DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived

Expert panelists elucidate the occurrence of graft vs host disease in patients receiving either stem cell or allogeneic transplantation.

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

Research with stem cells is becoming increasingly important, because stem cells can develop into any body cell—skin cells, nerve cells or organ cells such as liver cells, the so-called hepatocytes. Stem cells can therefore be used, for example, in therapy for organ damage or as an alternative to animal experiments.

For the first time, researchers can get a high-resolution view of single blood stem cells thanks to a

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

For the first time, researchers can get a high-resolution view of single blood stem cells thanks to a little help from microscopy and zebrafish.

Cell membrane-coated nanoparticles, applied in targeted drug delivery strategies, combine the intrinsic advantages of synthetic nanoparticles and cell membranes. Although stem cell-based delivery...

Imagine if one day blood transfusions from strangers were not needed because they could be produced from cells that line your own blood vessels' cells.

Cold atmospheric plasma can affect cell adhesion with a significant role in stem cell adhesion. In a new study now published in Scientific Reports, Kobra Hajizadeh and a team of researchers in the departments of physics and plasma research at the Islamic Azhad University and the CNRS, France, studied the effect of plasma treatment on human bone marrow mesenchymal stem cell (HBMMSC) adhesion to understand cell differentiation and cell fate.

A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair.

Research team intends to to try same process with human stem cells

What if, in people with blinding retinal disorders, one could simply introduce into the retina healthy photoreceptor cells

Rejuvenation Research, Ahead of Print.

The team in the Hematology Department at Henri Mondor AP-HP Hospital, coordinated by Dr. Christine Robin, and scientists from the Institut Pasteur (the Invasive Bacterial Infections Unit led by Professor Muhamed-Kheir Taha) recently studied protection against meningococcal infection in patients who had received hematopoietic stem cell transplantation.

JMIR Publications recently published "Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study" in JMIR Formative Research which reported that the authors launched a single-arm pilot study to investigate the feasibility of patient engagement with digital life coaching (DLC) during this intensive period.

A patient entered remission from cancer and HIV after a transplant.

To act as a robust barrier against pathogens while also absorbing needed nutrients, the lining of the intestines must regenerate on a daily basis to remain equal to the task.

Our bodies have evolved formidable barriers to protect themselves against foreign substances—from our skin, to our cells and every component within the cells, each part of our bodies has protective layers. These defenses, while essential, pose a significant challenge for pharmaceutical drugs and therapies, such as vaccines, that have to bypass multiple barriers to reach their targets.

The potential of stem cell therapy still lies ahead. The only outcome reliably achieved to date in human medicine is the reduction of chronic inflammation via transplantation of mesenchymal stem cells. The real goal for this field is, however, the replacement and enhanced performance of specific stem cell populations in order to produce regeneration that does not normally take place, or to restore youthful tissue maintenance in the old. That remains to be achieved in anything more than a preliminary way in even the most well studied stem cell populations, those of muscle, brain, and bone marrow. In murine models, there have been some therapeutic successes reported when aged systems have an influx of stem cells with restored or robust function. One such study showed […]

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind roadmap detailing how stem cells become sensory interneurons—the cells that enable sensations like touch, pain and itch.

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind roadmap detailing how stem cells become sensory interneurons -; the cells that enable sensations like touch, pain and itch.

Researcher Dhruv Sareen's own stem cells are now orbiting the Earth. The mission? To test whether they'll grow better in zero gravity.

Scientists have discovered only a handful of genes responsible for stem cell self-renewal, a property that allows stem cells to continue giving rise to a variety of cell types during an organism's lifespan. Now, a team has identified a new stem cell self-renewal factor, one essential for mice to produce sperm throughout their adult lives.

Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.

AL amyloidosis is a life-threatening disease related to bone marrow cancer, multiple myeloma. It is caused when a person's antibody-producing white blood cells (i.e. plasma cells) do not function properly and generate abnormal protein which misfolds to form amyloid fibrils and deposits made of components of antibodies called light chains, which then deposit in various organs of the body.

