Techh.info/biomedtechnology hourly

Life Extension

headlines texts
18.08.2022
13:21 FightAging.Org Towards the Widespread Use of Gerotherapeutic Drugs to Slow Aging

Many compounds, small molecules, plant extracts, and so forth, have been found to modestly slow aging in mice. Given accumulating evidence from animal studies and human clinical trials, and that a sizable fraction of these compounds are already approved by regulators for other uses, or otherwise readily available, it is inevitably the case that physicians and the population at large will begin make use of these treatments in increasing numbers. This will happen, sometimes ahead of the science, sometimes behind it, sometimes to little benefit to patients, sometimes with enough of a benefit to matter. Navigating the options will become a great deal harder than it was, as we transition from an era in which little to nothing could be done to change the pace […]

Скрыть анонс
17.08.2022
21:13 Technology.org Large number of stem cell lines carry significant DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived

Скрыть анонс
17:23 Technology.org RNA-based approach identified for treatment of premature aging and associated diseases

Scientists at King Abdullah University of Science and Technology (KAUST), in collaboration with a team at the Salk Institute and Alto Labs,

Скрыть анонс
13:21 FightAging.Org Using Public Support to Lobby for Greater Public Funding of Aging Research

I don't pay a great deal of attention to the political lobbying efforts that take place in the community of supporters of aging research, as governmental funding is usually the last to the table, arriving long after the hard work of opening up a new field is done. There are a number of lobbying groups actively working in the US political system, and some single-issue political parties in Europe performing an analogous function. The material here is an example of the work taking place amongst those who lobby, the Alliance for Longevity Initiatives in this case. It is the business of persuading politicians that it is in their short-term interest to divert more funding into useful programs, while hoping that said funding doesn't just get […]

Скрыть анонс
16.08.2022
22:11 Medscape.Com Treating the Growing Population of Centenarians

Less can be more in caring for the post-100 set.

Скрыть анонс
21:43 News-Medical.Net Peter Adams and Bing Ren receive NIH grant to join multi-institution initiative studying the aging process

Peter Adams, Ph.D., and Bing Ren, Ph.D., have been awarded a new grant from the National Institutes of Health (NIH) to join a multi-institution initiative studying the process of aging.

Скрыть анонс
16:23 News-Medical.Net Inventia Life Science partners with Xylyx Bio to develop tissue-specific, digitally-printed bioinks for drug discovery

Inventia Life Science and Xylyx Bio today announced their strategic partnership following promising results developing more realistic, scalable, and reproducible 3D cell cultures for drug discovery and biomedical research.

Скрыть анонс
16:04 CancerNetwork.com GVHD in the Context of Stem Cell or Allogeneic Transplant

Expert panelists elucidate the occurrence of graft vs host disease in patients receiving either stem cell or allogeneic transplantation.

Скрыть анонс
16:03 Phys.org Cells regulating blood stem cell maintenance are diverse and conserved between species

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

Скрыть анонс
15:03 News-Medical.Net Elderly populations: Global trends in the healthy aging market

To be decided by the editor

Скрыть анонс
13:32 FightAging.Org Discussing the State of the TAME Clinical Trial, Metformin to Slow Aging

The TAME clinical trial, still not started, intends to assess the ability of metformin to marginally slow aging in humans. Back at the start of this initiative, it required a long process of negotiation on the part of the trial organizers with the FDA to produce an endpoint that was agreed upon to sufficiently represent aging. To my mind, the TAME trial initiative has already achieved what needs to be achieved: to get the FDA to agree that there is a way to run trials to treat aging. One doesn't actually need to run the trial, and there is in fact little point in running the trial. Metformin is almost certainly a marginal treatment, and attention should be directed instead towards senolytics and other approaches […]

Скрыть анонс
15.08.2022
22:43 Phys.org Similarity of hepatocytes from liver and from stem cells improved

Research with stem cells is becoming increasingly important, because stem cells can develop into any body cell—skin cells, nerve cells or organ cells such as liver cells, the so-called hepatocytes. Stem cells can therefore be used, for example, in therapy for organ damage or as an alternative to animal experiments.

Скрыть анонс
16:53 Phys.org Potential anti-aging components of Moringa oleifera leaf

Moringa oleifera Lam., also known as Miracle Tree, primarily derived from India, is now widely distributed in tropical and subtropical regions. Previous studies have showed that M. oleifera has anti-aging effects, but there is a lack of in-depth research on the specific active ingredients and mechanisms of this anti-aging activity. Researchers are working to screen out the most effective active components of M. oleifera leaves.

