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Stem Cells

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25.03.2019
11:32 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Megakaryocyte Production, Radiation-induced Fibrosis Treatment, Ocular Surface Reconstruction, and Oncolytic Viruses!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Gas-Permeable Surfaces Enhance Megakaryocyte Production

Challenges related to storage and fluctuating supply have limited donor‐based platelet transfusions for patients suffering from acute or sustained thrombocytopenia. Researchers led by Andres F. Martinez and William M. Miller (Northwestern University, Evanston, Illinois, USA) hoped to develop cell‐culture technologies that will enable ex vivo and donor‐independent platelet production at a scalable and therapeutically relevant level. Now, the team's new STEM CELLS

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08:28 News-Medical.NetModulating stiffness of blood-forming stem cells could facilitate mobilization procedures

Scientists at Winship Cancer Institute of Emory University, Children's Healthcare of Atlanta and Georgia Tech have found that modulating blood-forming stem cells' stiffness could possibly facilitate mobilization procedures used for stem cell-based transplants.

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23.03.2019
00:02 ScienceDaily.comSquishing blood stem cells could facilitate harvest for transplants

How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities.

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22.03.2019
13:59 Phys.orgNot all stem cells are created equal, study reveals

Researchers from the University of Toronto's Institute for Biomaterials and Biomedical Engineering (IBBME) and the Donnelly Centre have discovered a population of cells – dubbed to be "elite" – that play a key role in the process of transforming differentiated cells into stem cells. The finding has important implications for regenerative medicine.

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10:54 Rejuvenation ResearchFrailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges

Rejuvenation Research, Ahead of Print.

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10:32 News-Medical.NetUnderstanding maintenance of quiescent stem cells in chronic myelogenous leukemia

Most patients with chronic myelogenous leukemia can be treated with tyrosine kinase inhibitors. These drugs are highly effective and lead to deep remission and prolonged survival.

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10:21 News-Medical.NetLian wins ENGINE grant for stem-cell-based therapy to treat Type 1 diabetes

Xiaojun "Lance" Lian, assistant professor of biomedical engineering, was one of three recipients of the College of Engineering's ENGineering for Innovation & Entrepreneurship grant for "Small Molecule-Based Definitive Endoderm Kit and Pancreatic Progenitor Kit for Stem Cell Research and Therapy."

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02:46 ScienceDaily.comHow 'sleeper cell' cancer stem cells are maintained in chronic myelogenous leukemia

Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular type of bone marrow cell controls quiescence of these treatment-resistant leukemic stem cells. The chemokine is CXCL12, and the particular bone marrow cells expressing it are mesenchymal stromal cells.

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21.03.2019
19:57 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Stem Cell-Derived Exosomes, MSC Therapy for Knee Osteoarthritis, Long-term Starvation of MSCs, and Cartilage Endplate Degeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Stem Cell-Derived Exosomes Alleviate Aging Traits

As previous studies discovered that extracellular vesicles (EVs) secreted by human mesenchymal stem cells (MSCs) play roles in tissue repair and regeneration, researchers led by Linzhao Cheng and Vasiliki Mahairaki (Johns Hopkins University School of Medicine, Baltimore, USA) examined EVS derived from human induced pluripotent stem cells (iPSCs) cultured in chemically defined medium free of any exogenous EVs. Interestingly, Liu et al. discovered that iPSCs generated

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19:57 StemCellsPortal.comlGene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Review of “Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing” from Cell by Stuart P. Atkinson 

A cardiovascular disease locus present at 9p21.3 strongly influences the risk of coronary artery disease, stroke, and aneurysms [1]; however, deciphering the function of this sizeable human-specific coding gene-free risk haplotype has proven problematic. Subsequent studies have implicated a crucial role for the vascular smooth muscle cells (VSMCs) that compose the majority of blood vessel walls [2], although the senescence of VSMCs in vitro and their known phenotypic heterogeneity across individuals, tissues, and disease states have made them difficult to study [3].

To solve these problems, researchers from the laboratory of Kristin K. Baldwin (The Scripps Research Institute, La Jolla, CA, USA) combined gene-editing and induced

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19:57 StemCellsPortal.comlNew Trial of Umbilical Cord Mesenchymal Stem Cells for Osteoarthritis Suggests Safety and Efficacy

Review of “Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Successful animal trials of mesenchymal stem cell (MSC) therapy as a means to inhibit progression to osteoarthritis have encouraged the assessment of MSCs derived from various sources in human patients, including a phase I trial of allogeneic bone marrow MSCs that reported improvements in joint pain and function [1]. Multiple studies, including those from the laboratory of Francisco Espinoza (Universidad de los Andes, Santiago, Chile), have discovered that umbilical cord MSCs exhibit enhanced clonogenic, proliferative, and

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10:08 Gizmag Revolutions: The incredible potential of induced pluripotent stem cells


Revolutions is a series that brings together a hand-picked selection of recent articles bringing together cutting-edge insights into major scientific advances. This installment brings you up to date with the ground-breaking new discoveries made around the regenerative possibilities of induced pluripotent stem cells, which can theoretically be coaxed into any kind of cell in the human body.
.. Continue Reading Revolutions: The incredible potential of induced pluripotent stem cells Category: Medical Tags: Induced Pluripotent Stem Cells (iPS) Regenerative Medicine Revolutions Stem Cells

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19.03.2019
19:06 Rejuvenation ResearchStem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice

Rejuvenation Research, Volume 22, Issue 1, Page 51-59, February 2019.

