
21:01 StemCellsPortal.comlUIC launches Center for Stem Cell and Regenerative Medicine

The University of Illinois at Chicago College of Medicine will launch a new center focused on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.
Researchers in the University of Illinois Center for Stem Cell and Regenerative Medicine will investigate the molecular signals that drive stem cells to mature into different cell types, such as blood, heart and blood vessel cells. The center will also study the epigenetic regulation of stem cells; determine the best approaches to transplant engineered cells, tissues and organs; and look for ways to efficiently produce the regenerative cells needed for novel treatments.
Asrar Malik, Ph.D., professor and head of pharmacology in the UIC College of Medicine, is guiding the effort. A search is under way to recruit a director and additional

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14:48 FightAging.OrgRegeneration of Structured, Full-Thickness Skin, Including Hair Follicles

The tissue engineering company PolarityTE is claiming regrowth of correctly structured skin in pigs, incorporating hair follicles and various glands. The press release and company website are light on some of the more interesting details, such as just how close to natural skin the end result is in this case, but we shouldn't have to wait too long to find out more. Clinical trials are starting this year. PolarityTE, Inc. today announced pre-clinical results demonstrating that the Company's lead product, SkinTE, regenerated full-thickness, organized skin and hair follicles in third degree burn wounds. The findings represent the first known successful regeneration of skin and hair in full-thickness swine wound models, the standard animal model for human skin. The Company expects to initiate a human clinical […]

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11.06.2017
19:11 DigitalTrends.comWe could be closer than ever to regenerating skin for burn victims

In initial experiments, Salt Lake City, Utah-based PolarityTED has successfully regenerated skin in pigs with burns and abrasions, and this could herald imminent success in humans as well.
The post We could be closer than ever to regenerating skin for burn victims appeared first on Digital Trends.

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14:45 FinancialExpress.comWorm regenerates into rare two-headed creature in space

In a first, an amputated worm regenerated into a double-head creature after spending five weeks aboard the International Space Station (ISS), scientists said.
The post Worm regenerates into rare two-headed creature in space appeared first on The Financial Express.

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12:46 DnaIndia.comWorm regenerates into rare two-headed creature in space

In a first, an amputated worm regenerated into a double-head creature after spending five weeks aboard the International Space Station (ISS), scientists said.

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11:18 DnaIndia.comWorm regenerates into rare two-headed creature in space

In a first, an amputated worm regenerated into a double-head creature after spending five weeks aboard the International Space Station (ISS), scientists said.

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10.06.2017
13:09 FinancialExpress.comZero gravity can affect regenerative health of space travellers

The research has implications for human and animal space travellers and for regenerative and bioengineering science.
The post Zero gravity can affect regenerative health of space travellers appeared first on The Financial Express.

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09.06.2017
20:38 News-Medical.NetResearchers study space-exposed worms to improve understanding of regenerative health

Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration.

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18:36 ScienceDaily.comSpace-traveling flatworms help scientists enhance understanding of regenerative health

Flatworms that spent five weeks aboard the International Space Station are helping researchers scientists study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper. The research has implications for human and animal space travelers and for regenerative and bioengineering science.

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16:10 Phys.orgSpace-traveling flatworms help scientists enhance understanding of regenerative health

Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration. The research has implications for human and animal space travelers and for regenerative and bioengineering science.

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08.06.2017
19:55 Reuters.com ScienceIn major breakthrough, tiny Utah firm regenerates skin, hair in pigs

(Reuters) - A small U.S. biotech has successfully regenerated skin and stimulated hair growth in pigs with burns and abrasions, paving the way for a scientific breakthrough that could lead to the regeneration of fully functional human skin.

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10:06 Technology.orgSowing Stem Cells: Lab-Grown Organoids Hold Promise for Patient Treatments

Ophir Klein is growing teeth, which is just slightly less odd than what Jeffrey Bush is growing – tissues

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01:17 FightAging.OrgYet More Research Groups are Aiming to Make the Heart More Regenerative

The heart is one of the least regenerative of tissues in mammals, and we might well stop for a moment to ask why this is the case. Species capable of exception regeneration, such as salamanders and zebrafish, can regrow entire sections of the heart when injured. But even restricting ourselves to a consideration of mammals, why is it that the heart cannot regenerate as well as, say, the liver, the most regenerative of adult mammalian organs? Asking why the heart cannot regenerate goes hand in hand with asking how to change this state of affairs. There are a fair number of research groups involved in various different approaches to the questions above and the consequent development of treatments. It is a busy corner of the […]

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07.06.2017
15:14 Phys.orgRetirement and regeneration—how robots and replicants experience death

In the 2014 film Interstellar, Matt Damon's Dr Mann explains that "a machine doesn't improvise well because you cannot program a fear of death."

