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Stem Cells

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25.05.2019
06:11 News-Medical.NetBenefit of allogeneic stem cell transplantation in non-Hodgkin lymphoma remains unclear

The German Institute for Quality and Efficiency in Health Care has investigated whether patients suffering from non-Hodgkin lymphoma have (better) chances of recovery when stem cells from another person are transplanted.

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24.05.2019
21:44 Reuters.com HealthIncyte's Jakafi wins FDA nod to treat complication of stem cell transplant

The U.S. Food and Drug Administration on Friday approved Incyte Corp's treatment for acute graft-versus-host disease, a complication from stem cell transplant.

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13:31 StemCellsPortal.comlReview: Translating Stem Cells for Stroke Clinical Trials

A new Concise Review from the laboratory of Cesario V. Borlongan (University of South Florida, USA) summarizes the current state of affairs regarding stem cell therapy in stroke patients, which currently are deemed safe but not effective. The authors believe that failed clinical trials may be due to a loss in translation of optimal stem cell transplantation protocols from the laboratory to clinical trial designs and advise a concerted effort between basic scientists and clinicians, with NIH and Food and Drug Administration guidance, to promote the safe and effective translation of stem cell therapy for stroke in the future. For a fascinating read, head over to STEM CELLS Translational Medicine now!

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13:17 StemCellsPortal.comlmTOR Inhibition and Limbal Stem Cell Deficiency

While the regulation of stem cell maintenance and function in a cell‐type and context‐dependent manner requires mammalian target of rapamycin (mTOR) signaling, the effects of mTOR signaling on corneal epithelial stem cells (CESCs) under inflammatory conditions remain unclear. Now, a new STEM CELLS report from the laboratory of Joo Youn Oh (Seoul National University Hospital, Seoul, South Korea) established that mTOR inhibition through rapamycin treatment induces corneal epithelial stem cell apoptosis in vivo, accompanied by the upregulation of sterile neutrophilic inflammation and downregulation of the IL‐10/STAT3 anti‐inflammatory response axis. Overall, Park et al. advise that pro‐inflammatory side-effects must be considered when using rapamycin in the

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13:14 News-Medical.NetAMSBIO introduces next-generation feeder-free medium for pluripotent stem cell culture

AMSBIO introduces StemFit Basic04, a next-generation feeder-free medium for the maintenance of Induced Pluripotent Stem and Embryonic Stem cells during the reprogramming, expansion and differentiation phases of stem cell culture.

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04:13 ScienceDaily.comAllogeneic stem cell transplantation in non-Hodgkin lymphoma: Benefit remains unclear

Meaningful studies are lacking for certain patient groups. Disease-specific registries could help close the data gap.

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23.05.2019
20:05 Phys.orgPlant stem cells require low oxygen levels

Plants function as the green lungs of our planet, and rightfully so, as the capacity of a large, single tree releases more than 120 kg of oxygen into the Earth's atmosphere every year through a series of sunlight-fuelled reactions in photosynthesis. However during flood events, plant tissues may experience severe oxygen shortage, a stressful situation that every year leads to substantial loss in yield for all major crops such as rice, wheat and barley.

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19:46 ScienceDaily.comPlant stem cells require low oxygen levels

New research reveals that low oxygen is required for proper development of plants.

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18:31 News-Medical.NetExperimental noninvasive tool assesses efficacy of stem cell transplantation

Stem-cell based therapies to strengthen the heart muscle and treat other diseases are beginning to show promise in human clinical trials.

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17:18 SingularityHub.ComNew Progress in Stem-Cell-Free Regenerative Medicine

Regenerative medicine and stem cells are often uttered within the same breath, for good reason. In animal models, stem cells have reliably reversed brain damage from Parkinson’s disease, repaired severed spinal cords, or restored damaged tissue from diabetes, stroke, blood cancers, heart disease, or aging-related tissue damage. With the discovery of induced pluripotent stem cells […]

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03:56 ScienceDaily.comA road map to stem cell development

Researchers have developed a way to map retinal cell development and potentially advance regenerative medicine.

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02:50 ScienceDaily.comExperimental noninvasive tool monitors effectiveness of stem cell transplantation

Other than clinical observations, the stem cell field lacks a repeatable, time-sensitive, noninvasive tool to assess the effectiveness of transplanted cells in the targeted organ. Researchers analyzed biomarkers secreted from transplanted human stem cells in the recipient blood of a rodent model of heart attack. Analysis of the blood test showed responding cells had changed their gene expression, behavior and secretions, suggesting this liquid biopsy could provide a window into stem cell activity and effectiveness.

