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CRISPR

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11.08.2022
01:31 MedicalNewsToday.com High cholesterol: New CRISPR treatment trial could offer permanent cure

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10.08.2022
12:43 Nanowerk.com Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability

Scientists have identify critical spots on the genome where gene editing could cause an unwanted response, and they provide recommendations for safer approaches.

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09.08.2022
18:13 Phys.org Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability

CRISPR/Cas9 is a precise gene editing technique whose development by Jennifer A. Doudna and Emmanuelle Charpentier was recognized with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors," CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

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28.07.2022
17:13 Technology.org CRISPR therapeutics can damage the human genome

A new study from Tel Aviv University (TAU) identifies risks in using CRISPR therapeutics, the innovative, Nobel-prize-winning method that

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04:00 Nature.Com Author Correction: Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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27.07.2022
21:00 Nature.Com Recording gene expression order in DNA by CRISPR addition of retron barcodes

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02:20 ScienceDaily.com CRISPR therapeutics can damage the genome, researchers warn

A new study identifies risks in the use of CRISPR therapeutics -- an innovative, Nobel-prize-winning method that involves cleaving and editing DNA, already employed for the treatment of conditions like cancer, liver and intestinal diseases, and genetic syndromes.

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26.07.2022
15:51 News-Medical.Net Using CRISPR to Lift the Lid on Probiotics

In this interview, we speak to Echo Pan, a Ph.D. student from North Carolina State University about her latest research that used CRISPR to uncover more on probiotics.

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25.07.2022
20:03 News-Medical.Net Using CRISPR technology to successfully prevent and treat SARS-CoV-2 infections

In what is believed to be a first, a research team led by Duke Health has demonstrated a way to use CRISPR technology to successfully prevent and treat COVID infections.

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13:32 News-Medical.Net Study identifies risks in the use of CRISPR therapeutics

The researchers caution: "The CRISPR genome editing method is very effective, but not always safe. Sometimes cleaved chromosomes do not recover and genomic stability is compromised - which in the long run might promote cancer."

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19.07.2022
15:42 News-Medical.Net Scientists manipulate good bacteria using CRISPR systems

New North Carolina State University research shows progress in gathering information on an important – yet difficult to characterize – human gut bacterium called Bifidobacterium, which is used in many probiotics that help maintain healthy microbiomes.

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15.07.2022
21:10 Nature.Com CRISPR ‘cousin’ put to the test in landmark heart-disease trial

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12.07.2022
15:33 TechnologyReview.com The Download: Cutting cholesterol with CRISPR, and the James Webb Space Telescope’s first image

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Edits to a cholesterol gene could stop the biggest killer on earth The news: A volunteer in New Zealand has become the first person to undergo DNA editing in order to lower their…

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08.07.2022
11:03 Technology.org Making CRISPR hype more of a reality

This year we celebrate 10 years of genome editing with CRISPR. The system is often referred to as

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07.07.2022
17:23 Nanowerk.com A potential danger of CRISPR gene editing - and why base editing may be safer

Experimental study in human cells finds large DNA insertions that could increase cancer risk.

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06.07.2022
18:43 Phys.org A potential danger of CRISPR gene editing—and why base editing may be safer

Gene therapy using CRISPR/Cas9 gene editing is currently in clinical trials around the world for a variety of diseases. A report from Boston Children's Hospital, published June 27 in Nature Communications, warns of a potential, previously undiscovered danger of CRISPR editing.

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18:03 Phys.org Making CRISPR hype more of a reality

This year, we celebrate 10 years of genome editing with CRISPR. The system is often referred to as molecular scissors, and this designation is quite accurate for its first applications. These short 10 years were marked by stunningly swift development and a great promise to cure thousands of genetic diseases with relative ease—with a single treatment dose that specifically corrects disease-causing DNA mutations in the body's cells. Sickle cell anemia and muscular dystrophy are two such diseases. And indeed, a decade later, we are now delivering on that promise in the form of many therapies currently being tested in human clinical trials.

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04.07.2022
17:50 Nature.Com Daily briefing: Ten years of CRISPR

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11:13 Nanowerk.com 'Soft' CRISPR may offer a new fix for genetic defects

Targeted repairs with 'nicks' of single DNA strands provide foundation for novel disease therapies.

