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Stem Cells

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03.08.2020
23:23 FightAging.Org How Calorie Restriction Improves Intestinal Stem Cell Function

The practice of calorie restriction, eating up to 40% fewer calories while still maintaining an optimal intake of micronutrients, is well demonstrated to slow aging and extend healthy life span in near all species and lineages tested to date. It produces sweeping effects on the operation of metabolism - near everything changes, which has made it something of a challenge to identify the principal points of action. Nonetheless, more efficient operation of the cellular housekeeping mechanisms of autophagy is the most plausible mechanism to account for the majority of the benefits. That calorie restriction fails to extend life when autophagy is disabled is the most telling evidence. The open access paper that I'll point out today is illustrative of a great many similar lines of […]

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16:45 StemCellsPortal.coml Study Shows Stem Cell 'Therapy' Injuries Widespread Than we Knew

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16:45 StemCellsPortal.coml Vison-preserving stem cells discovered

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15:38 StemCellsPortal.coml CD146-sorted Mesenchymal Stem Cells Provide for Enhanced Therapeutic Outcomes

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01.08.2020
00:21 ScienceDaily.com Researchers discover stem cells in optic nerve that preserve vision

Researchers have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and provides potential to treat a leading cause of blindness.

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30.07.2020
15:54 StemCellsPortal.coml “Self-Eating” Process of Stem Cells May Be the Key to New Regenerative Therapies

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29.07.2020
18:23 Nature.Com Stretch exercises for stem cells expand the skin

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28.07.2020
16:14 StemCellsPortal.coml Adult Stem Cells/Glaucoma Drug Combo Promotes Diabetic Wound Healing in Mice

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13:15 FightAging.Org Glycosylation Changes in Epidermal Stem Cells as a Biomarker of Aging

Researchers here analyze amounts and types of glycans in stem cells isolated from the skin of old and young mice. The differences observed might serve as a biomarker of aging, but also may be a contributing proximate cause of the age-related decline in skin stem cell function. As is usually the case, connecting downstream changes of this nature to the deeper causes of aging is a project yet to make any meaningful progress. It is also unclear as to whether glycan profile changes are a sizable cause of dysfunction versus all of the other possible proximate causes of stem cell functional decline. Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of […]

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11:01 Technology.org “Self-eating” Process of Stem Cells May be the Key to New Regenerative Therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve

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27.07.2020
16:26 StemCellsPortal.coml Skin Stem Cells Shuffle Sugars as They Age

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26.07.2020
18:37 ScienceDaily.com 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, researchers show.

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23.07.2020
21:05 Phys.org 'Self-eating' process of stem cells may be the key to new regenerative therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science.

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16:54 StemCellsPortal.coml Expanded Access Protocol Initiated for Stem Cell Treatment for Children With MIC-C Associated With COVID-19

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16:27 StemCellsPortal.coml New Platform Enables Long-Term Tracking of Stem Cell-Derived Tissues After Transplantation

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00:28 ScienceDaily.com Skin stem cells shuffle sugars as they age

Researchers have shown by in vitro experimentation that changes of glycans in mouse epidermal stem cells may serve as a biomarker of aging. Further, by overexpression of specific glycogenes in mouse keratinocytes, they replicated the glycome profile of aging cells as well as their decreased proliferation ability. These findings hold promise for stem cell research into skin disorders, specifically senile degeneration, wound healing and skin cancer.

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21.07.2020
21:17 News-Medical.Net Glycome shift' in epidermal stem cells could serve as potential biomarker of aging

Age shows nowhere better than on the skin. The ravages of time on skin and the epidermal stem cells that differentiate to replenish its outer layer have been hypothesized, but there has been no method to evaluate their aging at the molecular level.

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20.07.2020
22:08 Technology.org Human Sperm Stem Cells Grown in Lab, an Early Step Toward Infertility Treatment

Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial

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16:52 StemCellsPortal.coml New Clues From Fruit Flies About the Critical Role of Sex Hormones in Stem Cell Control

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11:35 Technology.org Turning off “junk DNA” may free stem cells to become neurons

For every cell in the body there comes a time when it must decide what it wants to

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17.07.2020
17:54 StemCellsPortal.coml Stem Cell Platform for Evaluation of Nanoplastics

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17:41 StemCellsPortal.coml Conjunctival Epithelial Stem Cells Enriched by p75

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16.07.2020
19:21 StemCellsPortal.coml How randomness and collective dynamics define a stem cell

KLOSTERNEUBURG (AT), July 2020 — Without stem cells, human life would not exist. Due to them, a lump of cells becomes an organ, a fertilized egg develops into a baby and tissues of our body can be continuously renewed. But what actually makes a stem cell? How do they know when to divide to replace a dying cell? Are these a stable population of specially gifted cells? Scientists at the Institute of Science and Technology (IST) Austria discovered that instead, stem cells might emerge due to the collective behavior of cells within the organs. They saw that the shape of the surrounding tissue, jointly to the pattern of seemingly random movements of the cells determined the cell’s role.  The scientists published their study in PNAS on July 1. Their results could lead to a deeper understanding of organ renewal and development. Stem cells are central to organ development and renewal. In most organs, stem cells are located in specific regions and, in some cases, can be