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22.05.2019
07:07 GizmagPlacental stem cells found to regenerate heart cells after heart attack


Broken hearts are notoriously difficult to repair. After a heart attack this vital organ remains damaged, which can eventually lead to heart failure and death. Now, researchers have managed to use placental stem cells to regenerate heart cells in mice, which could lead to groundbreaking new treatments for heart attack victims.
.. Continue Reading Placental stem cells found to regenerate heart cells after heart attack Category: Medical Tags: Cells Heart Heart attack Heart Disease Mount Sinai Hospital Stem Cells

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06:02 ScienceDaily.comStem cell differences could explain why women are more likely to develop adrenal cancer

Scientists have discovered a potential biological reason why women are more likely to develop adrenal disorders, including cancer. According to the researchers, the answer could lie in the increased turnover of hormone-producing cells found in the adrenal glands of females.

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00:12 ScienceDaily.comCertain placental stem cells can regenerate heart after heart attack

Researchers have identified a new stem cell type that can significantly improve cardiac function.

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21.05.2019
10:49 News-Medical.NetZebrafish may help researchers to use blood stem cells instead of bone marrow transplants

Blood diseases such as leukemia and lymphoma are currently treated with bone marrow transplants -- a transfer of blood stem cells from a healthy person to a patient in need.

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20.05.2019
20:07 StemCellsPortal.comlMesenchymal Stem Cells Protect Kidneys from Lipotoxicity

Researchers led by Sydney C.W. Tang (The University of Hong Kong, China) recently sought to discover if and how mesenchymal stem cells (MSCs) can treat lipotoxicity‐induced kidney injury. Interestingly, Li et al. now report that MSCs ameliorate endoplasmic reticulum stress, inflammation, and apoptosis in palmitic acid‐treated renal tubular cells and high-fat-diet-induced obese kidney in mice via activation of hepatocyte growth factor/c‐Met paracrine signaling in the obese kidney microenvironment. Furthermore, this new STEM CELLS Translational Medicine article suggests that induced pluripotent stem cell (iPSC) derived MSCs may represent a valuable alternative source to bone marrow-derived MSCs for therapeutic application in chronic kidney disease.
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20:07 StemCellsPortal.comlMesenchymal Stem Cells Improve Islet β-cell Function

A study from researchers at the lab of Peter M. Jones (King's College London, UK) recently assessed the effects of mesenchymal stem cells (MSCs) on pancreatic islets by investigating the importance of tissue source, coculture protocol configuration and length, the activated/inactivated status of MSCs, and different β‐cell secretory stimuli. Arzouni et al. discovered that 48 hours of preculture with inactivated adipose tissue-derived MSCs in a direct contact co-culture configuration optimally supported β‐cell insulin secretion from islets, thereby supporting this approach as an effective addition to human islet transplantation protocols. See STEM CELLS Translational Medicine now for all the details.

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20:07 StemCellsPortal.comlAllogenic Tendon and Mesenchymal Stem Cells for Anterior Cruciate Ligament Reconstruction

Free tendon allografts exhibit generally provide poor outcomes when employed as a material for anterior cruciate ligament (ACL) reconstruction. Researchers led by Zhenhan Deng (Shenzhen University, Shenzhen) and Jinzhong Zhao (Shanghai Jiao Tong University, Shanghai, China) have shown that bone marrow‐derived mesenchymal stem cells (MSCs) combined with a decellularized free tendon allograft is effective in improving ACL reconstruction results. The team now return with a STEM CELLS Translational Medicine study that provides evidence for the efficacy and feasibility of decellularized allogenic semitendinous tendon combined with autologous MSCs as a substitute to free tendon allograft in a rabbit model.


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19:31 StemCellsPortal.comlSingle Cell RNA-Sequencing Reveals the Inner Complexity of Stem Cell-derived Retinal Organoids

Review of “Deconstructing Retinal Organoids: Single cell RNA-Seq reveals the cellular components of human pluripotent stem cell-derived retina” from STEM CELLS by Stuart P. Atkinson

Recent advances have permitted the derivation of three‐dimensional retinal organoids containing structures akin to the developing eye from human pluripotent stem cells [1, 2]; however, we currently lack robust methods to accurately define and characterize the heterogeneous cell types within these organoids over time. 

While a few studies have reported single-cell RNA sequencing (scRNA‐Seq) in human retinal tissue and organoids [3-5] (See the STEM CELLS article here!), researchers from the laboratory of Majlinda Lako (Newcastle University, Newcastle-upon-Tyne, UK) postulated that such studies have yet to reveal the full

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17:23 StemCellsPortal.comlStudy shows all immature Cells can develop into Stem Cells

COPENHAGEN (DK), May 2019 — All cells in the fetal gut have the potential to develop into stem cells, a new study conducted at the Faculty of Health and Medical Sciences at the University of Copenhagen concludes. The researchers behind the study have discovered that the development of immature intestinal cells – contrary to previous assumptions – is not predetermined, but affected by the cells’ immediate surroundings in the intestines.
This discovery may ease the path to effective stem cell therapy, said Kim Jensen, Ph.D., from the Biotech Research & Innovation Centre (BRIC) and the Novo Nordisk Foundation Center for Stem Cell Biology (DanStem).
“We used to believe that a cell’s potential for becoming a stem cell was predetermined, but our new results show that all immature cells have the same probability for becoming stem cells in the fully developed organ. In principle, it is simply

