Techh.info/biomedtechnology hourly

Stem Cells

headlines texts
18.08.2019
13:46 StemCellsPortal.comlEngineered Stem Cells for Targeted Cancer Therapy

Multiple stem cell types exhibit inherent cancer tropism, while engineered stem cells have been used as therapeutic agents to specifically target cancer cells. More recently, stem cells engineering has been employed to target multiple surface‐receptors on tumor cells, as well as endothelial and immune cells of the tumor microenvironment. In a new review published in STEM CELLS, researchers led by Sanam L. Kavari and Khalid Shah (Harvard Medical School, Boston, Massachusetts, USA) discuss the rationales and strategies of developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges that they hold as cancer therapeutics.


Скрыть анонс
16.08.2019
18:10 News-Medical.NetDespite failed promises, stem cell advocates again want taxpayers to pony up billions

Californians voted in 2004 to shell out billions of dollars in taxpayer money to fund cutting-edge stem cell treatments.

Скрыть анонс
16:29 Technology.orgNew stem cell combination could help to repair damaged hearts

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed

Скрыть анонс
16:18 Technology.orgCambridge scientists reverse ageing process in rat brain stem cells

New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new

Скрыть анонс
03:42 MedicalNewsToday.comMedical News Today: Rejuvenating brain stem cells may hold key to future MS treatments

Scientists have found a way to rejuvenate brain stem cells in rats. The finding offers clues on how to restore lost brain function in diseases such as MS.

Скрыть анонс
15.08.2019
22:30 FightAging.OrgStiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination

Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect between (a) increasing stiffness of the brain tissue that hosts niches where stem cells reside, (b) dysfunction of those stem cells mediated by the specific stiffness-sensing mechanism of Piezo1, a process that may exist in other stem cell populations as well, (c) the loss of myelin-generating cells normally produced by the stem cells, and (d) the consequent degradation of myelin and nervous system function. Without looking into underlying causes of increasing […]

Скрыть анонс
19:07 News-Medical.NetResearchers reverse stem cell aging process

Scientists have shown that older stem cells can be reverted to a younger state. The discovery has important implications for degenerative disease research.

Скрыть анонс
16:03 StemCellsPortal.comlImplantable 3D blastocyst-like embryonic structure generated from mouse stem cells

SAITAMA (JP), August 2019 — After an egg is fertilized, it begins to divide and passes through several stages. Cells in the two-cell stage are totipotent — they can become any type of cell. After many more cell divisions, the embryo turns into a blastocyst that is implanted in the womb where it differentiates and grows into a fetus. A blastocyst is like an almost hollow ball. Inside are pluripotent cells — cells that can become any type of cell in the body, but not the placenta — while the outer shell is made from trophoblasts — cells that eventually form the placenta.
For several years, scientists have been able to convert somatic cells, like skin cells, into pluripotent cells. However, nobody has been able to convert differentiated cells into totipotent cells.
In an earlier study conducted at Gladstone, authors Cody Kime, Ph.D., and Kiichiro Tomoda, Ph.D., were able to convert

Скрыть анонс
06:00 StemCellsPortal.comlHuman amniotic fluid stem cells show promise in treating severest type of spina bifida

DURHAM, N.C. AUGUST 14, 2019 - A study released today in STEM CELLS Translational Medicine provides compelling evidence of how an injection of human amniotic fluid stem cells can be used to protect the spinal cord of a fetus from myelomeningocele (MMC). The finding could lead to a new strategy for treating this debilitating birth defect that affects about 1 out of every 4,000 children born in the United States each year.

The most severe form of spina bifida, myelomeningocele results when the backbone and spinal canal do not close before birth. It can leave a child with many disabilities, including partial or full paralysis, difficulty with bowel and bladder control, hydrocephalus and developmental delay.

“Despite the poor prognosis associated with MMC, the options

Скрыть анонс
04:41 GizmagCambridge study reverses aging of key brain stem cells in rodents


New research, led by a team of scientists from the University of Cambridge, has demonstrated a way to rejuvenate old, dysfunctional brain stem cells, making them act young again. The technique points to potential new treatments for multiple sclerosis (MS), but also broader ways to reverse general age-related brain changes.
.. Continue Reading Cambridge study reverses aging of key brain stem cells in rodents Category: Medical Tags: Aging Brain Cambridge University Multiple Sclerosis Neuroscience Stem Cells

Скрыть анонс
02:12 ScienceDaily.comScientists reverse aging process in rat brain stem cells

Scientists say the results have far reaching implications for how we understand the aging process, and how we might develop much-needed treatments for age-related brain diseases.

Скрыть анонс
14.08.2019
19:22 StemCellsPortal.comlβ-Cell Mass Formation in Stem Cell-Derived Implants

A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al. describe the optimization steps used to enhance this protocol in a STEM CELLS Translational Medicine study. The authors investigated the formation of a β‐cell mass inside the device to identify the underlying mechanisms and conditions that reduce variability and, in doing so, elucidated a protocol that resulted in the more consistent formation of a glucose‐controlling β‐cell mass.