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19:07 StemCellsPortal.coml Study shows RNA plays key role in stem cell differentiation

BOULDER, CO (US), July 2020 — Look deep inside our cells, and you’ll find that each has an identical genome – a complete set of genes that provides the instructions for our cells’ form and function.  But if each blueprint is identical, why does an eye cell look and act differently than a skin cell or brain cell? How does a stem cell – the raw material with which our organ and tissue cells are made – know what to become? In a study published July 6 in Nature Genetics, researchers at the University of Colorado Boulder (CU Boulder) come one step closer to answering that fundamental question, concluding that the molecular messenger RNA (ribonucleic acid) plays an indispensable role in cell differentiation, serving as a bridge between our genes and the so-called “epigenetic” machinery that turns them on and off. When that bridge is missing or flawed, the researchers report, a stem cell on the path to becoming a heart cell never learns how to beat. The paper

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15.07.2020
14:17 Technology.org Stem Cell Exhaustion in the Aging Lung

Stem cell activity declines with age throughout the body. In some cases this is because stem cells become

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14.07.2020
12:23 StemCellsPortal.coml Epitranscriptome Landscape of sncRNAs in Stem Cells

Comprising the epigenetic signatures decorating both coding and noncoding RNAs (ncRNAs), the epitranscriptome has recently emerged as a major regulator of stem cell biology. ncRNAs can be divided into large and small ncRNAs, with small (s)ncRNAs known to govern stem cell division, among other roles. Molecularly, the epitranscriptome controls the translation of global programs or specific mRNAs. Post‐transcriptional modifications coordinate stem cell decisions by orchestrating RNA processing, RNA structure, and reader‐eraser protein binding. While the epitranscriptome field remains in its infancy, with many RNA modifications roles unknown, researchers led by Abdulrahim Sajini (Khalifa University of Science and Technology, Abu Dhabi, UAE) now brings us up to date regarding how the

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13.07.2020
22:12 Phys.org Human sperm stem cells grown in lab, an early step toward infertility treatment

Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial stem cell (SSC) therapy. In this approach, sperm stem cells in the testis are transferred to a test tube, cultured and nudged into becoming fully fledged sperm. However, a key bottleneck has been identifying just the right conditions to get human SSCs to grow in the lab. There have been many attempts, but in most reported cases it was not clear whether the cells being cultured were actually SSCs, and no previously published method is routinely used.

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22:12 Phys.org Turning off 'junk DNA' may free stem cells to become neurons

For every cell in the body there comes a time when it must decide what it wants to do for the rest of its life. In an article published in the journal PNAS, NIH researchers report for the first time that ancient viral genes that were once considered "junk DNA" may play a role in this process. The article describes a series of preclinical experiments that showed how some human endogenous retrovirus (HERV-K) genes inscribed into chromosomes 12 and 19 may help control the differentiation, or maturation, of human stem cells into the trillions of neurons that are wired into our nervous systems. The experiments were performed by researchers in a lab led by Avindra Nath, M.D., clinical director, at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

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15:18 StemCellsPortal.coml Fat cell hormone boosts potential of stem cell therapy

OSAKA (JP), July 2020 — Mesenchymal stem cells (MSCs) have the potential to differentiate into a range of different cell types, including bone, fat and muscle cells. But it's their ability to stimulate the repair of damaged tissue that has captured the interest of researchers worldwide, with MSCs demonstrating therapeutic effects in the treatment of conditions such as heart disease, liver cirrhosis and diabetes. However, despite the success of several clinical trials, researchers have struggled to explain the sometimes variable results of MSC therapy. In a recent study published in Molecular Therapy, a research team led by Osaka University investigated possible reasons for the inconsistent outcomes of MSC therapy, showing that host factors and not just the MSCs themselves may be to blame. "We recently reported that adiponectin, a beneficial hormone secreted by fat cells that plays a role in muscle regeneration, binds to receptor protein T-cadherin on cell surfaces,"

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11:43 StemCellsPortal.coml Muscle Stem Cells – New Players in the Treatment of Inflammatory Diseases?

Review of "Skeletal Muscle Stem Cells Confer Maturing Macrophages Anti-inflammatory Properties through IGF-2" from STEM CELLS Translational Medicine by Stuart P. Atkinson Interactions between immune cells and muscle stem cells (MuSCs) within skeletal muscle influence the success of tissue repair and regeneration; however, we still lack a clear understanding of how MuSCs regulate the function of cells such as monocytes and macrophages. Given recent studies establishing that tissue stem cells can reprogram macrophage fate via metabolic rewiring [1, 2], researchers led by Changshun Shao and Yufang Shi (Medical College of Soochow University, Suzhou, Jiangsu, China) hypothesized that MuSCs may also impact the metabolism and function of

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11:29 StemCellsPortal.coml Deciphering the Role of Bone Marrow Niche Signals to Hematopoietic Stem Cell Activity

Review of “CXCR4 expression in the bone marrow microenvironment is required for hematopoietic stem and progenitor cell maintenance and early hematopoietic regeneration after myeloablation” from STEM CELLS by Stuart P. Atkinson The hematopoietic stem/progenitor cells (HSPCs) that provide for the life‐long production of blood and immune cells in adults reside in a bone marrow niche composed of blood vessels, perivascular mesenchymal stem cells (MSC), immune cells, and nerve fibers. The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), that derives from MSCs [1] supports the quiescence and retention of HSPCs within the bone marrow [2-4] by binding to the CXCR4 cognate G‐protein coupled

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11.07.2020
15:24 StemCellsPortal.coml Mesenchymal Stem Cells as Neural Therapeutics

A concise review article published recently in STEM CELLS Translational Medicine from Marcin Majka and Bogna Badyra (Jagiellonian University Medical College, Cracow, Poland) summarizes the results of preclinical and clinical trials in neurological diseases of different etiologies. Their review focuses on possible mechanisms of action of mesenchymal stem cells (MSCs) but also discusses approaches to augment their effects.