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17:23 StemCellsPortal.comlCancer Drugs promote Stem Cell properties of Colorectal Cancer

MANNHEIM (DE), May 2019 — Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and Mannheim University Medical Center (MUMC) have discovered that a certain group of cancer drugs, MEK inhibitors, activates the cancer-promoting Wnt signaling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses.
The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.
Cells react to external influences via the biochemical reactions of the Wnt signaling pathway. Wnt signals coordinate the development of the early embryo, but also play a role in many pathological processes and in cancer.
While researchers initially assumed that an excessively activated Wnt signaling pathway was

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18.05.2019
02:44 StemCellsPortal.comlStem cell scientists clear another hurdle in creating transplant arteries

MADISON, WI (US), May 2019 — Cardiovascular disease is a major cause of death worldwide, and treating it isn’t easy.  The disease wreaks havoc on patients’ blood vessels and can require complex bypass surgery.
Scientists at the Morgridge Institute for Research are working toward a dream of creating artery banks — similar to blood banks common today — with readily available material to replace diseased arteries during surgery. The latest work in the lab of regenerative biologist James Thomson, VMD, Ph.D., puts the science one step closer to that goal.
In a paper published online May 9 in Stem Cell Reports, the Thomson Lab highlights a better way to grow smooth muscle cells (one of the two cellular building blocks of arteries) from pluripotent stem cells. The work also identifies a potential drug for reducing post-surgical risks in patients who undergo

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17.05.2019
15:49 SeekingAlpha.comInternational Stem Cell reports Q1 results

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11:01 News-Medical.NetStudy: All immature cells have potential to develop into stem cells

New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

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16.05.2019
19:15 ScienceDaily.comSurprising research result: All immature cells can develop into stem cells

A new study challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy.

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16:10 ScienceDaily.comCancer drugs promote stem cell properties of colorectal cancer

Scientists have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses. The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.

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13:31 FightAging.OrgThe DNA Damage Response Falters in Old Stem Cells

Efficient DNA repair is necessary to prevent cells from becoming dysfunctional or senescent in response to stochastic nuclear DNA damage. This is particularly important in stem cell populations, as there is no outside source to replace their losses, or repair persistent dysfunction. Researchers here note that the DNA damage response fails to trigger sufficiently in old intestinal stem cell populations, and this may be an underlying contributing cause of higher levels of cellular senescence in these cells. Aging is related to disruption of tissue homeostasis, which increases the risks of developing inflammatory bowel diseases (IBDs), and colon cancer. However, the molecular mechanisms underlying this process are largely unknown. Various age-related dysfunctions of adult tissue-resident stem/progenitor cells (TSCs, also known as somatic stem cells) are associated […]

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15.05.2019
23:02 FightAging.OrgTowards Restoration of Neural Stem Cell Function in the Old

Every tissue in the body supported by its own specialized small stem cell populations. The vast majority of cells in the body, known as somatic cells, are limited in the number of times they can divide. Their telomeres shorten with each cell division, and they become senescent or self-destruct when reaching the Hayflick limit on replication, triggered by short telomeres. Stem cells have no such limitation, and use telomerase to maintain telomere length regardless of the number of divisions they undergo. They divide asymmetrically to generate daughter somatic cells with long telomeres that can replace lost somatic cells in order to maintain tissue function. This split between a small privileged cell population and a large, limited cell population most likely evolved because it greatly reduces […]

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20:20 Nature.ComTracing the origin of adult intestinal stem cells

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16:16 Nature.ComStem-cell and genetic therapies make a healthy marriage

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12:14 GizmagScientists discover self-defense "switch" for stem cells


With the power to turn themselves into any other cell in the body, stem cells have a future as a key treatment for a range of diseases and injuries. The problem is, they lack some of the self-defense mechanisms that other cells have, leaving them open to attack from viruses and other threats. Now, researchers from the University of Edinburgh may have found a way to switch this mechanism back on, making stem cell treatments more effective.
.. Continue Reading Scientists discover self-defense "switch" for stem cells Category: Biology Tags: Molecules Protein Stem Cells The Immune System University of Edinburgh Virus

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11:23 News-Medical.NetImmune system discovery could inform the development of new stem cell therapies

A discovery of how stem cells are protected from viruses could inform the development of therapies for use in medicine, research suggests.

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14.05.2019
22:49 ScienceDaily.comImmune system discovery could aid quest for stem cell therapies

Scientists have discovered how stem cells can develop resistance against viruses, a finding that could aid the development of stem cell therapies.

