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Stem Cells

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09.12.2019
14:41 FightAging.OrgAre Benefits from Cardiac Stem Cell Therapy Due to an Immune Response to Transplanted Cells?

As this article notes, researchers have recently suggested that the benefits to heart function observed over many years of stem cell therapies are not in fact due to any action of the cells themselves, not even cell signaling mechanisms such as release of exosomes, but are rather due to an immune response to the transplanted cells. The study reported here illustrates the point by showing some degree of regeneration of injured heart tissue to take place in mice when the debris of dead cells is transplanted. We might compare these findings with the body of work showing that delivery of exosomes can spur cardiac regeneration; few portions of the field of stem cell therapy are lacking a good supply of contradictory evidence. For 15 years, […]

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08.12.2019
21:31 News-Medical.NetGenetic features of AML in older patients can predict outcomes after stem cell transplant

For older patients with acute myeloid leukemia, the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the 61st American Society of Hematology (ASH) Annual Meeting.

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07.12.2019
01:44 ScienceDaily.com'Conductor' gene found in plant root stem cell 'orchestra'

Researchers lift the veil on the 'conductor' plant root stem cell gene that helps orchestrate and coordinate stem cell division of different root stem cell types, ensuring the harmonic communication necessary for plant growth and maintenance.

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06.12.2019
22:59 StemCellsPortal.comlStem Cell Therapy Helps Broken Hearts Heal in Unexpected Way

CINCINNATI, OH (US), November 2019 — Stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. This is the conclusion of a study published recently in Nature that shows an entirely different way that heart stem cells help the injured heart — not by replacing damaged or dead heart cells as initially proposed.
The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
Mediated by macrophage cells of the immune system, the secondary healing process provided a modest benefit to heart function after heart attack, according to Jeffery Molkentin, Ph.D., principal

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22:59 StemCellsPortal.comlIntestinal Stem Cell Genes May Link Dietary Fat and Colon Cancer

NEW BRUNSWICK, NJ (US), November 2019 — Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers University study.
The study, published in Gastroenterology, describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.
"This is important because scientists have shown that when there's too much dietary fat in the intestine, stem cell numbers increase, boosting susceptibility to colon cancer," said senior author Michael Verzi, Ph.D., an associate professor in the Department of Genetics in the School of Arts and Sciences at Rutgers University-New Brunswick. Dr. Verzi is also a research member in the Genomic Instability and Cancer Genetics Research Program at Rutgers Cancer Institute of New Jersey.
People naturally lose millions of intestinal

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14:24 Phys.org'Conductor' gene found in plant root stem cell 'orchestra'

In a new paper, researchers at North Carolina State University lift the veil on the "conductor" plant root stem cell gene that helps orchestrate and coordinate stem cell division of different root stem cell types, ensuring the harmonic communication necessary for plant growth and maintenance.

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04.12.2019
16:48 FierceBiotech.comOmeros hits endpoint in pivotal stem cell transplant study

A pivotal trial of Omeros’ narsoplimab in hematopoietic stem cell transplant patients has hit its primary endpoint. Omeros expects to use the data to win FDA approval, although secrecy around the design of the trial means there remains scope for skepticism about the results.

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03.12.2019
23:35 StemCellsPortal.comlAre All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network meta‐analysis of preclinical studies testing stem cell‐based therapies in experimental neonatal lung injury in the hope of improving regenerative treatments for bronchopulmonary dysplasia (BPD), a common preterm birth complication. While this STEM CELLS Translational Medicine article highlights mesenchymal stem cell-based therapies as the most effective treatments, the authors underscore the lack of head‐to‐head comparisons and the existence of an unclear risk of bias.


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23:35 StemCellsPortal.comlTargeted Stem Cell Attack Could Make Transplants Safer

MENLO PARK, CA (US),  — Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could make blood stem cell transplants — powerful but dangerous procedures that are used mainly to treat blood cancers — safer, and thereby broaden their use.
The studies come as evidence piles up that such transplants can also treat some autoimmune disorders and genetic diseases.
The work, to be presented this week at the American Society of Hematology annual meeting in Orlando, Florida, harnesses an understanding of the proteins made by different types of blood stem cell, the cells in the bone marrow that produce the different cellular components of blood.
Blood stem cell transplants work by replacing defective blood-making cells — which can give rise to blood cancer as well as

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19:26 ScienceDaily.comHow stem cells decide their identity

Several hundred different cell types of the adult human body are formed during embryonic development, starting from just a few identical stem cells. The differentiation potential of the cells is progressively restricted in the course of this process, causing changes in their morphology and functions.

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18:52 Phys.orgResearch team deciphers how stem cells decide their identity

A research team headed by Prof. Dr. Sebastian Arnold and Jelena Tosic from the Faculty of Medicine at the University of Freiburg has now succeeded in deciphering basic molecular control mechanisms by which stem cells decide which embryonic cell types to turn into. This is achieved at least partially through selective usage of the genes for each different cell type, despite the presence of the identical genetic information in every cell in the body. The scientists have published their findings in the journal Nature Cell Biology.

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04:41 MedicalNewsToday.comMedical News Today: Stem cell discovery could improve treatments for leukemia, other diseases

Scientists have found a way to boost blood stem cell self-renewal in the lab. The finding could improve treatments for leukemia and other blood diseases.