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10.07.2020
13:32 FightAging.Org Stem Cell Exhaustion in the Aging Lung

Stem cell activity declines with age throughout the body. In some cases this is because stem cells become less active in response to changes in the signaling environment. In other cases, the cells are damaged or the populations greatly reduced. The consequence of this decline is that fewer daughter somatic cells are produced to make up losses, repair damage, and maintain tissue function. A slow decline into organ dysfunction results, contributing to the onset of age-related disease, disability, and mortality. Finding ways to reverse this process is a very important component of of the broader field of rejuvenation research. Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its manifestation in the distal lung. We compared the lungs […]

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09.07.2020
17:23 ScienceDaily.com New clues from fruit flies about the critical role of sex hormones in stem cell control

In one of the first studies addressing the role of sex hormones' impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone, ecdysone, drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ.

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16:44 Technology.org Ex Vivo Mitochondrial Transfer as a Way to Improve Stem Cell Therapy Outcomes

A sizable portion of the variable efficacy of first generation stem cell therapies as presently practiced may be

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15:43 StemCellsPortal.coml New technology improves effectiveness of stem cells in regenerative medicine

MADRID (SP), July 2020 — Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others. Researchers and stem cell pioneers Sir John B. Gurdon and Shinya Yamanaka received the Nobel Prize in Physiology and Medicine in 2012 for this idea. However, one of the main limitations in the application of these cell therapies is the quality of the stem cells that can be generated in the laboratory, which impedes their use for therapeutic purposes. Now, a team from the Cell Division and Cancer Group of the Spanish National Cancer Research

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13:34 FightAging.Org Ex Vivo Mitochondrial Transfer as a Way to Improve Stem Cell Therapy Outcomes

A sizable portion of the variable efficacy of first generation stem cell therapies as presently practiced may be due to a poor quality of cells following expansion in culture. Regardless of quality, near all such cells die shortly after transplantation. Few clinics and few approaches to cell therapy lead to lasting survival and engraftment of transplanted cells, and beneficial effects are largely mediated by the short period of signaling produced by these cells. A range of approaches have been taken in attempts to make transplanted cells more robust: methodological improvements in the process of obtaining and culturing cells for transplant; transplanting a scaffold material along with cells; providing cells with supporting signals or nutrients; engineering cells to produce proteins that will help in survival; culling […]

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08.07.2020
18:25 StemCellsPortal.coml Adipose-derived stem cells considerably improve fat graft retention in breast augmentation

Durham, NC (July 8, 2020) - Results of a clinical trial released today in STEM CELLS Translational Medicine indicates that breast augmentation in patients treated with fat grafts enriched with autologous adipose-derived stem cells (ASCs) had significantly superior results compared to those treated with non-enriched grafts. The clinical trial, conducted by a multi-institutional group of researchers led by Stig-Frederik T. Kølle, M.D., Ph.D., chief surgeon in the Department of Plastic Surgery at Aleris Hamlet Hospitals in collaboration with the stem cell research and production facility Stemform (Copenhagen), was designed to examine whether ex vivo-expanded ASC-enriched fat grafts for breast augmentation could improve the results of conventional lipofilling while offering a safe procedure. It is the first study to investigate the effect

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05:49 News-Medical.Net RNA plays key role in helping stem cells know what to become

Look deep inside our cells, and you'll find that each has an identical genome -a complete set of genes that provides the instructions for our cells' form and function.

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07.07.2020
19:15 Phys.org RNA key in helping stem cells know what to become

Look deep inside our cells, and you'll find that each has an identical genome -a complete set of genes that provides the instructions for our cells' form and function.

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01:52 Medscape.Com COVID-19 Update: Airborne Virus Controversy, Stem Cells

The coronavirus stories Medscape's editors around the globe think you need to know about today.

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00:05 Medscape.Com Stem Cell Strategies Get Compassionate Use in COVID-19

Mesenchymal stem cells are being reimagined to tackle COVID-19-associated acute respiratory distress syndrome.

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06.07.2020
22:26 ScienceDaily.com Order from noise: How randomness and collective dynamics define a stem cell

Without stem cells, human life would not exist. Due to them, a lump of cells becomes an organ, and a fertilized egg develops into a baby. But what actually makes a stem cell? Are these a stable population of specially gifted cells? Scientists discovered that instead, stem cells might emerge due to the collective behavior of cells within the organs.

