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Researchers at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis have found a way to help more patients who want to stop smoking.
A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.
UVA Health and the Charlottesville-based Focused Ultrasound Foundation today announced the launch of the Focused Ultrasound Cancer Immunotherapy Center, the world's first center dedicated specifically to advancing a focused ultrasound and cancer immunotherapy treatment approach that could revolutionize 21st-century cancer care.
CRISPR-Cas9 is considered a revolutionary gene editing tool, but its applications are limited by a lack of methods by which it can be safely and efficiently delivered into cells. Recently, a research team has constructed a highly flexible CRISPR-Cas9 carrier using aminated polyrotaxane (PRX) that can not only bind with the unusual structure of Cas9 and carry it into cells, but can also protect it from intracellular degradation by endosomes.
A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a new study, a finding that has important implications for brain health and future therapies for brain disorders.
When pathogens attack, the NPR1 protein steps in to control a plant's immune response. Scientists have now figured out what the protein looks like and how it works --- a possible boon for agriculture.
CRISPR-Cas9 is considered a revolutionary gene editing tool, but its applications are limited by a lack of methods by which it can be safely and efficiently delivered into cells. Recently, a research team from Kumamoto University, Japan, have constructed a highly flexible CRISPR-Cas9 carrier using aminated polyrotaxane (PRX) that can not only bind with the unusual structure of Cas9 and carry it into cells, but can also protect it from intracellular degradation by endosomes.
Biologist Xinnian Dong says her "best Christmas gift ever" arrived in the form of a phone call. The call was from her longtime friend and collaborator at Duke University, Pei Zhou, who rang with long-awaited news: they had finally solved the structure of the plant protein NPR1.
After failed SPAC and phase 3 fumble, Amicus gene therapy hits another delay to approval jwaldron Wed, 05/11/2022 - 09:43
Salk scientists improve liver regeneration in mice, which could lead to new treatments for liver disease Mammals can’t
In mouse studies, gene therapy-induced pain-blocking neurotransmitters produced long-lasting benefit without detectable side effects. An international team of
UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.
staff@slashgear.com (Tushar Mehta) / SlashGearThe Motorola Razr 3 Might Be A Galaxy Flip Clone – Heres Why Thats A Good Thing - More details about the anticipated next-generation Motorola Razr foldable smartphone have surfaced, and it may take inspiration from Samsungs competing model.More details about the anticipated next-generation Motorola Razr foldable smartphone have surfaced, and it may take inspiration from Samsungs competing model. ...
Researchers have explored using medically trained dogs to sniff out cancer. Now French scientists say ants can do the job, too — only faster and cheaper.
Scientists reported on an experimental gene-therapy-like technique to restore the normal activity of the TCCF4 gene deficient in individuals with Pitt-Hopkins syndrome.
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(Nicole Wetsman) / The VergeGoogle relaxes ban on stem cell therapy ads - Illustration by Alex Castro / The Verge Google will allow ads for stem cell treatments that are approved by the US Food and Drug Administration a change from its previous policy, which banned all ads for this experimental category of medical care. The policy update was first reported by ...
Researchers in Liverpool and the US have made a breakthrough that could lead to improved immunotherapy treatments for
Young mice that received fecal microbiota transplants from older mice experienced "hallmark" signs of aging—indicators that could be reversed with transplants from other young, healthy mice. The post Fecal Transplants Reverse Key Signs of Aging appeared first on ExtremeTech.
An international team of researchers, led by scientists at University of California San Diego School of Medicine, report that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain with no detectable side effects in mice with spinal cord or peripheral nerve injuries.
Depression is a common mental health condition that affects approximately 1 million Australians each year. It is a significant risk factor for suicide, the leading cause of death in young adults.
Researchers report that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain with no detectable side effects in mice with spinal cord or peripheral nerve injuries.
Acute myeloid leukaemia is a rare and devastating blood cancer that is highly resistant to treatment. Now, scientists have discovered a way to suppress a specific protein that promotes drug resistance.