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18.03.2019
14:29 StemCellsPortal.comlNew Trial of Umbilical Cord Mesenchymal Stem Cells for Osteoarthritis Suggests Safety and Efficacy

Review of “Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Successful animal trials of mesenchymal stem cell (MSC) therapy as a means to inhibit progression to osteoarthritis have encouraged the assessment of MSCs derived from various sources in human patients, including a phase I trial of allogeneic bone marrow MSCs that reported improvements in joint pain and function [1]. Multiple studies, including those from the laboratory of Francisco Espinoza (Universidad de los Andes, Santiago, Chile), have discovered that umbilical cord MSCs exhibit enhanced clonogenic, proliferative, and

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14:06 StemCellsPortal.comlGene-editing in Induced Pluripotent Stem Cells Reveals How Risk Locus Influences Cardiovascular Disease

Review of “Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing” from Cell by Stuart P. Atkinson 

A cardiovascular disease locus present at 9p21.3 strongly influences the risk of coronary artery disease, stroke, and aneurysms [1]; however, deciphering the function of this sizeable human-specific coding gene-free risk haplotype has proven problematic. Subsequent studies have implicated a crucial role for the vascular smooth muscle cells (VSMCs) that compose the majority of blood vessel walls [2], although the senescence of VSMCs in vitro and their known phenotypic heterogeneity across individuals, tissues, and disease states have made them difficult to study [3].

To solve these problems, researchers from the laboratory of Kristin K. Baldwin (The Scripps Research Institute, La Jolla, CA, USA) combined gene-editing and induced

Скрыть анонс
13:55 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Stem Cell-Derived Exosomes, MSC Therapy for Knee Osteoarthritis, Long-term Starvation of MSCs, and Cartilage Endplate Degeneration!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Stem Cell-Derived Exosomes Alleviate Aging Traits

As previous studies discovered that extracellular vesicles (EVs) secreted by human mesenchymal stem cells (MSCs) play roles in tissue repair and regeneration, researchers led by Linzhao Cheng and Vasiliki Mahairaki (Johns Hopkins University School of Medicine, Baltimore, USA) examined EVS derived from human induced pluripotent stem cells (iPSCs) cultured in chemically defined medium free of any exogenous EVs. Interestingly, Liu et al. discovered that iPSCs generated

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15.03.2019
21:30 Nature.ComJapan poised to allow ‘reprogrammed’ stem-cell therapy for damaged corneas

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14.03.2019
12:24 Technology.orgGenetically Encoded Sensor Isolates Hidden Leukemic Stem Cells

All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most

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11:46 BBC HealthOscar Saxelby-Lee: Mum 'overwhelmed' by stem cell donor campaign

Thousands of people have registered to find a stem cell match for a five-year-old with leukaemia.

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00:05 SeekingAlpha.comU.S. Stem Cell reports FY results

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13.03.2019
21:38 ScienceDaily.comHematopoietic stem cells: Making blood thicker than water

A team revealed that Ragnase-1 is a key regulator of the self-renewal and differentiation of hematopoietic stem and progenitor cells. Knockout of this gene in mice resulted in aberrant blood cell composition and hematopoiesis, and caused health-related outcomes such as low hemoglobin, enlarged spleen, and early death. This insight into blood cell homeostasis and differentiation could lead to treatments for diseases such as leukemia in which these regulatory processes go awry.

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17:03 CancerNetwork.comStem Cell Transplant Approaches for Patients With Blood Cancers

Dr. Scadden discusses which blood cancer patients are eligible for stem cell transplantation, as well as the latest advances in the field.

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12.03.2019
23:23 News-Medical.NetNovel biosensor can isolate and target leukemic stem cells

All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. Understanding how leukemic stem cells are regulated has become an important area of cancer research.

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20:14 ScienceDaily.comGenetically encoded sensor isolates hidden leukemic stem cells

Researchers have devised a novel biosensor that can isolate and target leukemic stem cells. It can provide a prototype for precision oncology efforts to target patient-specific cells to fight the deadly disease.

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11.03.2019
17:16 StemCellsPortal.comlGenetic ‘Conductor’ of Brain Stem Cells Discovered

TRIESTE (IT), March 2019 — Our brain comprises 85 billion nerve cells and just as many so-called glial cells, which work in close contact with the former to guarantee their proper function. All originate from brain stem cells. But what decides when and how many of them become neurons or glial cells?
A new study led by the Laboratory of Cerebral Cortex Development of SISSA (Scuola Internazionale Superiore di Studi Avanzati) has shown how the Foxg1 gene, already involved in numerous processes of cerebral development and in rare disorders like Rett and West syndromes, plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment.
The work, published in Cerebral Cortex and conducted in collaboration with the University of Cambridge and the IRCCS Burlo Garofolo, opens new

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17:04 StemCellsPortal.comlStem cells provide greater insight into rotator cuff disease