Скрыть анонс
18:58 StemCellsPortal.comlPerspectives: Translation of Stem Cell Research: Points to Consider in Designing Preclinical Animal Studies

Summary Stem cell‐based therapies hold tremendous promise for the treatment of serious diseases and injuries. Although hematopoietic stem cell transplantation is routinely used as part of the treatment regime for some malignancies and genetic diseases, most stem cell‐based therapeutic products are investigational and still require preclinical and clinical studies to support their many novel therapeutic uses. Because of the multiple sources of stem cells, the plethora of potential applications, and the novel mechanism of action of stem cell‐based therapies, there is no single set of universal guidance documents that can be used to inform the preclinical development path for these therapeutics. Specific technical issues relating to the transplantation of human cells in animals, new delivery procedures, and laborious methods to characterize

Скрыть анонс
17:28 StemCellsPortal.comlHuman amniotic fluid stem cells show promise in treating severest type of spinal bifida

The most severe form of spinal bifida, myelomeningocele results when the backbone and spinal canal do not close before birth. It can leave a child with many disabilities, including partial or full paralysis, difficulty with bowel and bladder control, hydrocephalus and developmental delay.

“Despite the poor prognosis

Скрыть анонс
17:16 StemCellsPortal.comlPerspectives: The Alpha Stem Cell Clinic: A Model for Evaluating and Delivering Stem Cell-Based Therapies

Summary Cellular therapies require the careful preparation, expansion, characterization, and delivery of cells in a clinical environment. There are major challenges associated with the delivery of cell therapies and high costs that will limit the companies available to fully evaluate their merit in clinical trials, and will handicap their application at the present financial environment. Cells will be manufactured in good manufacturing practice or near‐equivalent facilities with prerequisite safety practices in place, and cell delivery systems will be specialized and require well‐trained medical and nursing staff, technicians or nurses trained to handle cells once delivered, patient counselors, as well as statisticians and database managers who will oversee the monitoring of patients in relatively long‐term follow‐up studies.

Скрыть анонс
16:31 StemCellsPortal.comlProfiles: California Institute for Regenerative Medicine: Accelerating Stem Cell Therapies in California and Beyond


Among the most prolific funders of stem cell research today is the California Institute for Regenerative Medicine (CIRM). CIRM was established in 2004 by Proposition 71 to accelerate the development of new therapies for chronic disease and injury by funding stem cell research programs throughout the state of California. Its mission is to support and advance stem cell research and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury. Renowned stem cell and in vitro fertilization expert Dr. Alan Trounson has been president of CIRM since 2008. He shares the organization's goals and strategies as well as its successes.
 
Introduction The California Institute for Regenerative Medicine (CIRM)

Скрыть анонс
16:16 News-Medical.NetNanotechnology could boost stem cell transplantation research

Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.

Скрыть анонс
14:01 Nanowerk.comNew nanotechnology platform could aid stem cell transplantation research

People with neurodegenerative diseases and central nervous system injuries could benefit.

Скрыть анонс
13:28 Phys.orgNew nanotechnology could aid stem cell transplantation research

Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.

Скрыть анонс
13.08.2019
23:35 FightAging.OrgReviewing Potential Strategies for the Rejuvenation of Stem Cell Populations

Every type of tissue is supported by its own dedicated stem cell population, delivering a supply of daughter somatic cells that replace losses and maintain tissue function. Unfortunately, stem cell function declines with age. This has numerous causes, all of which descend from the underlying accumulation of molecular damage outlined in the SENS research proposals for rejuvenation biotechnologies. Downstream of those causes, stem cells become less active due to some combination of internal damage, damage to their niche of supporting cells, and changes in the signaling environment. The latter two classes of issue appear more influential in the best studied stem cell populations, such as the satellite cells of muscle tissue. Thus most research and development intended to restore stem cell function is presently focused […]

Скрыть анонс
12:00 News-Medical.NetTooth repair using stem cells may soon be a reality

A team of researchers including those from Biotechnology Center of the TU Dresden (BIOTEC), have found that stem cells could be used for several forms of tissue engineering including tooth repair.

Скрыть анонс
12.08.2019
22:40 StemCellsPortal.comlNovel dual stem cell therapy improving cardiac regeneration

HONG KONG, August 2019 — As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team of scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells.
The findings give hope to develop a new treatment for repairing MI heart, as an alternative to the existing complex and risky heart transplant for seriously ill patients.
MI is a fatal disorder caused by a shortage of coronary blood supply to the myocardium. It leads to permanent loss of heart muscle cells (cardiomyocytes) and scar tissue formation, resulting in irreversible damage to cardiac function or even

Скрыть анонс
19:21 StemCellsPortal.comlXeno-free Culture Reagents Improves Bone Generation by Periosteum‐derived Stem Cells

Review of “Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture” from STEM CELLS Translational Medicineby Stuart P. Atkinson

The translation of basic stem cell research into clinically relevant therapies will require xeno‐free culture components used as part of highly efficient and scalable in vitro expansion and differentiation approaches. Researchers from the laboratory of Ioannis Papantoniou (KU Leuven, Leuven, Belgium) previously established the potential of expanding and differentiating human periosteum‐derived stem cells (hPDCs), crucial to bone fracture healing in vivo [1], in microcarrier‐containing bioreactors [2] as a means to develop sources of cells with osteogenic or chondrogenic potential for in vivo transplantation. 
Скрыть анонс

18:48 Benzinga.comCellect Shares Rally After Lead Stem Cell Program Receives Clearance For Midstage Study

The thinly traded nano-cap penny stock CELLECT BIOTECH/S ADR (NASDAQ: APOP) was soaring Monday.
read more