Скрыть анонс
14.08.2022
14:22 FightAging.Org Fight Aging! Newsletter, August 15th 2022

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents A Short Commentary on Why We Advocate for the Treatment of Aging The Anti-Longevity Rhetoric that Characterizes Much of Aging Research Cellular Senesence, a Key Target in the Treatment of Aging Epigenetic Clocks Do Not Strongly Reflect Inflammatory Status? […]

Скрыть анонс
12:23 LiveScience.com Does drinking coffee help you live longer?

Habitual coffee consumption may lower your risk of heart disease and death in a given time period, but the jury is still out on whether it promotes longevity.

Скрыть анонс
11:33 Technology.org Calorie reduction lowers protein linked to the aging process

Reduced calorie intake has been shown to improve health and lifespan in laboratory animals, and recent research shows

Скрыть анонс
13.08.2022
10:22 MedicalNewsToday.com What a blood transfusion experiment in mice can teach us about aging

Mnt News RSS Feed

Скрыть анонс
10:03 Technology.org See-through zebrafish, a new imaging method, put blood stem cells in a high-resolution spotlight

For the first time, researchers can get a high-resolution view of single blood stem cells thanks to a

Скрыть анонс
12.08.2022
13:31 FightAging.Org Pace of Life and and the Longevity Resulting From Growth Hormone Deficiency in Mice

The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of us. Mice with genetic growth hormone (GH) deficiency or GH resistance live much longer than their normal siblings maintained under identical conditions […]

Скрыть анонс
13:22 FightAging.Org Inflammation and Cellular Senescence in the Aging Lung

Here, researchers discuss what is known of the role of senescent cells, and the chronic inflammation that they create, in the aging of the lung. The first human trials of senolytic therapies to selectively destroy senescent cells were aimed at reversal of idiopathic pulmonary fibrosis. There is a good evidence for the growing presence of senescent cells to disrupt tissue maintenance and produce fibrosis as a result, the deposition of excessive, scar-like collagen structures that harm tissue function. There is a little that can be done to reverse fibrotic disease in the clinic, but animal studies showing improvement following clearance of senescent cells have given some hope for progress on this front. Cellular senescence, a coordinated cellular response to stress characterized by permanent cell cycle […]

Скрыть анонс
11.08.2022
23:44 DigitalTrends.com Oppo’s latest Apple Watch clone has an important spec under the hood

Oppo has just announced the first smartwatches with Qualcomm’s new Snapdragon W5 Gen 1 chip and a fascinating new design.

Скрыть анонс
18:03 Phys.org Large number of stem cell lines carry significant DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

Скрыть анонс
16:03 AzoNano.com Breakthrough Silicon Carbide Technology Brings Flexible, Implanted Devices Closer to Clinical Applications

Flexible implanted electronics are a step closer toward clinical applications thanks to a recent breakthrough technology developed by a research team from Griffith University and UNSW Sydney. ...

Скрыть анонс
13:32 FightAging.Org The Inflammatory Burden of Infection Accelerates Hematopoietic Aging

Researchers here provide evidence for the inflammatory burden of infection to accelerate the aging of the hematopoietic system responsible for generating blood and immune cells. A greater exposure to infectious disease throughout life may be causing presently irreversible damage in the stem cell populations that produce the immune system. It is already known that restoration of these stem cell populations is an important target for the rejuvenation of the aged immune system, along with regeneration of the thymus and clearance of misconfigured and damaged populations of immune cells. It is unclear as to which of the many potential approaches to rejuvenation of hematopoietic stem cells will first succeed to a useful degree, but it seems likely that some form of cell therapy will be needed, […]

Скрыть анонс
04:12 News-Medical.Net Scientists discover new target for treatment of premature aging disorders

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology in Saudi Arabia have discovered.

Скрыть анонс
01:13 News-Medical.Net Breakthrough technology brings flexible implanted electronics are a step closer toward clinical applications

Flexible implanted electronics are a step closer toward clinical applications thanks to a recent breakthrough technology developed by a research team from Griffith University and UNSW Sydney.

Скрыть анонс
10.08.2022
23:01 FightAging.Org Cellular Senesence, a Key Target in the Treatment of Aging

Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system. Later in life, this balance between creation and destruction shifts, however, particularly because the immune system becomes less capable. As a result senescent cells begin to accumulate in tissues throughout the […]

Скрыть анонс
19:03 Phys.org Performance life span of workers mapped in new research

The performance of workers across their employment life span has been mapped by a new study, which found that more complex jobs can help employees to maintain their ability to be proactive and adaptive at work as they grow older.

Скрыть анонс
18:03 Phys.org Female monkeys with female friends live longer

Female white-faced capuchin monkeys living in the tropical dry forests of northwestern Costa Rica may have figured out the secret to a longer life—having fellow females as friends.