ANN ARBOR, MI (US), March 2019 — Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult.
“Chronic tears often result in fat accumulation within the rotator cuff muscles, resulting in negative clinical outcomes including weakening and atrophy of the muscles,” said Manuel Schubert, M.D., resident in orthopedic surgery at Michigan Medicine, University of Michigan. “It’s believed that this process of fat infiltration makes rotator cuff muscle damage one of the most difficult to rehabilitate after injury.”
Dr. Schubert explained that the process of fat accumulation following a tear appears to occur more frequently in rotator cuff muscles than other muscle groups. But why this particular muscle set?
“We wanted to determine if there are cellular, molecular and genetic reasons for why rotator cuff muscles tend to develop this fat

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16:52 StemCellsPortal.comlPotentiating the Therapeutic Activity of Mesenchymal Stem Cells for Asthma Treatment

Review of “Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

As asthma patients suffer from chronic allergic immune and inflammatory responses in the airways, researchers have turned to the immunomodulatory power of mesenchymal stem cell (MSC) therapy as a potential treatment option. However, the inability of MSCs derived from the bone marrow to secrete the required levels of critical factors needed for tissue repair and remodeling [1-3] (See an SCTM article here!) suggests the necessity for an additional pre-treatment or “potentiation” step before MSC administration. 

Researchers from the laboratory of Patricia R. M. Rocco (Federal University of Rio de Janeiro, Rio

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16:26 StemCellsPortal.comlUncovering the Routes Linking Stroke to Neural Stem Cell Proliferation and Differentiation

Review of “Systemic factors trigger vasculature cells to drive Notch signaling and neurogenesis in neural stem cells in the adult brain” from STEM CELLS by Stuart P. Atkinson 

Experimental stroke from middle cerebral artery occlusion leads to increased neural stem cell proliferation and differentiation towards a neuronal fate (neurogenesis) [1]; however, how injury‐related signals drive this process remains unknown. Interestingly, studies describing extensive close contacts between vascular cells, such as endothelial cells and pericytes, and the cells of the neural stem cell niche [2, 3], suggest that this interaction may represent a potential signaling conduit connecting systemic signals to neural stem cells.

Most neural stem cell niches contain a permeable blood‐brain barrier, and previous research

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16:14 StemCellsPortal.comlNew Mapping Study in the Mouse Heart Finds No Evidence of Cardiac Stem Cells or Proliferative Cardiomyocytes

Review of “Profiling proliferative cells and their progeny in damaged murine hearts” from PNAS by Stuart P. Atkinson 

While studies have suggested that the differentiation of cardiac stem cells [1] or the division of preexisting cardiomyocytes [2] may contribute to the generation of new cardiomyocytes during the adult mammalian lifetime, doubts still surround the ability of the heart to regenerate post-injury [3]. 

Researchers from the group of Hans Clevers (Hubrecht Institute, Utrecht, The Netherlands) recently identified potential problems associated with related studies and sought to bypass any difficulty by employing a previously described Ki67 knockin reporter mouse models [4] to perform genetic lineage tracing and map proliferative cells in neonatal and adult healthy and damaged heart. 

Reporting in PNAS, Kretzschmar et al. now report a lack

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15:50 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? – Treating ALS with MSCs, Transdifferentiation with MIWI2, Exosomes from T1D BM-MSCs, and Esophageal Anastomotic Leakage Therapy!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Human Mesenchymal Stem Cells Reduce Necroptosis in ALS Model Mice

A recent study from Pavla Jendelova (Czech Academy of Science/Charles University, Prague, Czech Republic) sought to discover how human mesenchymal stem cell (hMSC) therapy functions when applied as a treatment for amyotrophic lateral sclerosis (ALS). Using a SOD1 rat model, Řehořová et al. demonstrated how repeated intrathecal and intramuscular application of hMSCs extended life span and protected motor neurons and neuromuscular junctions through the

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06.03.2019
14:31 FightAging.OrgModeling and then Realizing a Restoration of Stem Cell Activity in the Brain

Every month sees the passage of a great many papers describing the computational modeling of cells, protein biochemistry, tissue function, and so forth. All too few of those efforts go any further, moving into real cells and tissues in order to test predictions. Here, it is pleasant to see a group of researchers doing just that and obtaining promising results that add to the growing body of work regarding loss of stem cell activity with age, and means to at least partially reverse that loss. We all have the intuition that, yes of course greatly improved computational capacity has to be helping scientific initiatives move towards rejuvenation in some way, but good demonstrations of real progress remain all too thin on the ground. We are […]

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14:00 Geek.comSecond Patient Cleared of HIV After Stem-Cell Therapy

A second person appears to be in remission from human immunodeficiency virus (HIV) after receiving a stem-cell transplant first used a decade ago. Experts from the Universities of Cambridge and Oxford replaced the […]
The post Second Patient Cleared of HIV After Stem-Cell Therapy appeared first on Geek.com.

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00:34 Yahoo Science2nd ever HIV patient in remission after stem cell transplant: Doctors

A man who previously tested positive for HIV has shown no trace of the virus that causes AIDS since receiving a stem cell transplant more than a year ago, doctors say. The patient, a resident of the United Kingdom who has chosen to remain anonymous, appears to be the second known person to be declared free of HIV since the pandemic began. Both HIV-positive patients were diagnosed with cancer and received bone-marrow transplants from donors carrying two copies of a rare genetic mutation, known as CCR5-delta 32, that made them resistant to HIV-1, the most widespread and pathogenic strain of the human immunodeficiency viruses.