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19:48 Phys.org Order from noise: How randomness and collective dynamics define a stem cell

Stem cells are central to organ development and renewal. In most organs, stem cells are located in specific regions and, in some cases, can be identified through several intrinsic properties, like molecular markers. They can differentiate into various types of cells and divide indefinitely to produce more stem cells. However, does this mean the stem cell at the top is immortal? Or can any cell overthrow this? The scientific community is in an open debate whether stem cells actually arise from intrinsic cell properties or from the collective dynamics of the tissue itself. In this second scenario, potential stem cells are in constant competition to sit in certain "niche" regions. Each cell wants to overtake its neighbor by replication and, therefore, continuously pushes them. The functional stem cell will be the one that wins this competition, while losers will be pushed away from the niche, differentiate, and ultimately die.

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02.07.2020
17:49 News-Medical.Net New technology can increase the quality of stem cells used in regenerative medicine

Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others.

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17:26 StemCellsPortal.coml Clinical trial launched to evaluate Leukine® in T cell replete HLA-mismatched haploidentical stem cell transplant

LEXINGTON, MA (US), June 2020 — Partner Therapeutics, a commercial biotechnology company, has enrolled the first patient dosed in a Phase II study evaluating the efficacy and safety of Leukine® (sargramostim, rhu-GM-CSF) in T cell replete HLA-mismatched haploidentical stem cell transplant recipients who are receiving post-transplant cyclophosphamide (NCT04237623).  The study will enroll patients with high risk hematologic malignancies who are the recipients of a haploidentical cell transplant. The trial is designed to evaluate the effectiveness of Leukine compared to a matched control cohort of G-CSF treated patients, as well as evaluate the immune reconstitution profile of the treated patients compared to a contemporaneous cohort of 20 patients who receive G-CSF.  Many patients with high risk hematologic malignancies receive allogeneic hematopoietic cell transplants from a matched sibling to reestablish their immune system after

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01.07.2020
18:57 Technology.org USC Stem Cell scientists find a simpler way to make sensory hearing cells

Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida are whispering the secrets of a simpler way to

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30.06.2020
16:08 StemCellsPortal.coml Reviewing Glioblastoma-Mesenchymal Stem Cell Interactions

The unique properties of mesenchymal stem cells (MSCs) have made them an exciting resource for the treatment of a range of human conditions, including degenerative and inflammatory diseases, tissue damage, and cancer. Now, a new STEM CELLS Translational Medicine review article from the labs of Tullio Florio and Federica Barbieri (University of Genova, Italy) discuss recent findings from preclinical studies on MSCs in oncology as a source of soluble factors and extracellular vesicles with a specific focus on the interactions between MSCs and glioblastoma. As MSCs can promote or suppress tumor growth, they act as a double‐edged sword in the glioblastoma model, as in other tumor types. Additionally, Bajetto et al. also discuss the research required to explore

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16:08 StemCellsPortal.coml Antifibrotic Adipose‐derived Stem Cells

A recent study led by Derrick C. Wan (Stanford University, Stanford, CA, USA) described the in vitro and in vivo antifibrotic qualities of CD74-expressing adipose‐derived stem cells. Borrelli et al. believe that these cells may play a significant role in future strategies that address fibrotic remodeling following radiation exposure. For all the details, head over to STEM CELLS Translational Medicine now!

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29.06.2020
17:04 StemCellsPortal.coml Studying the Neandertal DNA found in modern humans using stem cells and organoids

BASEL (CH), June 2020 — Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available. Now, investigators are taking this technology and applying it to study the developmental effects of Neandertal DNA. The findings are reported June 18 in Stem Cell Reports. "Using iPSC lines to study the functions of archaic human DNA is an untapped but very interesting approach," said senior author J. Gray Camp of the Max Planck Institute for Evolutionary Anthropology in Germany and the University of Basel in Switzerland. "No one has ever been able to look at the role Neandertal DNA plays during development." Studies have found that about 2 percent of the genomes of modern humans from outside Africa are composed of Neandertal DNA. This

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17:04 StemCellsPortal.coml Primitive stem cells point to new bone grafts for stubborn-to-heal fractures

COLLEGE STATION, TX (US), June 2020 — Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers at Texas A&M University have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for the bone to regenerate at the site of repair. The researchers said these grafts could be used to promote swift and precise bone healing so that patients maximally benefit from the surgical intervention. “There are several problems that can occur with orthopedic implants, like inflammation and pain. Also, they can loosen, requiring revision surgeries that are often more complicated than the original surgery to put in the implant,” Roland Kaunas, Ph.D., associate professor in the Department of Biomedical Engineering and a corresponding author on the study. “So, by speeding up the bone healing process,

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16:50 StemCellsPortal.coml Targeting stem cells: The path to curing poor-prognosis leukemia

MELBOURNE (AU), June 2020 — Researchers at Children's Cancer Institute have discovered what could prove a new and improved way to treat the poor-prognosis blood cancer, acute myeloid leukemia or AML. Unlike acute lymphoblastic leukemia (ALL), the most common childhood cancer, AML is notoriously difficult to cure, often proving resistant to standard treatments. The researchers have been investigating what they believe to be the root cause of treatment resistance, leukemia stem cells, and have now hit on a new therapeutic approach that works by targeting these cells. Stem cells are special cells that are not only capable of giving rise to different types of cells, but also of copying themselves indefinitely in a process known as self-renewal. If stem cells in the blood becomes cancerous, they can multiply out of control, causing leukemia. And while leukemia stem cells remain in a child's body, that child remains at risk of relapse. "Leukemia stem cells have their own