LogicBio's sun and shares rise again after FDA releases clinical hold on pediatric genome editing therapy aarmstrong Mon, 05/09/2022 - 10:11
In an article recently published in ACS Applied Biomaterials, the authors summarized green nanocomposites and interpreted their uses in wound dressing and skin tissue engineering....
Northwestern Medicine scientists have identified critical regulatory processes that govern differentiation in embryonic stem cells, according to a study published in the Proceedings of the National Academy of Sciences.
A pig virus may have contributed to the death of first pig heart transplant patient The VergeVirus found in pig heart used in human transplant Yahoo NewsUniversity disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimoreSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesView Full Coverage on Google News
The man was the first person to receive a transplant using a heart from a genetically modified pig.
Virus found in pig heart used in human transplant Yahoo! VoicesUniversity disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimoreSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesVirus Found In Pig Heart Used In Human Transplant Performed In Baltimore WJZView Full Coverage on Google News
A new study in mice led by neuroscientists at UT Southwestern's Peter O'Donnell Jr. Brain Institute shows that it's not just calories that count.
Viral infection may explain why a pig's heart failed months after being transplanted in a ground-breaking surgery
University disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimoreSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesVirus Found In Pig Heart Used In Human Transplant Performed In Baltimore WJZVirus Detected in Man Who Died 2 Months After Receiving Pig Heart Transplant PEOPLE
Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes.
Virus found in pig heart used in human transplant Yahoo NewsSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesUniversity disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimorePig virus may have been factor in death of man who received pig heart transplant, researchers say Fox NewsPorcine Virus Likely Killed First-Ever Recipient of Pig Heart Transplant The Daily BeastView Full Coverage on Google News
Virus found in pig heart used in human transplant The Associated Press - en EspañolSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesUniversity disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimorePorcine Virus Likely Killed First-Ever Recipient of Pig Heart Transplant The Daily BeastPig virus may have been one factor in historic pig heart transplant patient's death USA TODAYView Full Coverage on Google News
Pig virus may have been one factor in historic pig heart transplant patient's death USA TODAYSigns of an Animal Virus Discovered in Man Who Received a Pig’s Heart The New York TimesUniversity disputes report on pig heart transplant patient's death WBAL-TV 11 BaltimorePorcine Virus Likely Killed First-Ever Recipient of Pig Heart Transplant The Daily BeastPig heart used in pioneering human transplant had virus: report New York Post View Full Coverage on Google News
Urgent action continues to be taken to ensure women across the UK will be able to more reliably access HRT products.
One recipe for longevity is simple, if not easy to follow: eat less. Studies in a variety of animals have shown that restricting calories can lead to a longer, healthier life.
The collaboration follows a National Academies of Sciences, Engineering and Medicine report that found significant disparities in the nation's organ transplant system.
Pig heart used in pioneering human transplant had virus: report New York Post The gene-edited pig heart given to a dying patient was infected with a pig virus MIT Technology ReviewPig heart transplanted into dying man in breakthrough operation was infected with virus, report says The IndependentGene-edited pig heart given to dying patient was infected with virus The Express TribuneDavid Bennett who died after pig heart transplant ‘was infected with pig virus’ STV News
A group of researchers recently published a paper in the journal Nano Energy that demonstrated a novel strategy for the rapid generation of peripheral nerves using piezoelectric stimulation and...
Pig heart used in pioneering human transplant had virus: report New York Post The gene-edited pig heart given to a dying patient was infected with a pig virus MIT Technology ReviewPig heart transplanted into dying man in breakthrough operation was infected with virus, report says The IndependentGene-edited pig heart given to dying patient was infected with virus The Express TribuneDavid Bennett who died after pig heart transplant ‘was infected with pig virus’ STV NewsView Full Coverage on Google News
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A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. Scientists at IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, demonstrate that these functions are two sides of the same coin. Upon injury, one molecular switch is enough to propel the stem cells from one state to the other. The findings, now published in Cell Stem Cell, could be instrumental in improving our understanding of gastric pathologies.