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18:01 StemCellsPortal.comlStem cells make more ‘cargo’ packets to carry cellular aging therapies

Baltimore, MD (US), May 2019 —Johns Hopkins University scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny “cargo packets” able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.
Extracellular vesicles are naturally abundant in many types of cells, which use the cargo-containing spheres to communicate with other cells. They are about one 100th the diameter of a cell and can carry anything from fats and proteins to nucleic acids. When a cell releases an extracellular vesicle, other cells nearby slurp up the tiny packet and its contents, making it an attractive

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13.05.2019
22:07 NYT ScienceStem Cell Treatments Flourish With Little Evidence That They Work

The F.D.A. has taken an industry-friendly approach toward companies using unproven cell cocktails to treat people desperate for relief from aging or damaged joints.

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21:54 NYT HealthStem Cell Treatments Flourish With Little Evidence That They Work

The F.D.A. has taken an industry-friendly approach toward companies using unproven cell cocktails to treat people desperate for relief from aging or damaged joints.

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20:33 StemCellsPortal.comlChronic Pancreatitis Patient Mesenchymal Stem Cells Can Support Islet Grafting

Review of “Mesenchymal Stem Cells from Chronic Pancreatitis Patients Show Comparable Potency Compared to Cells from Healthy Donors” from STEM CELLS Translational Medicine by Stuart P. Atkinson 

Recent research from the laboratory of Hongjun Wang (Medical University of South Carolina, USA) established that cotransplantation of syngeneic mouse islet with mesenchymal stem cells (MSCs) derived from patients suffering from chronic pancreatitis, a long‐standing inflammatory condition associated with endocrine and exocrine dysfunction [1, 2], fostered enhanced islet survival and function [3]. Furthermore, recent data from a pilot clinical trial of autologous islet cotransplantation for human patients undergoing total pancreatectomy also established the potential protective effects of chronic pancreatitis MSCs on islet

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12:16 Technology.orgStem cells provide information about neuron resilience in ALS

Researchers at Karolinska Institutet in Sweden have developed a stem cell based model in order to study the

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10:15 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Retinal Ganglion Cell Repair, Human Platelet Lysate, Female Germline Stem Cells, and Metabolic Reprogramming of iPSCs!

Retinal Ganglion Cell Repair by iPSC-Derived Müller Glia

The transplantation of Müller glial cells may represent a beneficial treatment for glaucoma, one of the leading causes of blindness. In an encouraging advance, researchers led by Karen Eastlake and G. Astrid Limb (UCL Institute of Ophthalmology, Moorfields Eye Hospital, London, UK) recently described the isolation of Müller glia from retinal organoids formed by human induced pluripotent stem cells (iPSCs) in a STEM CELLS Translational Medicine article. The team demonstrated how these cells partially restored visual function in rats depleted of retinal ganglion cells and may, therefore, represent an attractive means

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08:19 News-Medical.NetResearchers reveal ebb and flow of gene expression that may awaken neural stem cells

The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells -- neurons -- have limited ability to regenerate.

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10.05.2019
16:09 FierceBiotech.comHarvard-born diabetes startup Semma reports advances in turning stem cells into insulin producers

Semma Therapeutics has faced an obstacle with its process of turning undifferentiated pluripotent stem cells into insulin-producing pancreatic beta cells: Only 30% of the resulting cells turn out to be beta cells. Now, a Semma-Harvard University team has figured out how to boost the proportion of beta cells emerging from their process to 80%.

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15:57 FierceBiotech.comGrowing transplantable arteries from stem cells

Scientists at the Morgridge Institute for Research are developing a method for growing blood vessels for patients with cardiovascular diseases, and along the way they identified a drug that could help reduce complications in people undergoing bypass surgery.

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13:15 FightAging.OrgInduced Pluripotent Stem Cells as a Source of Extracellular Vesicles for Therapy

First generation stem cell therapies largely reduce chronic inflammation and, less reliably, increase regeneration via the effect of intracellular signals delivered by the transplanted cells. The transplanted cells die quite rapidly rather than surviving to integrate into tissues. Arguably a majority of intracellular signaling is carried by forms of extracellular vesicle, membrane-wrapped packages of molecules that pass between cells to influence their behavior. The contents of these vesicles are not well cataloged, but that isn't an obstacle to efforts to replace cell therapies with vesicle therapies, the vesicles harvested from cells that would otherwise have been transplanted. The use of vesicles rather than cells should present fewer logistical challenges when it comes to manufacture, storage, and quality control, and we might hope that this translates […]

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12:04 Technology.orgStem cell scientists clear another hurdle in creating transplant arteries

Cardiovascular disease is a major cause of death worldwide, and treating it isn’t easy.  The disease wreaks havoc

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08:42 News-Medical.NetScientists successfully create melanocyte precursor cells using stem cell technology

Our hair, skin and eyes are colored by a pigment called melanin, which is produced by pigment cells called melanocytes. Scientists have used stem cell technology to successfully create melanocyte precursor cells.

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01:11 ScienceDaily.comStem cell scientists clear another hurdle in creating transplant arteries

Recent work highlights a better way to grow smooth muscle cells, one of the two cellular building blocks of arteries, from pluripotent stem cells. This research is part of an effort to create artery banks -- similar to blood banks common today -- with readily-available material to replace diseased arteries during surgery.