Скрыть анонс
09:27 GizmagHarvard team grows cyborg mini-organs out of stem cells


Scientists could almost build a whole mini-body out of the mini-organs that have been grown over the last few years. But cell development has traditionally been tricky to study, thanks largely to the difficulty in getting sensors in there without damaging the organs. Now, researchers from Harvard have developed a way to create "cyborg organoids" by integrating nanoelectronics into cell cultures.
.. Continue Reading Harvard team grows cyborg mini-organs out of stem cells Category: Biology Tags: Artificial organs Cells Cyborg Electronic Harvard Medication Stem Cells

Скрыть анонс
06:34 GizmagNewly-discovered group of dental stem cells could patch up cavities


The dentist's drill is a sound that sends shudders down the spines of many people, so it sure would be nice if teeth could just repair themselves. Thankfully that's not as far-fetched as it sounds – researchers from the University of Plymouth have found a new population of stem cells in mice that are in charge of repairing tooth tissue and could be recruited to help us patch up cavities.
.. Continue Reading Newly-discovered group of dental stem cells could patch up cavities Category: Medical Tags: Dental Health Regenerative Medicine Stem Cells Teeth University of Plymouth

Скрыть анонс
10.08.2019
17:40 ScienceDaily.comNovel dual stem cell therapy improving cardiac regeneration

Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

Скрыть анонс
09.08.2019
07:58 News-Medical.NetTreatment with both targeted cancer therapy and MS drug halts glioblastoma stem cells

Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery.

Скрыть анонс
08.08.2019
22:12 StemCellsPortal.comlTargeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

SEATTLE, WA (US), August 2019 — Researchers at Fred Hutchinson Cancer Research Center have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.
It's the first time that scientists have specifically edited the genetic makeup of a specialized subset of adult blood stem cells that are the source of all cells in the blood and immune system.
The proof-of-principle study, published July 31 in Science Translational Medicine, suggests that efficient modification of targeted stem cells could reduce the costs of gene-editing treatments for blood disorders and other diseases while decreasing the risks of unwanted effects that can occur with a less discriminating approach.
"By demonstrating how this select group of cells can be efficiently edited for one type of

Скрыть анонс
19:35 ScienceDaily.comImplantable 3D blastocyst-like embryonic structure generated from mouse stem cells

Researchers have generated 3D blastocyst-like structures from stem cells. The study shows that the blastocyst-like structures very closely resemble actual blastocysts, and even induce proper changes in the uterus after being implanted in pseudo-pregnant mice.

Скрыть анонс
17:39 Benzinga.comBayer To Buyout Stem Cell Therapy Company BlueRock For Up To $600M

Biotech M&A has been on a roll this year, with companies striking up both mid- and large-sized deals. 
read more

Скрыть анонс
14:50 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

Скрыть анонс
14:39 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

Скрыть анонс
14:27 Yahoo.com BusinessBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline. Having established BlueRock as part of a 2016 joint venture with Versant Ventures, Bayer will acquire the remaining 59.2% stake for about $240 million upfront and an additional $360 million depending on certain development achievements, it said on Thursday. BlueRock, valued at about $1 billion by the deal, is working on induced pluripotent stem cells (iPSC), made by reprogramming mature body cells to behave like embryonic stem cells that are injected to restore diseased tissue in patients.

Скрыть анонс
14:23 ReutersBayer buys BlueRock in $600 million bet on stem cell therapies

German drugmaker Bayer is paying up to $600 million for full control of cell therapy developer BlueRock Therapeutics, stepping up investment in a promising new medical area to revive its drug development pipeline.

Скрыть анонс
08:21 News-Medical.NetNew method to enhance heart-attack repair using stem cell-derived cardiomyocytes

The heart cannot regenerate muscle tissue after a heart attack has killed part of the muscle wall. That dead tissue can strain surrounding muscle, leading to a lethal heart enlargement.

Скрыть анонс
00:27 SeekingAlpha.comU.S. Stem Cell reports Q2 results

© seekingalpha.com. Use of this feed is limited to personal, non-commercial use and is governed by Seeking Alpha's Terms of Use (https://seekingalpha.com/page/terms-of-use). Publishing this feed for public or commercial use and/or misrepresentation by a third party is prohibited.

Скрыть анонс
07.08.2019
12:17 Nature.ComWind-down of stem-cell institute leaves a void

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

Скрыть анонс
06.08.2019
20:56 StemCellsPortal.comlNeural Stem Cells from Neuroepithelial Stem Cells

A recent study from the labs of Philipp Koch (University of Heidelberg/Medical Faculty Mannheim) and Oliver Brüstle (University of Bonn, Germany) explored whether stable neuroepithelial stem (NESCs) derived from human pluripotent stem cells can give rise to neural stem cells with radial glia‐like properties. Ostermann et al. now report on the in vitro transition of human NESCs into radial glia‐like NSCs, define the developmental relationship between in vitro propagated human NSC systems, and provide a matrix for the relationship between pluripotent stem cell‐derived populations and their native counterparts in the brain. For all the exciting details, see STEM CELLS now!