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03:25 News-Medical.NetUIC to open new center dedicated for stem cell and regenerative medicine

The University of Illinois at Chicago College of Medicine will launch a new center that will focus on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and tissues.

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05.06.2017
22:17 StemCellsPortal.comlOne Gene Closer to Regenerative Therapy for Muscular Disorders

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues. A study published June 1 in Nature Communications reports scientists identify a new gene essential to this process, shedding new light on possible new therapeutic strategies.
Led by researchers at the Cincinnati Children’s Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein – which the scientists named “myomerger” – prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive. They also show that myomerger works with another gene, Tmem8c, and its associated protein “myomaker” to fuse cells that normally would not.
In laboratory tests on embryonic mice engineered to not express myomerger in skeletal

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19:22 MedicalNewsToday.comMedical News Today: Type 2 diabetes: New biopolymer injection may offer weeks of glucose control

New biopolymer injection could potentially replace daily or weekly insulin shots for type 2 diabetes with one that need only occur once or twice per month.

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01.06.2017
18:20 SingularityHub.ComLimitless Lab-Grown Blood Is ‘Tantalizingly Close’ After 20 Years

Blood stem cells are things of wonder: hidden inside each single cell is the power to reconstitute an entire blood system, like a sort of biological big bang. Yet with great power comes greater vulnerability. Once these “master cells” are compromised, as in the case of leukemia and other blood disorders, treatment options are severely […]

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31.05.2017
16:03 FightAging.OrgIn Search of Ways to Induce Heart Regeneration

The heart is one of the least regenerative organs in mammals, but this actually isn't the case in every circumstance; some types of injury and stimulus do produce a greater regenerative response, even if nowhere near as large as desired. The suspicion is that the capacity for greater regenerative exists, but is muted in some way, perhaps by cancer suppression mechanisms such as the ARF gene. Thus researchers are hunting for clues in the biochemistry of more regenerative species, such as zebrafish and salamanders, in order to discover whether or not mammalian heart cells can be adjusted to heal injuries more readily. Another place to look, as illustrated here, is in the biochemistry of the few circumstances in which mammalian hearts are known to regenerate […]

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29.05.2017
22:36 Technology.orgRegeneration of deprived neighbourhoods can improve residents’ mental health

Community-led regeneration in deprived neighbourhoods can improve the mental health of residents, concludes research by Cardiff University. The

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18:01 ScienceDaily.comThe immune system promotes spontaneous heart regeneration

In adult mammal hearts, cardiomyoctyes do not proliferate following damage, like that caused by myocardial infarction. However, the inability to proliferate is not true for all animals, and even in mammals, cardiomyocyte proliferation is known.

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26.05.2017
23:16 ValueWalk.comCan We Discard ‘Exploitative Capitalism’ For A ‘Regenerative Economy’?

Last year was a banner year for divestment. In 2016, divestment went from a protest strategy primarily used by socially-conscious groups on a rather limited scale to the topic of political debate in major American cities and on university campuses […]
The post Can We Discard ‘Exploitative Capitalism’ For A ‘Regenerative Economy’? appeared first on ValueWalk.

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25.05.2017
16:10 FightAging.OrgStem Cells versus Inflammation in Tendon Regeneration

Tendon tissue is one of many tissue types in mammals that is reluctant to heal completely following injury. Better methods of regeneration are desired, here as elsewhere in the body, and stem cell therapies show a great deal of promise in this regard. The most reliable of current stem cell therapy approaches, those with the greatest expectation of benefits to result for the patient, appear to work largely through a reduction in chronic inflammation. It is interesting to see that hold up in the case of tendons and their supporting stem cell populations. New research suggests that tendon stem cells (TSCs) may be able to significantly improve tendon healing by regulating inflammation, which contributes to scar-like tendon healing and chronic matrix degradation. This has implications […]

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24.05.2017
19:31 ModernHealthCare.comFuturists discuss bionic, regenerative medicine at HealthQuake Summit in Detroit

An invited group of 30 physicians, executives, medical researchers, lawyers and the media gathered Monday at the HealthQuake Summit in Detroit to talk about the future of medicine and how science and technology is changing not only how research will...