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10:33 Technology.org “Soft” CRISPR May Offer a New Fix for Genetic Defects

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, the

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03.07.2022
20:23 News-Medical.Net New, safer CRISPR approach may help correct genetic defects in the future

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

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01.07.2022
23:10 NewScientist.Com ‘Softer’ form of CRISPR may edit genes more accurately

Gene editing with CRISPR can cause off-target mutations, but this seems to happen less often with an enzyme that cuts one of the strands of DNA instead of both

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22:10 ScienceDaily.com 'Soft' CRISPR may offer a new fix for genetic defects

Scientists have developed a new CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new 'soft' CRISPR approach makes use of natural DNA repair machinery, providing a foundation for novel gene therapy strategies with the potential to cure a large spectrum of genetic diseases.

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21:03 Phys.org 'Soft' CRISPR may offer a new fix for genetic defects

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

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09:33 Technology.org In 10 years, CRISPR transformed medicine. Can it now help us deal with climate change?

Coming from a long line of Iowa farmers, David Savage always thought he would do research to improve crops.

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30.06.2022
14:33 Technology.org The experiment uses CRISPR-Cas to successfully diagnose diseases in space

Tel Aviv University (TAU) researchers recently conducted a unique experiment in the International Space Station to test genetic

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11:32 News-Medical.Net A fast, highly sensitive, point-of-care RT-LAMP and CRISPR/Cas12a assay for the detection of SARS-CoV-2

Researchers used isothermal amplification with CRISPR-Cas12a to detect SARS-CoV-2.

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08:22 News-Medical.Net HKUMed researchers discover more efficient CRISPR-Cas9 variants for gene therapy applications

A research team from the LKS Faculty of Medicine, The University of Hong Kong discovered more efficient CRISPR-Cas9 variants that could be useful for gene therapy applications.

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29.06.2022
14:20 NewScientist.Com What's next for the gene-edited children from CRISPR trial in China?

Scientists in China are considering how best to look after three children who were gene-edited as embryos in He Jiankui’s controversial experiment

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27.06.2022
20:12 NYT Science The Many Uses of CRISPR: Scientists Tell All

What do infectious diseases, T-cells, tomatoes, heart failure, sickle cell anemia and sorghum harvests have in common?

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20:02 NYT Science CRISPR, 10 Years On: Learning to Rewrite the Code of Life

The gene-editing technology has led to innovations in medicine, evolution and agriculture — and raised profound ethical questions about altering human DNA.

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20:02 NYT Health CRISPR, 10 Years On: Learning to Rewrite the Code of Life

The gene-editing technology has led to innovations in medicine, evolution and agriculture — and raised profound ethical questions about altering human DNA.

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20:02 NYT Health The Many Uses of CRISPR: Scientists Tell All

What do infectious diseases, T-cells, tomatoes, heart failure, sickle cell anemia and sorghum harvests have in common?

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20.06.2022
17:11 SingularityHub.Com Scientists Used CRISPR to Trace Every Human Gene to Its Function

Genes are like Egyptian hieroglyphs. Thanks to advances in whole-genome sequencing, it’s increasingly easy to read each DNA letter. But the strings of A, T, C, and G bring up a second puzzle: what, if anything, do they mean? It’s a problem that has haunted biologists since the completion of the Human Genome Project. By […]

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16.06.2022
14:00 NewScientist.Com Children to get CRISPR treatment for sickle cell disease in trial

CRISPR gene-editing trials for treating beta thalassemia and sickle cell disease are being extended to include people under the age of 12 after positive results in older people

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15.06.2022
18:53 Phys.org Highly effective CRISPR-mediated gene editing technique for cultured oysters

The oysters, as the representative bivalve mollusk, are widely distributed and support major aquaculture and fishery industries worldwide. However, oysters are still at an early stage of domestication.

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14.06.2022
13:22 TechnologyReview.com These scientists want to capture more carbon with CRISPR crops

Plants are the original carbon capture factories—and a new research program aims to make them better ones by using gene editing. The Innovative Genomics Institute (IGI), a research group in Berkeley, California, founded by CRISPR co-inventor Jennifer Doudna, has announced a new program to use the revolutionary gene-editing tool on plants to boost their aptitude…

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13.06.2022
16:33 Phys.org New 'decision aid' for CRISPR immune responses

Friend or foe? Immune systems constantly face this question. They must recognize and clear foreign invaders without eliciting autoimmunity. Prokaryotic CRISPR-Cas systems recognize invaders based on genetic sequence. But what happens if the host genome shares the same sequences? A research team from the Helmholtz Institute in Würzburg in cooperation with the North Carolina State University (U.S.) has now discovered a control mechanism exhibited by CRISPR-Cas systems that use Cas13 nucleases. These systems only trigger an extensive immune response if the concentration of the target RNA exceeds a certain threshold. This discovery opens new opportunities for the use of CRISPR-Cas13 in the treatment of hereditary and infectious diseases. The scientists have published their findings in the journal Cell Host & Microbe.

