Regeneration
Minuscule lab-grown models of human brains can be fitted with caps that measure their activity, just as electroencephalogram (EEG) caps record electrical signals produced by full-size human brains. The minibrains are examples of organoids—three-dimensional clusters of living cells, grown in a lab, that simulate the structure and function of human organs so that researchers can…

Inventia Life Science and Xylyx Bio today announced their strategic partnership following promising results developing more realistic, scalable, and reproducible 3D cell cultures for drug discovery and biomedical research.

Believe it or not, the fish sticks available in the frozen food sections of most supermarkets actually do come from a dead animal. One day in the future though, that may no longer be true. Seafood made without the sea is gaining ground in the ever-growing “cultured meat” world. Read more...

It’s sunburn season. Many of us have experienced the pain and peeling from unprotected sun exposure. Still, we

It's sunburn season. Many of us have experienced the pain and peeling that comes from unprotected time in the sun, but we may not focus on a remarkable and vital part of the process: the regeneration of skin as the damaged tissue is replaced with new.

Unknown to passersby, a modest little creature with amazing abilities lives and breeds in the forests and paddy fields of Japan. Now, researchers from Japan have discovered how these amphibians' superpowers are unleashed.

The European Union (EU) aims to be climate-neutral, with net-zero greenhouse gas (GHG) emissions, by 2050. Transforming the agricultural sector, which generates 11% (429 megatons of CO2-eq in 2019) of the EU's total GHG emissions, is vital, not only to mitigate climate change but also to guarantee food security in increasingly extreme environmental conditions. The EU's new common agricultural policy includes improvements in that regard but needs to be more ambitious. The Committee on Agriculture and Rural Development (AGRI) of the European Parliament therefore commissioned a report from experts to learn about the potential of the EU's agricultural soils to sequester carbon and how their capacity to do so can be increased.

Two years ago, prosthetics startup Unlimited Tomorrow launched TrueLimb, its next-generation bionic arm. Six years of research and development went into TrueLimb, and the technology has given hundreds of people in the US an affordable, non-invasive way to replace lost limbs. Now, a new initiative is taking TrueLimb to a part of the world where […]

Combatting life-threatening bacterial infections, reducing slime that clogs pipes, preventing plaque buildup on teeth—all could one day benefit from a new technology being developed by Montana State University researchers.

With the discovery of synthetic stem cells, better known as induced pluripotent stem cells, the field or regenerative medicine has been revolutionized. These synthetic stem cells are created by reprogramming adult cells from patients, such as human skin cells, blood cells, or urine cells, toward a pluripotent state—a cell that can become any type of cell in the human body. When forced to be one type of cells, these cells can become tiny versions of organs known as organoids. For his Ph.D. research, Johnick van Sprang developed an artificial nano-environment using next-generation materials based on supramolecular interactions, to control and refine organoid maturation through biomechanical cues.

A new UC Davis-led study sheds light on cell type-specific biomarkers, or signs, of melanoma. The research was recently published in the Journal of Investigative Dermatology.

Ken Muneoka is no stranger to disrupting the field of regeneration; for example, in a 2019 ground-breaking publication in Nature, the Texas A&M University College of Veterinary Medicine & Biomedical Sciences professor proved for the first time that joint regeneration in mammals was possible.

Ken Muneoka is no stranger to disrupting the field of regeneration; for example, in a 2019 ground-breaking publication in Nature, the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVMBS) professor proved for the first time that joint regeneration in mammals was possible.

Researchers are challenging a centuries-old beliefs about how mammals might regenerate damaged parts of the body. In humans, the natural ability to regenerate is limited to tissues like the epidermis, the outermost layer of skin, and some organs, such as the liver. Other species, most notably salamanders, have the ability to regenerate complex structures such as bones, joints, and even entire limbs. As a result, scientists have been studying these species for more than 200 years to try to understand the mechanisms behind limb regeneration in the hopes of someday translating those mechanisms to induce more extensive regeneration in humans. That research has led to a common belief that the single biggest key for limb regeneration is the presence of nerves.