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16:05 FightAging.OrgA View of How Senescent Cells Disrupt Tissue Regeneration

Normal tissue regeneration is disrupted in various ways in later life, such as the tendency for increased fibrosis, scar tissue formation rather than normal regrowth. Researchers here theorize on the role of growing numbers of lingering senescent cells in this age-related loss of function, a complex situation because the transient creation of senescent cells, soon destroyed, is an important part of the normal wound healing process. Despite their positive function in that scenario, the accumulation of long-lasting senescent cells is nonetheless one of the root causes of aging. These cells produce a harmful effect on surrounding tissue through the potent mix of signals they generate, known as the senescence-associated secretory phenotype (SASP), which drives chronic inflammation, among other items. The inability of adult tissues to […]

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23.05.2017
19:53 SeekingAlpha.comAeglea Bio expects to expand early-stage study of lead product candidate AEB1102 into specific tumors types by Q4/Q1; shares down 8%

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19:03 Phys.orgResearchers reveal bioelectric patterns guiding worms' regenerative body plan after injury

Researchers have succeeded in permanently rewriting flatworms' regenerative body shape by resetting their internal bioelectric pattern memory, causing even normal-appearing flatworms to harbor the "code" to regenerate as two-headed worms. The findings, published today in Biophysical Journal, suggest an alternative to genomic editing for large-scale regenerative control, according to the authors.

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22.05.2017
15:20 Phys.orgToward lab-grown designer babies

It gives new meaning to the vulgarity "a piece of tail." The latest way of divorcing baby-making from the old-fashioned method not only involves no sexual relations, it doesn't even involve eggs and sperm. At least at first.

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14:32 LiveScience.comCould Humans Ever Regenerate a Limb?

If you cut the leg off a salamander, it grows back. Humans, however, can't manage the trick. The reasons are far from simple, and to some extent are still a bit of a mystery.

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19.05.2017
16:24 Yahoo ScienceLab-grown ovaries prove promising in mice

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18.05.2017
17:56 Phys.org3-D-printed polymer stents grow with pediatric patients and biodegrade over time

A new study demonstrates proof-of-concept for combining computational design and simulation tools with 3D printing technology to produce self-expandable polymer stents that can grow with pediatric patients, are biodegradable, and require only a minimally-invasive procedure for implantation. This innovative method is described in an article in 3D Printing and Additive Manufacturing.

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15:42 ScientificAmerican.ComLab-Grown Blood Stem Cells Produced At Last

Two research teams cook up recipe to make long-sought cells in mice and people -- Read more on ScientificAmerican.com

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14:40 Yahoo ScienceLab-grown ovaries prove promising in mice

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10:57 News-Medical.NetTumor mutation load in patient's biopsy varies by age and type of cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors.

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17.05.2017
23:25 Reuters.com HealthLab-grown ovaries prove promising in mice

(Reuters Health) - Artificial ovaries grown in a lab might someday be available for women with infertility due to cancer treatments or other conditions, a study in mice suggests.

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15:35 FightAging.OrgComparing Regeneration of Fingertips Between Species

As a sidebar to yesterday's post on regeneration in mammals, here is a review paper that just considers fingertip regeneration in various species. This can occur in mammals, and even on rare occasions in adult humans, though it isn't well understood as to why it happens at all given the inability to regenerate most other lost appendages. It is possible that this is a useful point of investigation in order to better understand why mammals do not regenerate like salamanders, and how that state of affairs might be changed for the better. Mammalian fingertips and toes can partially regrow under certain conditions; however, regeneration is greatly limited compared to urodele amphibians such as newts and salamanders that can completely regrow an amputated limb. The question […]

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05:13 News-Medical.NetResearchers find macrophages to be crucial for tissue regeneration in mammals

A team of University of Kentucky researchers has discovered that macrophages, a type of immune cell that clears debris at injury sites during normal wound healing and helps produce scar tissue, are required for complex tissue regeneration in mammals.