In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the aging process.
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The gene-edited pig heart given to a dying patient was infected with a pig virus The pig heart transplanted into an American patient earlier this year in a landmark operation was infected with…
A village postmistress says she has been unable to work for three weeks due to the shortages.
The pig heart transplanted into an American patient earlier this year in a landmark operation carried a porcine virus that may have derailed the experiment and contributed to his death two months later, say transplant specialists. David Bennett Sr. was near death in January when he received a genetically edited pig heart in a pioneering…
When patients started showing adverse side effects during a cancer immunotherapy trial, researchers went back through the data and worked with patient samples to see what went wrong.
In the search for eternal youth, fecal transplants may seem like an unlikely way to reverse the aging process. However, scientists have provided evidence, from research in mice, that transplanting fecal microbiota from young into old mice can reverse hallmarks of aging in the gut, eyes, and brain. In the reverse experiment, microbes from aged mice induced inflammation in the brain of young recipients and depleted a key protein required for normal vision. These findings show that gut microbes play a role in the regulating some of the detrimental effects of ageing and open up the possibility of gut microbe-based therapies to combat decline in later life.
Gene Therapy Reverses Effects of Autism-Linked Mutation in Human Brain Organoids SciTechDailyView Full Coverage on Google News
In a study published in Nature Communications, scientists at the University of California San Diego School of Medicine
Researchers evaluated the immune responses after the third and fourth doses of homologous and heterologous mRNA vaccines against COVID-19 in kidney transplant recipients.
All Takeda wants for its billion-dollar gene therapy spending spree is functional cures aarmstrong Mon, 05/02/2022 - 15:36
Scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
By 2025, the two health systems are aiming to double their portfolio and own over 50 ambulatory surgery centers .
Another Pfizer gene therapy is free of FDA hold, but delay continues gmasson Tue, 05/03/2022 - 11:00
Wearable, AI-powered whole-breast ultrasound system cleared by the FDA apark Tue, 05/03/2022 - 10:13
In this interview, News-Medical interviews Michael Weingarten about his work as a director of the Small Business Innovation Research Development Center, helping to fund highly-innovative technologies that are revolutionizing cancer research.
FDA plays tooth fairy, awards clearance to VideaHealth's cavity-spotting AI apark Mon, 05/02/2022 - 15:42
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.
Nanox nets FDA clearance for osteoporosis and spine fracture AI chale Mon, 05/02/2022 - 14:51
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.
Biogen takes another dip into Scribe gene therapy collab with another disease target mbayer Mon, 05/02/2022 - 13:30
A group of rare diseases called ciliopathies -- polycystic kidney disease notable among them -- emerge from defects in cilia. These are the tiny hairlike structures on the surface of almost every cell type. Scientists experimentally 'knocked out,' or genetically deleted, the cilia in a population of otherwise normal human pluripotent stem cells. Subsequently, human tissues and mini-organ structures (organoids) derived from these cilia-free stem cells manifested ciliopathy-like symptoms, such those seen in polycystic kidney disease or in certain problems in brain development.
FDA crowns Johnson & Johnson's Monarch surgical robot with urology nod apark Mon, 05/02/2022 - 11:41
In a new article, researchers describe the 'longevity diet,' a multi-pillar approach based on studies of various aspects of diet, from food composition and calorie intake to the length and frequency of fasting periods.
Davina McCall says she was "a mush" when the menopause hit, as she calls for shortages to be sorted out.
Vauhini Vara’s “The Immortal King Rao” is about a lot of things, from a father-daughter bond to the end of human civilization.
Rest easy—research shows gene editing could hold the key to deep sleep jwaldron Fri, 04/29/2022 - 10:20
Urgent action is being taken to ensure women across the UK will be able to more reliably access HRT products, as the Health and Social Care Secretary Sajid Javid issues Serious Shortage Protocols (SSPs) to limit the dispensing of 3 HRT products to 3 months' supply.