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16:50 StemCellsPortal.coml Cord blood for stem cell transplant may outperform “gold standard” of matched sibling donors

AURORA, CO (US), June 2020 — When a cancer patient needs a bone marrow transplant, there are four common donor sources: a matched related donor (sibling), a matched unrelated donor (from a donor database), a half-matched donor, or umbilical cord blood. Of course, there are plusses and minuses to each approach, but consensus has generally ranked a matched sibling first, followed by a matched unrelated donor, with cord blood and half-matched donors reserved for patients without either of the first two options. Now a University of Colorado (UC) Cancer Center study published recently in Blood Advances, based on a decade of research and treatment, may reshuffle this list. In fact, the comparison of 190 patients receiving cord blood transplants with 123 patients receiving transplants from the “gold standard” of matched sibling donors showed no difference in survival outcomes between these two approaches, with significantly fewer complications due to chronic graft-versus-host

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26.06.2020
10:53 StemCellsPortal.coml CD34+ Stem Cell Therapy for Refractory Angina`

Patients with refractory angina who are suboptimal candidates for further revascularization display improved exercise time, decreased angina frequency, and reduced major adverse cardiac events following the intramyocardial delivery of CD34+ stem cells; however, the effect of CD34+ stem cell therapy on health care expenditures after treatment remains unclear. In a new STEM CELLS Translational Medicine article, researchers led by Jay H. Traverse (University of Minnesota School of Medicine, Minneapolis, Minnesota, USA) report on their determination of the effect of CD34+ stem cell therapy on cardiac‐related hospital visits and costs during the 12 months following stem cell injection compared with the 12 months before injection. Overall, Johnson et al. provide

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24.06.2020
18:29 Nature.Com Single-molecule imaging of transcription dynamics in somatic stem cells

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23.06.2020
13:19 FightAging.Org The Challenge of Cellular Senescence in Mesenchymal Stem Cell Therapy

The accumulation of senescent cells in tissues throughout the body is a cause of aging, but it is also a phenomenon that occurs in cell cultures. Senescent cells do not replicate and secrete a potent inflammatory mix of signal molecules that degrades tissue function. Senescence in cells expanded in culture is a challenge to the efficacy of cell therapies, and may go some way towards explaining the unreliability in benefits obtained from clinic to clinic and treatment to treatment. First generation mesenchymal stem cell therapies are now widely employed, and researchers are starting to give greater attention to ways to minimize senescence in the cells delivered to patients. Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and differentiation. There is increasing evidence of […]

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10:03 StemCellsPortal.coml Reviewing the Therapeutic Importance of Stem Cell Homing

The manipulation of hematopoietic stem and progenitor cell homing represents a fascinating approach to the improvement of engraftment following hematopoietic stem cell transplantation. Additionally, the homing of mesenchymal stem cells to sites of injury and regeneration also represents an essential step in tissue repair. Now, in a recent STEM CELLS review article, researchers led by Jane Liesveld (Wilmot Cancer Institute, Rochester, NY, USA) discusses the process of stem cell homing to highlight those strategies that may improve the process.

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09:50 StemCellsPortal.coml Cord Tissue Mesenchymal Stem Cells in Autism

A new STEM CELLS Translational Medicine article from researchers led by Jessica M. Sun (Duke University Medical Center, Durham, NC, USA) now reports the results of a phase I study that evaluated the therapeutic potential of mesenchymal stem cells derived (MSCs) from donated human umbilical cord tissue following intravenous administration in autistic children. The authors note safety and feasibility, and also report that half of the treated children showed improvements in autism symptoms, although whether these improvements directly related to the treatment remains uncertain. To this end, the authors note that a randomized, placebo‐controlled clinical trial is currently assessing the ability of cord blood MSCs to improve the core symptoms of autism. Скрыть анонс

02:32 News-Medical.Net Novel vaccine platform against COVID-19 based on engineered human mesenchymal stem cells

In a recent groundbreaking bioRxiv paper, Chinese researchers describe a novel approach towards coronavirus disease (COVID-19) vaccine design based on engineered human mesenchymal stem cells, with favorable and promising antibody response.

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19.06.2020
17:30 StemCellsPortal.coml Adult stem cell study shows fish oil may help with depression

CHICAGO, IL (US), June 2020 — A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication. Using stem cells from adults with a clinical diagnosis of depression, the University of Illinois at Chicago researchers who conducted the study also found that fish oil, when tested in the model, created an antidepressant response. Mark Rasenick, Ph.D., principal investigator of the study, said that the research provides a number of novel findings that can help scientists better understand how the brain works and why some people respond to drug treatment for depression, while others experience limited benefits from antidepressant medication. “It was also exciting to find scientific evidence that fish oil — an easy-to-get, natural product — may be an effective treatment for depression,” said Dr. Rasenick, professor of physiology and biophysics and

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17:30 StemCellsPortal.coml Researchers model human stem cells to identify degeneration in glaucoma