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03:31 FightAging.OrgMacrophages, and Possibly Senescent Cells, are the Keys to the Exceptional Regeneration of African Spiny Mice

In recent years, researchers have assembled a number of what appear to be important pieces of the puzzle when it comes to understanding regeneration and scarring. Why do mammals scar rather than regenerate like salamanders, and how do the exceptions to that rule function? Mutant MRL mice can heal small injuries without scarring, African spiny mice can regrow large sections of their skin without scarring, the liver can regrow sections of itself, and people can sometimes regenerate lost fingertips. It is of great interest to the medical community to come to a deeper understanding of the mechanisms of regeneration in our species and other mammals, as in principle anything that an MRL mouse can achieve in the healing of injury can be induced through suitable […]

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16.05.2017
23:15 ScienceDaily.comMacrophages identified as key factor for regeneration in mammals

New findings shed light on how immune cells might be harnessed to someday help stimulate tissue regeneration in humans.

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15.05.2017
18:39 StemCellsPortal.comlNew Muscle Stem Cell Expansion Technique May Boost Muscle Regeneration Strategies

Review of “Selective Expansion of Skeletal Muscle Stem Cells from Bulk Muscle Cells in Soft Three-Dimensional Fibrin Gel” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Studies have indicated that muscle stem cells (MuSCs) possess the potential to repair damaged or diseased muscle; however, the relative scarcity of adult MuSCs residing in muscle tissues currently inhibits any regenerative exploitation. Ex vivo expansion of sorted MuSCs represents one prospective solution, although current sorting steps are expensive, require large amounts of patient-derived cells, and involve the risk of contamination or the loss of regenerative capacity [1]. 

In a new STEM CELLS Translational Medicine study, researchers from the laboratory of Wen-Shu Wu (University of Illinois at Chicago, USA) now describe

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18:26 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Assessing Anti-tumor NSCs, Semaphorin 3A and Muscle Commitment, EPCR and Epidermal Stem Cells, and Adiponectin Control of Hematopoietic Regeneration!

A roundup of some the recent stories in the ever-changing world of stem cells and regenerative medicine
Assessing the Migration and Distribution of Anti-tumor Engineered NSCs

In the hope of enhancing the development and refinement of neural stem cell (NSC)-based anti-tumor therapies, the lab of Michael E. Barish (Beckman Research Institute of the City of Hope, California, USA) has recently completed a study on NSC migration and tumor coverage. Their STEM CELLS study employed a quantitative analysis of immunostained serially sectioned formalin-fixed paraffin-embedded (FFPE) brain tissue to provide a framework to assess the mechanisms that promote and limit this NSC-based

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16:16 FightAging.OrgDecorin as a Way to Reduce Scarring During Regeneration

Researchers here present a practical method of using decorin during wound healing in order to minimize scarring. This protein appears to influence a number of mechanisms associated with fibrosis in potentially beneficial ways, but has been challenging to make use of. It is possible that this work could have applications beyond wound healing, in other areas where tissue regeneration without scar formation is desired, such as in aged organs where fibrosis is a major issue. Scars form when the collagen scaffolding in skin is broken apart. Instead of re-forming in their original and neat basket-weave arrangement, the collagen fibres grow back in parallel bundles that create the characteristic lumpy appearance of scars. One way to reduce scarring is to apply decorin, a skin protein involved […]

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13.05.2017
20:03 Geek.comMoffat: 12th Doctor’s Regeneration ‘Impulsive, Reckless’

It’s easy to forget that this rip-roaring season of Doctor Who is in fact star Peter Capaldi and showrunner Steven Moffat’s last. Already a third of the way through series 10, we’re inching […]
The post Moffat: 12th Doctor’s Regeneration ‘Impulsive, Reckless’ appeared first on Geek.com.

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12.05.2017
22:23 ScienceDaily.comNew gelatin devices that imitate the activity of the body in bone regeneration

A team of scientists is developing structures that can be used as scaffolding in the regeneration of bone defects and which also release growth factors.

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17:03 Nanowerk.comNew gelatin devices that imitate the activity of the body in bone regeneration

Researchers are developing structures that can be used as scaffolding in the regeneration of bone defects and which also release growth factors.