Скрыть анонс
13:32 FightAging.Org Klotho in the Pathology of Aging

Klotho is a longevity-associated protein; more of it slows aging, less of it accelerates aging, at least in animal studies. While researchers have spent considerable effort investigating the effects of klotho on the brain, as it improves cognitive function, it seems likely that its effects arise via improved kidney function in old age. Loss of kidney function, and thus clearance of metabolic toxins and waste from the bloodstream, is harmful to tissues throughout the body. Manipulation of klotho may be a good way to assess just how much harm is generated by the age-related decline of the kidneys. The subject of this review is Klotho (kl), which is an antiaging gene, and the corresponding protein α-Klotho (henceforth denoted Klotho or KL). The gene was first […]

Скрыть анонс
13:22 FightAging.Org Hypoxia, Inflammation, and Cellular Senescence

Researchers here review what is know of links between hypoxia and the onset of inflammation in age-related disease. Hypoxia in tissues can arise for a range of reasons in aging, and the processes of regulation that respond to localized hypoxia, primarily in order to induce regrowth of blood vessels to the affected region, may be meaningfully detrimental when consistently triggered. Inflammation is involved in this response, while chronic inflammation is a well-known feature of aging, driving numerous forms of tissue dysfunction. When tissues are subjected to acute injury resulting in ischemia/hypoxia, cells adapt to the hypoxic environment by inducing the expression of a number of adaptive genes and regulating post-translational modifications. These adaptive changes in tissue cells in hypoxic environments are controlled by the HIF […]

Скрыть анонс
09:33 Phys.org See-through zebrafish, new imaging method put blood stem cells in high-resolution spotlight

For the first time, researchers can get a high-resolution view of single blood stem cells thanks to a little help from microscopy and zebrafish.

Скрыть анонс
06:20 NewScientist.Com Bats show fewer signs of ageing while they are hibernating

Similarly to marmots, a brown bat species (Eptesicus fuscus) expresses reduced ageing biomarkers while hibernating

Скрыть анонс
02:03 Phys.org Hibernation slows biological aging in bats

The most common bat in the United States, the big brown bat, boasts an unusually long lifespan of up to 19 years. A new study led by University of Maryland researchers identifies one of the secrets to this bat's exceptional longevity: hibernation.

Скрыть анонс
02:03 Phys.org New study shows that aging neutralizes sex differences in the brain

When male and female fruit flies age, their brains become desexualized. Age-related changes take place in both sexes, but the male brain becomes feminized to a larger extent than the female brain becomes masculinized. This is the conclusion of a study performed by a research group at Linköping University. The findings are published in the journal Proceedings of the Royal Society B: Biological Sciences.

Скрыть анонс
09.08.2022
22:22 FightAging.Org The Anti-Longevity Rhetoric that Characterizes Much of Aging Research

Sizable contingents in the aging research community and longevity industry like to assure us that greater human longevity is not in fact the goal of the growing level of investment in research and development of means to treat aging, or even desirable for that matter. It is a strange phenomenon. Cynically, one might suspect that those working on approaches based on cellular stress response upregulation, mimicking calorie restriction, that cannot in fact do much to extend life in longer-lived species such as our own, and will at best incrementally improve late-life health, are trying to make their work look better to the groups that funded it. Regardless of motivation, I think that propagating this sort of viewpoint is harmful to the future of the field. […]

Скрыть анонс
13:31 FightAging.Org SENS Research Foundation's Ending Aging Forum, September 2022

The SENS Research Foundation is hosting an online presentation of their work next month, a virtual Ending Aging Forum. If you are interested in the projects presently underway at the Foundation, and in allied labs, then mark your calendars. While the SENS view of aging as a process of damage accumulation, accompanied by a set of specific approaches to be taken to produce rejuvenation, has diffused somewhat into the broader longevity industry, that industry remains largely working on metabolic manipulation to slightly slow aging, not actual repair of damage. There is still a role for organizations focused on the SENS approach to aging and rejuvenation, accelerating the path towards meaningful rejuvenation therapies. Come spend a wonderful and thought provoking time with the team at SENS […]

Скрыть анонс
08.08.2022
22:21 FightAging.Org A Short Commentary on Why We Advocate for the Treatment of Aging

Recently, I had the occasion to make one of my very infrequent trips to the emergency room. As always the case to date, I get to walk out afterwards, after a very long period of hurry up and wait. Not everyone is so fortunate. One of the things one tends to find in emergency rooms is old people. So many more of life's slings and arrows become an emergency when one is frail, and old people are increasingly frail. Fall over? Emergency room. Sudden infection? Emergency room. And so on and so forth. Nurses and doctors are inordinately overworked, and there is a long backstory to this state of affairs in which the American Medical Association, generations of regulators, and hospital owners all play the […]