INDIANAPOLIS, IN (US), June 2020 — More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers at Indiana University School of Medicine found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process. The study, published recently in Stem Cell Reports, focused on targeting genetic mutations within retinal ganglion cells, which serve as the connection between the eye and the brain. Researchers found that when differentiating pluripotent human stem cells into retinal ganglion cells, they were able to identify characteristics associated with neurodegeneration in glaucoma. “Once you’ve identified a target like this — what’s going wrong in the cells — this opens up a number of possibilities for the eventual development of therapeutic approaches, especially pharmacology approaches to slow down and reverse

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13:25 StemCellsPortal.coml Stem Cell-derived Retinal Organoids: A Review

Retinal diseases that can lead to vision impairment or blindness currently suffer from a lack of effective treatment options. Advances in reprogramming of somatic cells to induced pluripotent stem cells and generation of three‐dimensional organoids resembling the native retina represent new and exciting tools regarding the deciphering of disease mechanisms and the evaluation of potential therapies. Now, in a new STEM CELLS review article, Kamil Kruczek and Anand Swaroop (National Institutes of Health, Bethesda, MD, USA) discuss the current status and future potential of combining retinal organoids as human models with recent technologies to advance the development of gene, cell, and drug therapies for retinopathies.

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04:58 News-Medical.Net Cloning stem cells to develop treatments for Crohn's disease

For over a decade Wa Xian, research associate professor of biology and biochemistry at the University of Houston Stem Cell Center, has been perfecting technology for cloning stem cells. Now she is using it to take aim at pediatric Crohn's disease.

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03:53 News-Medical.Net Using stem cells to study the developmental effects of Neandertal DNA

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

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03:00 Rejuvenation Research Exercise Partially Rejuvenates Muscle Stem Cells

Rejuvenation Research, Volume 23, Issue 3, Page 262-265, June 2020.

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18.06.2020
22:46 ScienceDaily.com Studying the Neanderthal DNA found in modern humans using stem cells and organoids

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available. Now, investigators are taking this technology and applying it to study the developmental effects of Neanderthal DNA.

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18:11 Phys.org Studying the Neandertal DNA found in modern humans using stem cells and organoids

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available. Now, investigators are taking this technology and applying it to study the developmental effects of Neandertal DNA. The findings are reported June 18 in the journal Stem Cell Reports.

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17.06.2020
16:27 Nature.Com Inside the stem-cell pharmaceutical factory

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05:32 News-Medical.Net Researchers create superior bone grafts using primitive stem cells

Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting.

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01:42 ScienceDaily.com Primitive stem cells point to new bone grafts for stubborn-to-heal fractures

Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for bone to regenerate at the site of repair.

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16.06.2020
16:12 StemCellsPortal.coml Replicates in Stem Cell Models

The routine differentiation of human pluripotent stem cells into a multitude of desired cell types has increased the complexity of the requirement for technical or biological replicates in stem cell‐based experimental studies. Traditional definitions of technical or biological replicates may no longer apply clearly to stem cell differentiation models due to line‐to‐line variability and heterogeneity in every individual stem cell differentiation. In a STEM CELLS commentary article, Jun Wei Chan and Adrian Kee Keong Teo (National University of Singapore, Singapore) now discuss current practices in the field with regards to experimental replication and provide their opinions on how to tackle the related issues.

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15.06.2020
20:47 Technology.org HUMAN EMBRYO-LIKE MODEL CREATED FROM HUMAN STEM CELLS

Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a

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17:16 StemCellsPortal.coml Magnetic guidance improves stem cells' ability to treat occupational lung disease

Durham, NC (June 15, 2020) - Results of a study released today in STEM CELLS Translational Medicine (SCTM) may point the way to a cure for a serious lung disease called silicosis that affects millions of workers worldwide. Silicosis results from years of breathing in dust microparticles of silica by workers in professions such as construction and sand blasting. The particles can eventually lead to inflammation and scarring of the lung tissue, which in turn makes it difficult to breathe and can result in death. There currently is no cure for silicosis and once the damage is done it cannot be reversed. Treatment is focused on relieving symptoms and slowing down the progression of the disease, while the medical world searches for a permanent solution. Among the more promising potential therapies are mesenchymal stem cells (MSCs), which can be

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16:23 StemCellsPortal.coml Improved Generation of Ventral Midbrain Neurons from Human Induced Pluripotent Stem Cells

Review of "Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine content in ventral midbrain cells induced from somatic cells" from STEM CELLS Translational Medicine by Stuart P. Atkinson  The screening of therapeutic approaches for ventral midbrain disorders, which includes childhood dystonia or Parkinson's disease, requires a source of high‐quality human dopamine‐producing ventral midbrain cells; furthermore, such cells may also play a key role in cell replacement and modeling approaches. The robust generation of dopaminergic cells from human induced pluripotent stem cells (hiPSCs) currently uses a modified dual SMAD inhibition approach to create neuroectoderm with simultaneous sonic

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16:09 StemCellsPortal.coml Improving Stem Cell Therapy for Diabetes by Naïve Reversion of iPSCs

Review of “Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina” from Nature Communications by Stuart P. Atkinson A previous study from the laboratory of Elias T. Zambidis (Johns Hopkins School of Medicine, Baltimore, MD, USA) [1] established that the transplantation of vascular progenitor cells derived from human induced pluripotent stem cells (hiPSCs) may represent a promising therapeutic strategy to reverse the ischemic death of retinal pericytes and endothelial cells observed in diabetic patients [2]. However, the highly variable differentiation efficiency and reduced in vivo functionality of iPSC-derived vascular progenitor cells have limited their therapeutic application.  Now, the Zambidis team return

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14.06.2020
07:09 News-Medical.Net Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

The Texas Heart Institute and 7 Hills Pharma received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.

