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Stem Cells

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17.10.2019
21:39 ScienceDaily.comStem cell study offers new way to study early development and pregnancy

For the first time, researchers have created mouse blastocyst-like structures, or 'blastoids,' from a single cultured cell. The work could help advance research into development as well as inform issues around pregnancy, infertility, or health problems later in the offspring's life.

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15.10.2019
22:53 News-Medical.NetUCLA researchers discover new way to eliminate leukemia stem cells

The introduction of the drug imatinib in 2001 revolutionized the treatment of a type of cancer called chronic myelogenous leukemia. In more than 80% of people with CML who received the drug, the disease went into complete remission.

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10:13 StemCellsPortal.comlPurine Salvaging in Hematopoietic Stem Cells

Given that metabolism controls stem cell function and that purine metabolism represents a critical component of cellular metabolism, researchers from the laboratory of Hartmut Geiger (Universität Ulm, Germany) set out to discover a potential link. In their new STEM CELLS study, Vogel et al. report that the reduced activity of the purine salvaging enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) in hematopoietic stem cells results in reduced fitness, an altered cell cycle profile, and the modulation of mitochondrial function. Overall, the authors suggest that the phenotype of HPRT low hematopoietic stem cells derives from elevated levels of purine degradation rather than a lack of purine recycling, implying a significant role for HPRT-mediated purine

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14.10.2019
15:33 FierceBiotech.comReNeuron shares clinical data on stem cell vision loss therapy

ReNeuron has presented detailed data from a phase 1/2a clinical trial of its stem cell treatment for retinitis pigmentosa. Shares in ReNeuron fell more than one-third after the release of top-line data at the start of the month, but the biotech argued the detailed results are positive for its prospects. 

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09.10.2019
13:19 FightAging.OrgDeletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice

Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the loss of stem cell activity with age, throughout the body and not just in the brain, is an evolved response to rising levels of damage that serves to reduce the risk of cancer that arises from the activity of damaged cells. The cost, however, is a slow decline into dysfunction and tissue failure. There are many therapeutic approaches under development in labs and startups that involve ways to force stem cell populations to go back to work, overriding their normal reaction to an aged environment. While this is nowhere as good a class of approach as repairing the underlying damage […]

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08.10.2019
16:43 News-Medical.NetSalford scientists identify new drug candidate to starve and suffocate breast cancer stem cells

Scientists have identified a new drug candidate that is able starve and suffocate cancer stem cells, paving the way for new therapies to treat breast cancer patients.

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13:05 StemCellsPortal.comlStem Cell-Derived EV Protects the Irradiated Brain

Cranial radiation therapy as a treatment of brain cancers can lead to adverse impacts on cognitive function; however, previous studies from the laboratory of Charles L. Limoli (University of California, Irvine, USA) discovered that human neural stem cells (hNSCs) can provide beneficial neurocognitive effects in the irradiated brain. Now, in a new STEM CELLS Translational Medicine study, Smith et al. revealed that hNSCs and hNSC‐derived extracellular vesicles (EVs) act in a comparable manner to preserve host neuronal morphology, reduce inflammation, and restore neurotrophic factors in the irradiated brain. Overall, this new study provides evidence for “potent far‐reaching neuroprotective effects mediated by grafted stem cells or EVs adjacent and distal to the

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07.10.2019
22:18 StemCellsPortal.comlStem Cell Studies Offer Hope for Childhood Neurological Condition

SAN FRANCISCO, CA (US), October 2019 —Two new studies by an international team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.
Often diagnosed at birth with symptoms of weakness and breathing difficulties, the progressive neurological problems in PMD are caused by disruptions in the formation of myelin, a fatty layer of insulation covering nerve fibers that enables rapid, long-distance communication and makes up the brain’s white matter. But it has been unclear why myelination fails in PMD, and therapies to help restore this vital substance in the brain have so far remained out of reach. 
For the past decade, scientists from UC San Francisco, Stanford University and the University of Cambridge have been leading complementary

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11:39 StemCellsPortal.comlCD166-CD166 Interaction Enhances Hematopoietic Stem Cell Function

Review of “CD166 engagement augments mouse and human hematopoietic progenitor function via activation of stemness and cell cycle pathways” from STEM CELLS by Stuart P. Atkinson

Previous research from the laboratories of Hal E. Broxmeyer and Edward F. Srour (Indiana University School of Medicine, Indianapolis, Indiana, USA) established CD166, a marker expressed on stem and progenitor cells of all three embryonic lineages, as a marker of immature osteoblasts of the bone marrow stem cell niche [1, 2]. Furthermore, they also defined CD166 as a functional marker of murine and human long-term marrow repopulating hematopoietic stem cells (HSCs) [3]. CD166, or activated leukocyte cell adhesion molecule (Alcam), mediates both homophilic (CD166‐CD166) and heterophilic (CD166‐CD6) interactions [4] and more recent studies from