Скрыть анонс
18:35 QuantaMagazine.org A Biochemist’s View of Life’s Origin Reframes Cancer and Aging

The biochemist Nick Lane thinks life first evolved in hydrothermal vents where precursors of metabolism appeared before genetic information. His ideas could lead us to think differently about aging and cancer. The post A Biochemist’s View of Life’s Origin Reframes Cancer and Aging first appeared on Quanta Magazine

Скрыть анонс
18:13 AzoNano.com Stem Cell Membrane-Coated Nanoparticles in Tumor Therapy

Cell membrane-coated nanoparticles, applied in targeted drug delivery strategies, combine the intrinsic advantages of synthetic nanoparticles and cell membranes. Although stem cell-based delivery...

Скрыть анонс
17:21 News-Medical.Net Prolonged loneliness in older adults may be an important risk factor for accelerated memory aging

Prolonged loneliness in adults over 65 may be an important risk factor for accelerated memory aging, according to a new study led by University of Michigan School of Public Health researchers.

Скрыть анонс
16:33 Phys.org Mystery cells that create blood stem cells in mammals identified

Imagine if one day blood transfusions from strangers were not needed because they could be produced from cells that line your own blood vessels' cells.

Скрыть анонс
16:10 Nature.Com Author Correction: An open science study of ageing in companion dogs

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

Скрыть анонс
16:03 Phys.org A van der Waals force-based adhesion study of stem cells exposed to cold atmospheric jets

Cold atmospheric plasma can affect cell adhesion with a significant role in stem cell adhesion. In a new study now published in Scientific Reports, Kobra Hajizadeh and a team of researchers in the departments of physics and plasma research at the Islamic Azhad University and the CNRS, France, studied the effect of plasma treatment on human bone marrow mesenchymal stem cell (HBMMSC) adhesion to understand cell differentiation and cell fate.

Скрыть анонс
07.08.2022
13:52 FightAging.Org Fight Aging! Newsletter, August 8th 2022

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Changes in the Behavior of Lipid Rafts in Aging Aging and the Severity of Inflammatory Infectious Disease Such as SARS-CoV-2 Are Pharmacological Approaches to Slow Aging in Fact Promising? Interviews on Aspects of Aging with Judith Campisi and Dena […]

Скрыть анонс
05.08.2022
16:42 News-Medical.Net NHS Golden Jubilee orthopedic surgeons perform the first meniscal transplant in Scotland

Orthopaedic surgeons at NHS Golden Jubilee have performed the first meniscal transplant on a patient in Scotland.

Скрыть анонс
15:00 NewScientist.Com Transfusing blood from an old mouse to a younger mouse causes ageing

The transfusion led an increased number of senescent cells – which accumulate as we get older - in the young mice, suggesting that cellular ageing isn't just a case of wear and tear

Скрыть анонс
13:13 Technology.org Scientists identify key mechanism controlling skin regeneration

It’s sunburn season. Many of us have experienced the pain and peeling from unprotected sun exposure. Still, we

Скрыть анонс
06:02 News-Medical.Net Hyaluranic acid wakes up stem cells to start muscle repair

A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair.

Скрыть анонс
04.08.2022
23:02 FightAging.Org Interviews on Aspects of Aging with Judith Campisi and Dena Dubal

Today I'll point out a pair of interviews with researchers Judith Campisi and Dena Dubal, in which they discuss quite different aspects of aging. Campisi's research has a heavy focus on cellular senescence in aging. Cells become senescent constantly in the body, most because they hit the Hayflick limit on replication imposed upon the somatic cells that are the overwhelming majority of cells in our tissues. Cells can also become senescent because of damage, or encouraged into senescence by the signaling of other, nearby senescent cells. Once senescent, cells are normally quickly removed by the immune system or programmed cell death mechanisms, but the balance between creation and destruction is disrupted with age, allowing the number of senescent cells to grow. These cells secrete a […]

Скрыть анонс
15:03 Phys.org Endogenous ceramide phosphoethanolamine modulates circadian rhythm and longevity in Drosophila

The circadian clock entrains rhythmic patterns in behavioral and physiological processes to temporally coordinate systemic metabolism with the rising and setting of the sun. In previous investigation on human subjects, sphingomyelins (SMs) exhibited strong rhythmicity on an individual basis. However, the mechanistic connection between SM and circadian regulation remains unclear.

Скрыть анонс
14:24 Drugs.com Space Travel Speeds Up Aging, Weakening of Bones

THURSDAY, Aug. 4, 2022 -- Astronauts may go to space for weeks or months, and their bones can lose years in that environment. Long periods in space can irreparably damage bone structure and cause parts of the human skeleton to age as much as 10...