Скрыть анонс
16:28 StemCellsPortal.comlComputer modeling predicts best stem cell donors and therapies for kids with heart disease

Durham, NC – A study released today in STEM CELLS Translational Medicine (SCTM) identifies a computational modeling system that could have far-reaching implications for personalized medicine, especially when seeking treatments for children with heart failure. The system, called partial least squares regression (PLSR), is able to predict which stem cell donors and manipulation methods might yield the best therapies for these patients.
According to the March of Dimes, nearly one out of every 100 babies born in the United States each year has a heart defect — a quarter of them critical, with symptoms including severe right ventricular heart failure (RVHF).The SCTM study team, made up of researchers from Emory University and Georgia Institute of Technology, had alreadyshown that aggregated c-kit+

Скрыть анонс
09:18 GizmagGiving stem cells some support helps heal damaged hearts


Considering how important an organ it is, it's a shame that the heart is so bad at repairing itself. One heart attack is rarely the end of the problem, as scarring prevents healing and often leads to further attacks. Stem cells are an emerging solution, and now researchers at the Universities of Cambridge and Washington have combined heart muscle cells and supportive cells to help mend broken hearts.
.. Continue Reading Giving stem cells some support helps heal damaged hearts Category: Medical Tags: Cambridge University Cells Heart Heart attack Heart Disease Stem Cells University of Washington

Скрыть анонс
05.08.2019
17:32 FierceBiotech.comStem cell combo repairs damaged hearts in rats

Scientists in the U.K. and U.S. worked together on a study showing that a combination of cardiac muscle cells and epicardial cells derived from stem cells could restore both damaged heart muscle and blood vessel cells in rat models of heart attack. They believe the combo could be key to improving stem-cell treatments for people with heart failure.

Скрыть анонс
15:49 StemCellsPortal.comlNew stem cell combination could help to repair damaged hearts

LONDON (UK), August 2019 — A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed treatment for heart failure, according to new research published in Nature Biotechnology.
Researchers have found that, by transplanting an area of damaged tissue with a combination of both heart muscle cells and supportive cells taken from the outer layer of the heart wall, they may be able to help the organs recover from the damage caused by a heart attack.
Scientists have been trying to use stem cells to repair damaged hearts for a number of years. Efforts have been unsuccessful so far, mainly because the vast majority of transplanted cells die within a few days.
Now, Sanjay Sinha, M.D., Ph.D., and his team at the University of Cambridge, in collaboration with researchers at the University of Washington, have used supportive epicardial

Скрыть анонс
13:17 News-Medical.NetSuperstar athletes popularize unproven stem cell procedures

Baseball superstar Max Scherzer — whose back injury has prevented him from pitching for the Washington Nationals since he last played on July 25 — is the latest in a long list of professional athletes to embrace unproven stem cell injections in an attempt to accelerate their recovery.

Скрыть анонс
11:45 GizmagStem cell map shows how immortal invertebrate regenerates itself


Our bodies do a decent enough job of repairing themselves, able to patch up wounds, fight off infections and even heal broken bones. But that only applies up to a certain point – lose a limb, for example, and it's not coming back short of a prosthesis. Other creatures have mastered this skill though, and now scientists at the University of California Davis (UC Davis) and Harvard have sequenced the RNA transcripts for the immortal hydra and figured out how it manages to do just that.
.. Continue Reading Stem cell map shows how immortal invertebrate regenerates itself Category: Biology Tags: Animals Genetics Harvard Regeneration Regenerative Medicine RNA Stem Cells UC Davis

Скрыть анонс
10:59 StemCellsPortal.comlA Role for hnRNP‐K in Regulating Open Chromatin in Embryonic Stem Cells

Review of “hnRNP-K targets open chromatin in mouse embryonic stem cells in concert with multiple regulators” from STEM CELLS by Stuart P. Atkinson

While the expression of the OCT4 transcription factor characterizes pluripotent stem cells, we still have an incomplete picture of the initiation of OCT4 gene expression and its maintenance during development. Researchers from the laboratory of Alexey N. Tomilin (Russian Academy of Sciences, St. Petersburg, Russia) recently sought to explore a role of hnRNP‐K in OCT4 gene expression, given several reports describing a role for hnRNP‐K in pluripotent stem cells and development [1-4]. hnRNP‐K itself is a KH‐domain poly(C)‐binding protein family member characterized by high‐affinity interactions with polycytosine strands in DNA and RNA [5].

In a new STEM CELLS article,

Скрыть анонс
02.08.2019
22:13 StemCellsPortal.comlStudy looks at stem cells for answers to how a type of autism develops

CHICAGO, IL (US), July 2-19 — Researchers have discovered how the genetic defect in fragile X syndrome — a type of autism — delays production of neurons (nerve cells) at a critical time in the embryo's brain development. In a study published in Cell Reports, Yongchao Ma, Ph.D., and colleagues describe a previously unknown regulatory mechanism controlling how stem cells differentiate into neurons.
They identified early disruptions in this process in fragile X syndrome, the most common inherited intellectual disability in children.By investigating the earliest stages in development of fragile X syndrome, researchers hope to identify new targets for potential treatments.
"During embryonic brain development, the right neurons have to be produced at the right time and in the right numbers," said Dr. Ma, senior author and researcher at Ann & Robert H. Lurie Children's Hospital of

Скрыть анонс
21:24 News-Medical.NetNew stem cell combination may help repair damage caused by heart attack

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed treatment for heart failure, according to new research part-funded by the British Heart Foundation (BHF) and published in Nature Biotechnology.

Скрыть анонс
15:20 FierceBiotech.comCould stem cell transplants make BMS' checkpoint inhibitors work in resistant lymphoma?

Scientists at Mount Sinai have found a possible way to make immune-oncology agents work better for tough-to-treat blood cancers, and it involves a well-established treatment for non-Hodgkin lymphoma: the transplant of blood-forming stem cells.