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04.10.2019
22:19 FightAging.OrgTargeting GAS1 to Put Muscle Stem Cells Back to Work in Old Tissues

A great many projects at various stages of development are characterized by their goal of forcing greater stem cell activity in old tissues, but without meaningfully addressing the underlying causes of stem cell decline in later life. This sort of research and development operates at the level of proximate causes, adjusting protein levels to change cell behavior. Among the potential therapies I'd place into this category: telomerase gene therapy; GDF11 upregulation; FGF2 inhibition; NAD+ upregulation; and so on. Muscle stem cells known as satellite cells are one of the better studied stem cell populations in this context, and many of the interventions are focused here. Today's open access research is a representative example, in that the authors describe a portion of the network of genes […]

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16:21 StemCellsPortal.comlHow Time Affects the Fate of Stem Cells

LAUSANNE (CH), September 2019 — How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.
In a new study published in Molecular Systems Biology, researchers at the lab of David Suter, M.D., Ph.D., at Ecole Polytechnique Fédérale de Lausanne (EPFL), have found that temporal fluctuations in protein concentrations can determine the type of cell that embryonic stem cells will become.
The scientists studied two important transcription factors, SOX2 and OCT4, whose levels in embryonic stem cells change over time. Both of these transcription factors are important for embryonic stem cell self-renewal and differentiation (or "fate") into specific

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11:34 Technology.orgStem Cell Studies Offer Hope for Childhood Neurological Condition

Two new studies by an international team of researchers report progress in using stem cells to develop new

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03.10.2019
22:01 ScienceDaily.comStem cell studies offer hope for childhood neurological condition

Two new studies report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.

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02.10.2019
00:34 News-Medical.NetMedStar Heart & Vascular Institute enrolls first patient in cardiac stem cell clinical study

MedStar Heart & Vascular Institute has enrolled its first patient to a clinical trial to determine whether cardiac stem cells reduce inflammation enough to improve heart function in patients with heart failure severe enough to require a left ventricular assist device, or LVAD.

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01.10.2019
21:02 ScienceDaily.comStem cell treatments for shoulder and elbow injuries flourish, but so far there's little evidence they work

Two critical reviews examine the current status of biologic approaches for common shoulder and elbow problems. The authors discuss areas where the current evidence base is weak or controversial and recommend where further studies are required.

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30.09.2019
21:04 StemCellsPortal.comlGene-Edited, Stem Cell Reporter Line Could Boost Cardiac Research

DURHAM, N.C. (SEPTEMBER 30, 2019) - As human induced pluripotent stem cells (hiPSCs) move closer to becoming a possible mainstream therapy and an accepted model for studying the development and diseases of the human heart, there is an increasing need for stable stem cell lines that allow electrical or potential activities of the progeny heart muscle cells to be clearly and easily recorded. A study released today in STEM CELLS details the development of one such line, CRISPR-generated ArcLight-hiPSCs.

The UC Davis Health research team that developed the line reported that it incorporates a tracking process that overcomes several drawbacks inherent in other methods for recording how hiPSC-derived cardiomyocytes (hiPSC-CMs) function. This feature makes CRISPR-generated ArcLight-hiPSC a promising tool for studying these cells and utilizing them for drug

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17:01 StemCellsPortal.comlStem Cell-Engineered Cells Attack Human Tumors in Mice

LOS ANGELES, CA (US), September 2019 — They've been called the "special forces" of the immune system: invariant natural killer T cells. Although there are relatively few of them in the body, they are more powerful than many other immune cells.
In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
"What's really exciting is that we can give this treatment just once and it increases the number of iNKT cells to levels that can fight cancer for the lifetime of the animal," said Lili Yang, Ph.D., a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and the study's senior author.
Scientists have

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14:31 News-Medical.NetStem cells derived from patients could lead to new treatments for congenital muscular dystrophies

Researchers at Queen Mary University of London and University College London have shown that using stem cells derived from patients could help find new treatments for a group of congenital muscular dystrophies.

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27.09.2019
18:15 News-Medical.NetFunctional three-organoid stem cell system could lead to unprecedented advances for precision medicine

Using iPS cells, a Japanese research group has successfully grown a connected set of organs at the same time, including a liver and a pancreas connected by a bile duct.

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16:49 News-Medical.NetStem cells lost in freezer malfunction: hospital apologizes and offers full support

Los Angeles hospital has apologized and offered full support after stem cells perish in fridge malfunction.

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26.09.2019
19:32 News-Medical.NetTemporal fluctuations in protein concentrations can determine fate of stem cells

How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

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18:28 ScienceDaily.comHow time affects the fate of stem cells

Scientists have discovered how temporal fluctuations in the levels of two transcription factors can push embryonic stems cells into becoming different cell types.

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17:32 Phys.orgHow time affects the fate of stem cells

How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

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15:50 News-Medical.NetNanoSurface Biomedical expands stem cell-based technologies with acquisition of Silene Biotech

Seattle biotech company NanoSurface Biomedical, Inc., a leading provider of biomimetic cell-based assay platforms and services, announced today that it has acquired Silene Biotech, a Seattle biotechnology company focused on stem cell banking and services.