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01:35 News-Medical.NetStem cell therapy shows promise for the first time in spinal cord injury

Researchers have published the results of their work where stem cell therapy has shown promise in a case of spinal cord injury. The results of their case study were published in the latest issue of the journal Mayo Clinic Proceedings last week.

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02.12.2019
22:57 StemCellsPortal.comlTargeted Stem Cell Attack Could Make Transplants Safer

MENLO PARK, CA (US),  — Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could make blood stem cell transplants — powerful but dangerous procedures that are used mainly to treat blood cancers — safer, and thereby broaden their use.
The studies come as evidence piles up that such transplants can also treat some autoimmune disorders and genetic diseases.
The work, to be presented this week at the American Society of Hematology annual meeting in Orlando, Florida, harnesses an understanding of the proteins made by different types of blood stem cell, the cells in the bone marrow that produce the different cellular components of blood.
Blood stem cell transplants work by replacing defective blood-making cells — which can give rise to blood cancer as well as

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20:06 News-Medical.NetPurification scheme allows collection of elusive blood stem cells from zebrafish

Hematopoietic stem cells are multipotent cells that can develop into every type of blood cell in the body.

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11:11 StemCellsPortal.comlAre All Stem Cells Equal in BPD?

A research team led by Sajit Augustine (Western University, Ontario, Canada) recently performed a systematic review and network meta‐analysis of preclinical studies testing stem cell‐based therapies in experimental neonatal lung injury in the hope of improving regenerative treatments for bronchopulmonary dysplasia (BPD), a common preterm birth complication. While this STEM CELLS Translational Medicine article highlights mesenchymal stem cell-based therapies as the most effective treatments, the authors underscore the lack of head‐to‐head comparisons and the existence of an unclear risk of bias.


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29.11.2019
18:56 Nature.Com Targeted stem-cell attack could make transplants safer

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17:14 StemCellsPortal.comlAdult Tissue-derived Neural Crest-like Stem Cells

Neural crest stem cells are multipotent, easy to isolate from adult tissues, and easy to expand, and a recent concise review from the labs of Pihu Mehrotra and Stelios T. Andreadis (University at Buffalo, Buffalo, New York, USA) summarizes the advantages of using these cells for the treatment of demyelinating disorders and spinal cord injury. The authors also describe how this technology can also be used for disease modeling and drug testing, paving the way for personalized therapeutics for neurological disorders. For all the details, see STEM CELLS Translational Medicine now!


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03:26 News-Medical.NetStem cells do help restore heart function – but in a different way

A new study published in the journal Nature shows that stem cells do work well to repair the damaged heart – but in an entirely different manner than was originally supposed. The study shows that stem cells, whether living or dead, when injected into the area of damage in the heart in mice, activate an intense acute inflammation. This triggers the classic wound healing response which finally results in the partial or complete recovery of mechanical function of the injured area.

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28.11.2019
06:42 News-Medical.NetUCLA scientists discover link between a protein and human blood stem cell self-renewal

UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions.

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06:13 News-Medical.NetPatients' own stem cells offer a step toward improving motor, sensory function after spinal cord injury

Stem cells derived from a patient's own fat offer a step toward improving -; not just stabilizing - motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.

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00:58 ScienceDaily.comStem cell therapy helps broken hearts heal in unexpected way

A study shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

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27.11.2019
21:30 Nature.ComStem-cell therapies use immune system to repair broken hearts

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21:30 Nature.ComAn acute immune response underlies the benefit of cardiac stem-cell therapy

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21:30 Nature.ComMLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

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21:09 FierceBiotech.comStem cells don't repair injured hearts, but inflammation might, study finds

A team from Cincinnati Children's Hospital tracked stem cells injected into the hearts of mice, and what they found could explain why clinical trials testing stem cell therapies in people with heart disease have been unsuccessful. They believe a smarter approach could be to harness the power of macrophages that provide healing in response to inflammation.

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26.11.2019
23:16 News-Medical.NetStem cells do not take the day off on national holidays

While most of us are stuffing ourselves with turkey and pumpkin pie at home on Thanksgiving Day, the staff at one Cedars-Sinai laboratory will be on the job, feeding stem cells.

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22:42 StemCellsPortal.comlRNA Regulation Is Crucial for Embryonic Stem Cell Differentiation

AARHUS (DK), November 2019 — Embryonic stem cells (ESCs) are distinguished by their dual ability to self-renew and their potential to differentiate, both of which require tight regulatory control. During the differentiation of ESCs, various cells develop into specialized cell types such as skin cells, nerve cells, muscle cells, etc. While our understanding of ESC regulation has been dominated by transcriptional and epigenetic models, the role of post-transcriptional regulation via nuclear RNA decay has remained less explored.
Now a Danish research team has identified a disruptive relationship between excess nuclear RNA levels, regulated by the PolyA-tail eXosome Targeting' (PAXT) connection, and transcriptional control by the Polycomb Repressive Complex 2 (PRC2). The researchers propose that excess RNA hampers PRC2 function through its sequestration from DNA. Their results highlight the

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18:51 ScienceDaily.comTendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper's knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. New research reveals the existence of tendon stem cells that could potentially be harnessed to improve tendon healing and even to avoid surgery.