Stem cells are a hot topic for creating medical treatments. However, scientists still do not fully understand how they choose to divide or differentiate to renew organs. Researchers have now found a new biophysical mechanism that regulates stem cells in the intestines of mice. There, a stem cell is not purely defined by intrinsic molecular markers but also by their location and movements in their environment. This could have implications for possible new treatments.

Your gut is a wondrous place. A special layer of cells that coats the insides of your small and large intestines takes in nutrients and water from what you ate while keeping anything bad out of your system.

The extracellular matrix is constructed and maintained by cells, and provides structural and other support to the cell populations of a tissue. The extracellular matrix changes with age, and is of great importance to tissue function, but the details of extracellular matrix aging do not receive anywhere near the attention given to the biochemistry of cells. The arrangement of molecules of the extracellular matrix determines the structural properties of tissue, and changes such as cross-linking alter that in harmful ways, such as by reducing the elasticity of skin and blood vessel walls. It is more than just structure, however. Countless molecules in the extracellular matrix are recognized by cells and their presence or absence changes cell behavior, just like other forms of cell signaling. In […]

In a new study in Cell Stem Cell, scientists from the USC laboratory of Andy McMahon generated simple kidney-like structures called

Bioengineers have shown that a new strategy can restore damaged stem cells and enable them to grow new tissues again. The new drug delivery system could help infants born from complicated pregnancies.

A new strategy can restore damaged stem cells and enable them to grow new tissues again.

Within a newborn's umbilical cord lie potentially life-saving stem cells that can be used to fight diseases like lymphoma and leukemia. That is why many new parents elect to store ("bank") their infant's stem cell-rich umbilical cord blood. But in the 6–15% of pregnancies affected by gestational diabetes, parents lack this option because the condition damages the stem cells and renders them useless.

A new stem cell study by KAUST researchers helps to explain a rare genetic disease called Wiskott-Aldrich syndrome (WAS), yielding molecular clues that could lead to new treatments for a devastating immune deficiency disorder. The results are published in Nature Communications.

Lab-grown human heart cells provide a powerful tool to understand and potentially treat heart disease. However, the methods

Unlike women, who are born with all the eggs they’ll ever have, men can continue to produce sperm

The Wake Forest Institute for Regenerative Medicine researchers who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells.

The Wake Forest Institute for Regenerative Medicine (WFIRM) researchers, who were the first to identify that stem cells in human urine have potential for tissue regenerative effects, continue their investigation into the power of these cells. In their latest published study, they focus on how telomerase activity affects the regenerative potential of these and other types of stem cells.

Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.

Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.

Throughout one's life, the blood is constantly being replenished from blood stem cells. However, these cells lose their functionality in old age. Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) have now found a gene mechanism that is responsible for the aging of hematopoietic stem cells. The gene Igf2bp2 is important in youth for the full function of these cells, as it activates their growth and metabolism. When the gene is missing, however, the aging-associated loss of function of the stem cells is surprisingly diminished. The eventual aging of hematopoietic stem cells is apparently already preprogrammed by their gene-driven growth in youth.

Reseachers here demonstrate that engineering the mesenchymal stem cells provided in a cell therapy to overexpress HIF1α produces regeneration in a pig model of heart failure. The mechanisms involved are up for debate, as they may or may not involve an extension of survival of the stem cells following transplant, versus a shift in cell signaling. Mesenchymal stem cells do not survive long in most such treatments, and their beneficial effects are the result of signals secreted in the short time they are present in tissues. Given the feasibility of engineering cells in vitro in any number of ways, this is a logical next step for the industry, now that first generation cell therapies are so well established. Recent preclinical investigations and clinical trials with […]

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.

Swedish court gives Paolo Macchiarini, once hailed as a pioneer in regenerative medicine, a suspended sentence

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors.

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells at a lower cost.

Recent work from Carnegie's Chenhui Wang and Allan Spradling reveals a surprising capability of renal stem cells in fruit flies—remodeling. Their work, which could eventually guide kidney stone treatments, was published by Science Advances.

Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.

As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems.

Imagine if you could repair damaged tissue in your organs. That is what stem cell research is working towards, because stem cells have tremendous potential to produce the cells of organs such as the liver, pancreas and intestine.