Скрыть анонс
02:28 ScienceDaily.comAssessing direct-to-consumer stem cell clinics

This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics or how the treatments they offer align with the expertise of their practitioners. Investigators now offer a detailed characterization of nearly 170 stem cell businesses across Arizona, California, Colorado, Nevada, New Mexico, and Utah, where about one-third of US stem cell clinics are located.

Скрыть анонс
01.08.2019
20:16 Drugs.comMore 'Buyer Beware' Warnings for Unregulated Stem Cell Clinics

THURSDAY, Aug. 1, 2019 -- Folks who get treatment from a stem cell clinic could be spending their money on what amounts to snake oil, a new study warns. Doctors administering stem cells might have no expertise in the condition they're trying to...

Скрыть анонс
17:47 Yahoo ScienceSelma Blair tries breakthrough stem cell treatment for MS

Actress Selma Blair is undergoing a treatment to reboot her immune system as she continues her battle with multiple sclerosis (MS). Blair is taking her Instagram followers along with her as she undergoes hematopoietic stem cell transplantation (HSCT), a treatment that has long been used to treat cancers of the blood and bone marrow. Doctors are now using the treatment to attempt to reboot the immune system of MS patients like Blair in hopes of stopping the attack on the brain and spinal cord.

Скрыть анонс
17:46 StemCellsPortal.comlStem cell therapy furthers research for infants with hypoplastic left heart syndrome

ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery. A paper detailing the clinical trial was published in the Journal of Thoracic and Cardiovascular Surgery.
The study focused on the safety and feasibility of stem cell treatments designed to strengthen the heart muscle of children with hypoplastic left heart syndrome, a severe congenital heart disease. The research is funded by the Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome — a collaborative network of specialists bonded by the vision of delaying or preventing heart failure for people affected by

Скрыть анонс
01:32 Nature.ComPublisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

Скрыть анонс
31.07.2019
23:15 ScienceDaily.comTargeting a blood stem cell subset shows lasting, therapeutically relevant gene editing

Researchers have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.

Скрыть анонс
22:59 Benzinga.com'I Didn't Want To Die': Why One Woman Turned To Trading Options To Fund Life-Extending Stem Cell Treatments

Nov. 22, 2017 started as a relatively uneventful day for Yvonne Shore.
She went to her job — "the best job ever" — as a car dealership auditor in Atlanta.
But for Shore, 70, the past few months had not been normal. She had been having a hard time breathing — deep breaths especially.
read more

Скрыть анонс
22:55 FightAging.OrgCells with Stem Cell Properties Identified in the Adult Liver

The liver is the most regenerative organ in adult mammals. Unlike any other organ, it is possible to cut out sections and the liver will regrow the lost tissue. The regrowth isn't perfect, unlike the case in highly regenerative species such as salamanders and zebrafish, but it does produce functional liver tissue. What makes the liver different? Despite a great deal of interest and activity in the research community, that question is nowhere near being comprehensively answered. Will practical regenerative therapies for the liver emerge before regenerative therapies for other organs? Maybe, maybe not. So far there is little sign that work on the liver is racing ahead of work on the rest of the portfolio of internal organs. Today's open access paper is a […]

Скрыть анонс
21:13 FierceBiotech.comReversing sickle cell disease with CRISPR-edited stem cells

Scientists at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to boost the production of fetal hemoglobin to treat blood disorders. By targeting a specific population of stem cells, they were able to slash the number of cells required for transplantation by 10-fold in monkey studies.

Скрыть анонс
13:32 FightAging.OrgAn Age-Related Epigenetic Change that Degrades Muscle Stem Cell Function

Stem cells support their tissues by generating daughter somatic cells and various forms of pro-regenerative signaling. Unfortunately, this activity declines with age. In the better studied stem cell populations, such as those in muscle tissue, this appears to be more a matter of signaling changes in the local environment than intrinsic damage to the stem cells themselves. The stem cells spend ever more time in a quiescent state, emerging ever more rarely to generate new daughter cells. At the high level, these changes must be a reaction to rising levels of molecular damage and its consequences such as chronic inflammation, but most of the research community is more interesting in finding proximate causes than in tackling root causes. The research here is an example of […]

Скрыть анонс
06:14 News-Medical.NetStem cell study provides insight into development, maintenance of the skin

For the first time, researchers from the University of Copenhagen have studied and outlined the development of sebaceous glands in the skin. The study provides greater insight into the development and maintenance of the skin and how cancer mutations affect the behavior of stem cells.

Скрыть анонс
01:16 Nature.ComAuthor Correction: Advanced maturation of human cardiac tissue grown from pluripotent stem cells

Скрыть анонс
30.07.2019
17:48 ScienceDaily.comStem cell research sheds new light on the skin

For the first time, researchers have studied and outlined the development of sebaceous glands in the skin. The study provides greater insight into the development and maintenance of the skin and how cancer mutations affect the behavior of stem cells.