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12:14 Technology.orgIntestinal Stem Cell Genes May Link Dietary Fat and Colon Cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role

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09:35 Technology.orgTendon stem cells could revolutionize injury recovery

The buildup of scar tissue makes recovery from torn rotator cuffs, jumper’s knee, and other tendon injuries a

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03:12 News-Medical.NetStudy reports discovery of tendon stem cells

Being made up of flesh and bone, the human body often suffers injuries due to tendon damage caused by various acute or chronic events. As these damaged tissues recover, scar tissue builds up, causing a slow and often painful recovery.

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25.11.2019
22:19 ScienceDaily.comIntestinal stem cell genes may link dietary fat and colon cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study. The study describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.

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19:28 News-Medical.NetGenes that help intestinal stem cells burn dietary fat may play a role in colon cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study.

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18:15 StemCellsPortal.comlMultiple Doses of Stem Cells Show Potential in Treating Severe Asthma

DURHAM, N.C. (November 20, 2019) - A study released today in STEM CELLS Translational Medicine (SCTM) describes how multiple doses of a type of stem cell called mesenchymal stromal cells (MSCs) might offer a new way to treat people suffering from severe asthma.

An asthma attack is triggered by allergens entering the lungs and causing swelling of the airways. This sets off a domino effect that results in narrowing of the airways from the nose and mouth to the lungs. The most severe cases can lead to death. According to the Centers for Disease Control and Prevention, one in 13 people have asthma. There is no cure, but it can be managed in most cases with proper prevention and treatment.

The study in SCTM, conducted by researchers at the Federal

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20.11.2019
19:04 Phys.orgMachine-learning approach helps discover new ways of controlling spatial organization of induced pluripotent stem cells

Model organs grown from patients' own cells may one day revolutionize how diseases are treated. A person's cells, coaxed into heart, lung, liver, or kidney in the lab, could be used to better understand their disease or test whether drugs are likely to help them. But this future relies on scientists' ability to form complex tissues from stem cells, a challenging undertaking.

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19.11.2019
19:58 StemCellsPortal.comlNew Biomarker Found for Cancer Stem Cells

HOUSTON, TX (US), November 2019 — In the world of cancer biology, not all biomarkers are created equal. These molecules that alert doctors that an abnormal process may be under way can appear as an array of aberrant proteins, such as hormones, enzymes or signaling molecules, and vary from patient to patient. Because they are a mixed bag, no one drug exists to attack them.
But now, a University of Houston College of Pharmacy associate professor has discovered a new biomarker in cancer stem cells that govern cancer survival and spread, and it's raising hope that drug discovery to kill cancer stem cells could follow suit.
"We have found a new biomarker, the protein plectin, on cancer stem cells. We believe plectin may be a more common biomarker that could lead to broadly applicable drug development," reported Gomika Udugamasooriya, Ph.D., in Nature Scientific Reports. "Plectin is a

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19:39 ScienceDaily.comRNA regulation is crucial for embryonic stem cell differentiation

Nuclear RNA levels are kept in check by RNA decay factors. Now, researchers show that an excess of RNA in the nucleus can have negative effects on a crucial regulator of stem cell differentiation.

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19:20 Phys.orgRNA regulation is crucial for embryonic stem cell differentiation

Embryonic stem cells (ESCs) are distinguished by their dual ability to self-renew and their potential to differentiate, both of which require tight regulatory control. During the differentiation of ESCs, various cells develop into specialised cell types such as skin cells, nerve cells, muscle cells, etc. While our understanding of ES cell regulation has been dominated by transcriptional and epigenetic models, the role of post-transcriptional regulation via nuclear RNA decay has remained less explored.

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12:56 Technology.orgStem Cells and AI: Better Together

One day in the future when you need medical care, someone will examine you, diagnose the problem, remove

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18.11.2019
10:41 StemCellsPortal.comlThe Softer, the Better - How Niche Stiffness Affects Aging Stem Cells

Review of “Niche stiffness underlies the ageing of central nervous system progenitor cells” from Nature by Stuart P. Atkinson

While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue regeneration during aging [1], the reasons for this loss remain incompletely explained. Researchers from the laboratories of Robin J. M. Franklin and Kevin J. Chalut (University of Cambridge, Cambridge, UK) sought to define the factors that reduced the regenerative capacity of oligodendrocyte progenitor cells (OPCs) during aging [2] by evaluating alterations to the stem cell niche [3, 4]. 

In their fascinating new study, Segel et al. use varying culture substrates to demonstrate how an increase to the stiffness of the OPC niche can cause the

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16.11.2019
02:43 ScienceMag.orgBallot initiative takes shape to give California stem cell agency a second life

Sponsor, CIRM board hash out vision for $5.5 billion in new funding

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15.11.2019
13:56 Technology.orgNIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues

Researchers used artificial intelligence (AI) to evaluate stem cell-derived “patches” of retinal pigment epithelium (RPE) tissue for implanting

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14.11.2019
23:43 StemCellsPortal.comlStem Cell Transplants Used to Grow Fully Functional Lungs in Mice

NEW YORK, NY (US), November 2019 — Researchers at Columbia University were able to grow fully functional lungs in mouse embryos using transplanted stem cells. The findings suggest that it may be ultimately possible to use the technique to grow human lungs in animals for patients who need transplants and to study new lung treatments.
The paper was published online in Nature Medicine.
"Millions of people worldwide who suffer from incurable lung diseases die without treatment due to the limited supply of donor lungs for transplantation," said co-senior author Wellington V. Cardoso, M.D., Ph.D., professor of medicine and of genetics and development at Columbia University Vagelos College of Physicians and Surgeons. "Our study shows that it may eventually be possible to develop new strategies for generating human lungs in animals for transplantation as an alternative to waiting for donor

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04:41 ScienceDaily.comDiscovery: New biomarker for cancer stem cells

Medical researchers have discovered a new biomarker in cancer stem cells that govern cancer survival and spread, and it's raising hope that drug discovery to kill cancer stem cells could follow suit.