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25.09.2019
13:09 Nature.ComThe potent effects of Japan’s stem-cell policies

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13:09 Nature.ComA stem-cell race that no one wins

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00:45 News-Medical.NetTapeworms need their head for stem cell-driven regeneration

Scientists have identified the stem cells that allow tapeworms to regenerate and found that their location in proximity to the head is essential, according to a new study in eLife.

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24.09.2019
18:16 StemCellsPortal.comlAmerican Academy of Stem Cell Physicians Visit Capitol Hill to Discuss Patient Safety

MIAMI, Sept. 23, 2019 - The American Academy of Stem Cell Physicians visited Capitol Hill on Thursday, Sept. 19, at an event hosted by Alliance for Cell Therapy Now, to meet with industry partners to discuss the future and direction of cell therapy in the United States.  
A panel of industry experts came together to start a conversation with industry partners moderated by Janet Marchibroda, President of the Alliance for Cell Therapy Now. Among the panel were Dr. Peter Marks, MD, Ph.D., Director at the Center for Biologic Evaluation and Research at the FDA; Amy Patterson, MD, Chief Science Advisor and Director of Scientific Research Programs and Strategic Initiatives at the National Institutes of Health; Bernard Siegel, JD, Executive Director for the Regenerative Medicine Foundation; Anthony Atala, MD, Director

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23.09.2019
21:48 Rejuvenation ResearchNatural Compounds as a Strategy to Optimize “In Vitro” Expansion of Stem Cells

Rejuvenation Research, Ahead of Print.

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17:52 StemCellsPortal.comlGene Editing Enables Researchers to Correct Mutation in Muscle Stem Cells in Dmd Model

COLUMBIA, MO (US), September 2019 — Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers at the University of Missouri School of Medicine have shown in a mouse study that the powerful gene-editing technique known as CRISPR may provide the means for lifelong correction of the genetic mutation responsible for the disorder.
Children with DMD have a gene mutation that interrupts the production of a protein known as dystrophin. Without dystrophin, muscle cells become weaker and eventually die. Many children lose the ability to walk, and muscles essential for breathing and heart function ultimately stop working.
"Research has shown that CRISPR can be used to edit out the mutation that causes the early death of muscle cells in an animal model," said Dongsheng Duan, Ph.D., professor in medical research at

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20.09.2019
07:07 News-Medical.NetAuthenticated mast cells successfully developed from hematopoietic stem cells

Mast cells are critically involved in immunity and immune disorders. However, they are rarely cultured ex vivo for experimental manipulation because of the difficulty in isolating useful numbers and limitations related to 2D culture.

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19.09.2019
22:51 StemCellsPortal.comlStem Cell Researchers Reactivate 'Back-Up Genes' in the Lab

LEUVEN (BE), September 2019 — Women and most female mammals have two X chromosomes, but only one of these is active in any given cell. This active X chromosome is selected through a flip-of-the-coin process in the very early stages of embryonic development: Rach chromosome has a 50/50 chance of remaining active and getting to express its genes, or to be inactivated through a process called X chromosome inactivation.
X chromosome inactivation is a perfectly normal process, but the consequences can be devastating when one of the X chromosomes carries a defective gene. This is the case in female patients with Rett syndrome. After one chromosome in each cell becomes inactive, about half of the patient’s cells will use the defective gene. Once born, the girls suffer a progressive loss of motor skills and speech. Male patients with Rett

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22:48 News-Medical.NetStem cells with 'dual identity' associated with loss of smell from inflammation in chronic sinusitis

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis.

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19:18 CancerNetwork.comQuiz: Stem Cell Transplantation in Multiple Myeloma

How much do you know about stem cell transplantation in multiple myeloma? Here's your chance to find out.

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12:26 Technology.orgRegulatory heft needed to curb false promises on stem cells, says health law expert

The legal and regulatory tools designed to protect the public from the marketing of unproven stem cell therapies

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10:59 Technology.orgTesting chemicals for birth defects using stem cells, not mice

Researchers at the University of California, Riverside, are part of an ambitious plan at the U.S. Environmental Protection Agency,

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04:43 ScienceDaily.comImaging reveals new results from landmark stem cell trial for stroke

Researchers reported today that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.

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18.09.2019
05:52 News-Medical.NetNew results revealed from pilot stem cell study for stroke

Researchers led by Sean I. Savitz, MD, reported today in the journal Stem Cells that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.

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17.09.2019
21:09 ScienceDaily.comGene editing enables researchers to correct mutation in muscle stem cells in DMD model

Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the genetic mutation responsible for the disorder.