Скрыть анонс
04:31 News-Medical.Net The aging human brain

Researchers describe alterations at the molecular and cellular levels that underly brain aging in otherwise healthy elderly adults.

Скрыть анонс
03.08.2022
23:23 Phys.org Scientists identify key mechanism controlling skin regeneration

It's sunburn season. Many of us have experienced the pain and peeling that comes from unprotected time in the sun, but we may not focus on a remarkable and vital part of the process: the regeneration of skin as the damaged tissue is replaced with new.

Скрыть анонс
22:52 FightAging.Org Are Pharmacological Approaches to Slow Aging in Fact Promising?

Today's open access review paper looks over a selection of what I would consider to be largely unpromising small molecules, each with evidence for their ability to slow aging, but very modestly and unreliably in most cases. Looking at the bigger picture, for much of the public it is still surprising to hear that the pace of aging can be adjusted via any form of therapy, so there is probably a role for simple, low-cost small molecule drugs in the process of education that leads to more serious efforts aimed at producing the means of human rejuvenation. Still, entirely too much effort is devoted towards small molecules that have inconsistent animal data (such as metformin), and also small effect sizes (such as metformin), and further […]

Скрыть анонс
20:53 LiveScience.com Scientists revived the cells of pigs an hour after death, a potential organ transplant breakthrough

Scientists revitalized cells in the bodies of dead pigs.

Скрыть анонс
15:23 ExtremeTech.com Diablo Immortal Player Drops $100K, Becomes Too Powerful to Find a Match

One streamer spent big on Immortal, and he's "won" the game. His prize: being too overpowered to play with anyone else.  The post Diablo Immortal Player Drops $100K, Becomes Too Powerful to Find a Match appeared first on ExtremeTech.

Скрыть анонс
15:23 LiveScience.com Seven science-backed benefits of the Mediterranean diet

Could it be the healthiest diet in the world? Here are seven science-backed benefits of the Mediterranean diet

Скрыть анонс
14:33 Technology.org Can we rejuvenate aging brains?

Neuroscientist Tony Wyss-Coray, PhD, has spent 20 years unearthing and examining various molecules with neuroprotective and neurodegenerative properties. These

Скрыть анонс
13:22 FightAging.Org Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?

Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a look at the evidence for this effect on life span to be mediated by changes in the gut microbiome. The gut microbiome changes with age: the relative numbers of harmful microbes increasing, contributing to the chronic inflammation of aging, while relative numbers of beneficial microbes decreases, causing a reduction in metabolites known to help tissue function. Directly changing the gut microbiome to a more youthful configuration via fecal microbiota transplantation has been shown to improve health and extend life in laboratory species, so it is not unreasonable to hypothesize that some of the pharmaceutical approaches that slow aging act at least in part by adjusting […]

Скрыть анонс
07:12 News-Medical.Net Novel age predictor helps investigate heterogeneity in brain aging

A new research paper was published in Aging (abbreviated as "Aging (Albany NY)" by Medline/PubMed and as "Aging-US" by Web of Science) on the cover of Volume 14, Issue 14, entitled, "Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer's disease."

Скрыть анонс
01:33 ScienceMag.org With innovative bioreactor as womb, mouse stem cells transform into organ-filled embryos

Research team intends to to try same process with human stem cells

Скрыть анонс
01:05 DigitalTrends.com Brain-computer interfaces have been implanted in humans for the first time

Neuralink might make headlines but Synchron is the first to do human testing of its brain-computer interface in the United States.

Скрыть анонс
02.08.2022
22:22 FightAging.Org Aging and the Severity of Inflammatory Infectious Disease Such as SARS-CoV-2

Today I'll point out a couple of papers on the topic of why SARS-CoV-2 is so much more severe in the old. There has been a great deal of discussion about the age-related nature of COVID-19 mortality these past few years, though near entirely within the scientific community. The more severe cases involve runaway inflammation, and old people already suffer a raised level of chronic inflammatory signaling, making them that much more vulnerable to cytokine storm events in which the immune system runs wild to cause severe pathology and death. Sepsis is a similar problem, similarly age-related for reasons relating to increased vulnerability. It isn't just a higher base level of inflammatory signaling with age, however. Nor is it only inflammatory signaling coupled with immunosenescence, […]

Скрыть анонс
18:45 Yahoo Science Even simple exercise may help aging brain, study hints

The latest news and headlines from Yahoo! News. Get breaking news stories and in-depth coverage with videos and photos.

Скрыть анонс
16:53 Phys.org Newts unleashed: Limb muscle regeneration needs metamorphosis and body growth

Unknown to passersby, a modest little creature with amazing abilities lives and breeds in the forests and paddy fields of Japan. Now, researchers from Japan have discovered how these amphibians' superpowers are unleashed.