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13.11.2019
23:52 News-Medical.NetNew biomarker discovered in cancer stem cells

In the world of cancer biology, not all biomarkers are created equal. These molecules that alert doctors that an abnormal process may be underway can appear as an array of aberrant proteins, such as hormones, enzymes or signaling molecules, and vary from patient to patient. Because they are a mixed bag, no one drug exists to attack them.

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12.11.2019
22:47 Technology.orgUSC stem cell scientists reveal key differences in male, female kidney

SC researchers have completed a detailed deconstruction of the kidney, revealing for the first time an intimate portrait

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10:59 StemCellsPortal.comlPluripotent Stem Cells and Genetic Heart Diseases

A new review article from the laboratory of Richard P. Davis (Leiden University Medical Center. Leiden, Netherlands) discusses how the combination of human induced pluripotent stem cells and genome editing offers a potential link in investigating the pathogenicity of primary genetic mutations affecting cardiac disease and also in determining the contribution of modifying variants. Van den Brink et al. believe that a more in-depth understanding should improve clinical decision‐making and advance the field toward making precision medicine a reality. For all the details, see STEM CELLS now!


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10:20 Technology.orgBetter Biosensor Technology Created for Stem Cells

A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for

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11.11.2019
18:44 StemCellsPortal.comlTransient Wave of Hematopoietic Stem Cell Production in Late Fetuses and Young Adults

UTRECHT (NL), November 2019 — Hematopoietic stem cells (HSCs) are responsible for the constant replenishment of all blood cells throughout life. One of the major challenges in regenerative medicine is to produce tailor-made HSCs to replace the defective ones in patients suffering from blood related diseases. This would circumvent the shortage of donor HSCs available for the clinic.
To achieve the controlled production of bona fide HSCs in vitro (that is, in a dish), a better understanding is required of where, when and how HSCs are physiologically produced in vivo (in the living body). Researchers from the groups of Catherine Robin, Ph.D., at Hubrecht Institute, and Thierry Jaffredo, Ph.D., of the Centre National de la Recherche Scientifique and Pierre and Marie Curie University – Paris, have found a previously unappreciated hematopoietic wave taking place in the bone marrow of late

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18:18 StemCellsPortal.comlHeart Attack Modeled With Human Stem Cells

OKAYAMA (JP), November 2019 — Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated from human induced pluripotent stem cells.The study was published in Biochemical and Biophysical Research Communications. Ken Takahashi, Ph.D., is corresponding author, and Wei Heng, MSc., a graduate student in the Naruse Lab, is first author.
To date, laboratory animals such as mice have been used to model diseases including myocardial infarction. However, there have been concerns about difference in characteristics of cardiomyocytes, e.g., heart rate and action of drugs, based on the difference of gene expression between laboratory animals and human.
Using this model, researchers can evaluate the extent of myocardial tissue damage by microscope morphologically, and

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17:59 ScienceDaily.comBetter biosensor technology created for stem cells

A team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons).

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17:27 Phys.orgBetter biosensor technology created for stem cells

A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders.

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15:57 News-Medical.NetImproved biosensor technology may lead to safe stem cell therapies for treating neurological disorders

A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders.

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14:29 Nanowerk.comBetter biosensor technology created for stem cells

Researchers have created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells.

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12:07 StemCellsPortal.comlMFAT vs. BMAC: Mesenchymal Stem Cell Therapy Showdown for Osteoarthritis Treatment

Review of “Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis” from STEM CELLS Translational Medicine by Stuart P. Atkinson

Osteoarthritis, a chronic degenerative disease of the articular cartilage, currently affects an estimated 30 million U.S. adults and costs over $185 billion a year to treat [1]; however, conventional conservative interventions often lack the ability to prevent the progression of osteoarthritis or providing long‐term improvements in pain and function [2]. Recent advances in treatments for osteoarthritis include therapies based on mesenchymal stem cells (MSCs) derived from the bone marrow or adipose tissue; but while both studies and clinical trials have provided evidence of the safety of said strategies

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11:54 StemCellsPortal.comlDelineating Tcf7l1-mediated Liver Cancer Stem Cell Regulation

Review of “Tcf7l1 Acts as a Suppressor for the Self‐Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β‐Catenin” from STEM CELLS by Stuart P. Atkinson

Multiple reports have linked the elevated expression of Transcription factor 7-like 1 (Tcf7l1), a key effector of the Wnt/β‐catenin signaling pathway, to tumorigenesis [1-4]. Additionally, a previous study from the laboratories of Yuanliang Wang and Cheng Qian (Chongqing University, Chongqing, China) established Tcf7l1 as a microRNA‐449a target and demonstrated its downregulated expression in liver cancer stem cells (CSCs) from hepatocarcinoma patients [5]. Further analyses also determined that Tcf7l1 overexpression reduced sphere and colony formation abilities, thereby implicating Tcf7l1 in the regulation of liver CSC

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09.11.2019
23:04 ScienceDaily.comHeart attack modeled with human stem cells

A model of ischemic heart disease was developed using human induced pluripotent stem cells (hiPSC). This model can provide a useful platform for developing effective drugs without sacrificing animals.