By tracing the steps of liver regrowth, MIT engineers hope to harness the liver’s regenerative abilities to help

Engineers have created a new liver tissue model that allows them to trace the steps involved in liver regeneration more precisely than has been possible before.

The Wake Forest Institute for Regenerative Medicine researchers who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells.

The Wake Forest Institute for Regenerative Medicine (WFIRM) researchers, who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells. In their latest published study, they focus on how telomerase activity affects the regenerative potential of these and other types of stem cells.

A joint research group led by Genki Kanda at the RIKEN Center for Biosystems Dynamics Research (BDR) has developed a robotic artificial intelligence (AI) system for autonomously determining the optimal conditions for growing replacement retina layers necessary for vision. The AI controlled a trial and error process spanning 200 million possible conditions that succeeded in improving cell culture recipes used in regenerative medicine. This achievement, published in the scientific journal eLife on June 28, is just one example of how the automated design and execution of scientific experiments can increase the efficiency and speed of life science research in general.

The human liver has amazing regeneration capabilities: Even if up to 70 percent of it is removed, the remaining tissue can regrow a full-sized liver within months.

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While lower vertebrates can repair their adult hearts after a heart attack, mammals -- including humans -- cannot. The ability to regenerate dead muscle tissue in mammalian hearts disappears just a few days after birth because the heart muscle cells, called cardiomyocytes, exit the cell cycle. In 2020, researchers reported that surgery to remove the left ventricle apex of the heart of pigs, one day after birth, somehow extended the replication ability of heart muscle cells. To better understand the underlying gene expression changes in this extended regeneration window, researchers now report nuclear RNA-sequencing of heart muscle cells, using this porcine model. From such knowledge, and much further research yet to come, clinicians may potentially learn how to regenerate adult heart cardiomyocytes after a heart attack.

The goal of the electronics industry has always been to build durable devices with stable performance that last a very long time. Self-destructing, transient electronics however, are designed with the exact opposite goal: to dissolve harmlessly into their surroundings after functioning for a predetermined amount of time. Researchers now demonstrate novel biodegradable, recyclable, conductive, flexible, and printable materials that can be applied across many electronic devices to serve as a cornerstone for the development of ecofriendly and recyclable electronics.

Researchers at the University of Houston are reporting a first-of-its-kind technology that not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction as its medically known.

Researchers are reporting new technology that not only repairs heart muscle cells in mice but also regenerates them following a heart attack, or myocardial infarction as its medically known.

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells at a lower cost.

Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth has seemed perpetually on the verge of success for a decade or so now; it has been achieved as a proof of concept in rats, for example. Restoration of dental pulp is a more viable, less complex project, given the present state of research into the use of scaffolds to provoke regrowth. Researchers have proposed an alternative to root canals in dentistry: restoring the lost tissue in the tooth cavity by inducing the body to regenerate it. Their goal is to develop a materials-based therapy that does not contain live cells and therefore could be sold off-the-shelf. It would be the first of its kind. The team has […]

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.

Heart attacks are damaging, and the severity depends on how long blood flow has been interrupted; when temporarily

A new study characterizes the role of fire refugia -- the green islands of live trees that remain after forest fires -- in forest regeneration following large and severe fires in the High Cascade mountains of Oregon and Washington. The results of this study can help determine when human intervention in the form of tree replanting is warranted, when it isn't, where replanting efforts should be targeted and what species should be prioritized. This is important to know since overplanting can be needlessly expensive and actually place forests at increased risk of future fires.

Each year, dentists in the United States perform more than 15 million root canals on infected teeth, removing the inflamed pulp and filling the emptied canal with inert materials such as rubber and cement. What remains is a mineral shell in place of a living tooth.