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10:35 StemCellsPortal.comlLimbal Stem Cell Versus Tissue Transplantation

Researchers led by Vincent M. Borderie (Sorbonne Université, France) recently reported on a comparison of autologous or allogeneic cultured limbal stem cell transplantation and autologous or allogeneic limbal tissue transplantation for the treatment of stage III limbal stem cell deficiency. In their new STEM CELLS Translational Medicine article, the authors noted that autologous cultured limbal stem cell transplantation associated with high long‐term survival, vision improvement, and overall safety, whereas limbal grafts featured low safety, and allogeneic grafts featured low success rate and serious adverse events.


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16.09.2019
18:39 BBC HealthOscar Saxelby-Lee: Cancer returns after stem cell transplant

Oscar's family aim to raise £500,000 to pay for further treatment they say is not available on the NHS.

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16:39 ScienceDaily.comTransplanted brain stem cells survive without anti-rejection drugs in mice

In experiments in mice, researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.

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11:04 StemCellsPortal.comlA Step Towards the Treatment of Hematopoietic Disease with Amniotic Fluid Stem Cells

Review of “In Utero Transplantation of Expanded Autologous Amniotic Fluid Stem Cells Results in Long‐Term Hematopoietic Engraftment” from STEM CELLS by Stuart P. Atkinson

Previous research from the laboratory of Paolo De Coppi (UCL Great Ormond Street Institute of Child Health, London, UK) provided proof of principle for the hematopoietic potential of amniotic fluid stem cells (AFSCs) [1] and their multilineage hematopoietic engraftment following in utero transplantation [2]. Their overarching hope is to develop a strategy for the prenatal treatment of congenital hematological diseases with AFSCs sampled from the amniotic fluid; however, the loss of hematopoietic potential following in vitro expansion under adherent culture conditions in the presence of serum-containing media has tempered the therapeutic potential of

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13.09.2019
21:23 StemCellsPortal.comlAntihistamines Show Potential to Destroy Leukemic Stem Cells

BARCELONA (ESP), September 2019 — Ruth M. Risueño, Ph.D., leads the leukemic stem cell group of the Josep Carreras Leukaemia Research Institute. This group investigates acute myeloid leukemia (AML) and the cell population responsible for the disease spreading, persisting and, if it has been treated and overcome, reappearing.
AML has a poor prognosis. Its treatment with chemotherapy has a high rate of recidivism. This relapse may be because a small number of diseased stem cells have become resistant to treatment, so it is only a matter of time before they start to spread.
Leukemic stem cells can be renewed or differentiated. They replicate themselves indefinitely to maintain their population. However, when they differentiate, they generate all the types of mature leukemic cells found in the tumor. These adult cells are more sensitive to chemotherapy.
"If we can differentiate all

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01:08 Nature.ComPublisher Correction: Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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12.09.2019
21:03 ScienceDaily.comStem cell researchers reactivate 'back-up genes' in the lab

Scientists have unraveled parts of a mechanism that may one day help to treat Rett syndrome and other genetic disorders linked to the X chromosome.

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20:10 Phys.orgStem cell researchers reactivate 'back-up genes' in the lab

Biomedical scientists at KU Leuven have unraveled parts of a mechanism that may one day help to treat Rett syndrome and other genetic disorders linked to the X chromosome.

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13:42 FightAging.OrgRepair of a Damaged Cornea Using Cells Derived from Induced Pluripotent Stem Cells

Since the discovery of induced pluripotency more than a decade ago, researchers have been working towards the use of this technology to produce cells for use in tissue engineering and regenerative therapies. Induced pluripotent stem cells are functionally equivalent to embryonic stem cells; given suitable recipes and methods for the surrounding environment and signals, they can be made to generate any of the cell types in the body. The cornea of the eye is a comparatively simple starting point for tissue engineering, easier to work with in many ways, in generating tissues and in delivering cells to the patient. Here, the first repair of a human cornea is reported, using tissue structures produced from induced pluripotent stem cells. A Japanese woman in her forties has […]

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13:06 Phys.orgBreakthrough stem cell platform could shed light on mysteries of early human development

A new method for making stem cell colonies that mimic parts of early human development could help investigate important questions in maternal and child health, such as: What chemicals pose risks to developing embryos, and what causes certain birth defects and multiple miscarriages?

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11:51 Technology.orgBreakthrough stem cell platform could shed light on mysteries of early human development

A new method for making stem cell colonies that mimic parts of early human development could help investigate

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00:20 Nature.Com Scientists use gene-edited stem cells to treat HIV — with mixed success

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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11.09.2019
20:12 Nature.ComEmbryo-like structures created from human stem cells

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20:12 Nature.ComControlled modelling of human epiblast and amnion development using stem cells

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19:09 CancerNetwork.comHow Does Pre-emptive Plerixafor Affect Stem Cell Mobilization for Myeloma Transplant?

A new study suggests there is a cost and efficiency benefit to pre-emptively administrating plerixafor during stem cell collection.