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09.05.2019
21:42 News-Medical.NetResearchers develop stem cell-based model to study neuron resilience and vulnerability in ALS

Researchers at Karolinska Institutet in Sweden have developed a stem cell-based model in order to study the resilience and vulnerability of neurons in the neurodegenerative disease ALS.

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19:23 ScienceDaily.comStem cells provide information about neuron resilience in ALS

Researchers have developed a stem cell based model in order to study the resilience and vulnerability of neurons in the neurodegenerative disease ALS. The results can aid in the identification of new genetic targets for treatments protecting sensitive neurons.

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17:30 StemCellsPortal.comlWhat´s the Stem Cells Buzz this Week? - Cardiac Differentiation Review, Comparing Hepatic Stellate Cells, ASC Trial for Pneumosepsis, and Advancing Cardiac Cell Therapy!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Molecular Mechanisms of Cardiac Differentiation

Human pluripotent stem cell (hPSCs)‐derived cardiomyocytes may be employed for the treatment of severe heart failure, although current protocols generate low yields of immature cells. To help the field advance, researchers from the laboratory of Jun Fujita (Keio University School of Medicine, Tokyo, Japan) have reviewed the literature and now summarize currently employed protocols in the hope of creating a knowledge base for the further development of effective therapies.

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08.05.2019
22:47 ScienceDaily.comNew ways to generate stem cells more efficiently

A new study could improve the efficiency of creating induced pluripotent stem cells.

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11:19 Technology.orgUW–Madison research team finds new ways to generate stem cells more efficiently

Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new

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10:30 Phys.orgResearch team finds new ways to generate stem cells more efficiently

Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of cell in the body, useful for regenerative therapies for everything from heart disease to diabetes.

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07.05.2019
18:45 ScienceDaily.comStem cells make more 'cargo' packets to carry cellular aging therapies

Scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny 'cargo packets' able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.

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18:15 StemCellsPortal.comlEmbryo Stem Cells Created from Skin Cells

JERUSALEM (ISR), May 2019 — A new, groundbreaking study by the Hebrew University of Jerusalem (HU) found a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. This work has significant implications for modeling embryonic disease and placental dysfunctions, as well as paving the way to create whole embryos from skin cells.
As published in Cell Stem Cell, Yossi Buganim, Ph.D., of HU's Department of Developmental Biology and Cancer Research and his team discovered a set of genes capable of transforming murine skin cells into all three of the cell types that comprise the early embryo: the embryo itself, the placenta and the extra-embryonic tissues, such as the umbilical cord. In the future, it may be possible to create entire human embryos out of human skin cells, without the need for sperm or eggs. This discovery also has vast

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18:02 StemCellsPortal.comlSpecialized Plant Cells Regain Stem Cell Features to Heal Wounds

KLOSTERNEUBURG (AT), May 2019 — If plants are injured, cells adjacent to the wound fill the gaps with their daughter cells. However, which cells divide to do the healing and how they manage to produce cells that match the cell type of the missing tissue has been unclear.
Scientists from the Institute of Science and Technology Austria (IST Austria) have now shown that to correctly replace dead cells, neighbors to the inside of the wound re-activate their stem cell programs.  
All plant organs — from the leaves to the root — regularly endure injuries to their tissue, be it due to mechanical forces, grazing animals or other factors. While animals rely on specialized migrating cells for wound healing, plants, whose cells are immobile, had to evolve other mechanisms. It has been known for almost a century that in plants, cells adjacent to the wound replace harmed tissue with new

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09:51 News-Medical.NetSkin-related stem cells could be used to regenerate vital part of the nervous system

Neurodegenerative diseases like multiple sclerosis affect millions of people worldwide and occur when parts of the nervous system lose function over time.

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06.05.2019
20:44 ScienceDaily.comPigment-producing stem cells can regenerate vital part of nervous system

Neurodegenerative diseases like multiple sclerosis (MS) affect millions of people worldwide and occur when parts of the nervous system lose function over time. Researchers have discovered that a type of skin-related stem cell could be used to help regenerate myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders.

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10:13 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Cardio‐oncology, Naïve Pluripotency, hnRNP‐K in Embryonic Stem Cells, and Insulin’s Role in hESCs!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Precision Matchmaking for Cardio‐oncology

Chemotherapeutic agents can cause acute and chronic cardiovascular complications; therefore, the development of rigorous preclinical models is necessary to predict human cardiotoxicity and elucidate the underlying mechanisms of cardiotoxicity. A recent review from the lab of Ioannis Karakikes (Stanford University School of Medicine, California, USA) now provides an overview of recent advances in preclinical cancer‐related cardiotoxicity testing, or cardio-oncology, focusing on

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10:00 GizmagArtificial embryos possible after embryonic stem cells breakthrough