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12:03 Technology.org A New CRISPR-based map ties every human gene to its function

The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew

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09.06.2022
19:03 Nanowerk.com Researchers use CRISPR technology to create map tying every human gene to its function

Scientists used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell and creating a free resource for other researchers.

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18:03 Phys.org Researchers use CRISPR technology to create map tying every human gene to its function

The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including Whitehead Institute, and was finally completed in 2003. Now, over two decades later, Whitehead Institute Member Jonathan Weissman and colleagues have gone beyond the sequence to present the first comprehensive functional map of genes that are expressed in human cells. The data from this project, published online June 9 in Cell, ties each gene to its job in the cell, and is the culmination of years of collaboration on the single-cell sequencing method Perturb-seq.

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06.06.2022
17:10 SingularityHub.Com New CRISPR Tool Protects Against Viruses Without Making Any DNA Cuts

When CRISPR first burst onto the biotech scene, it rose to fame for its precise cutting prowess—break a target DNA strand, silence a gene. But the tool came with hiccups. While far more efficient than previous tools for tinkering with the genome, CRISPR-Cas9 was at its core a genetic butcher. To edit a gene, the […]

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07:21 News-Medical.Net CRISPR-based diagnostics for SARS-CoV-2 detection

In a recent study posted to the Journal of Biochemical and Molecular Toxicology, researchers reviewed clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostics for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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02.06.2022
00:13 ScienceMag.org Better than CRISPR? Another way to fix gene problems may be safer and more versatile

Epigenome editing flips genetic on-off switches in mouse studies

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01.06.2022
00:33 Phys.org Neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme

Last year, researchers at MIT's McGovern Institute for Brain Research discovered and characterized Cas7-11, the first CRISPR enzyme capable of making precise, guided cuts to strands of RNA without harming cells in the process. Now, working with collaborators at the University of Tokyo, the same team has revealed that Cas7-11 can be shrunk to a more compact version, making it an even more viable option for editing the RNA inside living cells. The new, compact Cas7-11 was described May 27 in the journal Cell along with a detailed structural analysis of the original enzyme.

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31.05.2022
17:03 AzoNano.com Nano-CRISPR Approach to Clearing Food Industry Pathogens

Foodborne pathogens are multidrug-resistant (MDR) and cause a significant problem in food industries. An article published in the journal Materials Today Bio discusses repurposing the bacterial...

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26.05.2022
02:40 ScienceDaily.com Researchers use CRISPR technology to modify starches in potatoes

Humble potatoes are a rich source not only of dietary carbohydrates for humans, but also of starches for numerous industrial applications. Scientists are learning how to alter the ratio of potatoes' two starch molecules -- amylose and amylopectin -- to increase both culinary and industrial applications.

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25.05.2022
23:53 Phys.org Researchers use CRISPR technology to modify starches in potatoes

Humble potatoes are a rich source not only of dietary carbohydrates for humans, but also of starches for numerous industrial applications. Texas A&M AgriLife scientists are learning how to alter the ratio of potatoes' two starch molecules—amylose and amylopectin—to increase both culinary and industrial applications.

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20:24 Gizmodo.com Scientists CRISPR'd Tomatoes to Make Them Full of Vitamin D

The tomatoes of the future could help boost your levels of the sunshine vitamin. Researchers in the UK say they’ve developed genetically edited tomatoes that can produce high levels of vitamin D with just an hour of ultraviolet light exposure. These edited tomatoes would ideally help provide a rich and plant-based… Read more...

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24.05.2022
00:50 ScienceDaily.com New CRISPR-combo boosts genome editing power in plants

Scientists have developed CRISPR-Combo, a method to edit multiple genes in plants while simultaneously changing the expression of other genes. This new tool will enable genetic engineering combinations that work together to boost functionality and improve breeding of new crops.