Thanks to climate change, high-elevation forests in the Central Cascade mountains of the Pacific Northwest are burning more frequently and expansively than in the recent past, prompting researchers and fire managers to question whether forests will be able to recover from these emerging fire patterns and whether they will require human assistance to do so.

Although 4D printing is considered very promising for various biomedical applications - such as tissue scaffolds, neural scaffolds, grafts and stents, cardiac patches and valves, even bionic constructs - its broad-scale adoption for clinical use and tissue engineering purposes is complicated by a notable limitation of printable smart materials and the simplistic nature of achievable responses possible with current sources of stimulation. Nevertheless, 4D printing may offer a more favorable fabrication approach over 3D printing, as 4D constructs can respond to internal and/or external stimuli.

Cultivated meat is made from animals cells, not livestock. Here's how it's made, where the US stands on approval and how it could affect human and environmental health.

Your chance of breaking a bone sometime within the next year is nearly 4%. If you're unlucky enough to need a bone replacement, it'll probably be based on a metal part.

Scientists are working toward establishing the Mexican salamander, or axolotl, as a laboratory model for the study of regeneration. With the ability to regenerate almost any body part, the axolotl is nature's champion of regeneration. The development of new tools to work with the axolotl is elevating it to the level of established research models and positioning the community of scientists who work with it for exponential growth.

Breast cancer and type 2 diabetes would seem to be distinctly different diseases, with commonality only in their commonality.

Tulane University researchers discovered a new mechanism that may explain why human kidneys, which are comprised of almost a

About 12 million people in the U.S., particularly those with diabetes, experience obstructed arteries in their limbs. This condition, known as critical limb ischemia, leads to reduced blood flow to...

Nerve tissue is not capable of significant regeneration in mammals, but the existing limited capacity for regrowth is further diminished with age. Researchers here show that one of the major classes of T cell of the adaptive immune system causes a meaningful fraction of this diminished regenerative capacity. Prevent these T cells from engaging with injured tissue and nerve regeneration is improved as a result, at least in mice. The approach used here may form the basis for an approach to greater recovery following injury in older people, and possibly even improved maintenance of nervous system tissue in later life. Axonal regeneration and neurological functional recovery are extremely limited in the elderly. Consequently, injuries to the nervous system are typically followed by severe and long-term […]

Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be consistently reproduced and are easily analyzed with limited patient specimens.

Heart progenitors spontaneously regenerate cardiac muscle via a tight junction “honeycomb” in salamanders. Whether there are endogenous adult

Warm temperatures strongly enhance the regeneration of thale cress shoots, plant scientists at RIKEN have found. They have also uncovered the molecular mechanism behind this effect, which will help optimize the regeneration of plant cuttings for both plant-science research and horticulture.

Whether there are endogenous adult heart progenitors that can replenish damaged muscle cells remained controversial. Now researchers at Karolinska Institute in Sweden show that the outermost layer of the heart, called epicardium, acts as a source of cardiac muscle cells through formation of an intriguing honeycomb-like structure.

Islet cell transplants are a promising treatment that can cure difficult-to-treat type 1 diabetes. The cells, taken from

Islet cell transplants are a promising treatment that can cure difficult-to-treat type 1 diabetes. The cells, taken from

Hopeful diabetes treatment, islet cell transplantation, is now one step closer to the clinic following new study.

A team develops a novel biomaterial that, when mixed with islets, allows islets to survive after transplant without the need for long-term immunosuppression.

Researchers at Karolinska Institutet, Germany’s Technical University of Munich (TUM), and AstraZeneca, among others, have identified a unique

Healing the heart: Moderna cofounder, researchers near ‘Holy Grail’ for heart regeneration gmasson Thu, 05/12/2022 - 18:26

Genetic studies have revealed many genes linked to both common and rare disease, but to understand how those genes bring about disease and use those insights to help develop therapies, scientists need to know where they are active in the body. Research on single cells can help achieve this goal, by surveying gene activity in specific cell types. Scientists need to profile all cell types and compare them across organs in the body to learn about the full range of human diseases, but this is difficult to do with existing methods. Now researchers have developed a robust experimental pipeline that can profile many more cell types from more tissues than can be studied with other techniques, as well as machine learning methods to put this data together and query the resulting map, or atlas.