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08.11.2019
15:18 News-Medical.NetNew stem cell technology gives new hope for high-risk leukemia patients

Few people get a second chance at life. And fewer still are forced to take it before their 25th birthday. Tyler Rabey is one of those people. He was diagnosed with an aggressive form of leukemia at the prime of his life; a cancer that defied all standard treatments.

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11:30 StemCellsPortal.comlTunable Hydrogels for Mesenchymal Stem Cell Delivery

Stem cell therapies hold considerable promise, but their clinical application requires the development of appropriate delivery platforms; this includes synthetic hydrogels engineered to display fibrin‐like and other cell‐binding sites that promote cell adhesion and direct stem cell function and fate through “outside-in” signaling mechanisms. To better understand how the 3D culture environment and integrin‐binding attachment sites impact stem cells, researchers from the lab of Emanual Maverakis (University of California, Davis, California, USA) broadly examined the differentially gene expression profiles induced by well‐defined three dimensional hydrogel culture systems with and without tethered integrin‐binding small molecules and studied the impact of these

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11:17 StemCellsPortal.comlEndogenous Stem Cell Response After SCI

Emerging evidence suggests that many components of the secondary injury cascade following spinal cord injury (SCI), generally viewed as deleterious to host neuronal and glial cells, may trigger the activation of endogenous ependymal neural stem/progenitor cells (NSPCs). Now, researchers led by Charles H. Tator (University of Toronto, Canada) highlight new findings describing the response of endogenous NSPCs to spinal cord trauma, redefining the secondary mechanisms of spinal cord injury through the lens of the endogenous population of stem/progenitor cells. Moreover, Hachem et al. outline how these insights can fuel novel stem cell‐based therapeutic strategies to repair the injured spinal cord; see all the details in this new review article in STEM CELLS

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11:16 Technology.orgBlood cancers: a “new generation” stem cell transplant significantly reduces complications for patients

The discovery of the UM171 molecule, by Dr. Guy Sauvageau and Anne Marinier, made headlines in 2014 following

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04:47 ScienceDaily.comStem cell transplants used to grow fully functional lungs in mice

Researchers have used transplanted stem cells to grow lungs in mice. Findings could lead to new options for lung transplant patients.

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00:58 News-Medical.NetResearchers use transplanted stem cells to grow fully functional lungs in mouse embryos

Researchers at Columbia University were able to grow fully functional lungs in mouse embryos using transplanted stem cells. The findings suggest that it may be ultimately possible to use the technique to grow human lungs in animals for patients who need transplants and to study new lung treatments.

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07.11.2019
18:53 ScienceDaily.comPreemies who develop chronic lung disease had more stem cells at birth

In the first large-scale clinical study to characterize stem cells from the umbilical cord blood and tissues of premature infants with bronchopulmonary dysplasia -- a severe, chronic lung disease -- researchers found that these babies had more stem cells at birth.

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17:30 StemCellsPortal.comlAnti-Arthritis Drug Also Stops Tuberculosis Bacillus From Multiplying in Blood Stem Cells

LEUVEN (BE), November 2019 — New research shows that a drug used to fight arthritis also stops the process that allows the tuberculosis bacillus to infect and hijack blood stem cells.
Tuberculosis (TB) may affect any part of the body, but the spread of the disease might start in the bone marrow. Immunologists from KU Leuven and Brazil have shown that the TB bacillus hijacks the blood stem cells from the bone marrow to turn them into ideal host cells for multiplication. They also found that this mechanism can be stopped by administering an anti-arthritis drug.
About a quarter of the world population is a carrier of Koch’s bacillus, which can cause TB. Most people who are infected have latent TB, meaning that they don’t become ill. However, this latent TB can turn into active tuberculosis when the immune system becomes weaker, for instance in the elderly or in HIV patients. Worldwide,

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17:30 StemCellsPortal.comlMilk From Teeth: Dental Stem Cells Can Generate Milk-Producing Cells

ZURICH (CH), November 2019 — The ability of adult stem cells to generate various tissue-specific cell populations is of great interest in the medical and dental research fields. These cells can replace damaged cells and therefore represent a good alternative to classical medical treatments for tissue regeneration. This may even allow the de novo formation of entire tissues and organs in the future.
Dental epithelial stem cells are able to generate all epithelial cell types of the teeth; however, it was not yet clear whether these cells could also produce non-dental cell populations. In a recent paper published in Cells, a team of researchers led by Thimios Mitsiadis, DDS, Ph.D., professor at the Institute of Oral Biology of the University of Zurich (UZH), has shown for the first time that epithelial stem cells isolated from the continuously growing incisors of young mice are indeed able

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14:37 FightAging.OrgExtracellular Vesicles from Embryonic Stem Cells Make Mesenchymal Stem Cells More Effective in Therapy