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11:40 Technology.org3D-printed ‘bionic skin’ could give robots the sense of touch

Engineering researchers at the University of Minnesota have developed a revolutionary process for 3D printing stretchable electronic sensory

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11.05.2017
15:05 GenEngNews.comTissue Engineering Opens Door to Novel Type 1 Diabetes Therapy

Investigators from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine say they have produced the first clinical results demonstrating that pancreatic islet cells transplanted within a tissue-engineered platform can successfully engraft and achieve insulin independence in type 1 diabetes.  Their work ("Bioengineering of an Intraabdominal Endocrine Pancreas"), published in the New England Journal of Medicine , is part of an ongoing clinical study to test this novel strategy as an important step toward offering this therapy to millions living with the disease. Islet transplantation has demonstrated the ability to restore natural insulin production and eliminate severe hypoglycemia in people with type 1 diabetes. The insulin-producing cells have traditionally been implanted within the liver, but this transplant site poses some limitations for

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13:42 FinancialExpress.com3D-printed ‘bionic skin’ to give robots sense of touch

Scientists have developed a 3D printed stretchable electronic fabric that could give robots the ability to feel their environment.
The post 3D-printed ‘bionic skin’ to give robots sense of touch appeared first on The Financial Express.

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13:02 DnaIndia.com3D-printed 'bionic skin' to give robots sense of touch

Scientists have developed a 3D printed stretchable electronic fabric that could give robots the ability to feel their environment.

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09:51 Phys.org3-D-printed 'bionic skin' could give robots the sense of touch

Engineering researchers at the University of Minnesota have developed a revolutionary process for 3D printing stretchable electronic sensory devices that could give robots the ability to feel their environment. The discovery is also a major step forward in printing electronics on real human skin.

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10.05.2017
21:13 ScienceDaily.com3D-printed 'bionic skin' could give robots the sense of touch

Engineering researchers have developed a revolutionary process for 3D printing stretchable electronic sensory devices that could give robots the ability to feel their environment. The discovery is also a major step forward in printing electronics on real human skin.

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21:06 Nanowerk.com3D-printed 'bionic skin' could give robots the sense of touch (w/video)

Discovery could lead to electronics printed on real human skin.

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09.05.2017
16:40 Yahoo ScienceAbility to 'print off' new body parts within next 10 years as 3D bioprinting continues to grow

The 3D bioprinting market is predicted to be worth $1.8bn (£1.4bn, €1.7bn) by the year 2027, as we speed toward a future in which replacing damaged body parts will be as easy as printing off new ones – or so say experts. According to a report from IDTechEx, the 3D bioprinting industry is on the verge of a 'rapid expansion' during which the technology will become affordable and more widespread across industries. Most promising is its potential applications within healthcare, where 3D printing is poised to open up a new age of regenerative medicine allowing doctors to print off human cells.

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11:48 News-Medical.NetUAB symposium highlights use of tissue engineering to repair broken hearts

The third annual Cardiovascular Tissue Engineering Symposium met at the University of Alabama at Birmingham last month, a gathering of noted physicians and scientists who share the goal of creating new tissues and new knowledge that can prevent or repair heart disease and heart attacks.

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07.05.2017
01:51 ScienceDaily.comFixing broken hearts through tissue engineering

The third annual Cardiovascular Tissue Engineering Symposium met at the University of Alabama at Birmingham last month, a gathering of noted physicians and scientists who share the goal of creating new tissues and new knowledge that can prevent or repair heart disease and heart attacks.

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05.05.2017
15:48 FightAging.OrgOxidative Stress Caused by Immune Cells Contributes to the Age-Related Decline in Liver Regenerative Capacity

Researchers here provide evidence for the age-related decline in regenerative capacity of the liver to be caused in part by oxidative stress produced by innate immune cells. This makes the adult stem cells responsible for tissue maintenance less likely to activate, but when removed from the tissue environment the cells appear more or less as capable as those of younger individuals. In some other tissues, such as muscle, where stem cell biology is better studied, it is also thought that changes in the surrounding environment rather than internal damage drives the majority of the decline in stem cell activity with aging. This means that therapies capable of activating stem cells in older individuals may prove to be less risky and more useful than would otherwise […]

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04.05.2017
08:57 News-Medical.NetResearchers develop new model to analyze mechanical properties of tissue engineered cartilage

Researchers have developed a new model to analyze tissue engineered cartilage that allows for the use of a single method to assess functional tissue mechanics in cartilage constructs at all stages of development from the laboratory through large animal testing.