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23.05.2022
22:32 FierceBiotech.com Precision BioSciences makes case for 2 gene editing programs over CRISPR with preclinical data

Precision BioSciences makes case for 2 gene editing programs over CRISPR with preclinical data mbayer Mon, 05/23/2022 - 11:10

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22:13 Phys.org New 'CRISPR-Combo' method boosts genome editing power in plants

Ten years ago, a new technology called CRISPR-CAS9, made it possible for scientists to change the genetic code of living organisms. As revolutionary as it was, the tool had its limitations. Like the first cell phones that could only perform one function, the original CRISPR method can perform one function: removing or replacing genes in a genetic sequence. Later iterations of CRISPR were developed for another function that allowed scientists to change gene expression by turning them on or off, without removing them from the genome. But each of these functions could only be performed independently in plants.

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19.05.2022
23:40 ScienceDaily.com CRISPR-based strategy edits multiple genes and could treat polygenic diseases

Engineers introduce DAP, a streamlined CRISPR-based technology that can perform many genome edits at once to address polygenic diseases caused by more than one glitch.

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13:03 FierceBiotech.com J&J-backed Locus closes $35M financing to push CRISPR-based antibacterial drug into phase 2/3

J&J-backed Locus closes $35M financing to push CRISPR-based antibacterial drug into phase 2/3 gmasson Wed, 05/18/2022 - 15:08

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16.05.2022
20:50 ScienceDaily.com CRISPR now possible in cockroaches

Researchers have developed a CRISPR-Cas9 approach to enable gene editing in cockroaches, according to a new study. The simple and efficient technique, named 'direct parental' CRISPR (DIPA-CRISPR), involves the injection of materials into female adults where eggs are developing rather than into the embryos themselves.

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18:50 ScienceDaily.com CRISPR-Cas9 gene editing approach can alter the social behavior of animals

New gene-editing techniques are shedding light on how hormones impact social behavior in animals and possibly, humans.

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18:23 Phys.org Researchers find CRISPR-Cas9 gene editing approach can alter the social behavior of animals

Georgia State University scientists have created gene-edited hamsters for studies of social neuroscience and have found that the biology behind social behavior may be more complex than previously thought.

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18:03 Phys.org CRISPR now possible in cockroaches

Researchers have developed a CRISPR-Cas9 approach to enable gene editing in cockroaches, according to a study published by Cell Press on May 16th in the journal Cell Reports Methods. The simple and efficient technique, named "direct parental" CRISPR (DIPA-CRISPR), involves the injection of materials into female adults where eggs are developing rather than into the embryos themselves.

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17:10 SingularityHub.Com A One-and-Done CRISPR Gene Therapy Will Aim to Prevent Heart Attacks

In a few months, a daring clinical trial may fundamentally lower heart attack risk in the most vulnerable people. If all goes well, it will just take one shot. It’s no ordinary shot. The trial, led by Verve Therapeutics, a biotechnology company based in Massachusetts, will be one of the first to test genetic base […]

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11.05.2022
23:10 ScienceDaily.com Novel supramolecular CRISPR-Cas9 carrier enables more efficient genome editing

CRISPR-Cas9 is considered a revolutionary gene editing tool, but its applications are limited by a lack of methods by which it can be safely and efficiently delivered into cells. Recently, a research team has constructed a highly flexible CRISPR-Cas9 carrier using aminated polyrotaxane (PRX) that can not only bind with the unusual structure of Cas9 and carry it into cells, but can also protect it from intracellular degradation by endosomes.

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18:33 Phys.org Novel supramolecular CRISPR–Cas9 carrier enables more efficient genome editing

CRISPR-Cas9 is considered a revolutionary gene editing tool, but its applications are limited by a lack of methods by which it can be safely and efficiently delivered into cells. Recently, a research team from Kumamoto University, Japan, have constructed a highly flexible CRISPR-Cas9 carrier using aminated polyrotaxane (PRX) that can not only bind with the unusual structure of Cas9 and carry it into cells, but can also protect it from intracellular degradation by endosomes.

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10.05.2022
14:04 CancerNetwork.com CRISPR Patent Battle: Beautiful Science, Poor Public Policy

In this month's Letter to the Readers, ONCOLOGy co-editor-in-chief Howard Hochster, MD, reviews the implications of legal disputes surrounding patents for CRISPR technology.