Scientists have tested and confirmed a protocol for growing human embryonic stem cells into retina cells to treat eye diseases such as age-related macular degeneration.

Using a mouse model, researchers have deciphered an alternative route that certain cells take to make organs and used that knowledge to exploit a new type of stem cells as a potential source of organs in a dish.

Germline stem cells (GSCs), originating from primordial germ cells (PGCs) during embryogenesis, are a group of unique adult stem cells in gonads that are essential to genetic information transfer.

Chronic inflammation disrupts tissue function throughout the body, contributing to the onset and progression of age-related conditions. One of the wide variety of ways in which this happens is via detrimental changes in stem cell populations and their activities. Researchers here focus down on mesenchymal stem cells in bone marrow as one example of many that might be considered. That senescent cells act to maintain an inflammatory environment is one of the reasons why removal of senescent cells produces profound and rapid rejuvenation in animal studies. More methods of cleanly reducing chronic inflammation with minimal side-effects are very much needed, a necessary part of the toolkit of rejuvenation therapies presently under development. Mesenchymal stem cell (MSC) senescence is considered a contributing factor in aging-related diseases. […]

An investigative stem cell-based therapy called PEC-Direct, designed to act as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes, suggests a clinical study presented Saturday, June 11 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

Stem cell models of the retina and optic nerve have been used to identify previously unknown genetic markers

A girl with a rare disorder can now breathe more easily after receiving transfusions of a liquid that her sister's umbilical cord stem cells were grown in

Stem cells are essentially our body's raw materials—cells that give rise to all other cells and tissues with specialized functions. The conversion into specific cells occurs through a process called "differentiation," in which stem cells divide to form daughter cells. This lends itself to practical applications in regenerative therapy, where functional healthy cells generated from stem cells can be used to cure injuries and cellular damages in our body.

A new, detailed genetic roadmap of glaucoma will help researchers develop new drugs to combat the disease, by identifying potential target areas to stall or reverse vision loss.

Stem cell models of the retina and optical nerve have been used to identify previously unknown genetic markers of glaucoma, in research jointly led by scientists from the Garvan Institute of Medical Research, the University of Melbourne, and the Centre for Eye Research Australia.

Fasting sends muscle stem cells into a deep resting state that slows muscle repair but also makes them more resistant to stress, according to a Stanford Medicine study of laboratory mice.

Axol Bioscience Ltd. (Axol), an established provider of iPSC-derived cells, media, and characterization services for life science discovery, today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation.

Fasting sends muscle stem cells into a deep resting state that slows muscle repair but also makes them more resistant to stress, according to a Stanford Medicine study of laboratory mice.

Patients with multiple myeloma who have been treated with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study led by researchers at Dana-Farber Cancer Institute can help patients and their physicians weigh benefits and risks of each option.

A second patient who received Vertex's VX-880 has experienced glycemic improvements, whereas the first one is completely insulin-independent.

Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

Researchers have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

Scientists at the University of Toronto and Sinai Health say they have identified a new way to control

Fat could hold key to stem cell treatments for Parkinson's disease mbayer Fri, 05/27/2022 - 12:18

View CNN's Fast Facts about stem cells and learn more about these unspecialized cells capable of replicating themselves through cell division.

Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division. These changes occur at a high level of accuracy to prevent genome instability. Genome instability resulting from broken, missing, or rearranged chromosomes has been found to be the root cause of cell death, carcinogenesis, and congenital disorders. Studying genomic instability helps researchers identify the causes of cancer and may lead to new advancements in their diagnosis and treatment.

Two nationally recognized experts in cloning and stem cell science from the University of Houston are taking the first step toward limiting the consequences of chronic inflammation in cystic fibrosis (CF) by identifying the source of this persistent and enigmatic inflammation in CF lungs.

When researchers used sound to levitate stem cells, they found that the cells formed into spheres. The method could be used for growing tissues for transplants

Not an 'excellent outcome' for Athersys stock as stem cell therapy misses endpoint in Japanese trial jwaldron Fri, 05/20/2022 - 09:45

In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. This silencing is critical, yet how it happens has been relatively mysterious. Two new U-M studies reveal more about this silencing process and insights that could improve stem cell research.