Скрыть анонс
12:45 Nature.ComAuthor Correction: Epigenetic stress responses induce muscle stem-cell ageing by

Скрыть анонс
07:49 GizmagDiscovery of liver cell with stem cell-like properties could eliminate need for organ transplants


An exciting new study, led by scientists from King's College London, has discovered a new type of cell in the liver. The research describes the cell as having "stem cell-like properties," with the potential to regenerate damaged liver cells and treat disease in the organ without the need for a transplant.
.. Continue Reading Discovery of liver cell with stem cell-like properties could eliminate need for organ transplants Category: Medical Tags: Kings College Liver disease Organ donation Stem Cells

Скрыть анонс
29.07.2019
16:55 StemCellsPortal.comlMaking cancer stem cells visible to the immune system

HEIDELBERG (DE), July 2019 — Patients with acute myeloid leukemia (AML) often relapse after apparently successful treatment. Leukemia stem cells that survive the therapy are responsible for the return of the disease. Scientists can partially explain this phenomenon: The stem cells have protective mechanisms that make them resistant to chemotherapy.
But how do they manage to escape the immune defense?
A team of scientists from the University Hospitals of Basel and Tübingen, the German Cancer Research Center (DKFZ), the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM)* and the German Cancer Consortium (DKTK) have now investigated this phenomenon and discovered a surprising mechanism.
The researchers analyzed the leukemia cells of 177 AML patients and found that the cancer stem cells lack expression of NKG2D-L proteins on their surface. These

Скрыть анонс
26.07.2019
22:09 StemCellsPortal.comlStem cell regulator keeps breast cells healthy by promoting DNA repair

BOSTON, MA (US), July 2019 — A new study found that a transcription factor called Slug serves as “command central” for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage. The research team also discovered that Slug likely functions as a safeguard against age-related decline of breast stem cell function.
Transcription factors are proteins that bind to DNA sequences and play a role in cancer. The research team previously reported that Slug plays a central role in some types of breast cancers. Building on their prior work, the researchers used breast cells from both humans and mice to explore how Slug might be helpful in maintaining cell fitness.
“These findings help us understand how Slug functions in normal breast tissue and how it may function in breast cancer,” said breast cancer researcher Charlotte Kuperwasser, Ph.D., at

Скрыть анонс
21:46 StemCellsPortal.comlMaking cancer stem cells visible to the immune system

HEIDELBERG (DE), July 2019 — Patients with acute myeloid leukemia (AML) often relapse after apparently successful treatment. Leukemia stem cells that survive the therapy are responsible for the return of the disease. Scientists can partially explain this phenomenon: The stem cells have protective mechanisms that make them resistant to chemotherapy.
But how do they manage to escape the immune defense?
A team of scientists from the University Hospitals of Basel and Tübingen, the German Cancer Research Center (DKFZ), the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM)* and the German Cancer Consortium (DKTK) have now investigated this phenomenon and discovered a surprising mechanism.
The researchers analyzed the leukemia cells of 177 AML patients and found that the cancer stem cells lack expression of NKG2D-L proteins on their surface. These

Скрыть анонс
24.07.2019
22:25 Nature.ComCalifornia stem-cell agency’s supporters reveal plan for $5.5-billion ballot initiative

Скрыть анонс
15:54 News-Medical.NetResearchers explore stem cells for answers to how fragile X syndrome develops

The lab of Yongchao Ma, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, discovered how the genetic defect in fragile X syndrome – a type of autism – delays production of neurons (nerve cells) at a critical time in the embryo's brain development.

Скрыть анонс
23.07.2019
21:24 ScienceDaily.comStem cell therapy furthers research for infants with hypoplastic left heart syndrome

A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.

Скрыть анонс
12:50 Rejuvenation ResearchHow Could We Slow or Reverse the Human Aging Process and Extend the Healthy Life Span with Heterochronous Autologous Hematopoietic Stem Cell Transplantation

Rejuvenation Research, Ahead of Print.

Скрыть анонс
11:01 StemCellsPortal.comlNeural Stem Cell Interactions with Drugs

Neurodegenerative disease treatment may include the development of both stem cell- and pharmacology-based approaches; however, we know little about how neural stem cells, for example, and drugs interact. For this reason, researchers led by Marietta Zille (University of Lübeck, Germany) undertook a meta-analysis of data reported in the literature and now report a clear interaction between antidepressants drugs and the proliferative ability of neuronal stem cells. Ikhsan et al. believe that future cell therapeutic approaches and pharmacological interventions must be coordinated to create efficient, safe, and effective therapeutic strategies. See STEM CELLS Translational Medicine for all the details!


 

Скрыть анонс
22.07.2019
15:40 StemCellsPortal.comlFinding of STEMIN (STEM CELL INDUCING FACTOR) for feasible reprogramming in plants

OKAZAKI CITY (JP), July 2019 — Stem cells self-renew and give rise to cells that are differentiated during development. These differentiated cells can change into stem cells under appropriate conditions in most plants, in which this process is more readily apparent, and in some animals.
Researchers have previously succeeded in forming new shoots from intact leaves by inducing single transcription factors in Arabidopsis. However, it has not been clear whether these transcription factors induce meristematic tissue that subsequently induces stem cells or directly induces them.
To this end, Masaki Ishikawa, Ph.D., and Mitsuyasu Hasebe, Ph.D., at the National Institute of Basic Biology in Japan, Yoshikatsu Sato, Ph.D., of the Institute of Transformative Bio-Molecules (WPI-ITbM) at Nagoya University in Japan and their collaborators found that induction of the transcription factor STEM

Скрыть анонс
19.07.2019
09:48 StemCellsPortal.comlStem Cell Extracellular Vesicles Mediate Corneal Regeneration

Researchers led by James L. Funderburgh (University of Pittsburgh, Pittsburgh, Pennsylvania, USA) recently sought to understand the mechanisms by which corneal stromal stem cells enhance corneal wounding by assessing extracellular vesicles. In their new STEM CELLS Translational Medicine article, Shojaati et al. report that the delivery of miRNA to ocular tissues by extracellular vesicles leads to corneal regeneration. The authors hope that their findings will lead to the development of a rapid and inexpensive means of treating corneal blindness for millions of individuals who have no further options for treatment.