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10.09.2019
14:03 Phys.orgNanotherapy: Controlled delivery of chemotherapeutics to fight cancer stem cells

Chemotherapy is one of the most used treatments against cancer, along with surgery and radiotherapy. In a chemotherapy treatment, one or several drugs are administered to the patient to remove or damage cancer cells. Nevertheless, the treatment has several drawbacks that are hard to overcome, particularly the side effects. In this case, the inherent toxicity of the drugs employed causes a variety of symptoms including weakness, nausea and hair loss. As a result, chemotherapy is far from an ideal approach.

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09:52 StemCellsPortal.comlResistance of Neural Stem Cells to Chemo‐Radiation Therapy

Standard of care therapy for aggressive glioblastoma consists of safe maximum resection, concurrent temozolomide and X‐irradiation followed by adjuvant temozolomide therapy; however, we do not understand if this treatment approach affects adult neurogenesis in the ventricular‐subventricular zone (V‐SVZ) of the mammalian brain. Reporting in a new STEM CELLS study, researchers from the lab of Michael L. Freeman (Vanderbilt University Medical Center, Nashville, TN, USA) show that neural stem cells overexpress the anti‐apoptotic proteins Bcl2 and Mcl1 and do not undergo apoptosis in response to concurrent chemo‐radiation therapy. Overall, Cameron et al. therefore suggest that stem cell resistance will sustain neurogenesis and that targeting

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09.09.2019
21:41 DigitalTrends.comBiotech company 3D-prints a miniature human heart from stem cells

It's not science fiction anymore: 3D-printing a human heart is now a reality, which could help thousands who need a heart transplant.

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13:56 Nanowerk.comThe controlled delivery of chemotherapeutics to fight cancer stem cells

Researchers are investigating the efficiency of gold nanoclusters as drug carriers against cancer cells.

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10:24 StemCellsPortal.comlIrradiation-induced Damage to Human Skin-derived Stem Cells Inhibits Wound Healing

Review of “Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation” from STEM CELLS Translational Medicine by Stuart P. Atkinson

While ionizing radiation represents an effective treatment for many solid tumors, this therapeutic approach suffers from unwanted side-effects, including the inhibition of wound healing through unknown mechanisms [1]. One hypothesis suggests that irradiation affects dermal stem cells, such as skin-derived mesenchymal stem cells (SMSCs), leading to persistent depletion and altered function [2]; however, in vitro studies have provided inconclusive results perhaps due to the failure to fully recapitulate the complex microenvironment of irradiated human skin [3, 4]. Furthermore, the

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10:13 StemCellsPortal.comlTracking Pluripotent Stem Cells Through the Cell Cycle

Review of “Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation” from STEM CELLS by Stuart P. Atkinson

In previous studies, researchers led by Anshul Kundaje and Sundari Chetty (Stanford University, California, USA) demonstrated how dimethylsulfoxide (DMSO) priming of human pluripotent stem cells (hPSCs) activates the retinoblastoma protein (Rb) and increases the percentage of cells in the G1 phase of the cell cycle, leading to a significant increase in the propensity for differentiation across all germ layers [1, 2].

Now, the team returns with a new STEM CELLS study that employs Fluorescence Ubiquitin Cell Cycle Indicator (FUCCI) technology [3] to track cell division in DMSO primed and non-primed hPSCs and describes the overall importance of distinct signaling pathways in the

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08.09.2019
16:53 Technology.orgNanotherapy: the controlled delivery of chemotherapeutics to fight cancer stem cells

Researchers at IMDEA Nanociencia investigate the efficiency of gold nanoclusters as drug carriers against cancer cells. Chemotherapy is

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07.09.2019
06:41 News-Medical.NetResearchers discover potential of antihistamines that cause death of leukemic stem cells

Ruth M. Risueño leads the Leukaemic Stem Cell group of the Josep Carreras Leukaemia Research Institute. This group investigates Acute Myeloid Leukemia and the cell population responsible for the disease spreading, persisting, and if it has been treated and overcome, reappear.

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03:54 MedicalNewsToday.comMedical News Today: World first: Doctors use 'reprogrammed' stem cells to repair cornea

In a groundbreaking procedure, surgeons have successfully repaired a human cornea using 'reprogrammed' cells from the patient's skin.

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06.09.2019
21:40 Medscape.ComGoogle to Ban Ads for Stem Cell Therapies

The policy, which also applies to gene therapy, prohibits ads for treatments that might only be supported by early clinical studies as well as those without any evidence of benefits.

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21:20 StemCellsPortal.comlSignal Blocks Stem Cell Division in the Geriatric Brain

BASEL (SUI), September 2019 — Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results, published in Cell Reports, might be relevant for treating neurodegenerative disease in human brains.
Whether stem cells also occur in the human brain has long been controversial. Today, it is considered certain that the brain can form new neurons throughout life. The stem cells that have been found to be behind this process are restricted to specialized regions in the brain, so-called niches, which provide key signals that regulate stem cell self-renewal and differentiation. With increasing age, however, the stem cells become increasingly inactive and divide less

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20:11 CNBC technologyGoogle bans ads for 'unproven or experimental medical techniques' like stem cell therapy

The new Google ads policy may put the heat on for the stem cell clinic industry, which has until recently been largely unregulated.