Mesenchymal stem cell (MSC) is a category so broad as to be near meaningless, but many varieties are widely used for therapeutic purposes. MSCs are taken from any one of a variety of sources, expanded in culture, and introduced to the patient. Researchers here show that applying extracellular vesicles from embryonic stem cells to the cultured MSCs reduces the usual issues that arise when expanding cells in culture, such as senescence, and improves the effectiveness of MSCs as a therapy when tested in mice. On a practical basis, one would imagine that induced pluripotent stem cells would serve just as well as a source of extracellular vesicles with this capability. Mesenchymal stem cells (MSCs), derived from several kinds of tissues such as placenta, umbilical cord, […]

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06.11.2019
18:56 FierceBiotech.comExCellThera launches trial of drug to expand umbilical cord blood for stem-cell transplants in cancer

Scientists at the University of Montreal have identified a small-molecule drug that could boost stem cell counts in umbilical cord blood—a potential boon for the treatment of blood cancer patients. They have early clinical data showing a quick expansion of blood cells as well as a low complication rate.

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12:44 Technology.orgNew technology delivers genome editing complexes directly to stem cells

The development of a set of strategies for delivering genome editing complexes directly to stem cells has earned

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06:56 News-Medical.NetNew stem cell transplant lowers complications for patients with acute blood cancers

The discovery of the UM171 molecule, by Dr. Guy Sauvageau and Anne Marinier, made headlines in 2014 following an article in Science. Hailed by some as a revolution, even a miracle, in the field of blood stem cell transplantation, the UM171 molecule is delivering on its promise.

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06:45 News-Medical.NetPremature babies with bronchopulmonary dysplasia have more stem cells at birth

In the first large-scale clinical study to characterize stem cells from the umbilical cord blood and tissues of premature infants with bronchopulmonary dysplasia – a severe, chronic lung disease – researchers found that these babies had more stem cells at birth.

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05.11.2019
16:34 ScienceDaily.comTransient wave of hematopoietic stem cell production in late fetuses and young adults

A major challenge in regenerative medicine is producing tailor-made hematopoietic stem cells (HSCs) for transplantation. For this we need a better understanding of where, when and how HSCs are produced in vivo. Scientists have now discovered a new hematopoietic wave in the bone marrow that fills the gap between embryonic blood production and adult bone marrow hematopoietic production.

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11:04 StemCellsPortal.comlTargeting Cancer Stem Cells Via Lipid Metabolism

A recent STEM CELLS review article from the laboratory of Arun Dharmarajan (Curtin University, Western Australia, Australia) describes the significance of the altered lipid metabolism observed in cancer stem cells. Furthermore, the authors discuss the critical metabolic modifications occurring in cancer stem cells that enable tumorigenesis through enhanced dependence on fatty acid synthesis and β‐oxidation to fulfill their heightened energy and biomass requirements. Additionally, Visweswaran et al. summarize various anti‐cancer therapeutic strategies that target cancer stem cell lipid metabolism.


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10:51 StemCellsPortal.comlPrenatal Stem Cell Therapy - A Concise Review

A new review article from the laboratory of Åsa Ekblad‐Nordberg (Karolinska Institutet, Stockholm, Sweden) provides a summary of the past, the present progress, and the future potential of prenatal stem cell therapy. Writing in STEM CELLS Translational Medicine, the authors discuss those studies focusing on preclinical and clinical data and highlight the drawbacks and novel findings that may permit the accelerated progress of prenatal stem cell therapies into clinical translation.


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10:25 Technology.orgHigh-tech foam offers new tool for developing stem cells

Two Florida State University researchers are developing a high-tech material currently used in athletic equipment and prosthetics into

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04.11.2019
22:07 CancerNetwork.comNCCN Issues Guidelines for Stem Cell Transplantation

The National Comprehensive Cancer Network recently issued new guidelines on best practices in evaluating patients for hematopoietic cell transplantation, as well as how to manage complications associated with the procedure.

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19:11 Phys.orgTransient wave of hematopoietic stem cell production in late fetuses and young adults

hematopoietic stem cells (HSCs) are responsible for the constant replenishment of all blood cells throughout life. One of the major challenges in regenerative medicine is to produce tailor-made HSCs to replace the defective ones in patients suffering from blood-related diseases. This would circumvent the shortage of donor HSCs available for the clinic.

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11:01 StemCellsPortal.comlLoss of Myc mRNA Methylation Breaks the Symmetry of Hematopoietic Stem Cells

Review of “m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment” from Cell Reports by Stuart P. Atkinson

The METTL3-mediated N6-methyladenosine (m6A) modification of mRNA controls cell states in a context-dependent manner, and several recent studies have discovered that m6A and METTL3 contribute to the survival and maintenance of myeloid leukemia cells [1-3]. This finding has prompted the development of METTL3-targeted therapeutics; however, the disruption of m6A regulators can also significantly impact normal hematopoietic stem cell (HSC) function [4-6].