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27.04.2022
14:12 Nature.Com China focuses on ethics to deter another ‘CRISPR babies’ scandal

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13:53 News-Medical.Net CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

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26.04.2022
15:53 TechnologyReview.com The Download: Fertility for trans men, and a Q&A with CRISPR’s co-creator

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Trans men’s eggs have been matured in the lab—and could help them have children Ovaries contain hundreds of thousands of underdeveloped eggs, held in a kind of suspended animation. Each month, one matures…

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12:22 TechnologyReview.com The scientist who co-created CRISPR isn’t ruling out engineered babies someday

The day I spoke to Jennifer Doudna was a tough day: the US Patent Office had just ruled against her university on CRISPR’s most important uses, handing the commercial rights to her rivals at the Broad Institute of MIT and Harvard. Doudna is the co-discoverer of CRISPR editing, the revolutionary method for engineering genes that,…

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21.04.2022
18:53 Phys.org Nanocapsule carrying a CRISPR-Cas9 editing tool used for noninvasive brain delivery and tumor cell targeting

An international team of researchers has developed a nanocapsule that is capable of crossing the blood brain barrier (BBB) to carry the CRISPR-Cas9 editing tool to treat a brain tumor. In their paper published in the journal Science Advances, the group describes how they created their capsule and how well it worked when tested in mice with a glioblastoma.

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16:51 News-Medical.Net CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs

Researchers developed a clustered regularly interspaced short palindromic repeats-based diagnostic technique for detecting SARS-CoV-2 RNA.

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20.04.2022
23:20 NewScientist.Com CRISPR nanocapsule limits growth of aggressive brain tumours in mice

Tiny capsule that delivers CRISPR gene therapy to the brain could be used to target glioblastoma tumours

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09:21 News-Medical.Net Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance:

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14.04.2022
13:41 News-Medical.Net Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

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10.04.2022
13:32 Technology.org CRISPR gene editing reveals the biological mechanism behind common blood disorder

Asymptomatic sickle cell disease patients actually lack a tiny part of the genome, UNSW scientists have shown. UNSW

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08.04.2022
20:40 ScienceDaily.com CRISPR gene editing reveals biological mechanism behind common blood disorder

Researchers have used CRISPR gene editing -- a type of 'molecular scissors' -- to understand how deletions in one area of the genome can affect the expression of nearby genes. The work will help researchers investigate new therapeutic approaches for one of the world's most devastating genetic blood disorders -- sickle cell disease. Asymptomatic sickle cell disease patients actually lack a tiny part of the genome, scientists have shown.

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17:00 SingularityHub.Com Scientists Are Using CRISPR Gene Editing to Try to Create Hypoallergenic Cats

There’s been a lot of buzz in the last few years about the perils of using CRISPR gene editing on human germline cells—the reproductive cells that determine the DNA of every other cell in the body. The idea of CRISPR babies (hypothetical as far as we know, except in the case of Chinese scientist He […]

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06.04.2022
13:30 Nature.Com Daily briefing: CRISPR-baby scientist released from prison

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05.04.2022
13:43 Technology.org CRISPR and HIV: New technique in human blood unveils potential paths toward cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could

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01:12 FierceBiotech.com CRISPR patent dispute not over yet as Charpentier, universities appeal

CRISPR patent dispute not over yet as Charpentier, universities appeal aarmstrong Mon, 04/04/2022 - 16:12

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04.04.2022
20:42 TechnologyReview.com The creator of the CRISPR babies has been released from a Chinese prison

The daring Chinese biophysicist who created the world’s first gene-edited children has been set free after three years in a Chinese prison. He Jiankui created shockwaves in 2018 with the stunning claim that he’d altered the genetic makeup of IVF embryos and implanted them into a woman’s uterus, leading to the birth of twin girls. A…

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02.04.2022
20:40 ScienceDaily.com CRISPR and HIV: New technique in human blood unveils potential paths toward cure

Gene editing used to discover human proteins hijacked by HIV to replicate in blood • By better understanding how the virus replicates, treatments could one day become cures • 'This new assay is the most faithful representation of what's happening in the body during HIV infection that we could easily study in the lab,' researcher says • Over half the genes identified in the study had never been looked at in the context of HIV infection

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06:32 News-Medical.Net Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

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30.03.2022
00:40 ScienceDaily.com Researchers expand target range of CRISPR/Cas Systems

Researchers have created a genome editing technology that allows for slight variations in target DNA but retains local specificity, and which could help realize the potential of CRISPR/Cas-based gene therapy and pathogen diagnosis.