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05.03.2019
23:31 Nature.ComHIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

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23:05 Yahoo Science2nd ever HIV patient in remission after stem cell transplant: Doctors

A man who previously tested positive for HIV has shown no trace of the virus that causes AIDS since receiving a stem cell transplant more than a year ago, doctors say. The patient, a resident of the United Kingdom who has chosen to remain anonymous, appears to be the second known person to be declared free of HIV since the pandemic began. Both HIV-positive patients were diagnosed with cancer and received bone-marrow transplants from donors carrying two copies of a rare genetic mutation, known as CCR5-delta 32, that made them resistant to HIV-1, the most widespread and pathogenic strain of the human immunodeficiency viruses.

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21:21 FT.com HealthLondon patient ‘free’ of HIV after stem cell transplant

Man treated in UK is only the second person ever to go into remission from the virus

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21:21 FT.com ScienceLondon patient ‘free’ of HIV after stem cell transplant

Man treated in UK is only the second person ever to go into remission from the virus

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21:12 DigitalTrends.comFor the second time ever, a groundbreaking stem cell treatment has cured HIV

For the past decade, an American named Timothy Brown was the only person thought to have ever been cleared of the virus following an innovative cancer treatment procedure. Today, a study published in the journal Nature suggests that there may have finally been a second.
The post For the second time ever, a groundbreaking stem cell treatment has cured HIV appeared first on Digital Trends.

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18:21 StemCellsPortal.comlScientists Identify how Mutant Gene in Fish helps control Stem Cells

BATH (UK), March 2019 — Scientists at the University of Bath have identified how a mutant gene in fish is involved in controlling stem cells.
A new study from the group of Robert Kelsh, Ph.D., in the Department of Biology & Biochemistry looks at how a novel group of stem cells are controlled by mutations in a gene called parade.
They identified a new set of stem cells in zebrafish, which eventually become skin pigment cells of different colors. Populations of pigment stem cells are formed in the embryonic stages of development, but are then dormant and don’t mature into a final cell type until adulthood. This development is controlled by a range of factors called the “stem cell niche” – including surrounding cell types, blood supply and signals from nerves.
In parade mutants the zebrafish show large numbers of abnormally positioned pigment cells near the main blood vessels, lined

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18:21 StemCellsPortal.comlScientists Rejuvenate Stem Cells in Aging Mice Brains

LUXEMBOURG, March 2019— Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from the German Cancer Research Center (DKFZ) have been able to rejuvenate stem cells in the brains of aging mice.
The revitalized stem cells improve the regeneration of injured or diseased areas in the brains of old mice. The researchers expect that their approach will provide fresh impetus in regenerative medicine and facilitate the development of stem cell therapies. Their results were published in Cell.
All cells making up our organs originate from stem cells. With age, however, the stem cells of living organisms lose their ability to proliferate. Many of them lapse into a permanent state of quiescence.
In order to create computational models of stem cell behavior that are as accurate as possible, the LCSB’s Computational Biology Group led

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17:41 Nature.ComSecond patient free of HIV after stem-cell therapy

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14:29 TechnologyReview.comThe second person ever has been cleared of HIV after a stem cell treatment

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10:58 BBC HealthUK patient 'free' of HIV after stem cell treatment

In only the second case of its kind, a UK patient is in remission for HIV after stem cell treatment.

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08:57 Gizmag Stem cell treatment puts HIV into long-term remission in landmark study


An international team of scientists is reporting the "functional cure" of an HIV patient for only the second time ever. Known only as "the London patient," the man received a transplant of bone marrow stem cells from a donor that had a resistance to the virus. The patient has now been in remission for 18 months, with no sign of the HIV-1 virus in his bloodstream. But as exciting as the news is, there are a few caveats.
.. Continue Reading Stem cell treatment puts HIV into long-term remission in landmark study Category: Medical Tags: bone marrow Cambridge University Cancer HIV HIV and AIDS Leukemia Stem Cells University of Melbourne

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04.03.2019
18:24 ScienceDaily.comDiscovery of the genetic 'conductor' of brain stem cells

Our brain comprises 85 billion nerve cells and just as many so-called glial cells. But what decides when and how many of them become neurons or glial cells? A new study has shown how the Foxg1 gene plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment. The research opens new roads to understanding and treating incurable genetic diseases.

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16:10 News-Medical.NetUsing TGS technology to make the perfect match even better for stem cell transplant recipients

At Anthony Nolan we save the lives of people with blood cancers and blood disorders that need a stem cell transplant.

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15:05 StemCellsPortal.comlMesenchymal Stem Cells and Stimulated Macrophages: An Efficient Combination Treatment for Cirrhosis?