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13.06.2020
03:16 ScienceDaily.com Researchers model human stem cells to identify degeneration in glaucoma

More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process.

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03:16 ScienceDaily.com Adult stem cell study shows fish oil may help with depression

A new study shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response.

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12.06.2020
17:51 StemCellsPortal.coml Molecular landscape of the hematopoietic stem cell cradle

UTRECHT (NE), June 2020 — Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta that supports the generation of the first hematopoietic stem cells (HSCs) in the embryo. Such HSCs are responsible for the constant replenishment of all blood cells throughout life. The researchers investigated which genes and regulatory pathways were active in the aorta of zebrafish, chicken, mouse and human embryos at the time of HSC formation. By comparing the different species, they uncovered the complexity of the aortic microenvironment landscape and the finetuning of various factors interplaying to control HSC generation both in time and space in vivo. Understanding the regulatory function of the local environment where HSCs are formed will pave the way for improved HSC production in vitro and clinical

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15:24 Yahoo Science Scientists grow model human embryos from stem cells

Scientists have developed a human embryo "blueprint" using human stem cells, in a breakthrough that could provide vital insight into the early stages of infant development, new research showed Thursday. Teams from the University of Cambridge and the Netherlands-based Hubrecht Institute said their model will allow them to observe never-before-seen processes underlying the formation of the human body. The layout of humans -- known as the body plan -- happens through a process known as gastrulation, where three distinct layers of cells are formed in the embryo that will later give rise to the body's three main systems: nervous, musculoskeletal and digestive.

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13:07 StemCellsPortal.coml Human Ventral Forebrain Neural Stem Cells

Intraventricular hemorrhage (IVH) occurs in 15% to 40% of preterm births and is frequently associated with long‐term neurological deficits. The rupture of the proliferative germinal zone following IVH disturbs the late production of neurons, ependymal cells, and glial cells. Now, researchers led by Beatriz Fernández‐Muñoz (Red Andaluza para el diseño y traslación de Terapias Avanzadas, Sevilla, Spain) have employed a minimally-invasive neuroendoscopic procedure to retrieve neural stem cells (NSCs) from the cerebrospinal fluid in such patients. The authors report that NSCs can be readily expanded, cryopreserved, and differentiated in vitro and in vivo without showing signs of tumorigenic potential. Furthermore, the isolated NSCs display distinct hallmarks related to their

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05:43 News-Medical.Net Researchers use human stem cell models to analyze degeneration in glaucoma

More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers at Indiana University School of Medicine found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process.

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11.06.2020
22:10 CNN Health Stem Cells Fast Facts

View CNN's Fast Facts about stem cells and learn more about these unspecialized cells capable of replicating themselves through cell division.

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19:56 FierceBiotech.com New gene therapy technique shows promise in stem-cell model of retinitis pigmentosa

New gene therapy technique shows promise in stem-cell model of retinitis pigmentosa arlene.weintraub Thu, 06/11/2020 - 12:42

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18:03 News-Medical.Net New method uses human embryonic stem cells to generate 3D assembly of cells

Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a new model to study an early stage of human development, using human embryonic stem cells.

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17:31 ScienceDaily.com Human embryo-like model created from human stem cells

Scientists have developed a new model to study an early stage of human development, using human embryonic stem cells.

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12:08 Phys.org Human embryo-like model created from human stem cells

Scientists from the University of Cambridge, in collaboration with the Hubrecht Institute in The Netherlands, have developed a new model to study an early stage of human development, using human embryonic stem cells. The model resembles some key elements of an embryo at around 18-21 days old and allows the researchers to observe the processes underlying the formation of the human body plan never directly observed before. Understanding these processes holds potential to reveal the causes of human birth defects and diseases, and to develop tests for these in pregnant women.

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11:41 Technology.org Scientists generate early stem cells that form human placenta

Despite researchers’ efforts to understand pregnancy — both healthy and high-risk — the human placenta remains something of

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10.06.2020
18:44 Reuters.com Science Scientists create embryo-like research model from human stem cells

Scientists have used human embryonic stem cells to create an embryo-like research model to help them study some of the earliest stages of human development.

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18:31 Reuters.com Health Scientists create embryo-like research model from human stem cells

Scientists have used human embryonic stem cells to create an embryo-like research model to help them study some of the earliest stages of human development.

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09:49 News-Medical.Net Detachable microneedle depots deliver therapeutic stem cells to injured tissue sites

Mesenchymal stem cells (MSCs) are multipotent in that they naturally replenish the cell types that build our bone, cartilage and adipose tissues.