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28.04.2017
17:31 GenEngNews.comCRISPR-SMART Cells Regenerate Cartilage, Secrete Anti-Arthritis Drug

We have anti-arthritis drugs. What we lack is the ability to deploy them when and where they are needed in the body. The drugs would be far more effective, and occasion fewer side effects, if they were to appear only in response to inflammation, and only in the joints. If the drugs could be delivered so painstakingly—so smartly—they wouldn’t have to be administered systemically. Although conventional drug-delivery systems may be unable to respond to arthritic flares with such adroitness, cells may have better luck—if they are suitably modified. Stem cells, for example, have been “rewired” by means of gene-editing technology to fight arthritis. These stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), develop into cartilage cells that produce a biologic anti-inflammatory drug. Ideally, the new cartilage cells will replace arthritic cartilage, and the

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13:33 Technology.orgMouse Teeth Providing New Insights into Tissue Regeneration

Researchers hope to one day use stem cells to heal burns, patch damaged heart tissue, even grow kidneys and

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02:29 ScienceDaily.comMouse teeth providing new insights into tissue regeneration

Researchers hope to one day use stem cells to heal burns, patch damaged heart tissue, even grow kidneys and other transplantable organs from scratch.

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27.04.2017
20:40 SeekingAlpha.comFDA OKs BioMarin's cerliponase alfa for type of Batten disease; shares ahead 1%

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19:01 News-Medical.NetHair-derived keratin biomaterials show promise to regenerate skeletal muscle tissue and function

The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models of volumetric muscle loss.

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25.04.2017
05:34 DigitalTrends.comShoetopia is a 3D-printed, biodegradable shoe design prototype

For shoes, 3D-printing is the next step, as 3D-printed shoes could be an affordable way to manufacture customized shoes quickly. Two design students have already designed a prototype, 3D-printed shoe made of eco-friendly materials.
The post Shoetopia is a 3D-printed, biodegradable shoe design prototype appeared first on Digital Trends.

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20.04.2017
13:50 DigitalTrends.comFrom lab grown steaks to plant based blood, science is taking the animal out of meat

With the world's population booming, scientists are hard at work figuring out new ways to feed more people in a sustainable and ethical way.
The post From lab grown steaks to plant based blood, science is taking the animal out of meat appeared first on Digital Trends.

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19.04.2017
16:34 News-Medical.NetJohns Hopkins study shows that healthy adult gut loses and regenerates nerve cells

Johns Hopkins researchers today published new evidence refuting the long-held scientific belief that the gut nerve cells we're born with are the same ones we die with.

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12.04.2017
16:37 ScienceDaily.comSuccess of sensory cell regeneration raises hope for hearing restoration

Scientists have regenerated immature auditory hair cells in adult mice by manipulating two genes, suggesting that the research offers clues for better treatment of hearing loss.

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16:32 Geek.comWolverine’s Regenerative Powers Inspire Self-Healing Smartphone Tech

Your expensive smartphone sat on a wall. Your expensive smartphone had a great fall. Researchers have developed a self-repairing polymeric material that could put your expensive smartphone back together again. Scientists at the […]
The post Wolverine’s Regenerative Powers Inspire Self-Healing Smartphone Tech appeared first on Geek.com.

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05:02 News-Medical.NetResearchers use genetic manipulation to regenerate auditory hair cells in adult mice

In an apparent first, St. Jude Children's Research Hospital investigators have used genetic manipulation to regenerate auditory hair cells in adult mice. The research marks a possible advance in treatment of hearing loss in humans. The study appears today in the journal Cell Reports.

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11.04.2017
15:07 Geek.comCapaldi: Doctor’s Regeneration Isn’t ‘Straightforward’

The BBC last week released another look at the upcoming season of Doctor Who, teasing what appears to be an early bout of regenerative power coming from the Twelfth Doctor’s hand. Lead actor […]
The post Capaldi: Doctor’s Regeneration Isn’t ‘Straightforward’ appeared first on Geek.com.

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07.04.2017
03:41 Nanowerk.comScientists expand ability of stem cells to regrow any tissue type

Scientists are reporting their discovery of a chemical cocktail that enables cultured mouse and human stem cells to generate both embryonic and extra-embryonic tissues.

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06.04.2017
23:51 Phys.orgScientists expand ability of stem cells to regrow any tissue type

When scientists talk about laboratory stem cells being totipotent or pluripotent, they mean that the cells have the potential, like an embryo, to develop into any type of tissue in the body. What totipotent stem cells can do that pluripotent ones can't do, however, is develop into tissues that support the embryo, like the placenta. These are called extra-embryonic tissues, and are vital in development and healthy growth.

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22:56 ScienceDaily.comAbility of stem cells expanded to regrow any tissue type

A new technique, which allows scientists to generate both embryonic and non-embryonic tissues from cultured stem cells, is a step toward growing donor organs and replacement tissues to combat aging and diseases.

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