Review of “Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

A STEM CELLS report in 2006 established that infusions of bone marrow cells improved liver fibrosis and induced liver regeneration, leading to applications in experimental clinical trials for cirrhosis [1]. However, multiple questions remain unanswered, including those regarding the exact nature of the cell (or cells) with the greatest regenerative potential and the mechanisms involved. While mesenchymal stem cells (MSC) and macrophages play different functional roles, both cells types display promise in the treatment of cirrhosis. Alternatively activated M2 macrophages reduce inflammation and promote fibrosis

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13:46 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - KLF4-mediated Self-renewal, iPSC-derived Neutrophils, Modelling with iPSC Microglia, and Mouse ESC Proliferation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Reviewing KLF4 Regulation of Self-Renewal of ESCs and HSCs

Delineating the molecular regulation of self‐renewal in hematopoietic stem cells (HSCs) represents an essential step towards a deeper understanding of stem cell biology and regenerative medicine. However, this knowledge can also help to address the resistance of hematological malignancies to drug therapy and to develop novel therapies specific to leukemia stem cells, which represents an unmet medical need. Now, a new Review article from the lab of Daniel

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02.03.2019
03:39 ScienceDaily.comScientists rejuvenate stem cells in the aging brain of mice

Scientists have been able to rejuvenate stem cells in the brain of aging mice. The revitalized stem cells improve the regeneration of injured or diseased areas in the brain of old mice. The researchers expect that their approach will provide fresh impetus in regenerative medicine and facilitate the development of stem cell therapies.

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01.03.2019
02:33 ScienceDaily.comTurning them on, turning them off -- how to control stem cells

Scientists have identified how a mutant gene in fish is involved in controlling stem cells.

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28.02.2019
18:31 Phys.orgTurning them on, turning them off—how to control stem cells

Scientists at the University of Bath have identified how a mutant gene in fish is involved in controlling stem cells.

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17:00 FierceBiotech.comStemoniX rakes in $14.4M for micro-organ drug testing chips built from stem cells

Microtissue developer StemoniX has secured $14.4 million in funding to commercialize its organ-on-a-chip platforms for drug development.

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16:16 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - MSC Homing, iPSC-MSC Misidentification, Attenuating T1D Bone Loss, and Coordinated Tissue Repair!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
CREKA Improves the Targeted Homing Ability of Mesenchymal Stem Cells

A team of researchers from Fudan University, Shanghai (China) recently sought to improve mesenchymal stem cell (MSC) homing to the injured myocardium to improve therapeutic outcomes. To this end, the authors modified MSCs with a homing peptide (cysteine-arginine-glutamic acid-lysine-alanine - CREKA) that targets fibrin, which is involved in the repair process of tissue injury. Overall, this STEM CELLS article establishes their CREKA-associated

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27.02.2019
21:26 Nature.ComA radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

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21:26 Nature.ComA newly discovered stem cell that keeps bones growing

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18:40 StemCellsPortal.comlStudy Reveals new Mechanisms Regulating Neural Stem Cells

MUNICH (DE), February 2019 — The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. Scientists at (LMU) have discovered Helmholtz Zentrum München and Ludwig Maximilian University of Munich that the protein Akna plays a key role in this process. It controls, for example, the behavior of neural stem cells via a mechanism that may also be involved in the formation of metastases. The study was published in Nature.
The research team led by Magdalena Götz, Ph.D., director of the Institute for Stem Cell Research (ISF) at Helmholtz Zentrum München and chair of physiological genomics of the LMU Biomedical Center, wanted to identify the factors that regulate the maintenance or differentiation of neural stem cells. To this end, the scientists isolated neural stem cells, which either

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18:19 ValueWalk.comNew Stem Cell Therapy Can Treat Rare Blood Disorders

It’s extremely difficult to treat rare health disorders which can be fatal. However a new, private biotech project aims to change that, after combining CRISPR, a gene-editing tool which is bacteria-derived, and stem cell therapy. Now, this new stem cell […]
The post New Stem Cell Therapy Can Treat Rare Blood Disorders appeared first on ValueWalk.

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16:50 Phys.orgTurning stem cells into bone with nanoclay-reinforced hydrogel

Assistant Professor Alireza Dolatshahi-Pirouz and colleagues have developed a hydrogel that combines synthetic materials with living cells, and can turn stem cells into bone without adding external growth or differentiation factors.

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10:10 News-Medical.NetNew study explores stem cells to gain insight into rotator cuff disease

Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult.

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06:35 BBC HealthWas Shauna the victim of a rush to develop stem cell technology?

British teenager Shauna Davison died two weeks after an experimental transplant. Was she the victim of a rush to develop stem cell technology?

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26.02.2019
22:42 ScienceDaily.comStem cells provide greater insight into rotator cuff disease

New research explores stem cells in the rotator cuff in hopes of understanding why fatty accumulation happens at the tear site, instead of proper muscle healing.

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17:56 StemCellsPortal.comlDiabetes-free Donors are Best Source of Stem Cells for Bone Repair in Type 1 Patients

Durham, NC – A groundbreaking study released today in STEM CELLS Translational Medicine shows that the  gold standard for obtaining stem cells to use in transplantation therapy – harvesting them from the patient himself – is not the best way to go when attempting to regenerate bone in a person with type 1 diabetes.
Type 1 diabetes is linked to low bone density, which greatly increases the risk of fractures. Researchers don’t know exactly why — it might be that insulin, which is deficient in the disease, promotes bone growth and strength – but all agree that finding a way to address this issue is important.
While stem cell-derived exosomes have exhibited promise for bone regeneration, identifying an appropriate source to obtain them has proven difficult. Yimin Chai, M.D., Ph.D., and his team at Shanghai Jiao Tong University Affiliated Sixth