Researcher from the laboratories of Dan A. Landau (Weill Cornell Medicine) and Michael G. Kharas (Memorial Sloan Kettering Cancer Center, New York, NY, USA) sought to understand the influence of m6A-modified mRNA on HSCs

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01.11.2019
23:56 Technology.orgMilk from Teeth: Dental Stem Cells Can Generate Milk-Producing Cells

Stem cells of the teeth can contribute to the regeneration of non-dental organs, namely mammary glands. According to

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13:15 FightAging.OrgSenescent Mesenchymal Stem Cells Contribute to Osteoarthritis

Cellular senescence is a significant contributing cause of osteoarthritis in old age, and senolytic therapies capable of selectively destroying senescent cells are presently undergoing clinical trials in osteoarthritic patients. Researchers here investigate a specific population of senescent cells, the supporting mesenchymal stem cells found in and around joint tissue, and establish that they are important in the progression of osteoarthritis. Tissue accumulation of p16INK4a-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). These cell-cycle arrested cells affect tissue function through a specific secretory phenotype. The links between OA onset and senescence remain poorly described. Using experimental OA protocol and transgenic mice, we found that the senescence-driving p16INK4a is a marker of the disease, expressed by the synovial tissue, but is

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01:18 ScienceDaily.comMilk from teeth: Dental stem cells can generate milk-producing cells

Stem cells of the teeth can contribute to the regeneration of non-dental organs, namely mammary glands. According to a new study, dental epithelial stem cells from mice can generate mammary ducts and even milk-producing cells when transplanted into mammary glands. This could be used for post-surgery tissue regeneration in breast cancer patients.

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01:09 News-Medical.NetThree UCLA researchers receive multimillion-dollar grant from state's stem cell agency

Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state's stem cell agency.

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31.10.2019
17:53 Phys.orgDental stem cells can generate milk-producing cells

Stem cells of the teeth can contribute to the regeneration of non-dental organs, namely mammary glands. According to a new study from researchers at the University of Zurich, dental epithelial stem cells from mice can generate mammary ducts and even milk-producing cells when transplanted into mammary glands. This could be used for post-surgery tissue regeneration in breast cancer patients.

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30.10.2019
11:11 StemCellsPortal.comlSPARC Promotes Limbal Stem Cell Proliferation

In a recent STEM CELLS article, researchers led by Jing Zhou (Shandong University, Shandong, China) confirmed that secreted protein acidic and rich in cysteine (SPARC) had the ability to promote the proliferation and suppress the spontaneous differentiation of limbal epithelial stem cells (LESCs) in vitro through the JNK/p38 MAPK signaling pathway. The authors also revealed that exogenous SPARC accelerated corneal epithelial wound healing and promoted the proliferation of p63-alpha‐positive cells both in the limbus and epithelial healing front in a corneal wound model. Overall, these new findings suggest SPARC as a potential agent to cure LESC deficiency‐related diseases and as a potential supplement to aid the expansion of LESCs for corneal regenerative

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10:58 StemCellsPortal.comlRegeneration with Meniscus-derived Stem Cells

The results of a new study by researchers led by Weishan Chen and Weiliang Shen (Zhejiang University, Hangzhou, China) have demonstrated, for the first time, that meniscus‐derived stem cells (MeSCs) derived at earlier developmental stages may not be optimal for meniscus regeneration and articular cartilage protection when compared to MeSCs derived from day seven inner meniscus tissue. He et al. believe that their new findings could make a significant contribution to human meniscus tissue engineering in the future; for all the details, see STEM CELLS Translational Medicine.

 

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28.10.2019
16:25 StemCellsPortal.comlUltrastructure of Focal Adhesion Scaffold Unveiled in Human Pluripotent Stem Cells

TURKU (FI), (October 2019) —Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades. However, focal adhesions remain unstudied in the context of human pluripotent stem cells (hPSCs). The research group from the Turku Bioscience Centre at the University of Turku in Finland unveiled the ultrastructure of focal adhesion scaffold using state-of-the-art super-resolution microscopy, in collaboration with Howard Hughes Medical Institute.
hPSCs hold great promise for regenerative medicine. These cells can differentiate to virtually all adult cell types and proliferate endlessly. So far, the implementation of therapies derived from pluripotent stem cells into the clinics is dragging. This might be due to the lack of understanding of how the fundamental cell biological

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25.10.2019
22:55 News-Medical.NetResearchers unveil ultrastructure of focal adhesion scaffold in pluripotent stem cells

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades.

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16:54 Phys.orgUltrastructure of focal adhesion scaffold unveiled in human pluripotent stem cells

Focal adhesions are known as signaling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signaling cascades. However, focal adhesions remain unstudied in the context of human pluripotent stem cells. The research group led by Academy Professor Johanna Ivaska from the Turku Bioscience Centre at the University of Turku unveiled the ultrastructure of focal adhesion scaffold using state-of-the-art super-resolution microscopy in collaboration with the world-renowned Howard Hughes Medical Institute's Janelia Research Campus.