Скрыть анонс
13:32 FightAging.Org Complaining About the Remaining Unknowns in Aging, in the Context of the Hallmarks of Aging

This paper is, more or less, a complaint that the research community still knows far too little of the relative importance of different mechanisms of aging. That is fair enough, certainly true. The authors put that complaint in the context of the current prevalent attitude of using the hallmarks of aging as a checklist for development of therapies to intervene in aging, which in some cases (such as the dysregulation of nutrient sensing) is also fair enough. Not all of the hallmarks are evidently good places to intervene, as they are most likely far downstream of the causes of degenerative aging. That said, I do feel that the authors are deliberately ignoring the copious in vivo evidence for the efficacy of clearing senescent cells in […]

Скрыть анонс
01:21 CNN Health Cloning Fast Facts

Read CNN's Cloning Fast Facts and learn more about the process of creating a genetically identical copy of an original.

Скрыть анонс
01.08.2022
23:02 FightAging.Org Changes in the Behavior of Lipid Rafts in Aging

It is fair to say that everything changes with age, every aspect of cellular biochemistry. That doesn't mean that researchers can point to any specific change and say that it is important, however. It could be far downstream from underlying causes. It could be hard to fix in comparison to those causes. It may be shown to detrimentally affect a range of vital cellular processes, but those mechanisms could turn out to be minor and unimportant in comparison to others. The major challenge in aging research is exactly that everything changes. It is thus very hard to determine the importance of any given change, given that it takes place in this complex environment of interacting dysfunction, chains of cause and consequence, a network falling into […]

Скрыть анонс
31.07.2022
15:05 DigitalTrends.com Diablo Immortal on the iPhone SE is held back by one thing, but it’s not the screen

Surely the iPhone SE (2022)'s small 4.7-inch screen makes playing Diablo Immortal quite difficult? Surprisingly, it doesn't. But something else holds it back.

Скрыть анонс
14:52 FightAging.Org Fight Aging! Newsletter, August 1st 2022

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Considering the Longevity of Elephants Reviewing What is Known of the Longevity Gene INDY Mitrix Bio Works on the Production of Mitochondria for Transplantation Doubling Down on the Failure of Amyloid-β Clearance Efficient Epigenetic Clocks May Not Be Useful […]

Скрыть анонс
30.07.2022
21:13 Technology.org Progress toward a stem cell-based therapy for blindness

What if, in people with blinding retinal disorders, one could simply introduce into the retina healthy photoreceptor cells

Скрыть анонс
07:42 Rejuvenation Research Link Between Senescence and Cell Fate: Senescence-Associated Secretory Phenotype and Its Effects on Stem Cell Fate Transition

Rejuvenation Research, Ahead of Print.

Скрыть анонс
02:32 News-Medical.Net Researchers investigate the protection against meningococcal infection in hematopoietic stem cell transplant recipients

The team in the Hematology Department at Henri Mondor AP-HP Hospital, coordinated by Dr. Christine Robin, and scientists from the Institut Pasteur (the Invasive Bacterial Infections Unit led by Professor Muhamed-Kheir Taha) recently studied protection against meningococcal infection in patients who had received hematopoietic stem cell transplantation.

Скрыть анонс
01:22 News-Medical.Net Study examines the feasibility of patient engagement with digital life coaching during stem cell transplant

JMIR Publications recently published "Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study" in JMIR Formative Research which reported that the authors launched a single-arm pilot study to investigate the feasibility of patient engagement with digital life coaching (DLC) during this intensive period.

Скрыть анонс
29.07.2022
14:23 Phys.org Regenerating the poor soils of the southern EU countries and the Mediterranean

The European Union (EU) aims to be climate-neutral, with net-zero greenhouse gas (GHG) emissions, by 2050. Transforming the agricultural sector, which generates 11% (429 megatons of CO2-eq in 2019) of the EU's total GHG emissions, is vital, not only to mitigate climate change but also to guarantee food security in increasingly extreme environmental conditions. The EU's new common agricultural policy includes improvements in that regard but needs to be more ambitious. The Committee on Agriculture and Rural Development (AGRI) of the European Parliament therefore commissioned a report from experts to learn about the potential of the EU's agricultural soils to sequester carbon and how their capacity to do so can be increased.

Скрыть анонс
10:13 Technology.org Another byproduct of aging: Hypermutations in the brain

Genetic mutations in early development have been implicated in several psychiatric disorders such as autism and schizophrenia, symptoms

Скрыть анонс
07:42 News-Medical.Net Study investigates the combined effects of aging and HIV-1 Tat expression in mice

A new research paper was published in Aging ("Aging (Albany NY)" by Medline/PubMed, "Aging-US" by Web of Science) Volume 14, Issue 13, entitled, "Age-related neuroendocrine, cognitive, and behavioral co-morbidities are promoted by HIV-1 Tat expression in male mice."