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15:51 Benzinga.comCord Blood Stem Cells Market: Big Foresees Ahead For Medical Industry |Modern Medical Technology

MarketResearch.biz delivers in-depth insights on the global cord blood stem cells market in its upcoming report titled, "Global Cord Blood Stem Cells Market Analysis, Drivers, Restraints, Opportunities, Threats, Trends, Applications, and Growth Forecast to 2027".
read more

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25.02.2019
12:16 StemCellsPortal.comlSingle-cell Analysis Reveals the Impact of Aging on Mesenchymal Stem Cells

Review of “Single‐Cell Transcriptomics of Human Mesenchymal Stem Cells Reveal Age‐Related Cellular Subpopulation Depletion and Impaired Regenerative Function” from STEM CELLS by Stuart P. Atkinson 

The pro-regenerative properties of mesenchymal stem cells (MSCs) have promoted their widespread application in cell-based tissue-repair strategies; however, whether the natural aging process affects MSCs and their therapeutic output remains a contentious topic. While many failed to observe any adverse effects on MSC function, other groups have demonstrated diminished proliferation [1, 2], anti‐inflammatory activity [3], and multipotent differentiation potential [4] with increasing age.

Given these contrasting findings, researchers from the group of Geoffrey C. Gurtner (Stanford University, California, USA)

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11:53 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - RPE Transplantation, Stable Hyaline Cartilage, Fibrinogen-cultured iPSCs, and Boosting Fat Graft Survival!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Update on Retinal Pigment Epithelium Transplantation

A review from the lab of Marco Zarbin (Rutgers University, Newark, New Jersey, USA) brings us an update on cell‐based therapies for the treatment of age‐related macular degeneration (AMD), a vision‐threatening disease. This STEM CELLS Translational Medicine article focuses on the application of retinal pigment epithelium in cell transplants as a rescue or replacement therapy. The authors highlight cell‐based therapy as a potentially useful approach in chronic

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22.02.2019
14:32 FightAging.OrgTowards Universal Cell Lines and Tissues Grown from Induced Pluripotent Stem Cells

There is an enormous difference in logistics and cost between cell therapies that must use a patient's own cells and cell therapies that arise from a single universal cell line that can be used in any patient. While in principle it is perfectly possible to reprogram a patient's cells into induced pluripotent stem cells, differentiate those cells into the desired cell type, and then even grow functional organoids, that all takes a lot of time and effort, and is as yet far from reliable. It would be much cheaper and much faster to have a factory producing cell lines and organs that can be universally used. When organs and other large tissue sections can be reliably grown from cells in the laboratory, this point will […]

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13:49 Technology.orgCRISPR Gene Editing Makes Stem Cells ‘Invisible’ to Immune System

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that

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11:21 Nature.Com‘Reprogrammed’ stem cells to treat spinal-cord injuries for the first time

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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10:38 News-Medical.NetAkna protein plays a key role in the regulation of neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine.

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07:17 ScienceDaily.comNew mechanisms regulating neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. Scientists have discovered that the protein Akna plays a key role in this process. It controls, for example, the behavior of neural stem cells via a mechanism that may also be involved in the formation of metastases.

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21.02.2019
17:41 Phys.orgNew mechanisms regulating neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. Scientists at Helmholtz Zentrum München and Ludwig Maximilian University of Munich (LMU) have discovered that the protein Akna plays a key role in this process. It controls, for example, the behavior of neural stem cells via a mechanism that may also be involved in the formation of metastases. The study was published in the renowned journal Nature.

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17:19 News-Medical.NetScientists uncover new mechanisms regulating neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. Scientists at Helmholtz Zentrum München and Ludwig Maximilian University of Munich have discovered that the protein Akna plays a key role in this process.

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20.02.2019
10:52 News-Medical.NetResearchers engineer stem cell with ‘suicide genes’ to induce cell death in all but beta cells

Researchers have been advancing methods to generate insulin-producing beta cells from pluripotent stem cells for the clinical treatment of type 1 diabetes.

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19.02.2019
20:43 MedicalNewsToday.comMedical News Today: New stem cells could be 'universally transplanted'

Researchers have designed a type of stem cell that should be able to withhold transplantation into any recipient without facing rejection.

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14:33 FightAging.OrgA Small Molecule NNMT Inhibitor Puts Aged Stem Cells Back to Work to Improve Muscle Regeneration in Old Mice

In old tissues, stem cell activity is much reduced relative to youthful activity. This is thought to be the most important contribution to loss of muscle mass and strength with age, leading to the condition known as sarcopenia. It also diminished the ability to regenerate after muscle injury. Numerous studies in the regenerative medicine community have demonstrated that while this loss of stem cell function may be a defense against cancer, reducing the activity of cells that may bear potentially dangerous molecular damage, there appears to be a fair amount of room to push the balance towards greater activity without large increases in cancer risk. In mice, anyway. Researchers here demonstrate a novel way of increasing muscle stem cell activity, to add to a number […]

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05:02 Gizmag Landmark research creates “universal” stem cells using CRISPR gene editing


In an incredible milestone, scientists have for the first time created "universal" stem cells by using CRISPR gene-editing technology to produce pluripotent stem cells that can be transplanted into any patient without generating an immune system response.
.. Continue Reading Landmark research creates “universal” stem cells using CRISPR gene editing Category: Science Tags: CRISPR Stem Cells The Immune System Transplant

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18.02.2019
21:18 News-Medical.NetCRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants.