An incredible new study from researchers at the Hebrew University of Jerusalem has for the first time found a way to transform skin cells into all three of the stem cell types that make up an early-stage embryo. This extraordinary discovery points a way toward creating an embryo without the need for an egg or sperm.
.. Continue Reading Artificial embryos possible after embryonic stem cells breakthrough Category: Biology Tags: Fertility Induced Pluripotent Stem Cells (iPS) Reproduction Stem Cells

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03.05.2019
21:52 StemCellsPortal.comlStem cells from hair follicles have potential to repair damaged neurons in mice

BALTIMORE, MD (US), April 2019 — A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, according to a study led by Thomas Hornyak, M.D., Ph.D., of the VA Maryland Health Care System and the University of Maryland School of Medicine. The findings, published in PLOS Genetics, offer a new direction for finding therapeutic options for certain neurodegenerative diseases.
Hair and skin take on varying shades of red, brown, black and yellow due to the pigments produced by cells called melanocytes. Melanocytes originate embryonically from cells called neural crest cells, which are cells that can also give rise to neurons and their supporting glial cells. Previously, Dr. Hornyak and colleagues identified two different pockets of stem cells that create melanocytes inside mature hair follicles. In the current study, they show

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21:11 ScienceDaily.comSpecialized plant cells regain stem-cell features to heal wounds

If plants are injured, cells adjacent to the wound fill the gaps with their daughter cells. However, which cells divide to do the healing and how they manage to produce cells that match the cell type of the missing tissue has been unclear. Scientists have now shown that to correctly replace dead cells, neighbors to the inside of the wound re-activate their stem cell programs.

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10:53 News-Medical.NetPotential stem cell therapies moving from lab bench to clinical application

Stem cell research is leading to potential new therapies to treat disease, with several applications in clinical trials or expected to enter trials in the coming months.

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00:07 ScienceDaily.comEmbryo stem cells created from skin cells

Researchers have found a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. The work (in mouse cells) has significant implications for modeling embryonic disease and placental dysfunctions, as well as paving the way to create whole embryos from skin cells.

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02.05.2019
18:18 Phys.orgSpecialized plant cells regain stem-cell features to heal wounds

If plants are injured, cells adjacent to the wound fill the gaps with their daughter cells. However, which cells divide to do the healing and how they manage to produce cells that match the cell type of the missing tissue has been unclear. Scientists from the Institute of Science and Technology Austria (IST Austria) have now shown that to correctly replace dead cells, neighbors to the inside of the wound re-activate their stem cell programs.

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10:47 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - Retinal Stem Cell-Based Therapies, Bone Repair by SHEDs, Leukemia Stem Cells, and MSC from Human Irradiated Skin!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Optimal Conditions for Retinal Stem Cell-Based Therapies

The transplantation of induced pluripotent stem cell (iPSC)-derived retinal progenitor cells (RPCs) represents an exciting strategy to treat degenerative retinal blindness, and a recent study from the lab of Elliott H. Sohn (University of Iowa, Iowa City, Iowa, USA) sought to evaluate the effect of commonly employed cell isolation and surgical manipulation strategies on donor cell viability. In a new STEM CELLS Translational Medicine article, Scruggs et al.

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01.05.2019
19:48 Phys.orgForget sperm and eggs, researchers have created embryo stem cells from skin cells

A new, groundbreaking study by the Hebrew University of Jerusalem (HU) found a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. This work has significant implications for modelling embryonic disease and placental dysfunctions, as well as paving the way to create whole embryos from skin cells.

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30.04.2019
12:16 Nature.ComJapan responds: stem-cell therapy justified

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29.04.2019
22:54 StemCellsPortal.comlWelding with stem cells for next-generation surgical glues

BRISTOL (UK), April 2019 — Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method, pioneered by Adam Perriman, Ph.D., and colleagues, involves re-engineering the membranes of stem cells to effectively “weld” the cells together.
Cell membrane re-engineering is emerging as a powerful tool for the development of next-generation cell therapies, as it allows scientists to provide additional functions in the therapeutic cells, such as homing, adhesion or hypoxia (low oxygen) resistance. At the moment, there are few examples where the cell membrane is re-engineered to display active enzymes that drive extracellular matrix production, which is an essential process in wound healing.
In this research, published recently in Nature Communications,

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11:28 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - MSCs at Fifty, Hematopoietic Stem Cell Fitness, Aging Effect of Pesticides on MSCs, and Chronic Wound Healing!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
Mesenchymal Stem Cells at Fifty Years!