Скрыть анонс
02:22 News-Medical.Net Weill Cornell Medicine-led consortium secures $14 million grant to study emerging technologies for aging adults

A Weill Cornell Medicine-led consortium has been awarded a five-year, $14.7 million renewal grant from the National Institute on Aging of the National Institutes of Health for a research Center focused on employing emerging and existing technologies to help promote the well-being, quality of life and independence of diverse populations of older adults and provide support for older adults with cognitive impairments.

Скрыть анонс
28.07.2022
16:53 Phys.org A key process in asymmetric cell division preserves the immortality of the germline

During cell division, chromosomes are replicated into two copies—one for each daughter cell. These copies, called sister chromatids, are usually considered identical. In fact, it's the two pairs of sister chromatids that make up the symmetrical X shape usually shown when visualizing chromosomes.

Скрыть анонс
14:03 Technology.org Biological Age, Not Birthdate May Reveal Healthy Longevity

A first-of-its-kind study of 1,813 older women suggests that the accelerated biological aging of the body — epigenetic

Скрыть анонс
13:31 FightAging.Org A Lipid Based Aging Clock

All biological data changes with age, and enormous sets of such data can be recorded with comparative ease these days. Any sufficiently large set of data can be processed via suitable machine learning approaches in order to produce clocks that correlate with biological age. Some are better than others, some appear to be more sensitive or less sensitive to certain aspects or processes of aging. At the end of the day, these efforts will likely prove useful, but so far they have yet to result in the ability to reliably and rapidly assess a potential rejuvenation therapy for its ability to slow or reverse aging. A clock will always deliver a number, but since the connection between the clock and underlying processes of aging remains […]

Скрыть анонс
12:03 Technology.org Genetic study provides evidence that alcohol accelerates biological aging

Traditionally, investigating this has been challenging due to the lack of reliable methods to measure biological aging. In

Скрыть анонс
01:42 News-Medical.Net Epigenetic age acceleration could be used as a biomarker to estimate functional and cognitive aging

A first-of-its-kind study of 1,813 older women suggests that the accelerated biological aging of the body -; epigenetic age acceleration specifically -; is associated with lower odds of living to be 90 years old and also being physically mobile and having intact mental function.

Скрыть анонс
00:36 QuantaMagazine.org Why Do We Get Old, and Can Aging Be Reversed?

Everybody gets older, but not everyone ages in the same way. In this episode, Steven Strogatz speaks with Judith Campisi and Dena Dubal, two biomedical researchers who study the aging process. The post Why Do We Get Old, and Can Aging Be Reversed? first appeared on Quanta Magazine

Скрыть анонс
27.07.2022
23:33 LiveScience.com 66-year-old likely cured of HIV after stem cell transplant

A patient entered remission from cancer and HIV after a transplant.

Скрыть анонс
18:10 SingularityHub.Com A Startup Is 3D Printing Bionic Arms for Ukrainians Injured in Conflict

Two years ago, prosthetics startup Unlimited Tomorrow launched TrueLimb, its next-generation bionic arm. Six years of research and development went into TrueLimb, and the technology has given hundreds of people in the US an affordable, non-invasive way to replace lost limbs. Now, a new initiative is taking TrueLimb to a part of the world where […]

Скрыть анонс
05:52 News-Medical.Net Study shows the efficacy of Yoga of Immortals mobile app for urinary incontinence

People with loss of urinary control who used the Yoga of Immortals mobile app – a globally used app that combines specific yogic postures in the Sanatan tradition with breathing exercises, sound therapy and meditation – found significant improvement in the frequency and severity of urine leaks at four weeks of practice, according to a Rutgers study.

Скрыть анонс
26.07.2022
23:10 ScienceDaily.com Study links insulin resistance, advanced cell aging with childhood poverty

A study linked childhood poverty and teens' beliefs about their life prospects with accelerated immune cell aging and greater levels of insulin resistance in young adulthood.

Скрыть анонс
22:22 FightAging.Org Reviewing What is Known of the Longevity Gene INDY

INDY was one of the earlier longevity-related genes to be robustly identified, a discovery made 20 years ago now. Much of the exploratory work on INDY was carried out in flies, though more than enough time has now passed for mouse data to have also emerged. The authors of today's review paper characterize the benefits resulting from a reduced expression of INDY as a calorie restriction mimetic effect, more or less. That is a fair enough shorthand for any approach that improves cellular maintenance processes in a way that modestly slows the aging process, resisting the accumulation of damage, dysfunctional cells, and chronic inflammation. Most of the ways known to slow aging in short-lived species are quite similar, viewed from the high level. Given that […]

Скрыть анонс
19:44 Drugs.com Want to Live Longer? Exercise Is Key, Study Confirms

TUESDAY, July 26, 2022 -- Middle-aged people could add years to their lives just by getting off the couch and going for a walk every day -- though it wouldn't hurt to do even more, a large new study suggests. The researchers followed over 100,000...