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17:12 StemCellsPortal.comlResearchers Develop more Efficient System to Reprogram Stem Cells

ROCHESTER, MN (US), February 2019 — Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Researchers from the Mayo Clinic now report that using the measles virus vector, they have trimmed that process with four reprogramming factors down to a single “one cycle” vector process.
They say the process is safe, stable, faster and usable for clinical translation.
“If we’re going to successfully use reprogrammed stem cells to treat patients in the clinic, we need to ensure that they are safe and effective; that is, not prone to the risk of mutation and potential tumors,” said Patricia Devaux, Ph.D., Mayo Clinic molecular scientist and senior author of the study. “The measles virus vector has long been used safely at

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17:12 StemCellsPortal.comlResearchers Develop more Efficient System to Reprogram Stem Cells

ROCHESTER, MN (US), February 2019 — Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Researchers from the Mayo Clinic now report that using the measles virus vector, they have trimmed that process with four reprogramming factors down to a single “one cycle” vector process.
They say the process is safe, stable, faster and usable for clinical translation.
“If we’re going to successfully use reprogrammed stem cells to treat patients in the clinic, we need to ensure that they are safe and effective; that is, not prone to the risk of mutation and potential tumors,” said Patricia Devaux, Ph.D., Mayo Clinic molecular scientist and senior author of the study. “The measles virus vector has long been used safely at

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13:13 StemCellsPortal.comlMoving Pluripotent Stem Cell-derived Hepatocytes One Step Closer to the Clinic

Review of “Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell‐Derived Hepatocytes for Cell‐Based Therapy” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

The transplantation of functionally mature hepatocytes differentiated from human pluripotent stem cells may represent a viable therapeutic option for patients with end‐stage chronic liver disease or acute liver failure. Encouragingly, recent studies have described the differentiation of both human embryonic stem cells and patient-specific induced pluripotent stem cells into hepatocytes that can repopulate the rodent liver following transplantation [1-3]. 

To propel human pluripotent stem cell-derived hepatocytes one step closer to therapeutic applications in human patients, researchers led by S.

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13:02 StemCellsPortal.comlEnhancing CRISPR/Cas9 Gene Editing of Human Hematopoietic Stem Cells

Review of “Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair” from STEM CELLS by Stuart P. Atkinson 

The DNA double-strand breaks generated by the CRISPR/Cas9 gene editing system can be repaired throughout the cell cycle by the error‐prone non-homologous end joining (NHEJ) pathway or during S/G2 phases by the more precise homology‐directed repair (HDR). The application of HDR‐mediated gene editing in human hematopoietic stem cells to precisely correct disease‐causing mutations suffers from a relatively low efficiency in primitive long‐term reconstituting stem cells [1-3], which currently prohibits the exploration of ex vivo correction of hematopoietic stem cells as a therapeutic option for a range of diseases/disorders.

In a new STEM CELLS

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12:51 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - SCNT-hESC Endothelial Cells, Adult Prostatic Progenitors, Exosome‐educated Macrophages, and Prostate Cancer treatment with MSCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Functional human Somatic Cell Nuclear Transfer ESC-derived Endothelial Cells

Researchers from Konkuk University (Seoul, Republic of Korea) recently sought to discover the functional potential of human embryonic stem cells they previously derived by somatic cell nuclear transfer (hNT-ESCs). In their article, Park et al. report that endothelial cells differentiated from hNT-ESCs displayed signature endothelial characteristics in vitro, including tubule formation and uptake

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12:47 MedicalNewsToday.comMedical News Today: Parkinson's: How stem cells can help repair the brain

A new review examines the past, present, and future of stem cell therapy for replacing damaged brain cells in Parkinson's disease.

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15.02.2019
10:45 News-Medical.NetNewly developed stem cell technologies show promise for treating PD patients

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

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01:19 ScienceDaily.comCan we repair the brain? The promise of stem cell technologies for treating Parkinson's disease

Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

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14.02.2019
19:58 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Stem Cell-Derived EVs, Photoreceptor Neuritogenesis, Diabetic Dogs for Translational Research, and Skeletal Muscle MSC Delivery!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Proteome of Mesenchymal Stem Cell-Derived Extracellular Vesicles from Metabolic Syndrome Pigs

Researchers from the lab of Lilach O. Lerman (Mayo Clinic, Minnesota, USA) recently sought to discover if cardiovascular risk factors transformed the protein content of extracellular vesicles (EVs) released from mesenchymal stem cells (MSCs). Interestingly, Eirin et al. report that MSC-EVs derived from pigs with metabolic syndrome carried a more pro‐inflammatory signature than

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14:25 FightAging.OrgCD117 Antibodies for Low-Impact Selective Destruction of Hematopoietic Stem Cells

Hematopoietic stem cell transplant (HSCT) is, in essence, a way to replace a person's immune system. These stem cells give rise to all of the immune cells in the body. There are numerous reasons why HSCT is a traumatic procedure, with a comparatively high risk of death, and thus only widely used for very severe diseases. One of them is the struggle to rebuild the immune system rapidly enough for the patient not to succumb to infection; this is particularly challenging in old patients, where the thymus is much diminished and the pace of T cell creation is slowed in comparison to youth. The thymus is where thymocytes produced by hematopoietic stem cells go to mature into T cells, and the rate of production depends […]