In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of their cells. To avoid a double dose of X-linked genes in females, one of the Xs is silenced early in the developmental process. This silencing is critical, yet how it happens has been relatively mysterious. Two new studies reveal more about this silencing process and insights that could improve stem cell research.

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Investigators have devised a novel therapeutic method for treating glioblastomas post-surgery by using stem cells taken from healthy donors engineered to attack GBM-specific tumor cells. This strategy demonstrated profound efficacy in preclinical models of GBM, with 100 percent of mice living over 90 days after treatment.

Synthetic biology experiments suggest a “MultiFate” model for how genetically identical cells become the many different types found in complex organisms like us. The post Simple Gene Circuits Hint at How Stem Cells Find New Identities first appeared on Quanta Magazine

Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90 percent of GBM tumors return after being surgically removed, despite surgery and subsequent chemo- and radiation therapy being the most successful way to treat the disease.

Investigators uncovered a diagnostic method to identify receptors on cancer cells in the blood, then engineered a cell-based therapy to target and kill tumor cells in the brain, paving the way to clinical testing.

Stem cells that give rise to the mouse yolk sac have been isolated and cultured in the lab for the first time by RIKEN researchers, raising the possibility of artificially creating mouse embryos from stem cells in the future.

Creating the industry’s first stem cell analysis update in nearly 25 years, Beckman Coulter Life Sciences – a global leader in laboratory automation and innovation – launches an evolution of the gold standard in hematopoietic stem cell enumeration, the AQUIOS STEM System.

By turning off a single gene, University of Virginia researchers and their collaborators caused stem cells already becoming

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a new study, a finding that has important implications for brain health and future therapies for brain disorders.

Age-related decline in stem cell function is an important contributing cause of aging, and cellular senescence in stem cell populations and their supporting cells is a feature of this process. Mesenchymal stem cells are a well studied population that is not only relevant to tissue function but also widely used as a basis for stem cell treatments. These therapies also face challenges due to declining cell function and the onset of cellular senescence, occurring when stem cells are cultured and expanded for use in therapy. Aging is a multifaceted and complicated process, manifested by a decline of normal physiological functions across tissues and organs, leading to overt frailty, mortality, and chronic diseases, such as skeletal, cardiovascular, and cognitive disorders, necessitating the development of practical therapeutic […]

Google announced Monday it will allow ads for stem cell treatments approved by the Food and Drug Administration to appear in search results starting in July. The tech giant previously banned any ads for stem cell therapies, FDA-approved or otherwise. Read more...

Northwestern Medicine scientists have identified critical regulatory processes that govern differentiation in embryonic stem cells, according to a study published in the Proceedings of the National Academy of Sciences.

Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes.

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A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. Scientists at IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, demonstrate that these functions are two sides of the same coin. Upon injury, one molecular switch is enough to propel the stem cells from one state to the other. The findings, now published in Cell Stem Cell, could be instrumental in improving our understanding of gastric pathologies.

A group of rare diseases called ciliopathies -- polycystic kidney disease notable among them -- emerge from defects in cilia. These are the tiny hairlike structures on the surface of almost every cell type. Scientists experimentally 'knocked out,' or genetically deleted, the cilia in a population of otherwise normal human pluripotent stem cells. Subsequently, human tissues and mini-organ structures (organoids) derived from these cilia-free stem cells manifested ciliopathy-like symptoms, such those seen in polycystic kidney disease or in certain problems in brain development.

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

Sleep deprivation, which means getting too little high-quality sleep, is a serious health problem. More than one-third of people in the USA report getting less than the recommended minimum of seven hours sleep per night.

Blood-forming stem cells found in bone marrow are the life-saving component used in bone marrow transplants. However, suitable donors cannot be found in many cases. A new study reveals how the human embryo develops the precursor to blood-forming stem cells, which researchers say can be used in the novel method they developed to generate blood-forming stem cells from cells in a tissue culture.