Genetic studies have revealed many genes linked to both common and rare disease, but to understand how those genes bring about disease and use those insights to help develop therapies, scientists need to know where they are active in the body. Research on single cells can help achieve this goal, by surveying gene activity in specific cell types. Scientists need to profile all cell types and compare them across organs in the body to learn about the full range of human diseases, but this is difficult to do with existing methods.

The International Vaccine Institute (IVI) and SK bioscience announced today that SK bioscience obtained an export license from the Korean Ministry of Food and Drug Safety for SK's typhoid vaccine 'SKYTyphoid' which they jointly developed.

Salk scientists improve liver regeneration in mice, which could lead to new treatments for liver disease Mammals can’t

Most cellular meat startups focus on growing familiar foods (like beef and chicken) in a lab, but Primeval Foods has its sights set on something more exotic.

In an article recently published in ACS Applied Biomaterials, the authors summarized green nanocomposites and interpreted their uses in wound dressing and skin tissue engineering....

A group of researchers recently published a paper in the journal Nano Energy that demonstrated a novel strategy for the rapid generation of peripheral nerves using piezoelectric stimulation and...

While much of the focus on cell reprogramming these days is upon the ability of reprogramming factors to produce epigenetic and functional rejuvenation, there are other lines of research. Here, researchers show that short-term exposure to reprogramming factors can improve liver regeneration in mice. This is interesting, but as noted the liver is a very regenerative organ in comparison to other mammalian tissues, and the mechanisms of regeneration may be distinct from other tissues. Thus the ability to improve regeneration in the liver via reprogramming may or may not generalize to other organs. Researchers previously showed how four cellular reprogramming molecules Oct-3/4, Sox2, Klf4, and c-Myc, also called "Yamanaka factors", can slow down the aging process as well as improve muscle tissue regeneration capacity in […]

Age-related deafness is caused by some mix of loss of sensory hair cells of the inner ear, and loss of connections between those cells and the brain. A range of potential approaches to restore those cells are under development, and the work here is an example of this sort of work. Researchers have constructed an AAV viral vector that has some specificity for hair cells and nearby supporting cells, and which can be used to deliver a gene therapy payload that converts those supporting cells into new hair cells. Cells of the cochlea, such as hair cells (HCs) and supporting cells (SCs), are essential for hearing. While sensorineural hearing loss can result from genetic mutations in both HCs and SCs, non-genetic stresses, such as noise, […]

Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states-;allowing them to heal damaged tissue at a faster rate than previously observed.

Using lipidomics, a modern analytical method, researchers identified those lipids that are statistically associated with cardiovascular disease and type 2 diabetes. In addition, the scientists found that a diet with an increased proportion of unsaturated fatty acids leads to a reduction in risk-associated lipids and an increase in low-risk lipids.

Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, scientists have found a way to partially reset liver cells to more youthful states -- allowing them to heal damaged tissue at a faster rate than previously observed. The results reveal that the use of reprogramming molecules can improve cell growth, leading to better liver tissue regeneration in mice.

With the growing demand for new applications in tissue regeneration, the functionalization of melt electrowritten scaffolds has gained the attention of researchers in recent years to fulfill the needs...

Switching to "novel foods", like algae and lab-grown milk, could bring huge environmental benefits compared with the typical European diet

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In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

In proof-of-concept experiments, scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

Modern agriculture was broken long before pandemics, wars, supply chain disruptions and fertilizer shortages. Regenerative agriculture can fix that, and data can help

Killifish are one of the species capable of scar-free regeneration of organs following injury, a capability that researchers suspect exists in humans and other mammals, suppressed after early development, but accessible given the right manipulation of genetic controls, yet to be discovered. The study here notes that killifish appear to lose this capability in later life. Having a species that exhibits both proficient and limited regeneration under different circumstances may point the way towards specific genes and mechanisms relevant to the goal of enabling proficient regeneration in human patients. Or it may be entirely irrelevant to inter-species differences, a peculiarity unique to killifish. The only way to find out is to follow the thread and see where it leads. Over the recent years, the fast-aging […]

As demand for alternative protein sources grows, Australians are increasingly looking for options that are healthy, sustainable and ethically made.