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13:53 Technology.orgStem Cells Provide Greater Insight into Rotator Cuff Disease

Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult. “Chronic tears

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13.02.2019
19:08 ScienceMag.orgHindu nationalists claim that ancient Indians had airplanes, stem cell technology, and the internet

The rapid rise of pseudoscience in the Modi era triggers ridicule and concern

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10:47 News-Medical.NetNew process efficiently reprograms stem cells in one step using measles virus vector

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

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12.02.2019
22:08 ScienceDaily.comMore efficient system to reprogram stem cells

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

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08:47 Gizmag Clustered stem cells become working insulin producers in potential cure for diabetes


Diabetes is defined by the body's inability to keep blood-sugar levels in check, something that is normally handled by insulin. More and more research is tracing this problem back to faulty beta cells in the pancreas that are failing to produce the hormone, and more and more research is uncovering potential pathways to restore their function. Medical scientists have now made a promising breakthrough in this area, describing a novel technology that converts stem cells into insulin-secreting beta cells by harnessing an often overlooked step in their maturation.
.. Continue Reading Clustered stem cells become working insulin producers in potential cure for diabetes Category: Medical Tags: Diabetes Insulin University of California San Francisco

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11.02.2019
15:50 StemCellsPortal.comlOlfactory Stem Cell Transplantation: An Effective New Strategy for Facial Nerve Damage Repair?

Review of “Transplantation of Olfactory Stem Cells with Biodegradable Hydrogel Accelerates Facial Nerve Regeneration After Crush Injury” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

While surgical intervention can aid the restoration of the severe facial nerve damage often encountered following temporal bone trauma [1], the poor functional recovery observed in some patients has prompted the exploration of additional therapeutic approaches. In the vein, researchers from the laboratory of Shinichi Esaki (Nagoya City University, Aichi, Japan) sought to assess the potential of olfactory stem cells, which can engraft and support axonal outgrowth after spinal cord injury [2, 3], as an autologous approach in the treatment of facial nerve damage. In their new STEM CELLS Translational Medicine article,

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15:38 StemCellsPortal.comlNovel Long non-coding RNA Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells

Review of “LncRNA‐OG Promotes the Osteogenic Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Under the Regulation of hnRNPK” from STEM CELLS by Stuart P. Atkinson 

A fuller appreciation of the complex mechanisms controlling bone formation by bone marrow-derived mesenchymal stem cells (MSCs) may aid our understanding of the development of diseases such as ankylosing spondylitis and osteoarthritis [1, 2] and permit the elaboration of novel therapeutic approaches. As a step towards this lofty goal, researchers from the laboratory of Huiyong Shen and Yanfeng Wu (Sun Yat‐sen University, Guangzhou, Guangdong, China) analyzed long noncoding RNA (lncRNA) expression profiles during the osteogenic differentiation of BM‐MSC [3]. Now Tang et al. return with a STEM CELLS article [4] that reveals a

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15:16 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - von Willebrand Factor Expression, Allogeneic Limbal Stem Cell Therapy, FOXD3 in Lung Cancer, and SHED-EV Treatment of PD!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Regulation of von Willebrand Factor Gene Expression during Endothelial Differentiation

To generate a greater understanding of the molecular mechanisms underlying the attainment of an endothelial phenotype, researchers led by Nadia Jahroudi (University of Alberta, Edmonton, Alberta, Canada) studied the expression of a highly endothelial‐specific gene, von Willebrand factor, during the endothelial differentiation of induced pluripotent stem cells (iPSCs) generated from primary endothelial cells. In their new STEM

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08.02.2019
09:56 News-Medical.NetEU-funded project investigates molecular mechanisms of aging in adult stem cells

Stem cells are the ultimate mother cells of the human body. Not only do they have the capacity to self-renew, they can develop into specific cell types as the body requires. But as the human body ages, the regenerative capacity of our stem cells diminishes.

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07.02.2019
10:51 News-Medical.Net'Satellite' stem cells more likely to develop into fat cells after rotator cuff tears

Why are fat deposits more likely to occur after tears of the shoulder's rotator cuff, compared to other types of muscle injuries? An increased propensity of stem cells within with rotator cuff muscles to develop into fat cells may explain the difference, reports a study in the February 6, 2019 issue of The Journal of Bone & Joint Surgery.

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01:03 ScienceDaily.comIn their DNA: Rotator cuff stem cells more likely to develop into fat cells

Why are fat deposits more likely to occur after tears of the shoulder's rotator cuff, compared to other types of muscle injuries? An increased propensity of stem cells within with rotator cuff muscles to develop into fat cells may explain the difference.

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06.02.2019
18:54 News-Medical.NetRare stem cell may be the root of all metastatic cancers

Researchers have discovered a rogue stem cell that could be the cause of all metastatic cancers. The breakthrough could affect all future research projects.

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09:49 News-Medical.NetStudy of spermatogonial stem cells opens path for new strategies to treat male infertility

The production of sperm -- otherwise known as spermatogenesis -- generates more than 1,000 sperm per second in normal males.

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