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17:33 Technology.orgDiscovered the potential of a group of antihistamines that cause the death of leukaemic stem cells

Ruth M. Risueño leads the Leukaemic Stem Cell group of the Josep Carreras Leukaemia Research Institute. This group

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15:50 StemCellsPortal.comlStudy Shows Stem Cells May Be Better Choice Than Tissue Transplantation for Treating LSCD

DURHAM, N.C.  SEPTEMBER 05, 2019 - Results of a phase II clinical trial released today in STEM CELLS Translational Medicine (SCTM) indicate that a limbal stem cell (LSC) transplantation is superior to a tissue graft in treating limbal stem cell deficiency syndrome (LSCD).

This could result in a new and better treatment for LSCD, a condition that is mostly caused by burns to the eye. In its most extreme form, LSCD results in severe vision loss or total blindness. Until recently, the main treatment for this condition was a limbal tissue transplant using tissue from either the patient, a relative or a cadaver — a treatment that carried with it a high risk of rejection and a lifetime of immunosuppressant drugs for the patient.

However, recent advances in cell therapy techniques have introduced stem cell transplantation as a

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03:46 BBC HealthThis leukaemia sufferer is searching the world against the odds for a stem cell donor

Leukaemia sufferer Astrid is searching the world against the odds for a stem cell donor.

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04.09.2019
20:19 Nature.ComAsymmetric lysosome inheritance predicts activation of haematopoietic stem cells

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14:02 ScientificAmerican.ComDon't Believe Everything You Hear about Stem Cells

The science is progressing rapidly, but bad actors have co-opted stem cells’ hope and promise by preying on unsuspecting patients and their families -- Read more on ScientificAmerican.com

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03.09.2019
20:04 BBC HealthStem cell match found for boy with rare illness

Finley Hill, who has a rare immune system disorder, is due to undergo treatment in November.

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02.09.2019
16:27 Nature.ComWoman is first to receive cornea made from ‘reprogrammed’ stem cells

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10:35 StemCellsPortal.comlMouse Embryonic Stem Cell Study Highlights the Factors Controlling the Totipotent State

Review of “Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells” from Nature Cell Biology by Stuart P. Atkinson

Previous studies of late 1-cell and 2-cell embryos have revealed the transient activation of a group of genes and repeats at this time point [1, 2], suggesting their importance to the establishment of the totipotent state [3]. While mammalian embryos of this stage in development remain scarce for research purposes, studies have provided evidence for the existence of a reversible 2-cell-like state in mouse embryonic stem cell (mESC) cultures [2]. Encouragingly, 2C-like mESCs can also be readily isolated, thereby providing a relevant model system that will allow for a deeper understanding of the mechanisms involved in establishing and maintaining totipotency. 

Now, researchers from the laboratory of Yi Zhang (Howard

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10:11 StemCellsPortal.comlMouse Embryonic Stem Cell Study Highlight the Controlling Factors of the Totipotent State

Review of “Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells” from Nature Cell Biology by Stuart P. Atkinson

Previous studies of late 1-cell and 2-cell embryos have revealed the transient activation of a group of genes and repeats at this time point [1, 2], suggesting their importance to the establishment of the totipotent state [3]. While mammalian embryos of this stage in development remain scarce for research purposes, studies have provided evidence for the existence of a reversible 2-cell-like state in mouse embryonic stem cell (mESC) cultures [2]. Encouragingly, 2C-like mESCs can also be readily isolated, thereby providing a relevant model system that will allow for a deeper understanding of the mechanisms involved in establishing and maintaining totipotency. 

Now, researchers from the laboratory of Yi Zhang (Howard

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29.08.2019
15:06 Phys.orgPancreas on a chip: Scientists combine organ-on-a-chip and stem-cell technologies

By combining two powerful technologies, scientists are taking diabetes research to a whole new level. In a study led by Harvard University's Kevin Kit Parker, microfluidics and human, insulin-producing beta cells have been integrated in an "Islet-on-a-Chip". The new device makes it easier for scientists to screen insulin-producing cells before transplanting them into a patient, test insulin-stimulating compounds, and study the fundamental biology of diabetes.

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28.08.2019
21:53 ScienceDaily.comBrain stem cells have a good memory

During embryogenesis, dozens of types of neurons with distinct functions come together to form the circuits that drive our thoughts and actions. They are generated by progenitor cells, which produce them one after the other in a very precise order. Researchers now provide proof that progenitor cells are transplanted into a young mouse embryo, they recover their past skills and rejuvenate.

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17:40 ScienceDaily.comSignal blocks stem cell division in geriatric brain

Scientists have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results may be relevant for treating neurodegenerative disease in human brains.