Officials say women will only be be able to get three months' worth of certain HRT products at a time.
Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.
A UK-wide hormone-replacement therapy crisis has seen women turning to the black market.
While frailty is a common condition in older adults, its heterogeneous nature makes management more complex.
Young adults who received organ transplants as children may not be regularly attending their doctor appointments after leaving their pediatric providers.
Sleep deprivation, which means getting too little high-quality sleep, is a serious health problem. More than one-third of people in the USA report getting less than the recommended minimum of seven hours sleep per night.
Blood-forming stem cells found in bone marrow are the life-saving component used in bone marrow transplants. However, suitable donors cannot be found in many cases. A new study reveals how the human embryo develops the precursor to blood-forming stem cells, which researchers say can be used in the novel method they developed to generate blood-forming stem cells from cells in a tissue culture.
Pfizer's phase 3 DMD gene therapy test resumes after FDA hold, but trial changes for advanced patients remain unclear aarmstrong Thu, 04/28/2022 - 08:55
A group of rare diseases called ciliopathies — polycystic kidney disease notable among them — emerge from defects in
A group of rare diseases called "ciliopathies"—polycystic kidney disease notable among them—emerge from defects in cilia, the tiny hair-like structures on the surface of almost every cell type. But the specific molecular-level disruptions in cilia that trigger these diseases are poorly understood.
A new microsimulation projects that over the next 20 years, Japanese people will live longer without dementia, but older women with a less than high school education will benefit less than men.
A shortage of some hormone-replacement therapy has left some women struggling with menopause symptoms.
Zolgensma for dementia? AviadoBio gains orphan tag for one-dose gene therapy jwaldron Wed, 04/27/2022 - 07:12
Using a database of 40 million people, a new detailed microsimulation has examined the future of Japan’s aging
Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.
Cancer Research UK, today unveiled Cancer Research Horizons, its new and ambitious approach to driving innovation in the development of new treatments for patients.
Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states-;allowing them to heal damaged tissue at a faster rate than previously observed.
The protein FOXK2 promotes survival of cancer stem cells in ovarian cancer, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
Using lipidomics, a modern analytical method, researchers identified those lipids that are statistically associated with cardiovascular disease and type 2 diabetes. In addition, the scientists found that a diet with an increased proportion of unsaturated fatty acids leads to a reduction in risk-associated lipids and an increase in low-risk lipids.
Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, scientists have found a way to partially reset liver cells to more youthful states -- allowing them to heal damaged tissue at a faster rate than previously observed. The results reveal that the use of reprogramming molecules can improve cell growth, leading to better liver tissue regeneration in mice.
Oscar winners alive today are expected to die aged 81.3, on average, compared with 76.4 for their fellow nominees and 76.2 for their unnominated co-stars
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Trans men’s eggs have been matured in the lab—and could help them have children Ovaries contain hundreds of thousands of underdeveloped eggs, held in a kind of suspended animation. Each month, one matures…
Women are facing unacceptable delays accessing menopause treatments, the Royal Pharmaceutical Society says.
The day I spoke to Jennifer Doudna was a tough day: the US Patent Office had just ruled against her university on CRISPR’s most important uses, handing the commercial rights to her rivals at the Broad Institute of MIT and Harvard. Doudna is the co-discoverer of CRISPR editing, the revolutionary method for engineering genes that,…
Diablo Immortal was built for mobile, but now it's coming to PCs, too Ars TechnicaDiablo Immortal is launching on Android, iOS, and PC on June 2nd The VergeDiablo Immortal is coming to PC after all PC GamerDiablo: Immortal Is Now Coming to PC, Gets June Release Date - IGN IGNDiablo Immortal comes to iPhone and iPad on June 2, 2022 iMoreView Full Coverage on Google News
With the growing demand for new applications in tissue regeneration, the functionalization of melt electrowritten scaffolds has gained the attention of researchers in recent years to fulfill the needs...