The ever-evolving and continuously expanding field of mesenchymal stem cell (MSC) research has seen a rise in clinical interest in recent years, with nearly 1,000 registered clinical trials. A recent review article from researchers led by Miroslaw Janowski (Johns Hopkins University School of Medicine, Baltimore, MD, USA) aims to commemorate the 50th anniversary of the first paper on MSCs from 1968 and discuss their therapeutic activities, including immunomodulation,

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26.04.2019
22:06 FightAging.OrgDysfunctional and Senescent Immune Cells in Bone Marrow as a Cause of Age-Associated Lineage Skewing of Hematopoietic Stem Cells

The immune system declines with age for a range of reasons. The thymus atrophies, reducing the supply of new T cells; persistent infection by cytomegalovirus causes cells to become uselessly specialized rather than ready to tackle new threats; and the hematopoietic stem cells responsible for generating immune cells become damaged, inactive, and dysfunctional. One of these forms of dysfunction is that hematopoietic stem cells begin to generate too many myeloid cells and too few lymphoid cells, the so-called myeloid skew. The cause of this skewing in cell production is much debated, but researchers have found that chronic inflammation plays a role. Naturally, nowadays whenever inflammation appears to be an important aspect of any age-related dysfunction, attention turns towards senescent cells. Lingering senescent cells accumulate with […]

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18:12 FierceBiotech.comStem cells rebuild neurons’ protective sheaths in mice, inspiring new ideas for MS research

In multiple sclerosis and several other brain disorders, the protective sheath around neurons called myelin breaks down, which in turn disrupts the transmission of nerve signals. Maryland researchers have found a new way to rebuild myelin with a type of stem cell that lives in hair follicles.

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16:02 FinancialExpress.comIn a first, Mumbai hospital claims injecting stem cells saved infant’s life

In the future, newer breakthroughs at a global level may spearhead change and bring the ongoing debate to a more logical conclusion in the field of medical and clinical applications.

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25.04.2019
15:18 News-Medical.NetStem cells in hair follicles have potential to regenerate myelin sheath that coats neurons

A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, reports Thomas Hornyak of the VA Maryland Health Care System and the University of Maryland School of Medicine and colleagues, in a new study published 24th April in PLOS Genetics.

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07:51 News-Medical.NetCombining biomaterial scaffolds with stem cells for tissue engineering applications

StemJournal, a new open access, peer-reviewed journal published by IOS Press, announces publication of its inaugural article, "Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery," by Stephanie M. Willerth, PhD, and Shelly E. Sakiyama-Elbert, PhD.

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24.04.2019
23:26 ScienceDaily.comStem cells from hair follicles have potential to repair damaged neurons in mice

A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, report scientists.

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21:39 ScienceDaily.comWelding with stem cells for next-generation surgical glues

Scientists have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method involves re-engineering the membranes of stem cells to effectively 'weld' the cells together.

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20:05 Nature.ComSingle-cell transcriptomes of the regenerating intestine reveal a revival stem cell

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12:32 Technology.orgWelding with stem cells for next-generation surgical glues

Scientists at the University of Bristol have invented a new technology that could lead to the development of

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11:44 Technology.orgTo protect stem cells, plants have diverse genetic backup plans

Despite evolution driving a wide variety of differences, many plants function the same way. Now a new study

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23.04.2019
20:02 Gizmag"Welded" stem cells may help heal wounds


For many years now, scientists have been seeking methods of helping to heal chronic wounds such as those suffered by diabetics. One of the latest possible techniques involves re-engineering the membranes of stem cells, so that those cells essentially get welded together.
.. Continue Reading "Welded" stem cells may help heal wounds Category: Medical Tags: Healing Stem Cells University of Bristol Wound

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12:18 Technology.org‘Super-Hero’ Stem Cells Survive Radiation to Regrow Muscles

Muscle damage is a common side effect of radiation therapy for cancer treatment, and is made worse because

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12:07 Phys.orgWelding with stem cells for next-generation surgical glues

Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. The new method, pioneered by Dr. Adam Perriman and colleagues, involves re-engineering the membranes of stem cells to effectively 'weld' the cells together.

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11:42 MedicalNewsToday.comMedical News Today: Using stem cells to combat osteoarthritis

Osteoarthritis is a common condition without a cure. A recent small-scale pilot study concludes that stem cell therapies could offer some hope.

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22.04.2019
23:05 FightAging.OrgMesenchymal Stem Cells Derived via Reprogramming of Old Cells Exhibit a Transcriptomic Signature Closer to that of Younger Cells and Pluripotent Cells

In today's open access paper and publicity materials, researchers report on an assessment of induced mesenchymal stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs). The iPSCs were produced via the usual approach of reprogramming from tissue samples taken from old adults. The researchers then compared the gene expression profiles of these iMSCs with similar MSCs taken from fetal and adult tissues. They declare the the profile to be rejuvenated in comparison to that of the adult MSCs, but I think one has to be careful when using that word. We might better call the profile reflective of reprogramming, in that while it has commonalities with the fetal MSCs, it also has has commonalities with the iPSCs, expression of proteins usually not found in […]

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15:41 StemCellsPortal.comlStudy reveals factors behind embryonic stem cell state