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26.08.2019
16:45 StemCellsPortal.comlCertain Metabolites Linked to Stem Cell Function in the Intestine

CAMBRIDGE, MA (US), August 2019 ⏤ Biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a large pool of adult stem cells, which are crucial for keeping the intestinal lining healthy.

The researchers, from the Massachusetts Institute of Technology (MIT), also found that intestinal stem cells produce unusually high levels of ketone bodies even in the absence of a high-fat diet. These ketone bodies activate a well-known signaling pathway called Notch, which has previously been shown to help regulate stem cell differentiation.

"Ketone bodies are one of the first examples of how a metabolite instructs stem cell fate in the intestine," said Omer Yilmaz, M.D., Ph.D., senior author of the study and a member of

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16:42 News-Medical.NetKetogenic diet shown to support intestinal stem cells

Scientists have discovered that ketone bodies produced during the ketogenic diet trigger the proliferation of intestinal stem cells in adults.

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16:33 News-Medical.NetKetogenic diet may support stem cells in the intestines

Scientists have discovered that ketone bodies produced during the ketogenic diet trigger the proliferation of intestinal stem cells in adults.

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23.08.2019
13:24 FightAging.OrgInduced Pluripotent Stem Cells for Regenerative Medicine

This review paper looks over the technology of induced pluripotency in the context of its ability to advance the state of regenerative medicine. A little over a decade ago, it was discovered that expression just a few genes in any adult cell reprogrammed it to become an induced pluripotent stem cell, near identical to an embryonic stem cell. Such pluripotent cells are capable of forming any type of cell in the body, given the research and development needed to establish the right recipe of stimuli and signals. This technology is not just interesting as a way to potentially produce supplies of any cell and tissue type needed for regenerative therapies, but also for the fact that reprogrammed cells restore lost mitochondrial function and reverse their […]

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22.08.2019
21:40 StemCellsPortal.comlNew Technology Could Aid Stem Cell Transplantation Research

New Brunswick, NJ (US), August 2019 ⏤ Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.

The nanotechnology platform, which uses special tiny rods for sensing, allows researchers to confirm the identity of human stem cell fates and their biomarkers, or biological molecules, without destroying them, according to a study in ACS Nano. That's been a major issue during pre-clinical research on stem cells because it limits further analyses and biomedical applications.

"One of the major hurdles in the current cell-based therapies is the destructive nature of the standard cell characterization step. With our technology, we can sensitively and

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21:29 StemCellsPortal.comlSimple Protocol Assesses Hpc Maturation from Induced Pluripotent Stem Cells

New Rochelle, NY (US), August 2019 ⏤ Researchers have developed a guide to help labs standardize the production of mature hepatic-like cells (HPCs) from stem cells and easily compare gene expression of HPCs to actual human liver tissue. This moderately high throughput protocol can enable a relatively quick assessment of the efficacy of stem cell differentiation and help guide the optimization of differentiation conditions in regenerative medicine applications.

The protocol and its implications are published in Stem Cells and Development. The guide was co-authored by Stephen Strom, Ph.D., Karolinska Institutet (Stockholm, Sweden), and Alejandro Soto-Gutierrez, M.D., Ph.D., University of Pittsburgh (Penn.) and colleagues. The researchers used real time-quantitative polymerase chain reaction (rt-qPCR) to determine the mRNA expression of more than 60

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19:20 ScienceDaily.comCertain metabolites linked to stem cell function in the intestine

Researchers have found that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a functional stem cell pool, which are crucial for intestinal regeneration.

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18:51 Technology.orgStudy links certain metabolites to stem cell function in the intestine

MIT biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels

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09:26 Technology.orgNew Clues on Stem Cell Transplant Rejection Revealed in Study

In 2006, scientists discovered a way to “reprogram” mature cells – adult skin cells, for example – into

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21.08.2019
13:04 Yahoo ScienceCould Stem Cells Be the Key to Organ Regeneration?

GettyBy Tobias Deuse, Professor of Surgery, University of California, San FranciscoMany of the most common diseases, like heart failure, liver failure, Type 1 diabetes and Parkinson’s disease, occur when cells or whole organs fail to do their job. Wouldn’t it be fantastic if it were possible to replace cells in these defunct organs? That is exactly what physician-scientists in the field of regenerative medicine are trying to do.I am a surgeon and stem cell scientist and am interested in regenerating failing organs with stem cells—because for many diseases we don’t have good treatment options yet.In a recent paper, my colleagues and I figured out why stem cells derived from a patient’s own tissue are sometimes rejected by their own immune systems. We also developed a solution that we think may solve the problem:

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08:28 Yahoo ScienceStem Cells Could Regenerate Organs – But Only If the Body Won’t Reject Them