A study led by Prof. Qiuyu Zhang (Northwestern Polytechnical University), Prof. Ki-Bum Lee (Rutgers University), and Prof. Liang Kong (School of Stomatology, The Fourth Military Medical University) has established an injectable hybrid inorganic (IHI) nanoscaffold-templated stem cell assembly and applied it to the regeneration of critically-sized cartilage defects.

A new strategy in tissue engineering has been developed: Tiny spherical microscaffolds are created in a high precision 3D printer. They are cultivated with living cells and then assembled. The cells keep multiplying, creating a tissue, the scaffolds are eventually degraded.

Large granular lymphocyte (LGL) leukemia is a rare type of blood cancer. Like many other types of cancer,

Until now, there have been two completely different approaches to producing artificial tissue. A third approach has now been developed that combines the advantages of both.

Until now, there have been two completely different approaches to producing artificial tissue. At TU Wien, a third approach has now been developed that combines the advantages of both.

Large granular lymphocyte (LGL) leukemia is a rare type of blood cancer. Like many other types of cancer,

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

Researchers engineered the first injectable microtissue containing motor and sensory neurons encased in protective tissue, called tissue engineered neuromuscular interfaces (TE-NMIs).

Big Pharma partnerships, record $22.7B investment raise profile of regenerative medicine in 2021 aarmstrong Tue, 04/05/2022 - 13:56

London headquartered PLP Architecture has unveiled a masterplan for a 1.1 million sq m redevelopment of the Uchisaiwaicho 1-Chome district of Tokyo, acting as the master designer and placemaking strategist… The post PLP unveils designs for Tokyo’s biggest regeneration scheme appeared first on Global Construction Review.

Researchers at Weill Cornell Medicine have identified a key protein that induces the program to build specialized liver

A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania.

Researchers at Rutgers University working on U.S. National Science Foundation grants have stabilized an enzyme that can reverse and regenerate tissue damage from

A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered.

Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by

Stem cells can develop into many different types of cells in the body. For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. New nanotechnology developed by a team of researchers from Texas A&M University could leverage the body's regenerative potential by directing stem cells to form bone tissue.

Stem cells can develop into many different types of cells in the body. For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. New nanotechnology could leverage the body's regenerative potential by directing stem cells to form bone tissue.

New nanotechnology could leverage the body's regenerative potential by directing stem cells to form bone tissue.

Mehmet Asim Bilen, MD weighs in on various biomarker testing methodologies, sample considerations, and emerging data on novel biomarkers.


MIT spinout Frequency Therapeutics’ drug candidate stimulates the growth of hair cells in the inner ear. Most of

Sens. Diagn.DOI: 10.1039/D1SD00041A, Perspective Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert D. Crapnell, Alejandro Garcia-Miranda Ferrari, Nina C. Dempsey, Craig E. BanksHerein we review the use of electrochemical point-of-care SPE-based sensor technologies towards the detection of vital, established biomarkers related to cardiac injury, cancer diagnostics and acute inflammatory conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Strings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of their versatile and environmentally

Two clinically available drugs have shown promise in restoring the regenerative capacity of mouse lung cells, suggesting they could be used to treat chronic obstructive pulmonary disease

Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases. Yet,

To accurately diagnose and treat diseases, doctors and researchers need to see inside bodies. Medical imaging tools have come a long way since the humble x-ray, but most existing tools remain too coarse to quantify numbers or specific types of cells inside deep tissues of the body.