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09.06.2020
22:33 FightAging.Org Stem Cell Derived Exosomes as a Basis for Treating Skin Aging

Exosomes are a popular topic in the regenerative medicine field these days. Exosomes are a class of extracellular vesicle, membrane-bound packages of molecules that cells use as a means of communication. Much of the cell signaling that mediates the benefits of first generation stem cell therapies is in the form of exosomes rather than secreted proteins. Transplanted cells do not survive in large numbers, but their signals do meaningfully affect the behavior of native cells, producing results such as a reduction in chronic inflammation. Exosomes can be easily harvested from cell cultures and are a great deal easier to manage, logistically, than is the case for cells. Thus much of the clinical community presently offering stem cell therapies is shifting focus to exosomes. Today's open […]

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10:17 StemCellsPortal.coml Reviewing Aged Stem Cell Restoration

Researchers led by Isabel Beerman (NIH, Baltimore, Maryland, USA) discuss the current status of interventions to improve stem cell aging phenotypes in a recent concise review article published in STEM CELLS. Spehar et al. state that the restoration of aged stem cells may lead to a beneficial cascade throughout the entire system; however, as many interventions have been reported in only a few tissue‐specific stem cell types, a more comprehensive analysis of potential benefits and consequences to all stem cells is required. The authors highlight overlaps between interventions and proposed considerations required before translating interesting approaches into human trials.  

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08.06.2020
18:46 News-Medical.Net Study identifies potential biomarker for prescreening donor's stem cells

A new study released today in STEM CELLS addresses a significant problem that has been confronting human mesenchymal stem cells (hMSCs) therapy.

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17:58 StemCellsPortal.coml Stem cell treatments 'go deep' to regenerate sun-damaged skin

RIO DE JANEIRO (BZ), June 2020 — For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they've been getting good results, it's been unclear exactly how these treatments – using adult stem cells harvested from the patient's own body – work to rejuvenate "photoaged" facial skin. A new microscopic-level study provides the answer: Within a few weeks, stem cell treatment eliminates the sun-damaged elastin network and replaces it with normal, undamaged tissues and structures, even in the deeper layers of skin. Injection of the patient's own mesenchymal stem cells (MSCs) is "appropriate, competent and sufficient to elicit the full structural regeneration of the sun-aged skin," according to the report by Luis Charles-de-Sá, M.D. (of Universidade Federal do Rio de Janeiro, Brazil), Natale Gontijo-Amorim, M.D. and Gino Rigotti, M.D. (of Verone-Italy University) and colleagues. Their study appears in the June issue of Plastic

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17:58 StemCellsPortal.coml IU researchers grow hairy skin from human stem cells

INDIANAPOLIS, IN (US), June 2020 — Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells — developing one of the most complex skin models in the world. The study, published June 3 in Nature, shows that skin generated from pluripotent stem cells can be successfully grafted on a nude mouse to grow human skin and hair follicles. That discovery could lead to future studies in skin reconstruction, disease modeling and treatment. "This is the first study to show that human hair can be grown completely from stem cells in a dish, which has been a goal of the skin biology community for decades," said Karl Koehler, Ph.D., assistant professor of otolaryngology–head and neck surgery at Harvard Medical School and Boston Children's Hospital. The team of researchers was led by Dr. Koehler, who's also an adjunct assistant

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17:06 StemCellsPortal.coml Potential biomarker identified to screen quality of donor's stem cells before harvesting

Durham, NC (June 8, 2020) - A new study released today in STEM CELLS addresses a significant problem that has been confronting human mesenchymal stem cells (hMSCs) therapy. While hundreds of clinical trials involving thousands of patients are under way to test hMSCs' ability to treat everything from heart disease to brain injury, there has been no way to determine prior to the donor undergoing a painful and expensive surgical harvesting of bone marrow whether or not it would be worth the effort. However, this new study, conducted by scientists at the Agency for Science, Technology and Research (A*STAR), Singapore, identifies a potential biomarker for prescreening donors for their MSCs' growth capacity and potency. "With the global stem cell market predicted to reach over US$270 billion by 2025 (according to a report published by Transparency Market Research), there is a pressing need for effective biomarkers to be used in the screening of stem cells from prospective

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13:19 Technology.org Stem Cell Therapy Reverses Aspects of Photoaging in Skin

With few exceptions, the worldwide community of clinics offering first generation stem cell therapies is not usually a source of

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05.06.2020
14:28 Phys.org CYCLIN-B1/2 and CYCLIN-D1 act in opposition to coordinate cortical stem cell self-renewal and lineage commitment

The capacity of a stem cell population to generate several distinct cell types in a temporally defined manner is fundamental to both organ development and homeostasis. To achieve this, stem cells must carefully balance self-renewal and commitment to cellular differentiation, but how this is regulated at the genetic level has remained unclear.

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13:19 FightAging.Org Stem Cell Therapy Reverses Aspects of Photoaging in Skin

With few exceptions, the worldwide community of clinics offering first generation stem cell therapies is not usually a source of reliable data. They don't tend to conduct trials or even much report on the results of their work. Further, the stem cell therapies used can vary enormously in effectiveness. Cells are fickle things and tiny differences in how two groups run exactly the same protocol for sourcing and preparing cells can cause widely divergent outcomes, both between clinics, and from patient to patient for the same clinic. Not that groups are in fact usually running the same protocol; a very broad range of possibilities exist under the umbrella term "stem cell therapy." Results in one clinic may not generalize well to other clinics; standardization has […]

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