Скрыть анонс
13:32 FightAging.Org Inflammatory Pathways Triggered by the Aging Gut Microbiome Converge on NF-κB

While more knowledge is always a good thing in the long run, it is unclear as to what exactly can be done about age-related chronic inflammation in the near term with a better map of the regulatory processes that initiate, sustain, and suppress inflammation. The state of knowledge today strongly suggests that excessive, unwanted inflammation and necessary, important inflammation both run through the same systems of signaling between and within cells. Therapies based on interfering in more critical portions of that signaling can reduce inflammation, and indeed a number of such drugs already exist, but they have the serious side-effect of also interfering in the vital activities of the immune system. It seems likely that the practical way forward is to remove the causes of […]

Скрыть анонс
13:22 FightAging.Org An Omics View of the Inflammation of Aging

Aging is characterized by chronic inflammation, disruptive of cell and tissue function, a sizable contribution to the onset and progression of all of the common age-related conditions. The causes of this inflammation are known at the high level, such as the increasing presence of senescent cells and damage-associated molecular patterns, such as DNA debris from dead and dying cells. At the detail level, the real of genomics, transcriptomics, proteomics, and the other omics, much remains to be cataloged. There is the hope that a full map of inflammation in aging would point out more and better regulatory or signal molecules that could be targeted by therapies, but this type of approach has so far proven less effective than hoped, given the side-effects it produces. The […]

Скрыть анонс
01:11 News-Medical.Net Elevated insulin resistance, advanced cell aging associated with childhood poverty

Black adolescents who lived in poverty and were less optimistic about the future showed accelerated aging in their immune cells and were more likely to have elevated insulin resistance at ages 25-29, researchers found.

Скрыть анонс
25.07.2022
22:32 FightAging.Org Considering the Longevity of Elephants

Much of the recent research into the longevity of large mammals such as elephants has focused on Peto's paradox. If the odds of cancer are based on the number of cells in the body, all of which undergo stochastic and potentially cancerous mutations at some rate, then how is it that large mammals, with many times more cells in their body, do not exhibit a correspondingly larger risk of cancer? The answer being that for larger mammals to evolve at all, their cancer risk must be managed downward by changes in cellular biochemistry that reduce mutation rate or more efficiently destroy potentially cancerous cells. In elephants this appears to be achieved, in large part at least, by the 20-fold duplication of TP53, a cancer suppression […]

Скрыть анонс
22:00 ScienceDaily.com Researchers identify protein connected to aging and idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease caused by progressive scarring of the lungs, leading to respiratory failure and death. Therapies to treat IPF are limited, making studies on the mechanisms responsible for this crippling disease a priority. Now researchers have discovered a new mechanism linking the aging of blood vessels to the development of pulmonary fibrosis.

Скрыть анонс
21:45 Yahoo Tech Best Buy’s accessibility and aging lineup is shockingly vast

The latest news and headlines from Yahoo! News. Get breaking news stories and in-depth coverage with videos and photos.

Скрыть анонс
20:22 Rejuvenation Research Aqueous Extract from Astragalus membranaceus Can Improve the Function Degradation and Delay Aging on Drosophila melanogaster Through Antioxidant Mechanism

Rejuvenation Research, Ahead of Print.

Скрыть анонс
13:32 FightAging.Org Aubrey de Grey on Progress in SENS Rejuvenation Research

In this recent interview with Aubrey de Grey touches on a number of areas of progress made by the research and development community in recent years, projects that lead towards rejuvenation therapies based on the Strategies for Engineered Negligible Senescence (SENS). In the SENS view, supported by a very sizable literature accumulated over the past century, aging is caused by underlying processes of damage accumulation. What we think of as aging is a diverse collection of downstream consequences of that damage. Periodically repairing the underlying damage, allowing the normal maintenance of the body to continue as it would in youth, remains the most promising approach to aging. Senolytic drugs to clear senescent cells are one example of a rejuvenation therapy based on SENS, and in […]

Скрыть анонс
12:33 ExtremeTech.com Diablo Immortal Finally Launching in China After Mysterious Delay

Blizzard and its Chinese partners have reportedly been given permission to launch Immortal in China, which is the largest gaming market in the world. The post Diablo Immortal Finally Launching in China After Mysterious Delay appeared first on ExtremeTech.

Скрыть анонс
First← Previous12345678910Previous →