MELBOURNE (AU), April 2019 — Embryonic stem cells (ESC) have the ability to self-renew and, being pluripotent, the potential to create almost any cell type in the body. The embryonic stem cell state is established and maintained by multiple regulatory networks that include epigenetic regulators; the function of these epigenetic regulators though has not been well-defined.
An international collaboration led by Monash Biomedicine Discovery Institute (BDI) scientists has found for the first time that two new epigenetic regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells. The scientists also found that these proteins activate c-Myc (a well-known cancer gene) and its regulatory network.
Their findings were published in Molecular Cell.
Monash BDI's Partha Pratim Das, Ph.D., said TAF5L and TAF6L were discovered in a CRISPR-Cas9 loss-of-function genetic screen

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15:06 StemCellsPortal.comlWhat’s the Stem Cells Buzz this Week? - MSC Stemness, MSCs in Osteoarthritis, Diaphragmatic Muscle Constructs, and Shh Distribution!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!
TSG-6 Controls Mesenchymal Stem Cell Stemness

Studies have found that the potent tissue‐protective and anti‐inflammatory factor TSG‐6 plays a crucial role in the wound healing abilities of mesenchymal stem cells (MSCs), although we have limited knowledge on the specific role of this highly interesting protein. Now, researchers from the laboratory of Stefania Vetrano (Humanitas University, Milan, Italy) report that TSG‐6 acts as an autocrine factor to regulate morphology and MSC cellular processes and is crucial for the

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13:15 FightAging.OrgSTAT3, FAM3A, and Increased Muscle Stem Cell Activity

Expression of the STAT3 gene influences a number of vital cellular processes, such as mitochondrial activity, cellular differentiation, and cellular proliferation. Researchers have investigated its activity in the context of spurring greater regenerative activity in heart muscles, for example. Arguably this is a good example of a regulatory gene that is involved in too many processes to make it a good target for therapeutics, however. More specific, lower-level mechanisms for specific desired goals would be helpful. That requires slow and costly investigative work, however, picking apart the relationships between proteins and their roles. Researchers have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate - an insight that could lead to muscle-boosting […]

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19.04.2019
15:27 AzoNano.comScientists Use Near-Infrared Light and Injected DNA Nanodevice to Guide Stem Cells to a Wound

Imagine physicians having a remote control that they could employ to drive a patient’s own cells to a wound to accelerate the healing process. Such a device is still away from reality,...

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07:19 News-Medical.NetTwo new epigenetic regulators maintain self-renewal of embryonic stem cells

Embryonic stem cells have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body.

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07:05 News-Medical.NetScientists use NIR light and injected DNA nanodevice to guide stem cells to injury

What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process?

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00:44 LiveScience.comWhat Are Stem Cells?

Embryonic stem cells can morph into any cell in the human body.

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18.04.2019
12:34 NYT HealthLiving With Cancer: The Lifesaving Power in Stem Cells

Liars and thieves should not be allowed to detract from legitimate scientific research that has made umbilical cord blood mystic in its regenerative powers.

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00:05 ScienceDaily.comFactors behind embryonic stem cell state

An international collaboration has found for the first time that two new epigenetic regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells. The scientists also found that these proteins activate c-Myc (a well-known cancer gene), and its regulatory network. This is the first time scientists have been able to show what these regulators do and how they control gene expression.

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17.04.2019
16:44 StemCellsPortal.comlDiscovery of ‘kingpin’ stem cell may help in understanding cancerous tumors

HAMILTON, ONT (CA), April 2019 — A team of McMaster University researchers has discovered a unique subset of cells within human stem cells that appear to signal how the surrounding cells will develop and grow.
The discovery of these “kingpin” cells, named human pluripotent founder cells, along with the process of identifying the cells, is expected to open a new channel of research aimed at better understanding the growth of cancerous tumors and how human stem cells make decisions on what to become or not become.
The study was published in Cell.
“We found a population, unbeknownst to anyone, that seems to be a ‘kingpin’ of a stem cell ecosystem that is required to maintain and grow all the other cells,” said Mick Bhatia, Ph.D., director of the Stem Cell and Cancer Research Institute and professor of biochemistry and biomedical sciences at McMaster.
“This class of human

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16:26 ScienceDaily.comBoosting muscle stem cells to treat muscular dystrophy and aging muscles

Scientists have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate -- an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline.

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13:39 News-Medical.NetRutgers researchers identify new factor essential for maintaining stem cells in the brain and gut

The organs in our bodies house stem cells that are necessary to regenerate cells when they become damaged, diseased or too old to function.

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16.04.2019
17:01 CancerNetwork.comCombination Therapy Enhances Stem Cell Mobilization in Patients With Multiple Myeloma

A phase III trial evaluated intermediate-dose cytarabine plus granulocyte-colony stimulating factor (G-CSF) vs G-CSF alone prior to autoSCT in multiple myeloma.

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03:56 ScienceDaily.comTo protect stem cells, plants have diverse genetic backup plans

When it comes to stem cell management, all flowering plants work to maintain the same status quo. Researchers have now identified the various strategies plants use to preserve a single, essential genetic circuit.

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15.04.2019
18:24 ScienceNewsDaily.orgStem cells call the shots

That’s why flowering plants have genetic backup plans to protect them

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