Скрыть анонс
18.07.2019
22:13 News-Medical.NetEstrogen is essential to maintain muscle stem cell health, research shows

New University of Minnesota Medical School research is the first to show that estrogen is essential to maintaining muscle stem cell health.

Скрыть анонс
13:37 FightAging.OrgDysfunctional Stem Cells Contribute to Impaired Fracture Repair in Old Age

Stem cells perform the vital function of supporting surrounding tissue by providing new daughter somatic cells to make up losses and take their place to maintain tissue function. This stem cell activity declines with age, however, due to a combination of intrinsic damage to these cell populations, and increasing inactivity. The latter is an evolved reaction to rising levels of damage, one that serves to reduce cancer risk in earlier old age, but at the cost of a lengthy decline into incapacity. Pick near any dysfunction of aging and it is likely that loss of stem cell activity is to some degree contributing to the outcome. Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed […]

Скрыть анонс
13:25 FightAging.OrgCellular Senescence in Mesenchymal Stem Cells

Cellular senescence is a cause of aging. Cells become senescent in response to a variety of circumstances: damage, a toxic environment, reaching the Hayflick limit on replication, and so forth. In all cell populations, older individuals exhibit increasing numbers of senescent cells, perhaps largely due to the progressive decline of the immune system and its growing failure to clear out unwanted or harmful cells. Lingering senescent cells secrete a potent mix of signals that rouse the immune system into a state of chronic inflammation, and degrade tissue function and structure. The more of them there are, the worse the outcome. Mesenchymal stem cells (MSCs) are located in specific areas of tissues, called "niches", and are characterized as being in a state of relative quietness, from […]

Скрыть анонс
12:14 News-Medical.NetCancer stem cells elude the body's immune cells by deactivating danger detector

Acute myeloid leukemia stem cells elude the body's immune cells by deactivating a danger detector. The underlying mechanisms and the potential new therapeutic approaches that this gives rise to have been detailed in the journal Nature by researchers from the University of Basel and University Hospital Basel in collaboration with colleagues in Germany.

Скрыть анонс
17.07.2019
23:39 ScienceDaily.comMaking cancer stem cells visible to the immune system

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. Scientists now describe a new therapeutic approaches that can possibly be derived from these results.

Скрыть анонс
20:19 Nature.ComAbsence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Скрыть анонс
08:58 News-Medical.NetSlug serves as 'command central' for determining breast stem cell health

A new study published in Cell Reports found that a transcription factor called Slug serves as 'command central' for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage.

Скрыть анонс
16.07.2019
22:02 StemCellsPortal.comlNewly discovered molecules show promise targeting and killing cancer stem cells

TOLEDO, OH (US), July 2019 — Scientists at the University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.
Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone.
“Not all cancer cells are the same, even in the same tumor,” said William Taylor, Ph.D., a professor in the Department of Biological Sciences in the UToledo College of Natural Sciences and Mathematics. “There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”
Dr. Taylor and L.M. Viranga Tillekeratne, Ph.D., a professor in the

Скрыть анонс
18:48 ScienceDaily.comSlug, a stem cell regulator, keeps breast cells healthy by promoting repair of DNA damage

A new biomedical research study finds a transcription factor called Slug contributes to breast cell fitness by promoting efficient repair of DNA damage. The absence of Slug leads to unresolved DNA damage and accelerated aging of breast cells.

Скрыть анонс
13:20 FightAging.OrgSabotaging a Mechanism of Decline in Age-Related Stem Cell Activity

Stem cells are responsible for maintaining surrounding tissue function via generation of daughter cells to make up losses. Stem cell activity declines with age, and research of the past twenty years suggests that a sizable fraction of this decline is a reaction to rising levels of cell and tissue damage, rather than being due to intrinsic damage to the stem cells themselves. Thus researchers are searching for the signals that influence stem cell activity, with the intent of interfering in order to boost stem cell activity in old tissues. This seems a worse strategy than repairing the underlying damage that causes stem cell decline, but it is nonetheless a popular field of research, and there is plenty of evidence for it to be possible to […]

Скрыть анонс
09:48 StemCellsPortal.comlReviewing Adipose Stem Cells and Cancer

The interaction of cancer cells with the multitude of other cell types present within the tumor microenvironment plays a crucial role in cancer development and progression. Now, researchers from the laboratory of Bruce A. Bunnell (Tulane University, New Orleans, Louisiana, USA) discuss the interactions between adipose stem cells, a critical component of the tumor microenvironment, and various forms of cancer in a recently published STEM CELLS review article.

 

Скрыть анонс
08:02 News-Medical.NetEvaluating safety and efficacy of magnetically labeled mesenchymal stem cells

Cells equipped with superparamagnetic iron oxide nanoparticles can be directed to a specific location by an external magnetic field, which is beneficial for tissue repair.

Скрыть анонс
15.07.2019
09:48 StemCellsPortal.comlEpigenetic Priming - The Key to Effective Stem Cell Therapies for the Injured Heart?