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24.10.2019
17:24 StemCellsPortal.comlStem Cell Breakthrough Could Mean Cure for Heart Disease in Cats ... and Humans

LONDON (UK), October 2019 — In what is believed to be a world-first, researchers have identified the conditions required to generate pluripotent stem cells from domestic cats, a finding which could have significant benefits for feline and human health.
The Royal Veterinary College (RVC), in association with the Animal Health Trust (AHT), The Beryl Evetts and Robert Luff Animal Welfare Trust (BERLAWT) The Winn Feline Foundation and Boehringer Ingelheim, have created these cells as part of a study into feline hypertrophic cardiomyopathy (HCM).
HCM affects about 15 percent of the feline population in the UK, translating to over 1 million cats. It is caused by genetic mutations affecting the heart muscle cells. To date, there are no treatments proven to stop or reverse it, leading to a very poor prognosis for affected cats.
This is partly because a major issue with studying heart

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17:24 StemCellsPortal.comlStem Cell Study Offers New Way to Study Early Development and Pregnancy

LA JOLLA, CA (US), October 2019 — Although graduating from school, a first job and marriage can be important events in life, some of the most significant events happen far earlier: in the first few days after a sperm fertilizes an egg and the cell begins to divide.
The way the first 100 cells (collectively called a blastocyst) organize themselves has profound implications for whether a pregnancy is successful, how organs form and potentially even for diseases later in life, such as Alzheimer's. However, scientists have not had a good way to model how a blastocyst is formed, until now.
For the first time, researchers at the Salk Institute and the University of Texas Southwestern Medical Center have created mouse blastocyst-like structures, or "blastoids," from a single cultured cell, circumventing the need for natural embryos. As they reported in Cell, these cultured blastoids have

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15:46 ScienceDaily.comAnti-arthritis drug also stops tuberculosis bacillus from multiplying in blood stem cells

Immunologists have shown that a drug used to fight arthritis also stops the process that allows the tuberculosis bacillus to infect and hijack blood stem cells.

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23.10.2019
19:12 News-Medical.NetAnti-arthritis drug can stop tuberculosis bacillus from infecting blood stem cells

Immunologist Johan Van Weyenbergh (KU Leuven) and his Belgian-Brazilian colleagues have shown that a drug used to fight arthritis also stops the process that allows the tuberculosis bacillus to infect and hijack blood stem cells.

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11:40 Technology.orgHow Stem Cells Make Decisions

If you’re a human embryonic stem cell — and who among us hasn’t been — the G1 (“Gap

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22.10.2019
08:51 StemCellsPortal.comlThe Fate of Adipose-Derived Mesenchymal Stem Cells

While the exogenous administration of adipose‐derived mesenchymal stromal cells (ASCs) holds great promise as a treatment strategy for wound healing by promoting tissue repair and regeneration, the best route of administration remains undefined. Now, a new study from Karlien Kallmeyer (University of Pretoria, Pretoria, South Africa) and Ali Modarressi (University Hospital of Geneva, Switzerland) demonstrates how systemically and locally administered ASCs enhanced wound repair as evidenced by earlier wound closure; however, systemically administered ASCs enhanced wound repair distally as they become entrapped in the lungs, while locally administered ASCs migrated into the wound bed. For more information, head over to STEM CELLS Translational Medicine.
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08:51 StemCellsPortal.comlStem Cell Therapy in Idiopathic Pulmonary Fibrosis

A recent first‐in‐human clinical trial led by Vladimir Baklaushev (Federal Research Clinical Center FMBA of Russia, Moscow, Russia) revealed the safety and tolerability of a high cumulative dose of mesenchymal stem cells (MSCs) patients suffering from idiopathic pulmonary fibrosis with rapid lung function decline. Averyanov et al. describe how lung function increased in MSC-treated but not placebo-treated patients, overall suggesting safety, tolerability, and potential benefits of higher doses of MSCs than those used earlier in patients with idiopathic pulmonary fibrosis. See STEM CELLS Translational Medicine now to see how these findings might move future trials toward a new stage in stem cell transplantation.

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21.10.2019
22:39 News-Medical.NetPluripotent stem cells help advance understanding of how Huntington's disease develops

Huntington's disease (HD) is a fatal hereditary disease for which there is no cure. A novel study from Cedars-Sinai Medical Center, Los Angeles, using pluripotent stem cells advances understanding of how the disease develops and may help pave the way for identifying pathways for future treatments.

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13:27 FightAging.OrgThe Role of Adipogenic Progenitor Cells in Muscle Stem Cell Aging

The stem cells responsible for maintaining muscle tissue decline in function with age, becoming ever less active. This loss of function contributes to sarcopenia, the characteristic decline in muscle mass and strength that takes place with advancing age. Researchers here report on investigations of the role of adipogenic progenitor cells in the decline of muscle stem cell function. These progenitor cells are a necessary part of the muscle stem cell niche, but their behavior changes for the worse with advancing age, disrupting the balance of intracellular signaling needed for stem cell function. Declining stem cell function during aging leads to impaired tissue function and contributes to delayed tissue repair following damage. In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases […]

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11:19 StemCellsPortal.coml PI3K Signaling Inhibition - A New Way to Culture Trophoblast Stem Cells

Review of “Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast” from STEM CELLS by Stuart P. Atkinson

Trophoblast stem cells (TSCs), a self‐renewing population of extra‐embryonic cells that can differentiate into all trophoblastic cell types of the placenta, are derived from mouse blastocysts and early postimplantation stage embryos [1, 2]. Unfortunately, we know little regarding the precise signaling pathways required to support the stem cell state of TSCs, a fact exemplified by the generally heterogeneous nature of in vitro TSC cultures.

In the presence of inhibitors of specific pathways, embryonic stem cells (ESCs) form homogeneous colonies of cells that maintain epigenomic and transcriptional characteristics of a naïve ESC state [3, 4]. Researchers led by Myriam

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18.10.2019
22:50 Nature.ComOne stem cell morphs into a mouse embryo’s forerunner

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