Many of the most common diseases, like heart failure, liver failure, Type 1 diabetes and Parkinson’s disease, occur when cells or whole organs fail to do their job. Wouldn’t it be fantastic if it were possible to replace cells in these defunct organs? That is exactly what physician-scientists in the field of regenerative medicine are trying to do.I am a surgeon and stem cell scientist and am interested in regenerating failing organs with stem cells – because for many diseases we don’t have good treatment options yet.In a recent paper, my colleagues and I figured out why stem cells derived from a patient’s own tissue are sometimes rejected by their own immune systems. We also developed a solution that we think may solve the problem: stem cells that are stripped of their immune features and can’t trigger rejection.The

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20.08.2019
20:57 ScienceDaily.comMini kidneys grown from stem cells give new insights into kidney disease and therapies

Medical researchers have grown 'miniature kidneys' in the laboratory that could be used to better understand how kidney diseases develop in individual patients. These kidney organoids were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease. This method has paved the way for tailoring treatment plans specific to each patient, which could be extended to a range of kidney diseases.

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07:44 Rejuvenation ResearchRoads to the Fountain of Youth? Rejuvenating Intestinal Stem Cells

Rejuvenation Research, Volume 22, Issue 4, Page 342-347, August 2019.

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19.08.2019
16:08 StemCellsPortal.comlScientists Reverse Aging Process in Rat Brain Stem Cells

Cambridge (UK), August 2019 — New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. The results, published today in Nature, have far-reaching implications for how we understand the aging process and how we might develop much-needed treatments for age-related brain diseases.
As our bodies age, our muscles and joints can become stiff, making everyday movements more difficult. This study shows the same is true in our brains, and that age-related brain stiffening has a significant impact on the function of brain stem cells. 

A multidisciplinary research team, based at the Wellcome-MRC Cambridge Stem Cell Institute at the University of Cambridge, studied young and old rat brains to understand the impact of

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18.08.2019
13:46 StemCellsPortal.comlEngineered Stem Cells for Targeted Cancer Therapy

Multiple stem cell types exhibit inherent cancer tropism, while engineered stem cells have been used as therapeutic agents to specifically target cancer cells. More recently, stem cells engineering has been employed to target multiple surface‐receptors on tumor cells, as well as endothelial and immune cells of the tumor microenvironment. In a new review published in STEM CELLS, researchers led by Sanam L. Kavari and Khalid Shah (Harvard Medical School, Boston, Massachusetts, USA) discuss the rationales and strategies of developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges that they hold as cancer therapeutics.


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16.08.2019
18:10 News-Medical.NetDespite failed promises, stem cell advocates again want taxpayers to pony up billions

Californians voted in 2004 to shell out billions of dollars in taxpayer money to fund cutting-edge stem cell treatments.

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16:29 Technology.orgNew stem cell combination could help to repair damaged hearts

A combination of heart cells derived from human stem cells could be the answer to developing a desperately-needed

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16:18 Technology.orgCambridge scientists reverse ageing process in rat brain stem cells

New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new

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03:42 MedicalNewsToday.comMedical News Today: Rejuvenating brain stem cells may hold key to future MS treatments

Scientists have found a way to rejuvenate brain stem cells in rats. The finding offers clues on how to restore lost brain function in diseases such as MS.

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15.08.2019
22:30 FightAging.OrgStiffness in Brain Tissue Niches Causes Declining Stem Cell Activity and Myelination

Loss of the myelin layer that sheathes nerves is the proximate cause of severe conditions such as multiple sclerosis, but this sort of loss occurs to a lesser degree in the course of normal aging, and contributes to cognitive decline. In today's open access research materials, scientists draw a line of cause and effect between (a) increasing stiffness of the brain tissue that hosts niches where stem cells reside, (b) dysfunction of those stem cells mediated by the specific stiffness-sensing mechanism of Piezo1, a process that may exist in other stem cell populations as well, (c) the loss of myelin-generating cells normally produced by the stem cells, and (d) the consequent degradation of myelin and nervous system function. Without looking into underlying causes of increasing […]

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19:07 News-Medical.NetResearchers reverse stem cell aging process

Scientists have shown that older stem cells can be reverted to a younger state. The discovery has important implications for degenerative disease research.

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16:03 StemCellsPortal.comlImplantable 3D blastocyst-like embryonic structure generated from mouse stem cells

SAITAMA (JP), August 2019 — After an egg is fertilized, it begins to divide and passes through several stages. Cells in the two-cell stage are totipotent — they can become any type of cell. After many more cell divisions, the embryo turns into a blastocyst that is implanted in the womb where it differentiates and grows into a fetus. A blastocyst is like an almost hollow ball. Inside are pluripotent cells — cells that can become any type of cell in the body, but not the placenta — while the outer shell is made from trophoblasts — cells that eventually form the placenta.
For several years, scientists have been able to convert somatic cells, like skin cells, into pluripotent cells. However, nobody has been able to convert differentiated cells into totipotent cells.
In an earlier study conducted at Gladstone, authors Cody Kime, Ph.D., and Kiichiro Tomoda, Ph.D., were able to convert

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