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29.03.2022
05:12 NewScientist.Com US biofirm plans to make hypoallergenic cats using CRISPR gene editing

A US company has deleted the genes for the allergy-causing protein in cat cells as a first step towards creating cats that don't trigger allergies

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28.03.2022
17:10 SingularityHub.Com Redesigned CRISPR Gene Editing Tool Is 4,000 Times Less Error-Prone

CRISPR gene editing holds huge promise for tackling a wide range of inherited diseases, but concerns about unintended “off target” effects has slowed its rollout. A redesigned CRISPR system could finally have a practical solution to this problem. Last month, biomedical company Intellia reported promising results from a phase one trial of a CRISPR therapy […]

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25.03.2022
16:10 Phys.org Using CRISPR to turn off genes in corn and rice to improve crop yields

A team of researchers affiliated with a large number of institutions in China and one in Germany has found that turning off a certain gene in corn and rice can lead to improvements in crop yields. In their paper published in the journal Science, the group describes mapping the genomes of both plants as a way to search for genes associated with grain yield using CRISPR gene editing to improve yields in test crops.

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10:13 NewScientist.Com Rice and maize yields boosted up to 10 per cent by CRISPR gene editing

It is possible to significantly boost the yield of rice and maize using CRISPR gene editing, trials in farm fields show

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22.03.2022
20:43 Nature.Com Publisher Correction: Structural basis for mismatch surveillance by CRISPR–Cas9

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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14:10 Phys.org New CRISPR element regulates viral defense

What tasks need to be done today, and which is the most urgent? People have to constantly set priorities in their daily life. Bacteria are no different: They too must prioritize when combating viruses with CRISPR. However, it was unclear how this prioritization takes place. Scientists from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a joint venture of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Julius Maximilian University (JMU) Würzburg, in cooperation with researchers from the universities of Würzburg, Freiburg and Leipzig, have now described an underlying mechanism for the first time. Their study was published in the journal Nature Microbiology.

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05:49 News-Medical.Net Using CRISPR/Cas to develop biosafety materials

Researchers discuss the use of the highly efficient CRISPR/Cas technologies to identify viral genome sequences for biosafety purposes.

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21.03.2022
19:45 Nanowerk.com New CRISPR element regulates viral defense

Mechanism for prioritizing the immune response discovered.

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14.03.2022
13:48 News-Medical.Net Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

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12.03.2022
21:34 Nature.Com Daily briefing: CRISPR patent ruling won’t be the end of it

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09.03.2022
19:17 Nature.Com Major CRISPR patent decision won’t end tangled dispute

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19:08 Phys.org Beyond CRISPR: New DNA tools rewrite genes to fight diseases like COVID-19

When Emmanuelle Charpentier and Jennifer Doudna won the Nobel Prize in Chemistry in 2020, their CRISPR gene editor had revolutionized medicine, agriculture, and genetics in just a few short years. But already, plans were in the works to move beyond CRISPR's simple scissors, which snip genes out of a DNA sequence.

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08.03.2022
18:21 SingularityHub.Com CRISPR On-Off Switch Will Help Uncover Mysteries of Our Immune System

T cells are fierce warriors. With just a hint of an attack—be it an infection or a nascent cancer—they rally, ramp up in numbers, and launch a full-scale defense. But they’re not invincible. Sometimes the cellular soldiers become overzealous, attacking friendly tissues. Or their defenses are wiped out by particularly heinous foes, like HIV and […]

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02.03.2022
19:45 Nature.Com Structural basis for mismatch surveillance by CRISPR–Cas9

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26.02.2022
11:25 Nanowerk.com A boost for CRISPR research

Researchers demonstrate a new way to study CRISPR systems that can accelerate their conversion into tools.

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25.02.2022
17:17 Phys.org New approach enables faster characterization of CRISPR immune systems

For many diseases, the tools of medicine are reaching their limits. CRISPR technologies open new avenues for diagnostics and therapies, although the natural source of CRISPR remains largely untapped. Scientists from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a joint venture of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Julius Maximilian University (JMU) Würzburg, now demonstrate a new way to study CRISPR systems that can accelerate their conversion into tools. Their approach was published today in the journal Molecular Cell.

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05:37 Nature.Com How to protect the first ‘CRISPR babies’ prompts ethical debate

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

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16.02.2022
14:51 News-Medical.Net CRISPR-Cas12a assay to diagnose SARS-CoV-2 infection and detect strain-specific SNPs for variant identification

The multiplex detection approach outlined in this study has the potential to address the need to rapidly characterize the phenotype and clinical response to continually emerging SARS-CoV-2 variants as the COVID-19 pandemic continues.

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11.02.2022
19:26 AzoNano.com CRISPR-Cas9 Non-Viral Nanocarriers

Non-viral vectors based on nanotechnology are a novel piece of research for use as carriers in order to replace conventional viral vectors within the delivery of the CRISPR-Cas9 system. This research...

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