Review of “Epigenetic Priming of Human Pluripotent Stem Cell‐Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation” from STEM CELLS by Stuart P. Atkinson 

The relative immaturity of human pluripotent stem cell (hPSC)‐derived cardiomyocytes has limited their applications in disease modeling, drug development, and in therapeutic approaches, a failing that has prompted the development of multiple strategies that promote functional maturation. However, these often time‐consuming, cumbersome, and perhaps even clinically irrelevant methods contribute only minimally to the overall maturation status of resultant hPSC‐derived cardiomyocytes. 

Interestingly, recent studies have highlighted the importance of cell‐intrinsic processes in cardiomyocyte maturation and epigenetic factors in

Скрыть анонс
09:36 StemCellsPortal.comlAutophagy Induction by Neural Stem Cell-derived Extracellular Vesicles Aids Recovery from Spinal Cord Injury

Review of “Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy” from Cell Death and Disease by Stuart P. Atkinson

The transplantation of stem cells may promote functional recovery after acute spinal cord injury, partly through their neuroprotective capabilities; however, cells generally suffer from low survival rates in the inhospitable microenvironment of the injury, while the potential for surviving cell de-differentiation, immune rejection, and tumor formation represent additional obstacles. Treatment with neural stem cell-derived extracellular vesicles represents a potentially efficient solution to this problem, given their demonstrated potential as a treatment modality in neurodegenerative diseases thanks to their anti-inflammatory, neurogenic, and neurotrophic effects

Скрыть анонс
11.07.2019
16:33 FightAging.OrgQuiescence of Stem Cells in Aging as a Double Edged Sword

Stem cells spend much of their time in the quiescent stage of the cell cycle, resting without replication in a state of lower metabolic activity. The open access review paper here is an interesting look at why quiescence is both helpful and problematic in the context of the contribution of stem cell dysfunction to aging and age-related disease. The purpose of stem cells is to support the surrounding tissue by providing a supply of daughter somatic cells to replace losses and repair damage. Stem cell populations decline in this activity with aging, due to a mix of cellular damage, a fall in numbers, and increasing quiescence. To the degree that the latter of these issues is dominant, it should be possible to find ways to […]

Скрыть анонс
09:55 News-Medical.NetNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patients

A newer form of shingles vaccine reduced outbreaks of the painful rash among patients who were transplanted with their own stem cells, according to a study led by a Duke Health researcher and published today in JAMA.

Скрыть анонс
00:24 ScienceDaily.comShingles vaccine safely prevents outbreaks among stem cell transplant patients

A newer form of shingles vaccine reduced outbreaks of the painful rash among patients who were transplanted with their own stem cells, according to a new study. The vaccine appears to offer protection from one of the most common and painful side effects of cell therapy and shows promise for patients with immune-compromising conditions.

Скрыть анонс
10.07.2019
13:32 FightAging.OrgApplying Bacterial Homing Strategies to Target Stem Cells to Heart Tissue

Most classes of therapy benefit from some form of targeting or selectivity, helping to direct them to the tissue of interest, and away from other places where they might cause side-effects. Cells are difficult to work with, but they are also much more capable of selective targeting, since they can migrate. Many types of cell reliably find their way from one part of the body to another in the course of their functions, but where no suitable mechanism exists in human biochemistry, it is sometimes possible to look elsewhere. Here, researchers adapt a bacterial targeting system and apply it to the stem cells that might be used in regenerative therapies for damaged heart tissue. To date, trials using stem cells, which are taken and grown […]

Скрыть анонс
09.07.2019
23:55 ScienceMag.orgCalifornia’s stem cell research fund dries up

Researchers hope a planned ballot initiative will renew funding in 2020

Скрыть анонс
22:53 ScienceDaily.comKilling the seeds of cancer: A new finding shows potential in destroying cancer stem cells

When doctors remove a tumor surgically or use targeted therapies, the cancer may appear to be gone. However, evidence suggests a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations. A collaborative research project has identified an entirely new class of molecules that shows promise in rooting out and killing those cancer stem cells.

Скрыть анонс
19:30 Nature.ComAuthor Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation

Скрыть анонс
18:23 News-Medical.NetEngineered stem cells offer new treatment for metastatic bone cancer

Engineered stem cells could help treat metastatic cancers in bone without killing normal surrounding bone.

Скрыть анонс
10:44 News-Medical.NetNew class of cancer-killing agents shows promise in destroying cancer stem cells

Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.

Скрыть анонс
08.07.2019
16:44 StemCellsPortal.comlStem cell stimulation improves stroke recovery

ATLANTA, GA (US), July 2019 — Stem cell stimulation shows promise as a potential noninvasive stroke treatment, according to research in mice published in JNeurosci. If extended to humans, this technique could greatly improve patients' quality of life.
Ling Wei, M.D., Shang Ping Yu, M.D., Ph.D., and colleagues at Emory University injected neural stem cells into the brains of mice after a stroke and activated the cells through nasal administration of a protein. The stem cells activated by this new, noninvasive technique called optochemogenetics grew healthier and formed more connections compared to the stem cells that did not receive stimulation. Additionally, the mice that received both stem cells and stimulation displayed the most recovery, with some behaviors returning to pre-stroke levels.
The combination of stem cell injection and stimulation increased the likelihood of a

Скрыть анонс
05.07.2019
02:35 ScienceDaily.comWorld first: Homing instinct applied to stem cells show cells 'home' to cardiac tissue

In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK (1).

Скрыть анонс
04.07.2019
07:41 News-Medical.NetScientists discover new way to direct stem cells to heart tissue

In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK.

Скрыть анонс
First← Previous12345678910Previous →Last